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The Relation between Fasting Blood Glucose and Triglyceride with GFR in Type 2 DM Patients Hartia, Nabila Putri; Puspitasari, Metana; Sintowati, Retno; Fithriyah, Saidatul
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5523

Abstract

Purpose: Identify the relation between FBG and triglyceride with GFR in T2DM patients. Methodology: This observational quantitative research used a cross-sectional design. Data were obtained from the medical records of 50 Prolanis T2DM patients in 2023 at the Puskesmas Karangnongko, Klaten Regency, using consecutive sampling technique. The bivariate analysis used was the Spearman test. Results: Spearman test results show that there is no significant relation between FBG with GFR in type 2 diabetes mellitus patients (p-value=0.695; r-value=0.057). Apart from that, there is also no relation between triglycerides with GFR in type 2 diabetes mellitus patients (p-value=0.654; r-value=-0.065). Applications/Originality/Value: This research provides information regarding considerations for FBG and triglycerides as important components for detecting a decrease in GFR which can be an indicator of diabetic nephropathy.
Correlation of Length of Fever before Hospital Admission, Hematocrit, Platelet Count, and Leukocytes with Length of Hospitalization Dengue Virus Infection Patients in Children Pambudi, Nasrurrofiq Risvana Bayu; Puspitasari, Metana; Jatmiko, Safari Wahyu; Aisyah, Riandini; Alfajri, Asri
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5525

Abstract

Purpose: To analyze the relationship between fever duration before admission, hematocrit, platelet count, and leukocyte count with length of hospital stay in pediatric patients with dengue infection. Methodology: This observational study with cross-sectional design was conducted at PKU Muhammadiyah Sampangan Hospital, Surakarta, using secondary data from medical records. Forty pediatric patients were selected through consecutive non-probability sampling technique. Statistical analysis was performed with Spearman correlation test using statistical applications. Results: There was a significant association between fever duration before admission and length of hospitalization (r = -0.407, p = 0.009). However, there was no significant association between hematocrit (r = 0.136, p = 0.403), platelet count (r = 0.101, p = 0.536), or leukocyte count (r = 0.111, p = 0.496) with length of hospitalization. Applications/Originality/Value: This study highlights the importance of early detection and intervention in managing pediatric dengue cases. The significant correlation found between fever duration prior to admission and length of stay underscores the need for prompt treatment to minimize hospital stay due to associated inflammation in the body. In contrast, the lack of significant associations between hematocrit, platelet count, leukocyte level and duration of hospitalization highlights the complexity of factors influencing outcomes and the need to explore other prognostic markers. This study conducted in an endemic region of Indonesia contributes to understanding the management of dengue virus infection and underscores the importance of a comprehensive multifactorial approach to improve patient care strategies.
Blood Parameters and Length of Hospitalization in Pediatric Dengue Virus Infection Patients Salsabiela, Salwa; Puspitasari, Metana; Jatmiko, Safari Wahyu
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5539

Abstract

This research aims to evaluate the correlation between erythrocyte level, hematocrit, hemoglobin, and Hb/RDW ratio with the length of hospitalization in pediatric patients with DVI. This observational study used a cross-sectional design and analyzed secondary data from 41 pediatric DVI patients at PKU Muhammadiyah Sampangan Surakarta Hospital. The correlation between hematological parameters and length of hospitalization was analyzed using the Spearman test. Laboratory results showed a mean erythrocyte count of 5.05 million cells/nL (SD 0.61), a median hematocrit of 39.5%, hemoglobin of 13.6 g/dL, and Hb/RDW ratio of 1.03. Bivariate correlation test showed erythrocyte level (r = 0.027, p = 0.867), hematocrit (r = -0.004, p = 0.983), hemoglobin (r = 0.079, p = 0.625), and Hb/RDW ratio (r = 0.116, p = 0.472) showed no significant association with length of hospitalization. This study provides insights into the relationship between hematological parameters and the length of hospital stay in pediatric dengue patients. While no significant correlation was found, it highlights the complexity of factors influencing outcomes and the need to explore other prognostic markers. Conducted in an Indonesian endemic region, the research contributes to understanding DVI management and underscores the importance of a comprehensive, multifactorial approach to improving patient care strategies.
Aggregate Index of Systemic Inflammation is Correlated with Plasma Leakage Indicator in Dengue Virus Infection Jatmiko, Safari; Puspitasari, Metana; Aisyah, Riandini
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 02 (2025): Qanun Medika Vol 09 No 02 July 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i02.25847

