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All Journal Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY Pharmascience Jurnal Farmasi Sains dan Komunitas Majalah Farmaseutik Indonesian Journal of Chemistry JURNAL PENGABDI Cendekia Journal of Pharmacy Jurnal Pengabdian Kesehatan Rengganis Jurnal Pengabdian Masyarakat Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat MEDICINUS JURNAL JAMU KUSUMA Journal of Food and Pharmaceutical Sciences
Florentinus Dika Octa Riswanto
Faculty Of Pharmacy, Sanata Dharma University, Yogyakarta 55282
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Kemangi (Ocimum basilicum L.): Kandungan Kimia, Teknik Ekstraksi, dan Uji Aktivitas Antibakteri Adithya Guntur; Monica Selena; Anastasia Bella; Giovanny Leonarda; Adelsiana Leda; Dewi Setyaningsih; Florentinus Dika Octa Riswanto
Journal of Food and Pharmaceutical Sciences Vol 9, No 3 (2021): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.3376

Abstract

Resistensi terhadap beberapa antibiotik disebabkan oleh adanya penggunaan antibiotik yang rasional masih sering diabaikan. Kemangi (Ocimum basilicum L.) merupakan salah satu tanaman yang memiliki aktivitas antibakteri. Salah satu kandungan kemangi yang diduga memiliki aktivitas antibakteri yaitu minyak atsiri. Penelitian terkait aktivitas antibakteri pada kemangi sebagian besar dilakukan dengan menggunakan sampel segar maupun simplisia dari daun kemangi yang kemudian diekstraksi, namun ada beberapa uji yang menggunakan bagian batang. Metode uji aktivitas antibakteri kemangi terhadap beberapa bakteri gram positif dan gram negatif dilakukan dengan metode difusi cakram agar, difusi cakram kertas, mikrodilusi broth, mikrodilusi dalam microtiter plates, difusi sumuran agar, dan macro-dilusi. Hasil uji aktivitas antibakteri menunjukkan bahwa kandungan minyak atsiri yang terdapat dalam kemangi memiliki aktivitas penghambat aktivitas bakteri.
Potensi Daun dan Bunga Telang (Clitoria ternatea L.) sebagai Antioksidan Florentinus Dika Octa Riswanto; Anastasia Melin Fitria Wulandari; Faustina Evania Ngai; Corina Febrianti Isabel; Agatha Kania Ugahari Dyatmika; Filisia Putri Rosari; Dewi Setyaningsih
MEDICINUS Vol. 35 No. 2 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (154.205 KB) | DOI: 10.56951/medicinus.v35i2.92

Abstract

Indonesia has various traditional plants that are potential to be used as medicinal agents. The telang plant (Clitoria ternatea L.) has been studied regarding its’ potency as a traditional medicine. The parts of the telang plant that are often used are leaves and flowers. Telang leaves and flowers contain several compounds with antioxidant activity including phenolics, flavonoids, anthocyanins, and tannins. Antioxidant activity can be tested using several methods, e.g. DPPH, ORAC, and FRAP. Based on the results of the literature review, it is known that telang leaves and flowers have antioxidant activity and do not show any potential toxicity, therefore they can be considered as safe to be used.
Potensi Tanaman Sukun (Artocarpus altilis) sebagai Agen Antiinflamasi dan Antidiabetes Ni Gusti Ayu Diantari; Debby Yunita; Maria Aurelia Afila Tutonugi; Theresia Helena Tokan; Teresia Kiki Oktavianti; Florentinus Dika Octa Riswanto; Dewi Setyaningsih
MEDICINUS Vol. 36 No. 2 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i2.122

