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All Journal Althea Medical Journal Majalah Kesehatan FKUB Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Syntax Literate: Jurnal Ilmiah Indonesia Indonesian Journal for Health Sciences (IJHS) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Ilmiah Kesehatan (JIKA) Journal of Innovation Research and Knowledge Proceeding ISETH (International Summit on Science, Technology, and Humanity) Jurnal Pengabdian Masyarakat Medika JHeS (Journal of Health Studies) Biomedika Jurnal Ilmiah Kesehatan Sandi Husada International Journal of Health Science Jurnal Ilmiah Kesehatan Sandi Husada (JIKSH) Jurnal Implementa Husada (JIH)
Metana Puspitasari
Universitas Muhammadiyah Surakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Macrovascular and Microvascular Complications of Diabetic Patients: Study form in Gatak Primary Health Care, Sukoharjo, Indonesia Iin Novita Nurhidayati Mahmuda; Metana Puspitasari; Sahilah Ernawati; Sulistyani Sulistyani; Rada Citra Saputra
Althea Medical Journal Vol 13, No 2 (2026)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v13n2.4401

Abstract

Background: Diabetes is a major global health problem, and Indonesia being one of the countries with high prevalence. Fasting plasma glucose (FPG) and HbA1c are the main biomarkers used to assess glycaemic control. Screening for macrovascular and microvascular complications is necessary for early intervention to prevent permanent disability. This study aimed to determine the incidence of macrovascular and microvascular complications in diabetic patients in primary health care.Methods: A descriptive cross-sectional study was conducted from July to September 2022 among patients with diabetes who routinely attended Gatak Primary Health Care. Screening for macrovascular complications included PAD with Ankle-Brachial Index assessment; whereas the microvascular complications using monofilament testing for neuropathy, eye examination for retinopathy, and microalbuminuria for nephropathy.Result: Among 65 patients with diabetes, most were female (83.1%), with a mean age of 62.43±9.47 years. The mean fasting plasma glucose (FPG) was 192.62±86.92 mg/dl, and the mean HbA1c was 12.55±3.59%. Both macrovascular complication (PAD 32.3%) and microvascular complications (retinopathy 57.1%, neuropathy 44.9%, nephropathy 49.2%) were identified, demonstrating the burden of diabetes-related outcomes in primary care.Conclusion: Macrovascular and microvascular complications were highly prevalent among patients with diabetes in primary care, with microvascular complications occurring more frequently. These findings indicate that inadequate glycaemic control contributes substantially to complication rates.
Relationship of acid–base imbalance with hemorrhage volume and mortality in intracerebral stroke hemorrhage Gavin Mukti; Iwan Setiawan; Metana Puspitasari; Sulistyani Sulistyani
JHeS (Journal of Health Studies) Vol. 10 No. 1 (2026): Maret
Publisher : Universitas 'Aisyiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31101/jhes.4008

Abstract

This study aimed to evaluate the relationship between acid-base balance disturbances and intracerebral hemorrhage volume with mortality rates in hemorrhagic stroke cases. The research used an observational analytic design with a cross-sectional approach and was conducted at Dr. Soeratno Gemolong General Hospital, Sragen, from September to November 2024. The study population consisted of medical records of patients diagnosed with hemorrhagic stroke at the hospital between August 2021 and August 2024 who met the inclusion criteria. A total of 50 samples were selected using a purposive sampling technique. Data analysis included univariate analysis, bivariate analysis using the Chi-Square test, and multivariate analysis using logistic regression. The results showed a significant relationship between acid–base balance disturbances and intracerebral hemorrhage volume with mortality in hemorrhagic stroke cases (p=0.001). In addition, intracerebral hemorrhage volume was significantly associated with mortality (p=0.007). Multivariate analysis confirmed that both acid–base imbalance and hemorrhage volume significantly influence mortality outcomes. These findings indicate that acid–base imbalance and intracerebral hemorrhage volume greater than 30 ml are strong predictors of mortality in hemorrhagic stroke patients. Therefore, strict monitoring of arterial blood gases, neurological status, and hemodynamic stability is essential during the acute phase of care. Early detection of physiological deterioration and prompt intervention may help reduce the risk of adverse outcomes. Future research is recommended to use prospective multicenter designs with larger sample sizes to further clarify causal relationships and evaluate whether early correction of acid–base disturbances can improve mortality outcomes in hemorrhagic stroke patients.
Larvicidal Activity of Ethanol Extracts of Bidara (Ziziphus mauritiana) Leaves and Fruits Against Aedes aegypti Rochmadina Suci Bestari; Muhammad Ihsanul Fikri; Riandini Aisyah; Metana Puspitasari; Sri Wahyuni; Mitoriana Porusia
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.586