Abstract

Severe dengue virus infection (DVI) is characterized by thrombocytopenia and plasma leakage (PL) due to the release of vasoactive cytokines by immune cells such as monocytes, lymphocytes, neutrophils, and platelets in response to dengue virus (DENV). This immune response triggers systemic inflammation, altering monocyte, lymphocyte, and neutrophil kinetics, which in turn affects leukocyte differentials. PL is indicated by an increase in hematocrit (Hct). This study aims to evaluate the potential use of the Aggregate Index of Systemic Inflammation (AISI) as an indicator of plasma leakage. A correlative analytical study with a cross-sectional approach was conducted on 70 pediatric DVI patients diagnosed according to the 2009 WHO criteria and confirmed by anti-DENV IgM/IgG tests. Patients with a history of malignancy, autoimmune thrombocytopenic purpura, or secondary DVI were excluded. Absolute neutrophil, monocyte, platelet, and lymphocyte counts, AISI, and Hct levels were obtained from complete blood count results using a hematology analyzer. The results showed that AISI and lymphocytes correlated with Hct, with correlation values of (r=0.410, p<0.001) and (r=0.446, p<0.001), respectively. In contrast, monocytes, neutrophils, and platelets did not correlate with Hct, with correlation values of (r=-0.009, p=0.942), (r=-0.059, p=0.628), and (r=-0.175, p=0.147), respectively. In conclusion, AISI levels in DVI were low and negatively correlated with Hct, a known indicator of PL. These findings suggest that AISI has potential as a marker for PL and disease severity in DVI.
EFEKTIVITAS PENYULUHAN KESEHATAN TERHADAP PEMAHAMAN PENYAKIT DIABETES MELITUS DAN FAKTOR RISIKONYA Puspitasari, Metana; Rahmah, Sandawi Rianda; Marchelina, Sherly
Jurnal Pengabdian Masyarakat Medika Vol 5. No. 2, September 2025
Publisher : Universitas Muhamamdiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jpmmedika.v5i2.5866

Abstract

ABSTRAK Diabetes melitus adalah kondisi medis yang mengakibatkan peningkatan kadar gula darah akibat gangguan fungsi atau produksi insulin. Berdasarkan klasifikasi Perkeni tahun 2021, terdapat empat tipe diabetes, yaitu tipe 1, tipe 2, gestasional, dan tipe lain yang disebabkan oleh faktor spesifik. Menurut hasil SKI 2023 menunjukkan peningkatan prevalensi Diabetes Melitus tipe 2 di Indonesia meningkat menjadi 11,7% pada tahun 2023, naik dari 10,9% pada tahun 2018 pada kelompok usia ≥15 tahun. Pendekatan menyeluruh dan holistik diperlukan untuk mengelola Diabetes Melitus, melibatkan tindakan yang bersifat promotif, preventif, kuratif, dan rehabilitatif. Penyuluhan ini bertujuan untuk meningkatkan pemahaman masyarakat mengenai penyakit diabetes, sebagai langkah promotif dan preventif dalam mengatasi Diabetes Melitus. Studi ini menggunakan metode one group pre-test post-test dengan melibatkan 40 peserta dari Kelurahan Sigran, Kecamatan Geneng, Kabupaten Sukoharjo. Analisis data dilakukan dengan Wilcoxon test. Temuan dari penelitian menunjukkan adanya peningkatan skor dari rata-rata 67 pada pretest menjadi 85,25 pada posttest. Berdasarkan hasil ini dan nilai p < 0,05, dapat disimpulkan bahwa penyuluhan kesehatan telah berhasil meningkatkan pengetahuan peserta tentang diabetes melitus.   ABSTRACT Diabetes melitus is a medical condition that results in elevated blood sugar levels due to issues in insulin function or production. According to Perkeni's 2021 classification, there are four types of diabetes: Type 1, Type 2, gestational, and other types caused by specific factors. The 2023 Health Survey (SKI) indicated an increase in the prevalence of Type 2 Diabetes Melitus in Indonesia, rising to 11.7% in 2023 from 10.9% in 2018 in the age group of 15 years and older. A comprehensive and holistic approach is essential for managing Diabetes Melitus, involving promotive, preventive, curative, and rehabilitative measures. This community service activity aims to enhance public awareness and knowledge about diabetes as a preventive and promotive measure against the disease. This study applied a one-group pre-test post-test design approach. Forty participants from Sigran community in Geneng District, Sukoharjo Regency participated. Data was analyzed using the Wilcoxon test. Results showed that the average score at the pretest stage was 67, while the post-test average score was 85.25. The analysis indicates that health education significantly improved community knowledge about diabetes melitus, as evidenced by a p-value < 0.05.
HUBUNGAN HBA1C, MIKROALBUMINURIA DAN KOLESTROL DENGAN ESTIMASI GLOMERULAR FILTRASION RATE (GFR) PADA PASIEN DIABETES MELLITUS TIPE 2 Akbar Wardhana; Iin Novita Nurhidayati Mahmuda; Sulistyani , Sulistyani; Sahilah Ermawati; Metana Puspitasari; Raafika Studiviani Dwi Binuko
Journal of Innovation Research and Knowledge Vol. 4 No. 2: Juli 2024
Publisher : Bajang Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53625/jirk.v4i2.8068

