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All Journal Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas Majalah Farmaseutik Indonesian Journal of Chemistry JURNAL PENGABDI Cendekia Journal of Pharmacy Jurnal Pengabdian Kesehatan Rengganis Jurnal Pengabdian Masyarakat Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat MEDICINUS JURNAL JAMU KUSUMA Journal of Food and Pharmaceutical Sciences Journal of Pharmascience
Florentinus Dika Octa Riswanto
Faculty Of Pharmacy, Sanata Dharma University, Yogyakarta 55282
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Potensi Daun dan Bunga Telang (Clitoria ternatea L.) sebagai Antioksidan Florentinus Dika Octa Riswanto; Anastasia Melin Fitria Wulandari; Faustina Evania Ngai; Corina Febrianti Isabel; Agatha Kania Ugahari Dyatmika; Filisia Putri Rosari; Dewi Setyaningsih
MEDICINUS Vol. 35 No. 2 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (154.205 KB) | DOI: 10.56951/medicinus.v35i2.92

Abstract

Indonesia has various traditional plants that are potential to be used as medicinal agents. The telang plant (Clitoria ternatea L.) has been studied regarding its’ potency as a traditional medicine. The parts of the telang plant that are often used are leaves and flowers. Telang leaves and flowers contain several compounds with antioxidant activity including phenolics, flavonoids, anthocyanins, and tannins. Antioxidant activity can be tested using several methods, e.g. DPPH, ORAC, and FRAP. Based on the results of the literature review, it is known that telang leaves and flowers have antioxidant activity and do not show any potential toxicity, therefore they can be considered as safe to be used.
Potensi Tanaman Sukun (Artocarpus altilis) sebagai Agen Antiinflamasi dan Antidiabetes Ni Gusti Ayu Diantari; Debby Yunita; Maria Aurelia Afila Tutonugi; Theresia Helena Tokan; Teresia Kiki Oktavianti; Florentinus Dika Octa Riswanto; Dewi Setyaningsih
MEDICINUS Vol. 36 No. 2 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i2.122

Abstract

Background: Artocarpus altilis is a plant whose every part is beneficial for health. In Indonesia, the distribution of this plant is only found in certain places and has not been cultivated. Breadfruit is basically rich in flavonoid, tannin, and saponin compounds that are known to be potential as antidiabetic and antiinflammatory. Diabetes is a group of metabolic disease characterized by hyperglycemia, due to lack of insulin production and/or sensitivity. Type 2 diabetes is a degenerative disease that is a global health problem. Type 2 diabetes is treated using antidiabetic agents and/or insulin. Inflammation is a local reaction of the body characterized by certain symptoms. Treatment of inflammation using synthetic drugs is associated with various side effects. Objective: This review is aimed to provide information about antidiabetic and anti-inflammatory activities in breadfruit plant. Results: Substance of breadfruit plant with antidiabetic efficacy was found in the stem, leaf, and fruit, showed by results of phytochemical test. Antidiabetic activity was proven by in vivo, in vitro, and AlCl calorimetry tests, while anti-inflammatory substance was found in the leaf and fruit, and the anti-inflammatory activity was showed by results of in vivo and in vitro tests. Conclusion: Breadfruit plants can be potentially developed as an alternative treatment for diabetes and inflammation.
Pemanfaatan Pengolahan Big Data secara Analisis Korespondensi Berganda dalam Pemetaan Profil Penggunaan Antibiotika pada Masyarakat Desa Beradolu, Kecamatan Loli, Kabupaten Sumba Barat, Nusa Tenggara Timur Bili, Juita Putrinda; Hartayu, Titien Siwi; Riswanto, Florentinus Dika Octa
Majalah Farmaseutik Vol 19, No 3 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i3.84961

