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All Journal Majalah Kesehatan FKUB Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Syntax Literate: Jurnal Ilmiah Indonesia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Medfarm: Jurnal Farmasi dan Kesehatan Journal of Innovation Research and Knowledge Proceeding ISETH (International Summit on Science, Technology, and Humanity) Jurnal Pengabdian Masyarakat Medika JHeS (Journal of Health Studies) Biomedika Jurnal Ilmiah Kesehatan Sandi Husada International Journal of Health Science Jurnal Ilmiah Kesehatan Sandi Husada (JIKSH)
Metana Puspitasari
Fakultas Kedokteran Univestas Muhammadiyah Surakarta
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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RASIO EOSINOFIL-MONOSIT TIDAK BERKORELASI DENGAN MARKER DERAJAT PENYAKIT INFEKSI VIRUS DENGUE PADA ANAK Jatmiko, Safari Wahyu; Puspitasari, Metana; Widyastuti, Noor Hafida; Aisyah, Riandini
Majalah Kesehatan Vol. 13 No. 1 (2026): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2026.013.01.4

Abstract

Rasio Eosinofil-Monosit (REM) telah digunakan sebagai marker inflamasi yang berhubungan dengan derajat penyakit seperti stroke iskemik akut, gagal jantung, dan Grave’s disease, namun belum pernah dilakukan pada infeksi virus dengue (IVD). Eosinofil dan monosit berperan dalam patogenesis IVD dan terdapat laporan bahwa jumlah monosit berbanding terbalik dengan jumlah eosinofil pada kondisi inflamasi. Di sisi lain, platelet dan hematokrit merupakan bagian dari marker derajat penyakit pada IVD. Semakin berat derajat IVD semakin tinggi hematokrit dan semakin rendah platelet. Maka, penelitian mengenai REM dan penyusun REM yang dikaitkan dengan platelet dan hematokrit perlu dilakukan. Tujuan penelitian untuk mengetahui korelasi antara monosit dengan hematokrit, sel esoinofil dengan hematokrit dan platelet, dan REM dengan hematokrit dan platelet pada IVD anak. Metode penelitian observasional dengan desain cross-sectional. Penelitian dilakukan di RS PKU Muhammadiyah Sampangan Surakarta dari Desember 2023-2024 terhadap populasi pasien IVD di bawah 15 tahun, sesuai kriteria IVD WHO 2009, dan terkonfirmasi melalui tes antibodi anti-dengue. Pasien dengan riwayat gangguan homeostasis, komorbid, riwayat vaksinasi dengue, alergi, malignansi, kecacingan, atau sedang mengalami infeksi lainnya dikecualikan dari penelitian. Berdasarkan rumus besar sampel untuk uji korelasi Pearson  menggunakan transfor-masi Fisher’s Z didapatkan jumlah sampel sebanyak 50. Analisis monosit, eosinofil, REM, hematokrit, dan platelet dilakukan menggunakan Hematology Analyzer. Hasil penelitian ditemukan bahwa terdapat korelasi antara monosit dengan Hct (r = 0,361, p = 0,001), namun tidak ada korelasi yang signifikan secara statistik antara eosinofil dan REM dengan platelet dan hematokrit. Kesimpulan menunjukkan monosit berpotensi sebagai indikator derajat keparahan IVD, namun tidak dengan eosinofil dan REM.  
Relationship of acid–base imbalance with hemorrhage volume and mortality in intracerebral stroke hemorrhage Mukti, Gavin; Setiawan, Iwan; Puspitasari, Metana; Sulistyani, Sulistyani
JHeS (Journal of Health Studies) Vol. 10 No. 1 (2026): Maret
Publisher : Universitas 'Aisyiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31101/jhes.4008