Abstract

Background: Artocarpus altilis is a plant whose every part is beneficial for health. In Indonesia, the distribution of this plant is only found in certain places and has not been cultivated. Breadfruit is basically rich in flavonoid, tannin, and saponin compounds that are known to be potential as antidiabetic and antiinflammatory. Diabetes is a group of metabolic disease characterized by hyperglycemia, due to lack of insulin production and/or sensitivity. Type 2 diabetes is a degenerative disease that is a global health problem. Type 2 diabetes is treated using antidiabetic agents and/or insulin. Inflammation is a local reaction of the body characterized by certain symptoms. Treatment of inflammation using synthetic drugs is associated with various side effects. Objective: This review is aimed to provide information about antidiabetic and anti-inflammatory activities in breadfruit plant. Results: Substance of breadfruit plant with antidiabetic efficacy was found in the stem, leaf, and fruit, showed by results of phytochemical test. Antidiabetic activity was proven by in vivo, in vitro, and AlCl calorimetry tests, while anti-inflammatory substance was found in the leaf and fruit, and the anti-inflammatory activity was showed by results of in vivo and in vitro tests. Conclusion: Breadfruit plants can be potentially developed as an alternative treatment for diabetes and inflammation.
Pemanfaatan Pengolahan Big Data secara Analisis Korespondensi Berganda dalam Pemetaan Profil Penggunaan Antibiotika pada Masyarakat Desa Beradolu, Kecamatan Loli, Kabupaten Sumba Barat, Nusa Tenggara Timur Bili, Juita Putrinda; Hartayu, Titien Siwi; Riswanto, Florentinus Dika Octa
Majalah Farmaseutik Vol 19, No 3 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i3.84961

Abstract

Analisis korespondensi berganda (AKB) merupakan suatu teknik yang digunakan untuk menganalisis data secara statistika melalui pengubahan variabel ke dalam bentuk yang lebih sederhana dengan dukungan visualisasi untuk mempermudah proses yang diperlukan. Penelitian ini bertujuan untuk mengaplikasikan metode AKB dalam evaluasi profil penggunaan antibiotika pada masyarakat dengan menggunakan kuesioner yang diberikan secara daring melalui media sosial (Whatsapp/ Facebook/Instagram).Jenis penelitian ini termasuk deskriptif analitik dengan desain cross sectional. Responden yang terlibat dalam penelitian ini sebanyak 96 orang dengan 10 variabel penelitian meliputi lima jenis antibiotik dan lima jenis penyakit/gejala yang dialami pasien. Data yang diperoleh kemudian dicatat dan diolah menggunakan AKB untuk menghasilkan pemetaan profil penggunaan antibiotika.Hasil penelitian yang diperoleh yaitu dari antara lima antibiotika, amoxicillin merupakan yang paling banyak digunakan. Antibiotika yang paling jarang digunakan adalah chloramphenicol. Pemetaan profil penggunaan antibiotika telah berhasil dilakukan untuk analisis data individual, variabel, korelasi, evaluasi visual, serta ditunjang dengan data deskripsi dimensi.
Edukasi Hipertensi pada Pasien PROLANIS Puskesmas Wonosari II Hendra, Phebe; Pramono, Zita Dhirani; Julianus, Jeffry; Riswanto, Florentinus Dika Octa
Jurnal Pengabdi Vol 7, No 2 (2024): Oktober 2024
Publisher : Universitas Tanjungpura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/jplp2km.v7i2.85251

Abstract

Hipertensi merupakan salah satu penyakit yang menjadi penyebab kematian terbanyak di dunia. Pengendalian hipertensi dapat dilakukan dengan berbagai cara. BPJS Kesehatan telah menetapkan PROLANIS (Program Pengelolaan Penyakit Kronis) sebagai salah satu program yang ditujukan untuk pasien dengan penyakit kronis. Puskesmas Wonosari II merupakan salah satu layanan primer yang mengadakan program PROLANIS secara rutin. Kegiatan pengabdian masyarakat ini bertujuan untuk memberikan edukasi kepada peserta PROLANIS terkait penyakit hipertensi melalui media booklet. Kegiatan ini diselenggarakan atas kerjasama dari tim dari Fakultas Farmasi Universitas Sanata Dharma dan Puskesmas Wonosari II. Sebanyak 26 peserta menghadiri kegiatan edukasi yang bersamaan dengan kegiatan rutin yakni senam PROLANIS. Adanya edukasi melalui media booklet ini diharapkan dapat meningkatkan kualitas hidup dan mengontrol tekanan darah pasien.
Quality Assessment of Extemporaneous Capsule Preparation containing Methylprednisolone, CTM, and Theophylline using Spectrophotometrics and Chemometrics Techniques Darmawangzah, Muhammad; Riswanto, Florentinus Dika Octa; Irnawati, Irnawati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008772