Abstract

Dengue fever vector control uses abate chemicals can harm the ecosystem. One of the plants that can be used as a natural larvicide is bidara. Bidara leaves and fruits easily available and contains flavonoids, saponins, alkaloids, and tannins. The compound have an impact on the mortality of Aedes aegypti mosquito larvae. Contains study design, subject, methods, data collection and data analysis. Research on ethanol extract of bidara leaves and bidara fruit with Poly Ethylene Glycol (PEG) was experimental laboratory design with post-test only controlled group design. The technique of extraction is maseration. The larvae of Aedes aegypti instar III-IV are used, 800 in total, divided into 8 groups. At 6, 12, 18, and 24 hours, the number of dead larvae was counted .Normality and homegenity tests obtained the results of data not normally distributed and not homogeneous, so it is necessary to do the Kruskall-Wallis non-parametric test followed by Mann-Whitney post hoc .The result is bidara leaf extract with a concentration of 1.5% + 3% PEG resulted in 100% larval death in the 24th hour, meanwhile bidara fruit extract with concentration of 1.5% + 3% PEG resulted 70% larval death in 24th hour. Ethanol extract of bidara leaves has better effectiveness than bidara fruit extract in its ability as a larvicide, where bidara leaf extract with a concentration of 1.5% + 3% PEG resulted in 100% larval death in the 24th hour.
IMPLEMENTASI PROGRAM EDUKASI DISLIPIDEMIA UNTUK MENINGKATKAN PENGETAHUAN DAN PERILAKU HIDUP SEHAT Metana Puspitasari; Muhammad Yusuf; Zulfiona Dianes
Jurnal Pengabdian Masyarakat Medika Vol 6. No. 1, Maret 2026
Publisher : Universitas Muhamamdiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jpmmedika.v6i1.12747