Abstract

Analisis korespondensi berganda (AKB) merupakan suatu teknik yang digunakan untuk menganalisis data secara statistika melalui pengubahan variabel ke dalam bentuk yang lebih sederhana dengan dukungan visualisasi untuk mempermudah proses yang diperlukan. Penelitian ini bertujuan untuk mengaplikasikan metode AKB dalam evaluasi profil penggunaan antibiotika pada masyarakat dengan menggunakan kuesioner yang diberikan secara daring melalui media sosial (Whatsapp/ Facebook/Instagram).Jenis penelitian ini termasuk deskriptif analitik dengan desain cross sectional. Responden yang terlibat dalam penelitian ini sebanyak 96 orang dengan 10 variabel penelitian meliputi lima jenis antibiotik dan lima jenis penyakit/gejala yang dialami pasien. Data yang diperoleh kemudian dicatat dan diolah menggunakan AKB untuk menghasilkan pemetaan profil penggunaan antibiotika.Hasil penelitian yang diperoleh yaitu dari antara lima antibiotika, amoxicillin merupakan yang paling banyak digunakan. Antibiotika yang paling jarang digunakan adalah chloramphenicol. Pemetaan profil penggunaan antibiotika telah berhasil dilakukan untuk analisis data individual, variabel, korelasi, evaluasi visual, serta ditunjang dengan data deskripsi dimensi.
Edukasi Hipertensi pada Pasien PROLANIS Puskesmas Wonosari II Hendra, Phebe; Pramono, Zita Dhirani; Julianus, Jeffry; Riswanto, Florentinus Dika Octa
Jurnal Pengabdi Vol 7, No 2 (2024): Oktober 2024
Publisher : Universitas Tanjungpura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/jplp2km.v7i2.85251

Abstract

Hipertensi merupakan salah satu penyakit yang menjadi penyebab kematian terbanyak di dunia. Pengendalian hipertensi dapat dilakukan dengan berbagai cara. BPJS Kesehatan telah menetapkan PROLANIS (Program Pengelolaan Penyakit Kronis) sebagai salah satu program yang ditujukan untuk pasien dengan penyakit kronis. Puskesmas Wonosari II merupakan salah satu layanan primer yang mengadakan program PROLANIS secara rutin. Kegiatan pengabdian masyarakat ini bertujuan untuk memberikan edukasi kepada peserta PROLANIS terkait penyakit hipertensi melalui media booklet. Kegiatan ini diselenggarakan atas kerjasama dari tim dari Fakultas Farmasi Universitas Sanata Dharma dan Puskesmas Wonosari II. Sebanyak 26 peserta menghadiri kegiatan edukasi yang bersamaan dengan kegiatan rutin yakni senam PROLANIS. Adanya edukasi melalui media booklet ini diharapkan dapat meningkatkan kualitas hidup dan mengontrol tekanan darah pasien.
Pendampingan Penurunan Stunting Area Puskesmas II Wonosari Gunung Kidul Putri, Dina Christin Ayuning; Dwiastuti, Rini; Riswanto, Florentinus Dika Octa; Kinanti, Valentina Putri Embun; Tiara, Carolina; Padmadiayu, Hana; Meissy, Angelina; Bintari, Resita Widya; Jihan, Rimatul
Jurnal Pengabdian Kesehatan Vol 8, No 2 (2025): Jurnal Pengabdian Kesehatan
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM) STIKES Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/jpk.v8i2.463

Abstract

Angka stunting di Kabupaten Gunungkidul adalah yang tertinggi di wilayah Daerah Istimewa Yogyakarta. Banyak faktor mempengaruhi kejadian stunting, salah satunya adalah tingkat pengetahuan orang tua dan juga anak-anak. Dalam upaya penurunan angka stunting di Gunungkidul, diperlukan edukasi bagi orang tua dan anak-anak tentang stunting dan bagaimana cara mengatasinya. Kegiatan ini bertujuan untuk meningkatkan pengetahuan orang tua tentang stunting dan cara mengatasinya, serta mengenalkan makanan sehat bagi anak-anak. Kegiatan dilakukan dengan edukasi dalam bentuk penyuluhan-evaluasi-refleksi bagi orang tua. Materi bagi orang tua meliputi tinjauan medis stunting dan tatalaksana stunting. Edukasi makanan sehat bergizi bagi anak-anak disampaikan melalui video dan permainan. Evaluasi kegiatan dilakukan dengan proses refleksi yang menunjukkan bahwa orangtua yang mengikuti kegiatan ini memiliki peningkatan pengetahuan. Hal ini diperkuat dengan nilai postest peserta dengan rerata 88,75. Edukasi pada anak-anak juga berjalan baik, ditunjukkan dengan ketepatan anak-anak dalam menjawab dan menyebutkan makanan-makanan sehat tinggi gizi dalam aktivitas yang dilakukan.
Exploring the Potential of NIR Spectroscopy and Chemometrics to Verify the Flavonoid Content in Litsea cubeba Cendekiawan, Khrisna Agung; Susanti, Dhina Ayu; Isnawati, Nafisah; Mayasari, Shinta; Riswanto, Florentinus Dika Octa
Majalah Obat Tradisional Vol 30, No 2 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.99185

