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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Biotropika JC-T (Journal Cis-Trans): Jurnal Kimia dan Terapannya JRST (Jurnal Riset Sains dan Teknologi) Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ JSMARTech : Journal of Smart Bioprospecting and Technology Berkala Penelitian Hayati Pharmademica: Jurnal Kefarmasian dan Gizi Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Makara Journal of Science Jurnal Tumbuhan Obat Indonesia Biosaintifika: Journal of Biology & Biology Education Metamorfosa: Journal of Biological Science Open Access DRIVERset
Ernanin Dyah Wijayanti
Akademi Farmasi Putra Indonesia Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Journal : Makara Journal of Science

 1 
Antimicrobial Activity of Ferulic Acid in Indonesian Purple Rice through Toll-like Receptor Signaling Wijayanti, Ernanin Dyah; Safitri, Anna; Siswanto, Dian; Triprisila, Lidwina Faraline; Fatchiyah, Fatchiyah
Makara Journal of Science Vol. 25, No. 4
Publisher : UI Scholars Hub

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Abstract

Purple rice is a potential source of ferulic acid, which has antimicrobial properties. However, the inhibitory mechanism of ferulic acid on the growth of bacteria, particularly Salmonella and Listeria, has not been elucidated. This study aimed to determine the bioactivity of ferulic acid from purple rice as an antimicrobial agent against Salmonella typhimurium and Listeria monocytogenes using in vitro and in silico analyses. The antimicrobial activity of a purple rice ferulic acid extract was tested using the agar well diffusion method. Its effect on bacterial cells was observed using scanning electron microscopy. Ferulic acid was confirmed to have antimicrobial properties using in silico software to attenuate the binding of bacterial virulence factors (lipoproteins, lipopolysaccharides, and flagellins) to Toll-like receptors (TLRs) and to prevent interactions with peptidoglycans. The purple rice ferulic acid extract inhibited bacterial growth. The inhibitory effects included induction of a biofilm and shrinkage of S. Typhimurium, as well as osmotic lysis of L. monocytogenes. This activity was supported by the ability of ferulic acid to inhibit the binding of bacterial virulence factors with TLRs and block bacterial peptidoglycans. These findings indicate that the purple rice ferulic acid extract acts as antimicrobial, both directly to bacterial cells and indirectly through TLRs. We conclude that ferulic acid from Indonesian purple rice has a biological function as an antimicrobial agent.
Molecular Interaction of Purple Rice Ferulic Acid and Skin Aging-Related Enzymes Wijayanti, Ernanin Dyah; Fatchiyah, Fatchiyah; Safitri, Anna; Siswanto, Dian
Makara Journal of Science Vol. 29, No. 1
Publisher : UI Scholars Hub

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Purple rice is rich in ferulic acid, a phenolic acid abundant in rice. Ferulic acid (FA) has long been recognized for its anti-oxidant properties, which are linked to its skin anti-aging activity owing to its ability to scavenge free radicals and pro-tect cells from damage. Skin anti-aging activity could be assessed by inhibiting skin aging enzymes. However, there was limited information on the mechanism of FA inhibition of these enzymes. This study focused on the molecular interac-tion between purple rice FA and collagenase or tyrosinase, both with and without their substrates. The interaction be-tween FA (CID 445858), collagenase (2Y6I), tyrosinase (5M8M), collagenase substrate (CID 5486160), and tyrosinase substrate (CID 6057) was docked using Hex 8.0.0 Cuda with the default settings. Discovery Studio 2020 and LigPlot software were used to visualize the docking results. Ascorbic acid (CID 54670067) and kojic acid (CID 3840) were used as positive controls for collagenase and tyrosinase, respectively. Molecular docking revealed that FA formed electro-static, hydrogen, and hydrophobic bonds with all aging enzymes, substrates, and enzyme–substrate complexes. FA could bind to both free enzymes and free substrates, consequently attenuating enzyme–substrate bonding, and preventing the substrate from binding appropriately in its normal position. Molecular dynamics simulations demonstrated that FA formed a stable bond with tyrosinase, similar to kojic acid, although the bond with collagenase was less stable. However, the pattern of each parameter during the simulation was comparable with that of ascorbic acid. The current study indicated that the FA from purple rice had the potential to act as an inhibitor of skin aging en-zymes and could be developed as a skin anti-aging candidate
Co-Authors Afriliana, Dwi Agustanti, Khalimatus Nur Eka Ayunda, Fiddini Robetta Dian Siswanto Djara, Selfiana Dzulaikha, Shovia Eko Suyanto Elrica Maggian Murelina Elwin Dwi Novitasari Endang Susilowati fatchiyah . Fatchiyah Fatchiyah Fitri Husniatin Nisa Hardiansi, Fitri Husnah, Yeni Avidhatul Ibrahim, Zalikha Joko Raharjo, Sentot Lidwina Faraline Triprisila Linda Jaushica Yustin Munteira, Anita Noor Annisa Susanto Nur Hayati Nur Laela nurmiati Dyah nurmiati Oktavina Kartika Putri Rahayu, Lina Oktavia Riki Purwosutanto Safitri, Anna Sari, Dewi Ratih Tirto Sentot Joko Raharjo Setiawan, Nur Candra Eka Syafah, Lailiiyatus Syarifah, Anisa Lailatusy Tri Ardyati Uswatun, Uswatun Wulandari, Dita Yunita Yunita