Abstract

Nefropati diabetik merupakan salah satu komplikasi mikrovaskuler diabetes mellitus yang disebabkan oleh kerusakan ginjal dan dapat mengakibatkan gagal ginjal terminal dan dapat dideteksi dengan menghitung estimasi GFR. Penelitian ini bertujuan untuk mengetahui hubungan Hba1C, mikroalbuminuria dan kolestrol dengan estimasi glomerular filtrasion rate (GFR) pada pasien diabetes mellitus tipe 2. Penelitian ini menggunakan desain penelitian analitik observasional dengan pendekatan cross-sectional. Penelitian ini dilakukan di Puskesmas Gatak, Kabupaten Sukoharjo, Jawa Tengah. Populasi dalam penelitian ini yaitu semua pasien prolanis yang menderita DM dan rutin kontrol di Puskesmas Gatak yang memenuhi kriteria. Sampel pada penelitian ini merupakan semua penderita DM yang memiliki dengan jumlah sebanyak 65 sampel. Teknik Analisis data yang digunakan pada penelitian ini dengan menggunaan uji Chi-Square. Berdasarkan hasil penelitian, diketahui bahwa (1) ada hubungan HbA1C dengan estimasi GFR pada pasien diabetes mellitus tipe 2 dengan p-value sebesar 0,040 (<0,05). (2) Ada hubungan antara Mikroalbuminuria dengan estimasi GFR pada pasien diabetes mellitus tipe 2 dengan p-value sebesar 0,035 (<0,05). Ada hubungan kolestrol dengan estimasi GFR pada pasien diabetes mellitus tipe 2 dengan p-value sebesar 0,016 (<0,05). Sehingga dapat disimpulkan bahwa terdapat hubungan Hba1C, mikroalbuminuria dan kolestrol dengan estimasi glomerular filtrasion rate (GFR) pada pasien diabetes mellitus tipe 2.
Hubungan Kadar Hba1c dan Kolesterol Total dengan Kejadian Peripheral Arterial Disease pada Pasien Diabetes Mellitus Tipe 2 Puspitasari, Metana; Mahmuda, Iin Novita Nurhayati; Chandra, Ilham Edgar Fadhila; Najib, Yazid Aufa
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v8i11.13930

Abstract

Type 2 diabetes mellitus (DMT2) is caused by the inability of pancreatic beta cells to produce insulin and tissue resistance to insulin. T2DM requires ongoing treatment to control blood sugar and prevent complications such as Peripheral Arterial Disease (PAD) and high cholesterol problems. HbA1c measurement and total cholesterol monitoring are important in diabetes management and prevention of serious complications. An observational analytical study, cross-sectional approach was conducted in September 2022 at Gatak Health Center, Sukoharjo on 65 patients with T2DM. The data were analyzed with a 2x2 chi square test table. The results of the study found that 21 (32.3%) research subjects experienced PAD. Bivariate test between total cholesterol and Hba1c with consecutive PAD incidence p = 0.377; p = 0.416. It can be concluded that there is no significant relationship between the variables total cholesterol and Hba1c with the incidence of PAD. This can be caused by lack of control over other risk factors for PAD events such as smoking, hypertension, duration of diabetes, age, and gender.
Role of laboratory examinations in the diagnosis of vasomotor rhinitis: A Review of Literature Arfiana, Nur Wisma; Jayati, Nurul Sari; Zufar, M Irvan; Putra, Kresna Aditya Nugraha; Hasmy, Alya Fauzizah; Puspitasari, Metana
Jurnal Ilmiah Kesehatan Sandi Husada Vol 14 No 2 (2025): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v14i2.1302