Abstract

The ancient records about herbal medicine show traditional healing practices are deeply rooted in Indonesian culture. The medical use of plants decreased because of inheritance customs combined with the lack of written documentation on medicinal plants but dependent on oral information transmission. Traditional research and preservation activities of local healing plants which belong to specific cultural communities become possible through this phenomenon. Researchers conducted ethnopharmacological research about antidiarrheal medicinal plant uses that included traditional knowledge about flavonoid-containing plants within the Osing ethnic group of West Java Indonesia. The goal of this research was to verify flavonoid compounds in Osing's medicinal plants through Near Infra-Red (NIR) spectroscopy combined with chemometric methods. The evaluation of antidiarrheal potential for these compounds relied on flavonoid standard reference substances because these compounds demonstrate strong antioxidant properties which stabilize intestinal functioning. Chemometric techniques together with Near Infra-Red spectroscopy (NIR) were applied to analyze krangean leaves (Litsea cubeba) in order to establish their flavonoid compound levels. The quality assessment of multivariate calibration models shows that PLS regression produces RMSEC of 2.870 and RMSEP of 0.0124 with R2cal = 0.9931 and R2val = 0.9919. The analysis using linear discriminant analysis (LDA) succeeded in its completion with recognition rates above 90% for each discriminating class.
Pemberdayaan Kesehatan Masyarakat Dusun Kemantren II Semawung Melalui Edukasi Pengelolaan Obat Hendra, Phebe; Riswanto, Florentinus Dika Octa; Setyani, Wahyuning; Julianus, Jeffry; Rajagukguk, ⁠Greysianita; Santi , Nyoman Pradnya Yoni Meytri; Bramantyo , Dominicus Adyatma; Siallagan , Angela Meirella; Putri , Elsha Tiany
Rengganis Jurnal Pengabdian Masyarakat Vol. 5 No. 2 (2025): November 2025
Publisher : Pendidikan Matematika, FKIP Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/rengganis.v5i2.608

Abstract

The misuse of drugs is a major health issue in Indonesia, largely due to a lack of understanding about proper drug management. Knowledge of correct medication use is essential to prevent administration errors. Key issues in Dusun Kemantren II, Semawung Village include a limited understanding of medication usage and inadequate drug storage systems. Engaging the community with information on effective drug management is essential to address this. This community service initiative aims to improve drug management knowledge in Dusun Kemantren II, Semawung Village, Purworejo District. The activity was carried out on May 4, 2025, with 23 participants. Evaluation results showed increased participants' knowledge after the education, based on average pre-test and post-test scores. This program successfully improved public knowledge and awareness regarding the importance of proper drug management. It provided practical means, such as medicine boxes, to support the implementation of this knowledge at the household level.
Authentication of Drimys piperita Hook f. Tree Bark Infusion from the Adulteration of Cinnamomum burmannii Nees Ex Bl. using the Combination of UV Spectroscopy and Chemometrics Techniques Sabela, Vivian Yulias; Laurendy, Chesie; Prarathana, Dicky; Riswanto, Florentinus Dika Octa
MPI (Media Pharmaceutica Indonesiana) Vol. 7 No. 2 (2025): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v7i2.7964