Abstract

Currently, doctors in developing countries still prefer to prescribe compounding drugs because certain drugs are not available in ready-made dosage forms. It is considered that the capsule formulation can increase patient compliance because it requires a smaller amount of medication. In particular, for asthma patients, extemporaneous capsule preparation containing methylprednisolone, CTM, and theophylline is usually prescribed. However, theophylline, which has a narrow therapeutic index, combined with small doses of methylprednisolone and CTM, may result in inconsistent drug content in the compounded drug. This study aimed to assess the quality of the capsule mixture containing methylprednisolone, CTM, and theophylline formulated at the “X” Kolaka Community Health Center, Southeast Sulawesi, Indonesia. Extemporaneous capsules are tested using various methods such as organoleptic tests, water content tests, disintegration time tests, and content uniformity tests of compounding drugs. The quality test results of the compounding capsule with the active substance a combination of methylprednisolone, CTM, and theophylline formulated at the “X” Kolaka Health Center met the quality requirements with organoleptic tests, moisture content tests, and disintegration time tests. The content uniformity test does not meet the requirements according to the Indonesian Pharmacopoeia VI edition based on the acceptance values of L1% and L2%.
Pendampingan Penurunan Stunting Area Puskesmas II Wonosari Gunung Kidul Putri, Dina Christin Ayuning; Dwiastuti, Rini; Riswanto, Florentinus Dika Octa; Kinanti, Valentina Putri Embun; Tiara, Carolina; Padmadiayu, Hana; Meissy, Angelina; Bintari, Resita Widya; Jihan, Rimatul
Jurnal Pengabdian Kesehatan Vol 8, No 2 (2025): Jurnal Pengabdian Kesehatan
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM) STIKES Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/jpk.v8i2.463

Abstract

Angka stunting di Kabupaten Gunungkidul adalah yang tertinggi di wilayah Daerah Istimewa Yogyakarta. Banyak faktor mempengaruhi kejadian stunting, salah satunya adalah tingkat pengetahuan orang tua dan juga anak-anak. Dalam upaya penurunan angka stunting di Gunungkidul, diperlukan edukasi bagi orang tua dan anak-anak tentang stunting dan bagaimana cara mengatasinya. Kegiatan ini bertujuan untuk meningkatkan pengetahuan orang tua tentang stunting dan cara mengatasinya, serta mengenalkan makanan sehat bagi anak-anak. Kegiatan dilakukan dengan edukasi dalam bentuk penyuluhan-evaluasi-refleksi bagi orang tua. Materi bagi orang tua meliputi tinjauan medis stunting dan tatalaksana stunting. Edukasi makanan sehat bergizi bagi anak-anak disampaikan melalui video dan permainan. Evaluasi kegiatan dilakukan dengan proses refleksi yang menunjukkan bahwa orangtua yang mengikuti kegiatan ini memiliki peningkatan pengetahuan. Hal ini diperkuat dengan nilai postest peserta dengan rerata 88,75. Edukasi pada anak-anak juga berjalan baik, ditunjukkan dengan ketepatan anak-anak dalam menjawab dan menyebutkan makanan-makanan sehat tinggi gizi dalam aktivitas yang dilakukan.
Exploring the Potential of NIR Spectroscopy and Chemometrics to Verify the Flavonoid Content in Litsea cubeba Cendekiawan, Khrisna Agung; Susanti, Dhina Ayu; Isnawati, Nafisah; Mayasari, Shinta; Riswanto, Florentinus Dika Octa
Majalah Obat Tradisional Vol 30, No 2 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.99185