Abstract

ABSTRAK Dislipidemia merupakan kelainan metabolik yang ditandai ketidakseimbangan kadar lipid dan lipoprotein dalam sirkulasi darah yaitu berupa hiperkolesterolemia, hipertrigliseridemia, peningkatan LDL, atau rendahnya kadar HDL dalam darah, yang menjadi faktor risiko utama penyakit kardiovaskular. Kondisi ini sering tidak menunjukkan gejala (silent disease) sehingga banyak kasus tidak terdeteksi secara dini. Rendahnya tingkat pengetahuan masyarakat tentang dislipidemia merupakan hambatan dalam implementasi strategi pencegahan dan pengendalian penyakit tidak menular. Kegiatan pengabdian ini mempunyai tujuan untuk menambah pemahaman masyarakat mengenai faktor risiko, dampak, dan usaha promotif serta preventif terhadap dislipidemia. Kegiatan dilaksanakan dalam bentuk penyuluhan dan diskusi interaktif yang melibatkan 20 ibu-ibu warga Tirtasani Residence di Kabupaten Karanganyar. Desain pengabdian masyarakat yang digunakan adalah pre-test dan post-test, dengan analisis data dilakukan melalui uji Wilcoxon. Terdapat peningkatan signifikan pada rata-rata skor pengetahuan dari 41,87 sebelum penyuluhan menjadi 91,87 setelah penyuluhan, dengan nilai p < 0,001. Namun, peningkatan pengetahuan memerlukan strategi intervensi berkelanjutan untuk mendorong perubahan perilaku jangka panjang yang nyata dan berdampak. ABSTRACT Dyslipidemia is a metabolic disorder characterized by an imbalance in lipid and lipoprotein levels in the blood circulation, namely an hypercholesterolemia, hypertriglyceridemia, LDL or a low HDL levels in the blood, which serve as major risk factors for cardiovascular disease. This condition often presents without symptoms (a silent disease), resulting in many cases going undetected. The low level of public awareness regarding dyslipidemia remains a challenge in efforts to prevent and control non-communicable diseases. This community service activity aimed to improve public understanding of the risk factors, impacts, as well as promotive and preventive efforts related to dyslipidemia. The activity was carried out in the form of health education and interactive discussions involving 20 women residents of Tirtasani Residence, Karanganyar Regency. A pre-test and post-test design was utilized, with the Wilcoxon test applied for data analysis. The average knowledge score increased significantly from 41.87 to 91.8 following the educational session, with a p-value <0.001. However, improved knowledge requires sustained intervention strategies to drive real, long-term behavioral change with lasting impact.
Profile of Glomerular Filtration Rate Estimation Using the CKD-EPI Method in Type 2 Diabetes Mellitus Patients: Assessing the Risk of Kidney Complications Metana Puspitasari; Eko Dewi Ratna Utami
Jurnal Ilmiah Kesehatan (JIKA) Vol. 8 No. 2 (2026): Volume 8 Issue 2 August 2026
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v8i2.767

Abstract

Diabetes mellitus is a metabolic disease that occurs due to the body's inability to produce and/or use insulin effectively, resulting in high blood sugar levels. Type 2 diabetes mellitus (DM) accounts for 90% of all diabetes cases globally, with significant contributing factors such as obesity, sedentary lifestyles, and poor dietary habits. In 2019, Indonesia ranked seventh in the world for the number of diabetes cases, with 10.7 million individuals affected. This research used a retrospective, observational, descriptive-analytic approach to assess kidney dysfunction in newly diagnosed type 2 diabetes mellitus patients, using the CKD-EPI equation to estimate eGFR.. The eGFR analysis revealed that most patients had eGFR values below the normal threshold of <90 mL/min/1.73 m², with an average of 77.5 ± 28.51 mL/min/1.73 m², indicating kidney impairment at the early stage. The largest group (45%) showed normal kidney function, while 21% had mild dysfunction. Patients with kidney impairment (eGFR < 90 mL/ min/ 1.73m²) had a higher average fasting blood glucose level (240 ± 82.9 mg/dL) compared to those without kidney impairment. These findings emphasized the importance of early detection and intervention for managing both blood glucose levels and kidney function effectively. Early detection of kidney impairment in type 2 diabetes mellitus patients is crucial in preventing further complications and preserving kidney health.
Correlation between Total Monocyte, Lymphocyte and Basophil Counts, as well as Monocyte-Lymphocyte Ratio with Hematocrit as Indicators of Plasma Leakage in Dengue Virus Infection Safari Wahyu Jamiko; Desita Yulistina; Regita Ardhana; Metana Puspitasari
Biomedika Vol 16, No 2 (2024): Biomedika Agustus 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v16i2.4904