Abstract

Introduction: Vasomotor rhinitis (VMR) is a subtype of non-allergic rhinitis characterized by chronic nasal symptoms such as congestion, rhinorrhea, and sneezing without allergic or infectious causes. The absence of specific biomarkers makes VMR difficult to distinguish from allergic rhinitis, resulting in diagnostic challenges and potentially inappropriate therapy. This review aims to assess the contribution of laboratory examinations in the differential diagnosis of VMR. Methods: A comprehensive literature search was performed using PubMed and Google Scholar databases for articles published between January 2021 and September 2025. Keywords included “non-allergic rhinitis,” “laboratory,” “IgE,” “eosinophil,” “nasal cytology,” “FeNO,” and “biomarker.” Out of 8,350 identified publications, 407 titles were relevant, and 57 full-text articles were reviewed. After applying inclusion and exclusion criteria, nine studies were selected for detailed analysis. Results: No single laboratory test can confirm the diagnosis of VMR. Total and specific IgE levels, as well as peripheral eosinophil counts, mainly serve to exclude allergic rhinitis. Nasal cytology plays a crucial role in identifying subtypes of non-allergic rhinitis, including NARES and NARNE. Measurements of nasal nitric oxide (nNO/FeNO) and newer biomarkers, including diamine oxidase (DAO), show potential as supportive indicators, though findings remain inconsistent. Conclusion: Laboratory examinations contribute primarily as adjunctive tools in differentiating VMR from allergic rhinitis. A multimodal diagnostic approach that integrates serological, cytological, and biomarker evaluations with clinical findings offers the most reliable strategy for improving diagnostic accuracy and guiding appropriate therapy.
Larvicidal Activity of Ethanol Extracts of Bidara (Ziziphus mauritiana) Leaves and Fruits Against Aedes aegypti Bestari, Rochmadina Suci; Fikri, Muhammad Ihsanul; Aisyah, Riandini; Puspitasari, Metana; Wahyuni, Sri; Porusia, Mitoriana
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.586

Abstract

Dengue fever vector control uses abate chemicals can harm the ecosystem. One of the plants that can be used as a natural larvicide is bidara. Bidara leaves and fruits easily available and contains flavonoids, saponins, alkaloids, and tannins. The compound have an impact on the mortality of Aedes aegypti mosquito larvae. Contains study design, subject, methods, data collection and data analysis. Research on ethanol extract of bidara leaves and bidara fruit with Poly Ethylene Glycol (PEG) was experimental laboratory design with post-test only controlled group design. The technique of extraction is maseration. The larvae of Aedes aegypti instar III-IV are used, 800 in total, divided into 8 groups. At 6, 12, 18, and 24 hours, the number of dead larvae was counted .Normality and homegenity tests obtained the results of data not normally distributed and not homogeneous, so it is necessary to do the Kruskall-Wallis non-parametric test followed by Mann-Whitney post hoc .The result is bidara leaf extract with a concentration of 1.5% + 3% PEG resulted in 100% larval death in the 24th hour, meanwhile bidara fruit extract with concentration of 1.5% + 3% PEG resulted 70% larval death in 24th hour. Ethanol extract of bidara leaves has better effectiveness than bidara fruit extract in its ability as a larvicide, where bidara leaf extract with a concentration of 1.5% + 3% PEG resulted in 100% larval death in the 24th hour.
Depression and Anxiety as Risk Factors for Vitiligo Lulu Setyawati Purwaningsih; Moh. Shoim Dasuki; Metana Puspitasari; Ratih Pramuningtyas
International Journal Of Health Science Vol. 5 No. 3 (2025): November : International Journal of Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/ijhs.v5i3.5922

Abstract

vitiligo is a disease characterized by the selective loss of melanocytes, resulting in non-scaly chalk-white macules. There is no hypothesis that can clearly explain the scientific cause of vitiligo. However, some studies have indicated that stress and emotional pressure factors, such as anxiety, may contribute to the development or exacerbation of this condition.  Research Objective: this study aims to determine whether there is a relationship between depression and vitiligo, whether there is a relationship between anxiety and vitiligo, whether there is a relationship between smoking and vitiligo, and whether there is a relationship between depression and anxiety with vitiligo. Method: analytical observational research using a cross-sectional method is the research design employed. Purposive sampling is used to select the population based on inclusion and exclusion criteria, resulting in 53 responses. This study was conducted by interviewing patients using the Beck Depression Inventory and Beck Anxiety Inventory questionnaires, assisted by the researcher. Data analysis used univariate, bivariate, and multivariate analysis. Results: findings indicate that the significance value of Pearson chi-square is 0.001 < 0.05, meaning there is a significant relationship between depression and vitiligo. There is a significant relationship between anxiety and vitiligo with a significance value of Pearson chi-square 0.003 < 0.05. Simultaneously, depression and anxiety have a significant relationship with vitiligo. Conclusion: from the research results, it can be concluded that 30% of depression and anxiety can be the cause of vitiligo occurrences. Based on these conclusions, the suggestion that can be used as a consideration is that this research can be used as a basis for further research that links risk factors with the severity of vitiligo.