Abstract

The ancient records about herbal medicine show traditional healing practices are deeply rooted in Indonesian culture. The medical use of plants decreased because of inheritance customs combined with the lack of written documentation on medicinal plants but dependent on oral information transmission. Traditional research and preservation activities of local healing plants which belong to specific cultural communities become possible through this phenomenon. Researchers conducted ethnopharmacological research about antidiarrheal medicinal plant uses that included traditional knowledge about flavonoid-containing plants within the Osing ethnic group of West Java Indonesia. The goal of this research was to verify flavonoid compounds in Osing's medicinal plants through Near Infra-Red (NIR) spectroscopy combined with chemometric methods. The evaluation of antidiarrheal potential for these compounds relied on flavonoid standard reference substances because these compounds demonstrate strong antioxidant properties which stabilize intestinal functioning. Chemometric techniques together with Near Infra-Red spectroscopy (NIR) were applied to analyze krangean leaves (Litsea cubeba) in order to establish their flavonoid compound levels. The quality assessment of multivariate calibration models shows that PLS regression produces RMSEC of 2.870 and RMSEP of 0.0124 with R2cal = 0.9931 and R2val = 0.9919. The analysis using linear discriminant analysis (LDA) succeeded in its completion with recognition rates above 90% for each discriminating class.
Pemberdayaan Kesehatan Masyarakat Dusun Kemantren II Semawung Melalui Edukasi Pengelolaan Obat Hendra, Phebe; Riswanto, Florentinus Dika Octa; Setyani, Wahyuning; Julianus, Jeffry; Rajagukguk, ⁠Greysianita; Santi , Nyoman Pradnya Yoni Meytri; Bramantyo , Dominicus Adyatma; Siallagan , Angela Meirella; Putri , Elsha Tiany
Rengganis Jurnal Pengabdian Masyarakat Vol. 5 No. 2 (2025): November 2025
Publisher : Pendidikan Matematika, FKIP Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/rengganis.v5i2.608

Abstract

The misuse of drugs is a major health issue in Indonesia, largely due to a lack of understanding about proper drug management. Knowledge of correct medication use is essential to prevent administration errors. Key issues in Dusun Kemantren II, Semawung Village include a limited understanding of medication usage and inadequate drug storage systems. Engaging the community with information on effective drug management is essential to address this. This community service initiative aims to improve drug management knowledge in Dusun Kemantren II, Semawung Village, Purworejo District. The activity was carried out on May 4, 2025, with 23 participants. Evaluation results showed increased participants' knowledge after the education, based on average pre-test and post-test scores. This program successfully improved public knowledge and awareness regarding the importance of proper drug management. It provided practical means, such as medicine boxes, to support the implementation of this knowledge at the household level.
Caffeine and Caffeic Acid as Acetylcholinesterase Inhibitors: In Silico Perspectives Wira Waskitha, Stephanus Satria; Wiranata, Bonifacius Ivan; Mark, Julyus Jason; Krisantia, Herluin Sekar; Kristina, Natalia; Ardine, Glory Ivana; Prasetyo, Chrisologus Ivan; Gani, Michael Raharja; Riswanto, Florentinus Dika Octa; Istyastono, Enade Perdana
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.009687