Abstract

Background: Severe dengue virus (DVI) infection is characterized by plasma leakage (PL) due to the release of vasoactive cytokines by immunocytes such as monocytes, lymphocytes, and basophils. The response to Dengue Virus (DENV) also affects the kinetics of monocytes, lymphocytes, and basophils, thus changing the examination results of leukocyte types and monocyte-lymphocyte ratio (MLR). MLR has been used as a biomarker and outcome predictor in various diseases but not to predict PL in DVI. Objectives: To see the correlation of monocytes, lymphocytes, basophils, and MLR with hematocrit (Hct) which is a PL indicator. Methods: Correlative analytical research with a cross-sectional approach was conducted on 71 pediatric DVI patients at PKU Muhammadiyah Sampangan Hospital, Surakarta, in February- April 2024. The diagnosis of DVI was confirmed by a pediatrician according to WHO 2009 criteria. DVI patients who had a history of allergies, worms, malignancies, and DVI with secondary infections were excluded from the study. Absolute monocyte (AMC), lymphocyte (ALC), and basophil (ABC) count values ​​, as well as MLR and Hct, were obtained from the results of a complete blood examination using a hematology analyzer. The Spearman Rho’s correlation test was used to determine the relationship between variables with values ​​of p<0.05 and r>0.4 considered significant. Results: research obtained AMC=median 313 (IQR 192) mm-3, ALC= median 1225 (IQR 1039) mm-3, ABC=0 mm-3, MLR=0.22 (0.23). The results of the correlation analysis of AMC, ALC, and MLR with Hct are AMC (r=0.01, p=0.918), ALC (r=0.351, p=0.003), and MLR (r=0.41, p<0.001), while the correlation between ABC and Hct could not be done due to no data variation. Conclusion: There is a significant correlation between MLR and Hct, but not with AMC, ALC, and ABC and Hct. MLR can potentially predict plasma leakage in patients with dengue virus infection.
Efektivitas Penyuluhan Kesehatan Sekolah terhadap Peningkatan Pemahaman Anemia pada Remaja Putri: The Effectiveness of School-Based Health Education on Improving Knowledge of Anemia among Adolescent Girls Metana Puspitasari; Nur Mahmudah; Linda Jana Sintaningtyas; Muhammad Daffa Qory; Aura Veranisyah Sudarto
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 11 No. 5 (2026): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v11i5.11791

Abstract

Anemia is a prevalent public health problem among adolescent girls who are undergoing rapid growth and have increased iron requirements. This condition is often worsened by unbalanced dietary habits, restrictive dieting, and limited knowledge about daily nutritional needs and anemia prevention. This community service activity aimed to improve adolescents' understanding of anemia through a school-based health education program. The education was delivered interactively through visual presentations and was accompanied by pre-test and post-test assessments to measure changes in knowledge. A total of 113 students participated in the program. Data were analyzed to evaluate differences in knowledge levels after the intervention. The results showed an increase in the mean knowledge score from 89 to 98, with a statistically significant difference under the Wilcoxon test (p <0,001). Most participants demonstrated improved scores after the session, indicating the effectiveness of the educational method. The program's success was supported by the delivery of communicative materials, the use of easy-to-understand visual media, and strong participant engagement. This activity highlights the important role of health education in improving health literacy among adolescent girls and suggests its potential as a promotive and preventive strategy to reduce anemia. Similar educational programs are recommended for continued implementation to foster long-term anemia-prevention behaviors and support improved health outcomes for future generations.
Correlation of AISI and PLR as Systemic Inflammatory Markers with Hospitalization Duration in Pediatric Typhoid Fever Patients Metana Puspitasari; Muhammad Yusuf; Zulfiona Dianes; Safari Wahyu Jatmiko
JURNAL IMPLEMENTA HUSADA Vol 7, No 1 (2026)
Publisher : UMSU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/jih.v7i1.26734

Abstract

Introduction: Typhoid fever remains a major public health problem in developing countries, including Indonesia, with a high incidence among children requiring hospitalization. Simple systemic inflammatory markers such as the Aggregate Index of Systemic Inflammation (AISI) and Platelet Lymphocyte Ratio (PLR) are increasingly studied because they can be calculated from routine blood tests and may serve as clinical indicators. Method: This retrospective cross-sectional study involved 57 pediatric patients with typhoid fever at PKU Muhammadiyah Sampangan Hospital, Surakarta, who met the inclusion and exclusion criteria. Data were analyzed using the Kolmogorov–Smirnov test for normality and the Spearman correlation test to evaluate associations between variables. Result : The results showed no significant correlation between AISI and the length of hospitalization (p = 0.994; p 0.05) or between PLR and the length of hospitalization (p = 0.320; p 0.05). Discussion: These findings indicate that AISI and PLR have no prognostic value in predicting hospitalization duration in pediatric typhoid fever patients. Further studies with larger sample sizes, prospective designs, and the inclusion of additional inflammatory biomarkers are needed to validate and strengthen these findings.
inggris M Daffa Qory Maulana; Metana Puspitasari; Riandini Aisyah; Asri Alfajri
Indonesian Journal of Health Science Vol 10 No 02 (2026): September
Publisher : Universitas Muhammadiyah Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24269/ijhs.v10i02.13368