Abstract

This study aims to develop a method to authenticate akway bark (Drimys piperita Hook f.) infusion using UV spectroscopy and chemometrics techniques. The background initiative of this study is the consideration of the high economic value of akway bark which may potentially lead to the adulteration of the akway raw materials for traditional medicine. The sample used in this study was akway bark obtained from Manokwari, Papua, Indonesia. Samples of akway bark, cinnamon, and a mixture of both were prepared in the form of powder and then infused. The infusion was examined using UV spectroscopy to obtain the absorption value of each wavelength. Chemometrics techniques including principal component analysis (PCA) and multivariate calibration using principal component regression (PCR) and partial least squares (PLS) regression were carried out during the study. Additionally, computational discrimination using sparse partial least squares discriminant analysis (sPLS-DA) was performed afterwards. A total of 36 distinctive wavelengths were obtained. The absorption values were then used to form a PCA model. The best multivariate calibration model was derived from PCR data processing on the original spectra for both akway and cinnamon bark infusion samples. The AUC-ROC values obtained from the application of the sPLS-DA technique for each sample were 1.000, 0.956, and 0.633 for akway bark, cinnamon, and the mixture of both, respectively. Authentication of akway bark infusion has been successfully conducted on the presence of cinnamon as the adulterant.
A Structure-Based Virtual Screening Protocol Utilizing PyPLIF HIPPOS and Vina for Targeting BACE-1 Primana, Mala Hikmawan; Oka, Mitsue; Istyastono, Enade Perdana; Riswanto, Florentinus Dika Octa
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24790

Abstract

Alzheimer’s Disease (AD) is a leading cause of dementia, characterized by progressive cognitive decline driven in part by amyloid-β (Aβ) accumulation. The β-site amyloid precursor protein cleaving enzyme 1 (BACE-1) is responsible for initiating Aβ generation, making it a central therapeutic target. Yet, developing effective BACE-1 inhibitors has proven difficult due to structural complexity and pharmacological limitation. This study aimed to construct and validate a structure-based virtual screening (SBVS) workflow combining Vina and PyPLIF HIPPOS to facilitate the identification of promising BACE-1 ligands. The protocol was validated through 100 independent redocking experiments of the native ligand (PDB ID: 3L5F), all reproducing the crystallographic pose with RMSD < 2.0 Å. Large-scale screening of the DUDE dataset (283 active ligands; 18,100 decoys) generated interaction fingerprint, which were subsequently analyzed using Recursive Partitioning and Regression Trees (RPART) under varying prior probabilities. At the optimal prior ratio of 0.82:0.18, the model achieved an enrichment factor (EF) of 10.03, surpassing the DUDE benchmark (EF = 8.1). analysis consistently highlighted ionic interactions with Asp289 and hydrophobic contacts with Trp137 as key determinants of ligand activity. From 283 active ligands, 32 were classified as true positives, narrowing the pool of candidates and interpretable SBVS protocol and proposing a dual anchoring strategy involving Asp289 and Trp137 as a rational design principle for novel BACE-1 inhibitors in AD therapy.
A Structure-Based Virtual Screening Protocol Utilizing PyPLIF HIPPOS and Vina for Targeting BACE-1 Primana, Mala Hikmawan; Oka, Mitsue; Istyastono, Enade Perdana; Riswanto, Florentinus Dika Octa
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24790