Abstract

Alzheimer's disease (AD) has been recognized as a significant issue affecting population health globally and tended to increase over the years. The utilization of natural products for AD treatments has been widely studied, which possibly offers better outcomes with minimum side effects. Coffee consumption has been subjected as a lifestyle propensity, which offers beneficial advantages including reducing the risk of AD. Bioactive natural compounds contained in coffee such as caffeine and caffeic acid have been experimentally proven to be acetylcholinesterase (AChE) inhibitors, a pivotal target enzyme for AD treatments. This research aimed to explore the dynamics interactions of caffeine and caffeic acid in the AChE active site using the in silico approach. In this study, 100 redocking and docking simulations were implemented before the molecular dynamics (MD) simulations. The 55-ns MD simulations of huprine X, caffeine, and caffeic acid were implemented to study the dynamics interactions. Conformational stability, free energies of binding, and interaction hotspots were identified during the simulations. Our findings informed that caffeine interacted in the active site during the simulations, revealing the importance of the imidazole ring in maintaining the interactions. In contrast, caffeic acid interacted longer in the plausible allosteric site, forming ionic, hydrogen bonds, and aromatic interactions.
Co-Authors Abdul Rohman Abdul Rohman Adelsiana Leda Adithya Guntur Agatha Kania Ugahari Dyatmika Agnes Margaretta Sihombing Agustina Setiawati Alni Desra Anandha Nabila Prjanaparamita Anastasia Bella Anastasia Melin Fitria Wulandari Angelina Kinsha Pandhita Ardine, Glory Ivana Arief Dzulfianto Arini Safti Sandrapitaloka Arya Pratama Nugraha Pede Bili, Juita Putrinda Bintari, Resita Widya Birgita Elsia Setiarini Bramantyo , Dominicus Adyatma Christofori Maria Ratna Rini Nastiti Corina Febrianti Isabel Darmawangzah, Muhammad Debby Yunita Debi Kristiananda Debi Kristiananda Desy Natalia Rambu Padji Mahemba Dewi Setyaningsih DEWI SETYANINGSIH Dina Christin Ayuning Putri Dita Maria Virginia Enade Perdana Istyastono Enade Perdana Istyastono Enade Perdana Istyastono Enade Perdana Istyastono Familia Putri Wulandari Faustina Evania Ngai Febrina Dameria Marbun Filisia Putri Rosari Florentina Yohana Ngelu Fransisca Wahyu Indriastuti Indriastuti Fransiska Revana Restiana Gani, Michael Raharja Giovanny Leonarda Indriastuti, Fransisca Wahyu Indriastuti Indriastuti, Fransisca Wahyu Indriastuti Irnawati Irnawati Jeanne Magistra Noverita Jeanne Magistra Noverita Jeffry Julianus Jihan, Rimatul Jullius Ivan Mahadhika Juvita Lisu Allo Juvita Lisu Allo Katharina Floransia Walburga Resmianto Katrina Imaculata Tema Pedha Khrisna Agung Cendekiawan Kinanti, Valentina Putri Embun Klemen Wahyu Kurniadi Krisantia, Herluin Sekar Kristina, Natalia Kurniadi, Klemen Wahyu Kurniadi, Klemen Wahyu Lintang Adelya Lusiana Lusiana Lusiana Lusiana Mahenu, Novia Indah Permatasari Putri Mahenu, Novia Indah Permatasari Putri Marchaban Marchaban Maria Aurelia Afila Tutonugi Maria Theresia Mawarni Mark, Julyus Jason Mase Mase Maywan Hariono Meissy, Angelina Michael Raharja Gani Monica Selena nafisah isnawati Ni Gusti Ayu Diantari Novia Indah Permatasari Putri Mahenu Noviayanti Chandra Padmadiayu, Hana Paulina Nadya Feranti Pebby Lorenza Petrus Damiani Tosan Aji Phebe Hendra, Phebe Pisga Chrisita Dewi Pramono, Zita Dhirani Prasetyo, Chrisologus Ivan Putri , Elsha Tiany Putri Natasya Br Siregar Radhita Tyastu Puteri Winengku Rajagukguk, ⁠Greysianita Rini Dwiastuti Rini Dwiastuti Rinjani Mustika Sari RR. Endang Lukitaningsih Santi , Nyoman Pradnya Yoni Meytri Setiarini, Birgita Elsia Setiarini, Birgita Elsia Shinta Mayasari Siallagan , Angela Meirella Sri Hartati Yuliani Sudibyo Martono Sudibyo Martono Susanti, Dhina Ayu Suwidjiyo Pramono Teresia Kiki Oktavianti Theodora Dominika Gadi Seran Theresia Helena Tokan Tiara, Carolina Titien Siwi Hartayu Valentino Thomas Vania Rambu Kaha Milla Ate Veronica Arien Widyarahma Veronica Arien Widyarahma Vinsensia Nalita Maharani Wahyuning Setyani Wira Waskitha, Stephanus Satria Wiranata, Bonifacius Ivan Wulandari, Familia Putri Wulandari, Familia Putri Yoanes Fransiskus Regis Widyo Utomo Yohana Manalu Yohana Maria Bina Zerlinda Clara Auw