Abstract

This study aimed to evaluate the relationship between acid-base balance disturbances and intracerebral hemorrhage volume with mortality rates in hemorrhagic stroke cases. The research used an observational analytic design with a cross-sectional approach and was conducted at Dr. Soeratno Gemolong General Hospital, Sragen, from September to November 2024. The study population consisted of medical records of patients diagnosed with hemorrhagic stroke at the hospital between August 2021 and August 2024 who met the inclusion criteria. A total of 50 samples were selected using a purposive sampling technique. Data analysis included univariate analysis, bivariate analysis using the Chi-Square test, and multivariate analysis using logistic regression. The results showed a significant relationship between acid–base balance disturbances and intracerebral hemorrhage volume with mortality in hemorrhagic stroke cases (p=0.001). In addition, intracerebral hemorrhage volume was significantly associated with mortality (p=0.007). Multivariate analysis confirmed that both acid–base imbalance and hemorrhage volume significantly influence mortality outcomes. These findings indicate that acid–base imbalance and intracerebral hemorrhage volume greater than 30 ml are strong predictors of mortality in hemorrhagic stroke patients. Therefore, strict monitoring of arterial blood gases, neurological status, and hemodynamic stability is essential during the acute phase of care. Early detection of physiological deterioration and prompt intervention may help reduce the risk of adverse outcomes. Future research is recommended to use prospective multicenter designs with larger sample sizes to further clarify causal relationships and evaluate whether early correction of acid–base disturbances can improve mortality outcomes in hemorrhagic stroke patients.
Role of laboratory testing in the diagnosis of acute viral rhinitis: A Narrative Review Kemal Hanief Al Ghifari; Naysa Maharani Putri; Ayudya Dimas Rizky Utama; Renata Aurellia Laksita; Farah Najma Haristsah; Metana Puspitasari
Jurnal Ilmiah Kesehatan Sandi Husada Vol. 14 No. 2 (2025): July - December
Publisher : LPPM Politeknik Sandi Karsa, South Sulawesi, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiksh.v14i2.273

