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All Journal Nexus Kedokteran Komunitas Nexus Biomedika Nexus Kedokteran Translasional Nutriology: Jurnal Pangan, Gizi, Kesehatan Proceeding of International Conference Health, Science And Technology (ICOHETECH)
Ratih Puspita Febrinasari
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Health Professions Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health

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Screening Effectiveness of The Leaf Extract of Psidium guajava, Euphorbia hirta, and Piper betle L. as Antidengue AGYA GHILMAN FAZA; Hudiyono .; Ratih Puspita Febrinasari
Nexus Biomedika Vol 5, No 1 (2016): Nexus Biomedika
Publisher : Nexus Biomedika

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Introduction: Dengue Hemorrhagic Fever (DHF) is an infectious disease caused by dengue virus which commonly found in the tropic and sub-tropic region. Nowadays, the main treatment of DHF is supporting therapy by giving a replacement fluid. However, the number of cases and deaths due to dengue infection in Indonesia still high enough. Another solution to fix this problem is using Indonesians native plants which potentially has antiviral effect for dengue virus, such as guava leaf (Psidium guajava), patikan kerbau leaf (Euphorbia hirta), and betel leaf (Piper betle L.). The aim of this study is to determine the effectiveness of the leaf extract of guava (Psidium guajava), patikan kerbau (Euphorbia hirta), and betel (Piper betle L.) as antidengue in vitro. Methods: This study was laboratory experimental research. The subject of this research was dengue virus serotype 2 strain New Guinea C (DENV2 NGC) which was infected into Huh-7 cell line. The study was held in two places, they were Virology and Biology Molecular Laboratory, Department of Microbiology, Faculty of Medicine, University of Indonesia and Pharmaceutical Laboratory, Faculty of Mathematic and Science, Sebelas Maret University. The study was conducted in 2 parts. First, dengue virus solution was mixed with herbal extract in well which its bottom contained Huh-7 cell monolayer to obtain percent infectivity by FFU assay. Second, Huh-7 cell monolayer was exposed to the herbal extract solution to obtain percent viability by MTT assay. The effectiveness of herbal extract was based on two criterias, there were average percent infectivity 20% and average percent viability > 50%. Results: The leaf extract of Psidium guajava, Euphorbia hirta, and Piper betle L. have average percent infectivity respectively: 7.4%, 65.3%, and 68.4%. While the average percent viability of them were: 88.7%, 95.3%, 96.2%. Conclusion: The leaf extract of Psidium guajava is effective as antidengue in vitro. Keywords: Psidium guajava, Euphorbia hirta, Piper betle L., dengue virus serotype 2 strain New guinea C (DENV2 NGC), Huh-7 cell
Uji Sitotoksik Ekstrak Curcumin Pada Kultur Sel Limfosit T Penderita Systemic Lupus Erythematosus (SLE) Hanif Mustikasari; Ratih Puspita Febrinasari; . Widardo
Nexus Biomedika Vol 2, No 1 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: Systemic lupus erythematosus (SLE) is an autoimmune disease that causes chronic inflammation in multiorgan, in which its etiology and pathogenesis are unclear. Curcumin has been found to have a selective cytotoxic effects on various types of cancer cells through induction of apoptosis on the various pathways. This study aimed to demonstrate whether curcumin extract had cytotoxic effects on T lymphocytes autoreactivity of patients with SLE. Methods: This research was an experimental laboratory with post test only controlled group design. Samples were using cell cultures of T lymphocytes from the veins blood of a patient with SLE and normal people. Each of T lymphocytes cell culture consisted of media control (KM), cells control (KS), the positive control with cyclophosphamide (KP1), and a group treated with curcumin extract (KP2). Curcumin extracts and cyclophosphamide were divided into 8 serial doses (50 g/mL, 25 g/mL, 12.5 g/mL, 6.25 g/mL, 3.125 g/mL, 1.5625 g/mL, 0.78125 g/mL, 0.390625 g/mL). Cell inhibition was calculated based on a percentage (%) of cell viability. Then, the data was analyzed using probit analysis to determine the dose of IC50 with SPSS for Window Release 17.0. Results: The result of cell inhibition probit analysis (IC50) on T lymphocytes cell culture of patients with SLE using curcumin extract was active (score 3) and T lymphocytes cell culture of patients with SLE using cyclophosphamide was moderately active (score 2).While, T lymphocytes cell culture of normal people using curcumin extract was active (score 3) and T lymphocytes cell culture of normal people using cyclophosphamide was moderately active (score 2). Conclusions: Curcumin extract had cytotoxic effect on T lymphocytes cell culture of SLE. The cytotoxic effect of curcumin extract on T lymphocytes cell culture of patients with SLE was stronger than cyclophosphamide. Keywords: curcumin extract, cytotoxic, SLE
The Protection Effect of Centella asiatica L.Urban extract on the Kidney Histological Structure of Mice (Mus musculus ) induced by toxic doses of paracetamol Berlian Permata Sakti; Muthmainah .; Ratih Puspita Febrinasari
Nexus Biomedika Vol 4, No 1 (2015): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: Centella asiatica L.Urban contains antioxidant compounds such as triterpenoid, essential oil and flavonoid. The compounds have significant activities to reduce oxidative stress that can make damage of kidney cells. This study aimed to investigate protection effect of Centella asiatica L.Urban extract on the kidney histological structure of mice (Mus musculus ) induced by toxic doses of paracetamol. Method: This study was an experimental laboratory research. Samples were 30 mice, Swiss webster type, 2-3 weeks old and 20 grams of weight. Samples were divided into 5 groups, each group consisted of 6 mice (Mus musculus). The control group (KK) was given no treatment, just regular feed. Induction group (KI) was induced by paracetamol but did not get any treatment, just got distilled water. KP1, KP2, and KP3 groups induced by paracetamol got treatment with Centella asiatica L.Urban extract at a dose of 5 mg, 10 mg and 20 mg per 20 gram of body weight. Kidney histological damage were assessed by the sum of the cell nucleus pyknosis, karyorrhexis, and karyolysis. Data were analyzed using one-way ANOVA and post hoc multiple comparison test. Result: The ANOVA test for all groups showed that p value was 0.000 (p < 0.05). The post hoc multiple comparisons test showed the significant differences between group KK-KI, KK-KP1, KK-KP2, KK-KP3, KI-KP1, KI-KP2, KI-KP3, KP1-KP2, KP1-KP3, and KP2-KP3. Conclusion: Centella asiatica L.Urban extract has a protection effect to kidney histological structure of mice (Mus musculus) induced by paracetamol. Keyword : Centella asiatica L.Urban, paracetamol, kidney damage.
The Influence of Broccoli Extract (Brassica oleracea var. Italica) to Liver Cells Damage in Mice (Mus musculus) Induced by Paracetamol Shinta Retno Wulandari; Endang Listyaningsih Suparyanti; Ratih Puspita Febrinasari
Nexus Biomedika Vol 5, No 2 (2016): Nexus Biomedika
Publisher : Nexus Biomedika