Abstract

Typhoid fever is a systemic infection caused by Salmonella typhi bacteria that predominantly affects children. Monocyte to Lymphocyte Ratio (MLR) and Neutrophil to Lymphocyte Ratio (NLR) are simple hematological parameters that potentially describe the inflammatory response. This study aims to determine the correlation between the MLR and NLR and the length of hospital stay in pediatric typhoid fever patients.This study used an analytical observational design with a cross-sectional approach and involved 48 pediatric typhoid fever patients treated at PKU Muhammadiyah Sampangan Hospital, Surakarta. Data on MLR, NLR, and length of hospital stay for pediatric typhoid fever patients were obtained from medical records. Statistical analysis was used to evaluate the correlation between variables. MLR (p = 0.653, r = -0.067) and NLR (p = 0.231, r = 0.176). These findings indicate that MLR and NLR values are not accurate predictors of length of stay in pediatric typhoid fever patients. MLR and NLR are not significantly correlated with length of hospital stay in pediatric typhoid fever patients. This study confirms that simple hematological parameters are insufficient to describe the factors affecting length of hospital stay in pediatric typhoid fever patients
Co-Authors Agustina, Dinda Dwi Akbar Wardhana Alfajri, Asri Alim, Fika Nurul Arfiana, Nur Wisma Aura Veranisyah Sudarto Ayudya Dimas Rizky Utama Chandra, Ilham Edgar Fadhila Desita Yulistina Eko Dewi Ratna Utami Faqihudin, Fadli Rizal Farah Najma Haristsah Fikri, Elfin Ainul Fithriyah, Saidatul Gavin Mukti Hartia, Nabila Putri Hasmy, Alya Fauzizah Iin Novita Nurhidayati Mahmuda Iwan Setiawan Iwan Setiawan Jatmiko, Safari Jatmitko, Safari Wahtu Jayati, Nurul Sari Kemal Hanief Al Ghifari Kencana, Nabila Safhira Titan kusumaningsih, dwi Linda Jana Sintaningtyas Listiana Masyita Dewi Lulu Setyawati Purwaningsih M Daffa Qory Maulana Mahmuda, Iin Novita Nurhayati Marchelina, Sherly MI. Diah Pramudianti Mitoriana Porusia Moh. Shoim Dasuki Muhammad Daffa Qory Muhammad Ihsanul Fikri Muhammad Yusuf Muhammad Yusuf Najib, Yazid Aufa Naysa Maharani Putri Nida Faradisa Fauziyah Noor Hafida Widyastuti Nur Mahmudah Pambudi, Nasrurrofiq Risvana Bayu Paramadina, Izzati Putra, Kresna Aditya Nugraha Raafika Studiviani Dwi Binuko Rada Citra Saputra Rahmah, Sandawi Rianda Ratih Pramuningtyas Regita Ardhana Renata Aurellia Laksita Retno Sintowati Riandini Aisyah Rochmadina Suci Bestari Safari Wahyu Jamiko Safari Wahyu Jatmiko Sahilah Ermawati Sahilah Ernawati Salsabiela, Salwa Sri Wahyuni Sulistyani , Sulistyani Sulistyani Sulistyani Sulistyani Sulistyani Sulistyani Sulistyani Sulistyani, S Yamsun, Rahmat Dani Yunitama, Alifa Agil Dhillu Yuwono Hadisuparto Zufar, M Irvan Zulfiona Dianes Zulfiona Dianes