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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Medical Journal of Indonesia The Indonesian Biomedical Journal Paediatrica Indonesiana Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indonesian Journal of Applied Research (IJAR) Cermin Dunia Kedokteran Indonesian Journal of Cancer Jurnal Kedokteran Meditek Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute Cermin Dunia Kedokteran
Ninik Sukartini
Department Of Clinical Pathology, Faculty Of Medicine, Indonesia University-Dr.Cipto Mangunkusumo Hospital Jakarta, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Elevated Serum Cathelicidin and Inverse Correlation with Vitamin D in Patients with Intestinal Tuberculosis Nuri Dyah Indrasari; Astuti Giantini; Ninik Sukartini; Dewi Wulandari; Dean Handimulya Djumaryo; Nindy Auliana; Pande Made Satrya Dharma Pathni; Fathoni Afif
The Indonesian Biomedical Journal Vol 18, No 3 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i3.4169

Abstract

BACKGROUND: Intestinal tuberculosis (ITB) is a type of tuberculosis (TB) that affects the gastrointestinal tract. Cathelicidin, an antimicrobial peptide, contributes to defense against Mycobacterium tuberculosis, which causes TB. Its expression is tightly regulated by vitamin D through vitamin D receptor signaling and autophagy pathways. Despite the increasing evidence on TB, studies exploring the correlation between cathelicidin and vitamin D in the ITB remain poorly characterized and almost exclusively derived from pulmonary TB. Therefore, the present study was conducted to compare serum cathelicidin and vitamin D levels between subjects with ITB and without ITB, and to determine the correlation between these two biomarkers.METHODS: This comparative cross-sectional study utilized stored serum samples obtained from participants enrolled in a previous ITB project. Twenty-two ITB and 22 non-ITB subjects aged >18 years who had undergone colonoscopy, histopathological examinations, and fulfilled predefined clinical and diagnostic criteria were included. Serum cathelicidin and vitamin D levels were measured using sandwich enzyme-linked immunosorbent assay (ELISA) and chemiluminescent microparticle immunoassay (CMIA), respectively.RESULTS: Significantly higher levels of serum cathelicidin were identified in ITB subjects, with a median level of 3.67 (2.27‒5.95) ng/mL, compared with non-ITB subjects with a median level of 2.04 (1.66‒2.46) ng/mL (p<0.0001). Although the difference was not statistically significant (p=0.091), vitamin D level tended to be lower in subjects with ITB, with a median level of 11.05 (6.80‒25.25) ng/mL, compared to non-ITB subjects with a median level of 17.95 (12.13‒23.63) ng/mL. A significant moderate negative correlation was found between cathelicidin and vitamin D (r=-0.485, p=0.001).CONCLUSION: The ITB is associated with elevated cathelicidin levels and a tendency toward lower vitamin D levels. The inverse correlation suggests a complex relationship between vitamin D status and cathelicidin expression, highlighting immunological mechanisms involved in ITB pathogenesis.KEYWORDS: antimicrobial peptide, cathelicidin, innate immunity, intestinal tuberculosis, vitamin D
Co-Authors -, Yudhistira Agus Susanto Kosasih Aldri Frinaldi Alyssa Diandra Arif Kurniawan Arif Riswahyudi Hanafi Arini Setiawati Astuti Giantini Banundari Rachmawati Basti Andriyoko Beauty, Venny Bidasari Lubis Bidasari Lubis Damayanti R. Sjarif Damayanti Rusli Sjarif Dean Handimulya Djumaryo Dewi Wulandari Dewi Wulandari Dian Cahyanti Dwikinta, Made Anindya Fathoni Afif Ferry Sandra Fify Henrika, Fify Fitri Primacakti, Fitri Gunawan Eka Putra Herqutanto - Ida Parwati Indrasari, Nuri Dyah Indriani Silvia Iris Rengganis Isabella Valentina Joedo Prihartono Joedo Prihartono Kartika Anastasia Kosasih Kumalawati, July Linny Luciana Lyana Setiawan Marina Ludong Mariska Pangaribuan Markus Yovian Muhammad Alfin Hanif Nadhifa Tazkia Ramadhani Nindy Auliana Novie Amelia Chozie Pande Made Satrya Dharma Pathni Paramita, Rafika Indah Petriana Primiastanti Pustika Amalia Wahidiyat Pustika Amalia Wahidiyat, Pustika Amalia Putra, Gunawan Eka Ramadhan Ramadhan Ramadhani, Nadhifa Tazkia Saleha Sungkar Sarwono Waspadji Setiabudy, Rahajuningsih D Sheila Claudhea Salsabila Siskawati Suparmin Sonar Panigoro Sri Agustini Kurniawati Suzanna Immanuel Suzanna Immanuel Suzanna Immanuel Suzanna Immanuel Tanjungsari, Dian Wahyu Tonny Loho Venna, Venna Victor, Andi A Willy Pandu Ariawan Wirastuti, Aulia Yohanes Salim Yudhistira Yudhistira -