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Introduction : Broccoli is known to contain antioxidants such as vitaminC, flavonoids and sulforaphane. Antioxidants can protect liver from damage caused by free radicals. This study aims to prove that broccoli extract protect liver cell from damage in mice induced by paracetamol in toxic dose and an increased doses of broccoli extract enhance the effects of protection to liver cell in mice. Methods : This study was an experimental laboratory with post test only controlled group design. Samples (30 mice) were taken by incidental sampling. Samples divided randomly into 5 groups, each group consisted of 6 mice. K1 was given distilled water. K2 was given paracetamol in toxic dose. KP1, KP2 and KP3 were given broccoli extract dose I, II and dose III respectively for 14 days and also were given paracetamol in toxic dose on day 12, 13 and 14. On day 15, the livers of mice were taken for making preparations with HE staining. The liver cell damages were observed by counting the nuclei of cells undergoing pyknosis, karyorrhexis and karyolysis. Data were analyzed by Oneway ANOVA and Post Hoc LSD analysis test (? = 0.05). Result : K2 had the most damaged cells (157.17 7.834 cells) and the least damaged cells were at K1 (1.50 1.049 cells). Oneway ANOVA test result was p = 0.00 (p < 0.05). Result of Post Hoc LSD analysis test showed a significant difference between groups on all pairs with p = 0.00 (p < 0.05). Conclusions : Broccoli extract protect liver cells from damage in mice induced by paracetamol. Increased doses of broccoli extract were proven to increase the protection effect on liver cells. Keywords: broccoli extract, paracetamol, liver cell damage
Quality and Efficiency of Health Services in The Implementation of Electronic Medical Records: Bibliometric Analysis Maryati, Warsi; Hartono, Hartono; Puspita Febrinasari, Ratih
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2024: Proceeding of the 5th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/icohetech.v5i1.4252

