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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Andalas JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Hilirisasi IPTEKS (JHI) Buletin Ilmiah Nagari Membangun JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmasi Higea Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Pharmaceutical Sciences and Research (PSR) Journal of Pharmaceutical and Sciences. Journal of Public Health and Pharmacy
Dian Ayu Juwita
Fakultas Farmasi Universitas Andalas
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Efek Ekstrak Etanol Kulit Batang Sirsak Terhadap Penurunan Kadar Gula Darah dan Kolesterol Dian Ayu Juwita; Husni Muchtar; Dolly Martha
Jurnal Sains Farmasi & Klinis Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (491.069 KB) | DOI: 10.29208/jsfk.2015.2.1.44

Abstract

This study aims to determine effect of the ethanolic extract of soursop stembarks in the increasing of blood glucose and cholesterol levels. Maceration technique has been used to extract the soursop stembarks with ethanol 96% as a solvent extraction. Furthermore, the ethanolic extract of soursop stembarks was prepared in a suspension form with Na CMC 0.5 % as a suspending agent. The suspension was administered orally at dose of 50, 100, 300, 1000 mg/kg BW daily to white male mice for seven days. The level of blood sugar and cholesterol were measured at 8th day using digital tools Nesco®Multicheck. The result showed that the blood glucose level in mice at dose of 50, 100, 300, 1000 mg/KgBW were 123.25, 129.75, 132.25, 121.25 mg/dl. The cholesterol level mice at dose of 50, 100. 300, 1000 mg/kg BW were 156.5, 118.5, 149.75, 156.75 mg/dl respectively. Biostatistically, the ethanolic extract of soursop stembark showed the decreasing of cholesterol level significantly (p <0.05), but not significant to reduce the blood glucose level (p >0.05).
The comparison between combination of candesartan-amlodipine and candesartan-furosemide on blood pressure in hypertensive patients with chronic kidney disease Fitri Rachmaini; Dian Ayu Juwita; Almahdy A; Rahmad Abdillah; Yolanda Mayestika Wati
Pharmaciana Vol 12, No 2 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (446.191 KB) | DOI: 10.12928/pharmaciana.v12i2.21491

Abstract

Chronic renal disease is significantly increased by hypertension. Controlling blood pressure is critical in hypertensive individuals. Patients who have good blood pressure (BP) control can reduce morbidity and mortality. This study aimed to compare blood pressure reduction of candesartan-amlodipine with the candesartan-furosemide combination in hypertensive patients with chronic renal disease. The study was conducted by a cohort study design. Retrieval of medical record data was carried out prospectively during the period February-April 2019. The blood pressure reduction was assessed by changes in mean systolic and mean diastolic blood pressure and mean diastolic blood pressure and was analyzed statistically with the SPSS program. A total of 54 patients met the inclusion criteria, consisting of 27 patients receiving candesartan-amlodipine combination and 27 patients receiving candesartan-furosemide combination therapy. The results of the sociodemographic characteristics patients were male 30 patients (55.6%), age 56-65 years 24 patients (44.4%), senior high school education level 31 patients (57.4%). Candesartan-amlodipine and candesartan-furosemide combinations both decreased blood pressure in patients. However, the result of the statistical analysis revealed that there was no significant difference in blood pressure decline. (p> 0.05) between the two combinations.
Effect of Propolis on Bone Quality and Cortical Bone Thickness of Ovariectomized Female Wistar White Rats as A Model for Osteoporosis Juwita, Dian Ayu; Ahmadin, Almahdy; Rachmaini, Fitri; Abdillah, Rahmad; Fatma, Rosalia Medisa
Pharmaceutical Sciences and Research Vol. 8, No. 3
Publisher : UI Scholars Hub

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Abstract

Estrogen deficiency increases the rate of osteoporosis, especially in menopausal women, by altering the bone tissue microarchitecture. Propolis has compounds that could be used as an alternative therapy to treat estrogen deficiency and to protect against bone damage. This study aims to determine the effect of propolis on bone quality and cortical bone thickness of femoral metaphysis in ovariectomized female Wistar white rats as a model for menopausal osteoporosis. The rats were divided into five groups: negative control group (not subjected to ovariectomy), sham group (subjected to ovariectomy), and treatment groups that were subjected to ovariectomy and given propolis orally at a dose of 180 mg/kg BW, 360 mg/kg BW, and 720 mg/kg BW for 30 days. Bone quality and cortical bone thickness testing were undertaken on the 31st day. The osteoblast and osteoclast cell examination was evaluated using an Olympus BX 51 light microscope at 400x magnification for bone quality and the Betaview program, Beta 3.1MP Sony Exmor CMOS Sensor camera at 40x magnification for cortical bone thickness. Data were analyzed using the one-way ANOVA and continued with Duncan’s multiple range tests. It was found that propolis had a significant effect on the ratio of osteoblast and femur bone osteoclasts (p0.05). The administration of propolis at a dose of 180 mg/kg BW, 360 mg/kg BW, and 720 mg/kg BW had an effect in decreasing the ratio of osteoblasts and metaphysical osteoclast cells of femoral metaphysics. However, propolis administration did not affect the thickness of the femoral metaphysical cortical bone
The Effect of Medication Adherence and Asthma Control in Asthma Patients at a Public Health Center in Padang, Indonesia Dita Permatasari; Dian Ayu Juwita; Hesti Rachmawati Putri; Nurul Qalbi Desri
Jurnal Sains Farmasi & Klinis Vol 9 (2022): J Sains Farm Klin 9(suplemen), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.sup.190-195.2022

