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All Journal CHEMISTRY PROGRESS Alchemy : Journal of Chemistry Jurnal Kesehatan Prima Jurnal IDAMAN (Induk Pemberdayaan Masyarakat Pedesaan) Nutriture Journal Current Biomedicine Media Penelitian dan Pengembangan Kesehatan
Zuri Rismiarti
Brawijaya University
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Education Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Current Biomedicine

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Sensitivity and specificity of the lipoarabinomannan test compared to GeneXpert in urine samples for tuberculosis diagnosis Irawan, Danni; Rismiarti, Zuri; Tantan, Acep; Merdekawati, Fusvita
Current Biomedicine Vol. 3 No. 1 (2025): January
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.3.1.7

Abstract

Background Mycobacterium tuberculosis (MTB) is the causative agent of tuberculosis (TB), primarily affecting lung tissue but also capable of infecting pleura, lymph nodes, bones, and other extrapulmonary sites. Lipoarabinomannan (LAM) is a critical lipopolysaccharide in the outer wall of mycobacterial cells and can be detected in the urine of TB patients as an antigen. Objective This study aimed to assess the sensitivity and specificity of the LAM test compared to GeneXpert in urine samples from suspected TB patients. Methods A quasi-experimental design was employed, where urine samples were collected from patients diagnosed with TB at Sidawangi Lung Hospital, West Java Province. The LAM test was performed on 40 samples by applying 60 µL of urine onto LAM test strips, while MTB presence in urine was examined using GeneXpert. Results LAM test results showed 32.5% positivity, while 67.5% were negative. GeneXpert results indicated 20% positivity and 80% negativity. The LAM test demonstrated a sensitivity of 100% and specificity of 79.4% compared to GeneXpert, with an area under the curve (AUC) value of 0.897. Conclusion The LAM test showed high sensitivity and moderate specificity compared to GeneXpert in urine samples of suspected TB patients.
Effect of solvent variation on results of antibiotic susceptibility test using the disk diffusion method against Staphylococcus aureus Habibah, Firda Nurul; Sufa, Hafizah Ilmi; Kurniati, Iis; Rismiarti, Zuri
Current Biomedicine Vol. 3 No. 2 (2025): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.3.2.60

Abstract

Background Mueller-Hinton agar (MHA) is widely used for disk diffusion tests to assess antibiotic susceptibility in non-fastidious bacteria. The type of water used to prepare the MHA may have affected the test outcomes. Objective This study evaluated the effect of different water types as solvents on the antibiotic susceptibility test results of tetracycline and gentamicin against Staphylococcus aureus. Methods MHA was prepared using four types of water: distilled (control), bottled, reverse osmosis (RO), and municipal tap water (PDAM). Antibiotic susceptibility testing was performed using the Kirby-Bauer disk diffusion method, and data were analyzed using One-Way ANOVA and Tukey’s Post Hoc test. Results The mean inhibition zones for tetracycline were 23.8 ± 0.99 mm (distilled), 23.4 ± 0.37 mm (bottled), 23.0 ± 0.43 mm (RO), and 17.8 ± 1.41 mm (tap), categorized as sensitive except for tap water (intermediate). For gentamicin, the zones were 11.7 ± 0.37 mm (distilled), 12.7 ± 0.77 mm (bottled), 9.8 ± 0.18 mm (RO), and 17.6 ± 1.19 mm (tap), with the first three classified as resistant and tap water as sensitive. The tap water results were significantly different (p<0.05) from those of the other antibiotics. Conclusion The use of non-standard solvents in MHA preparation, particularly tap water, may lead to inconsistent antibiotic susceptibility results. Standardized use of distilled water is recommended to ensure test accuracy and reliability.
Co-Authors Agustini, Siti Fajarwati Alfanaar, Rokiy Atikah . Chasan Bisri Habibah, Firda Nurul Iis Kurniati Indra, Asep Iin Nur Irawan, Danni Makbul Paneja, Rosmini Binti Mamat Rahmat Merdekawati, Fusvita Nur Indra, Asep Iin Renny Indrawati, Renny rohayati rohayati Sufa, Hafizah Ilmi Syaindi, Amanda Afifah Tantan, Acep Yeni Wahyuni Yuyun Irnawati, Yuyun Yuyun Yuniati