Abstract

Background: Electronic medical records (EMR) were growing rapidly because they were believed to improve the quality and efficiency of health services. Literature studies related to EMR have been carried out, but the bibliometric analysis was not yet known. This study aimed to analyze the bibliometrics of research related to EMR and its impact on quality and patient care. Methods: We have carried out bibliometric analysis using VOS viewer and Mendeley on articles from the Scopus database for 2014-2023. Articles have been filtered based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) diagram. We used the keywords electronic medical records, quality and efficiency to search for articles. Articles that were not in English, could not be downloaded in full text and were not related to quality or efficiency were excluded. Articles that met the criteria were analyzed. Results: We obtained 24 articles from the screening results. Most articles in 2020 (6), there was a significant increase in 2019 (4). Most articles have been published in Journal of Medical Internet Research (3). The International Journal of Medical Informatics received the most citations (160 from 2 articles). There were 8 research articles from the United States. The most frequently used keywords were electronic medical record(s). Meanwhile, the issues most commonly associated with the implementation of EMR include; quality improvement, health care quality, patient satisfaction, and cost. Conclusion: Bibliometric analysis was important to carry out in future research to map the characteristics of research with wider data sources.
Efektivitas Soygurt Kacang Hijau Sari Kurma sebagai Terapi Adjuvan pada Tikus Diabetes Tipe 2: Sebuah Studi Eksperimental Jannah, Miftakhul; Setyo Sri Rahardjo; Ratih Puspita Febrinasari
Nutriology : Jurnal Pangan, Gizi, Kesehatan Vol. 6 No. 2 (2025): Oktober 2025
Publisher : Program Studi Gizi, Universitas Bumigora

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30812/81vy6612

Abstract

Diabetes Mellitus (DM) is a metabolic disorder characterized by hyperglycemia resulting from abnormalities in insulin secretion, insulin action, or both. Management of DM involves pharmacological therapy, nutritional intervention, and physical activity. Recently, adjuvant therapies based on functional foods containing probiotics and natural bioactive compounds have gained increasing attention, one of hich is Soygurt. When combined with mung beans and date juice as a natural sweetener, soygurt has the potential to improve glucose metabolism and influence body weight. This study aimed to analyze the effects of mung bean soygurt with date palm extract as an adjuvant therapy in a type 2 diabetes mellitus (T2DM) mouse model, focusing on body weight and fasting blood glucose levels. The research employed a pre-posttest control group experimental design using male Wistar rats (Rattus norvegicus) induced with T2DM. A total of 30 rats were divided into six groups: healthy control, negative control, positive control (metformin 9 mg/kgBW/day), and three treatment groups receiving different doses of soygurt (1 ml, 2 ml, and 3 ml) combined with metformin for 28 days. The results showed a significant increase in body weight across all groups (p < 0.05), and a significant decrease in fasting blood glucose in the positive control and treatment groups (P1, P2, P3) (p < 0.05). Conclusion, the study shows that mung bean soygurt with date extract has the potential as an adjuvant therapy for type 2 diabetes mellitus.
Quality and Efficiency of Health Services in The Implementation of Electronic Medical Records: Bibliometric Analysis Maryati, Warsi; Hartono, Hartono; Puspita Febrinasari, Ratih
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2024: Proceeding of the 5th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/icohetech.v5i1.4252

Abstract

Background: Electronic medical records (EMR) were growing rapidly because they were believed to improve the quality and efficiency of health services. Literature studies related to EMR have been carried out, but the bibliometric analysis was not yet known. This study aimed to analyze the bibliometrics of research related to EMR and its impact on quality and patient care. Methods: We have carried out bibliometric analysis using VOS viewer and Mendeley on articles from the Scopus database for 2014-2023. Articles have been filtered based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) diagram. We used the keywords electronic medical records, quality and efficiency to search for articles. Articles that were not in English, could not be downloaded in full text and were not related to quality or efficiency were excluded. Articles that met the criteria were analyzed. Results: We obtained 24 articles from the screening results. Most articles in 2020 (6), there was a significant increase in 2019 (4). Most articles have been published in Journal of Medical Internet Research (3). The International Journal of Medical Informatics received the most citations (160 from 2 articles). There were 8 research articles from the United States. The most frequently used keywords were electronic medical record(s). Meanwhile, the issues most commonly associated with the implementation of EMR include; quality improvement, health care quality, patient satisfaction, and cost. Conclusion: Bibliometric analysis was important to carry out in future research to map the characteristics of research with wider data sources.
Co-Authors . Suyatmi . Widardo AGYA GHILMAN FAZA Berlian Permata Sakti Brian Wasita Dedi Febriandaru Endang Listyaningsih Suparyanti Hanif Mustikasari Hartono Hartono Hudiyono . Hutami Sri Ummiyati Kisrini . Leli Saptawati Lilik Wijayanti Maryati, Warsi MIFTAKHUL JANNAH Mochammad Fairuz Zahran Mustiqa Febriniata MUTHMAINAH . Naila Shofwati Putri Nanang Wiyono Nur Hidayah Riris Arizka Wahyu Kumala Selvia Anggraeni Setyo Sri Rahardjo Shinta Retno Wulandari Siti Fatimah R Suyatmi . Widardo .