Abstract

Introduction: Acute viral rhinitis is one of the most prevalent upper respiratory conditions, primarily caused by rhinovirus, with other viruses such as coronavirus, adenovirus, RSV, and influenza contributing to smaller proportions. Although diagnosis is typically clinical, laboratory testing plays an increasingly important role in distinguishing between viral and bacterial etiologies, preventing unnecessary antibiotic use, and enhancing clinical decision-making. Methods: A literature search was conducted using PubMed and Google Scholar for articles published from 2020 to 2025. Keywords included “Acute Viral Rhinitis,” “Common Cold,” “Laboratory Diagnosis,” “Multiplex PCR,” and “Point-of-Care Test.” From 89 initially identified studies, screening based on inclusion and exclusion criteria resulted in nine eligible publications. These were synthesized using a narrative review approach and evaluated using the SANRA instrument. Results: Molecular diagnostic methods such as RT-PCR and multiplex PCR demonstrated the highest diagnostic accuracy (>95%) for detecting respiratory viral pathogens. Classic immunological tests, including skin prick testing and ImmunoCAP, remain relevant for assessing allergic rhinitis but are less useful for differentiating between viral and bacterial infections. Basic biomarkers such as CRP and procalcitonin provided moderate sensitivity and supported early clinical screening. Emerging point-of-care tests, particularly assays measuring MxA and CRP, have shown promising accuracy in distinguishing between viral and bacterial infections, making them valuable for primary care settings. Conclusion: No single laboratory method is ideal for diagnosing acute viral rhinitis. A combined approach integrating classical, molecular, and point-of-care diagnostics enhances diagnostic precision and promotes rational antibiotic stewardship. Future practice should prioritize wider access to molecular testing, the adoption of validated point-of-care tools, and the continued development of novel biomarkers to enhance rapid and accurate diagnosis in diverse clinical settings.
IMPLEMENTASI PROGRAM EDUKASI DISLIPIDEMIA UNTUK MENINGKATKAN PENGETAHUAN DAN PERILAKU HIDUP SEHAT Puspitasari, Metana; Yusuf, Muhammad; Dianes, Zulfiona
Jurnal Pengabdian Masyarakat Medika Vol 6. No. 1, Maret 2026
Publisher : Universitas Muhamamdiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRAK Dislipidemia merupakan kelainan metabolik yang ditandai ketidakseimbangan kadar lipid dan lipoprotein dalam sirkulasi darah yaitu berupa hiperkolesterolemia, hipertrigliseridemia, peningkatan LDL, atau rendahnya kadar HDL dalam darah, yang menjadi faktor risiko utama penyakit kardiovaskular. Kondisi ini sering tidak menunjukkan gejala (silent disease) sehingga banyak kasus tidak terdeteksi secara dini. Rendahnya tingkat pengetahuan masyarakat tentang dislipidemia merupakan hambatan dalam implementasi strategi pencegahan dan pengendalian penyakit tidak menular. Kegiatan pengabdian ini mempunyai tujuan untuk menambah pemahaman masyarakat mengenai faktor risiko, dampak, dan usaha promotif serta preventif terhadap dislipidemia. Kegiatan dilaksanakan dalam bentuk penyuluhan dan diskusi interaktif yang melibatkan 20 ibu-ibu warga Tirtasani Residence di Kabupaten Karanganyar. Desain pengabdian masyarakat yang digunakan adalah pre-test dan post-test, dengan analisis data dilakukan melalui uji Wilcoxon. Terdapat peningkatan signifikan pada rata-rata skor pengetahuan dari 41,87 sebelum penyuluhan menjadi 91,87 setelah penyuluhan, dengan nilai p < 0,001. Namun, peningkatan pengetahuan memerlukan strategi intervensi berkelanjutan untuk mendorong perubahan perilaku jangka panjang yang nyata dan berdampak. ABSTRACT Dyslipidemia is a metabolic disorder characterized by an imbalance in lipid and lipoprotein levels in the blood circulation, namely an hypercholesterolemia, hypertriglyceridemia, LDL or a low HDL levels in the blood, which serve as major risk factors for cardiovascular disease. This condition often presents without symptoms (a silent disease), resulting in many cases going undetected. The low level of public awareness regarding dyslipidemia remains a challenge in efforts to prevent and control non-communicable diseases. This community service activity aimed to improve public understanding of the risk factors, impacts, as well as promotive and preventive efforts related to dyslipidemia. The activity was carried out in the form of health education and interactive discussions involving 20 women residents of Tirtasani Residence, Karanganyar Regency. A pre-test and post-test design was utilized, with the Wilcoxon test applied for data analysis. The average knowledge score increased significantly from 41.87 to 91.8 following the educational session, with a p-value <0.001. However, improved knowledge requires sustained intervention strategies to drive real, long-term behavioral change with lasting impact.
Co-Authors Agustina, Dinda Dwi Akbar Wardhana Alfajri, Asri Alim, Fika Nurul Ardhana, Regita Arfiana, Nur Wisma Ayudya Dimas Rizky Utama Chandra, Ilham Edgar Fadhila Dianes, Zulfiona Faqihudin, Fadli Rizal Farah Najma Haristsah Fikri, Elfin Ainul Fikri, Muhammad Ihsanul Fithriyah, Saidatul Hartia, Nabila Putri Hasmy, Alya Fauzizah Iin Novita Nurhidayati Mahmuda Iwan Setiawan Jamiko, Safari Wahyu Jatmiko, Safari Jatmitko, Safari Wahtu Jayati, Nurul Sari Kemal Hanief Al Ghifari Kencana, Nabila Safhira Titan kusumaningsih, dwi Listiana Masyita Dewi Lulu Setyawati Purwaningsih Mahmuda, Iin Novita Nurhayati Marchelina, Sherly MI. Diah Pramudianti Mitoriana Porusia Moh. Shoim Dasuki Muhammad Yusuf Mukti, Gavin Najib, Yazid Aufa Naysa Maharani Putri Nida Faradisa Fauziyah Noor Hafida Widyastuti Pambudi, Nasrurrofiq Risvana Bayu Paramadina, Izzati Putra, Kresna Aditya Nugraha Raafika Studiviani Dwi Binuko Rahmah, Sandawi Rianda Ratih Pramuningtyas Renata Aurellia Laksita Retno Sintowati Riandini Aisyah Rochmadina Suci Bestari Safari Wahyu Jatmiko Sahilah Ermawati Salsabiela, Salwa Sri Wahyuni Sulistyani , Sulistyani Sulistyani Sulistyani Sulistyani, S Yamsun, Rahmat Dani Yulistina, Desita Yunitama, Alifa Agil Dhillu Yuwono Hadisuparto Zufar, M Irvan