Abstract

Alzheimer’s Disease (AD) is a leading cause of dementia, characterized by progressive cognitive decline driven in part by amyloid-β (Aβ) accumulation. The β-site amyloid precursor protein cleaving enzyme 1 (BACE-1) is responsible for initiating Aβ generation, making it a central therapeutic target. Yet, developing effective BACE-1 inhibitors has proven difficult due to structural complexity and pharmacological limitation. This study aimed to construct and validate a structure-based virtual screening (SBVS) workflow combining Vina and PyPLIF HIPPOS to facilitate the identification of promising BACE-1 ligands. The protocol was validated through 100 independent redocking experiments of the native ligand (PDB ID: 3L5F), all reproducing the crystallographic pose with RMSD < 2.0 Å. Large-scale screening of the DUDE dataset (283 active ligands; 18,100 decoys) generated interaction fingerprint, which were subsequently analyzed using Recursive Partitioning and Regression Trees (RPART) under varying prior probabilities. At the optimal prior ratio of 0.82:0.18, the model achieved an enrichment factor (EF) of 10.03, surpassing the DUDE benchmark (EF = 8.1). analysis consistently highlighted ionic interactions with Asp289 and hydrophobic contacts with Trp137 as key determinants of ligand activity. From 283 active ligands, 32 were classified as true positives, narrowing the pool of candidates and interpretable SBVS protocol and proposing a dual anchoring strategy involving Asp289 and Trp137 as a rational design principle for novel BACE-1 inhibitors in AD therapy.
Co-Authors Abdul Rohman Abdul Rohman Adelsiana Leda Adithya Guntur Agatha Kania Ugahari Dyatmika Agnes Margaretta Sihombing Agustina Setiawati Alni Desra Anandha Nabila Prjanaparamita Anastasia Bella Anastasia Melin Fitria Wulandari Angelina Kinsha Pandhita Arief Dzulfianto Arini Safti Sandrapitaloka Arya Pratama Nugraha Pede Bili, Juita Putrinda Bintari, Resita Widya Birgita Elsia Setiarini Bramantyo , Dominicus Adyatma Christofori Maria Ratna Rini Nastiti Corina Febrianti Isabel Debby Yunita Debi Kristiananda Debi Kristiananda Desy Natalia Rambu Padji Mahemba Dewi Setyaningsih DEWI SETYANINGSIH Dina Christin Ayuning Putri Dita Maria Virginia Enade Perdana Istyastono Enade Perdana Istyastono Enade Perdana Istyastono Enade Perdana Istyastono Familia Putri Wulandari Faustina Evania Ngai Febrina Dameria Marbun Filisia Putri Rosari Florentina Yohana Ngelu Fransisca Wahyu Indriastuti Indriastuti Fransiska Revana Restiana Giovanny Leonarda Indriastuti, Fransisca Wahyu Indriastuti Indriastuti, Fransisca Wahyu Indriastuti Jeanne Magistra Noverita Jeanne Magistra Noverita Jeffry Julianus Jihan, Rimatul Jullius Ivan Mahadhika Juvita Lisu Allo Juvita Lisu Allo Katharina Floransia Walburga Resmianto Katrina Imaculata Tema Pedha Khrisna Agung Cendekiawan Kinanti, Valentina Putri Embun Klemen Wahyu Kurniadi Kurniadi, Klemen Wahyu Kurniadi, Klemen Wahyu Laurendy, Chesie Lintang Adelya Lusiana Lusiana Lusiana Lusiana Mahenu, Novia Indah Permatasari Putri Mahenu, Novia Indah Permatasari Putri Marchaban Marchaban Maria Aurelia Afila Tutonugi Maria Theresia Mawarni Mase Mase Maywan Hariono Meissy, Angelina Michael Raharja Gani Monica Selena nafisah isnawati Ni Gusti Ayu Diantari Novia Indah Permatasari Putri Mahenu Noviayanti Chandra Oka, Mitsue Padmadiayu, Hana Paulina Nadya Feranti Pebby Lorenza Petrus Damiani Tosan Aji Phebe Hendra, Phebe Pisga Chrisita Dewi Pramono, Zita Dhirani Prarathana, Dicky Primana, Mala Hikmawan Putri , Elsha Tiany Putri Natasya Br Siregar Putri Natasya Br Siregar Radhita Tyastu Puteri Winengku Rajagukguk, ⁠Greysianita Rini Dwiastuti Rini Dwiastuti Rinjani Mustika Sari RR. Endang Lukitaningsih Sabela, Vivian Yulias Santi , Nyoman Pradnya Yoni Meytri Setiarini, Birgita Elsia Setiarini, Birgita Elsia Shinta Mayasari Siallagan , Angela Meirella Sri Hartati Yuliani Sudibyo Martono Sudibyo Martono Susanti, Dhina Ayu Suwidjiyo Pramono Teresia Kiki Oktavianti Theodora Dominika Gadi Seran Theresia Helena Tokan Tiara, Carolina Titien Siwi Hartayu Valentino Thomas Vania Rambu Kaha Milla Ate Veronica Arien Widyarahma Veronica Arien Widyarahma Vinsensia Nalita Maharani Wahyuning Setyani Wulandari, Familia Putri Wulandari, Familia Putri Yoanes Fransiskus Regis Widyo Utomo Yohana Manalu Yohana Maria Bina Zerlinda Clara Auw