Abstract

Asthma is characterized by reversible swelling or narrowing of the airways. Low adherence can negatively affect the effectiveness of therapy, increasing asthma morbidity and mortality. The long-term goal of asthma treatment is to achieve and maintain controlled asthma, but this goal is still challenging for most patients. This study examines the relationship between medication adherence and asthma control in patients. This study is observational, with a cross-sectional approach conducted on 40 asthma patients who received treatment at a Public Health Center. Patient medication adherence was measured by Medication Possession Ratio (MPR) method, and the level of control was measured by the Asthma Control Test (ACT) questionnaire. The results showed that most patients based on sociodemographic characteristics were female (80.0%), elderly group ≥60 years (45.0%), high school education (55.0%), and housewives (45.0%). The category of medication adherence was divided into 47.5% adherent patients and 52.5% non-adherent patients. The level of patient control was divided into fully controlled (2.50%), partly controlled (35.0%), and uncontrolled (62.5%). There was a significant relationship between adherence and asthma control (r=0.508; p<0.05). Therefore, improving patient medication adherence can potentially improve asthma control levels.
Drugs Related Problems (DRPs) Pada Pasien Penyakit Ginjal Kronik (PGK) Di RSUP Dr. M. Djamil Dian Ayu Juwita; Fitri Rachmaini; Rahmad Abdillah; Meliani Meliani
Jurnal Sains Farmasi & Klinis Vol 9 (2022): J Sains Farm Klin 9(suplemen), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.sup.184-189.2022

Abstract

Penyakit Ginjal Kronis (PGK) ditandai dengan penurunan fungsi ginjal secara ireversibel yang dapat mempengaruhi proses eliminasi obat dari dalam tubuh. Drugs Related Problems (DRPs) merupakan suatu peristiwa terkait pengobatan bersifat aktual ataupun potensial yang dapat mempengaruhi hasil terapi pasien. Penelitian ini bertujuan untuk mengetahui persentase kejadian DRPs dan hubungan antara kejadian DRPs dengan kondisi pulang pasien didiagnosis PGK. Penelitian ini dilakukan secara retrospektif. Pengumpulan data dilakukan melalui rekam medis pasien pada tahun 2021. Analisis data dilakukan secara deskriptif dan uji korelasi Spearman Rank. Sebanyak 74 pasien memenuhi kriteria inklusi, terdiri dari 44 pasien laki-laki (59,46%) dan 30 pasien perempuan (40,54%). Rentang usia pasien PGK terbanyak adalah 46-55 tahun, yakni 22 pasien (29,73%). Ditemukan kejadian DRPs yakni indikasi tanpa terapi pada 7 pasien (35%), dosis obat kurang pada 1 pasien (5%), dan dosis obat berlebih pada 12 pasien (60%). Pada penelitian ini 67 orang pasien (90,54%) pulang dengan kondisi perbaikan, 5 orang pasien (6,76%) pulang dengan kondisi belum sembuh, dan 2 orang pasien (2,74%) meninggal. Dapat disimpulkan bahwa pada terdapat kejadian DRPs meliputi indikasi tanpa terapi, dosis obat kurang, dan dosis obat berlebih yang ditemukan pada pasien dengan Penyakit Ginjal Kronis (PGK) dalam penelitian ini. Tidak ada hubungan bermakna antara kejadian DRPs dengan kondisi pulang pasien (p>0,05).
Pengaruh Penggunaan Obat Antihipertensi Terhadap Tekanan Darah Dan Proteinuria Pada Pasien Preeklampsia Berat Di RSUP Dr. M. Djamil Fitri Rachmaini; Dian Ayu Juwita; Rahmad Abdillah; Melvi Auliya Rifqi
Jurnal Sains Farmasi & Klinis Vol 9 (2022): J Sains Farm Klin 9(suplemen), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.sup.175-183.2022

Abstract

Kondisi preeklampsia dapat berkembang menjadi eklampsia yang beresiko meningkatkan angka kematian bagi ibu dan janin. Obat antihipertensi dapat digunakan untuk pengobatan preeklampsia. Penelitian ini bertujuan mengetahui pengaruh penggunaan obat antihipertensi terhadap nilai tekanan darah dan proteinuria pasien didiagnosis preeklampsia berat. Metode yang digunakan adalah retrospektif cross-sectional. Pengumpulan data dilakukan melalui rekam medis dari Januari sampai Desember 2021. Data disajikan dalam 76 pasien memenuhi kriteria inklusi. Hasil penelitian menunjukkan terdapat 19 pasien (23%) menggunakan monoterapi antihipertensi metildopa atau nifedipin, 30 pasien (39,47%) menggunakan kombinasi metildopa dan nifedipin, dan empat pasien (5,26%) menggunakan kombinasi metildopa, nifedipin dan furosemide. Rata-rata penurunan tekanan darah sistolik dan diastolik (TDS/TDD) paling besar yaitu 85,25 mmHg dan 29,5 mmHg. Sedangkan rata-rata penurunan nilai proteinuria paling besar yaitu 2. Berdasarkan hasil tersebut diketahui bahwa terdapat pengaruh signifikan penggunaan obat antihipertensi terhadap TDS (p=0,000), TDD (p=0,000), dan nilai proteinuria (p=0,002). Penurunan nilai tekanan darah dan proteinuria lebih efektif terjadi pada terapi kombinasi dibandingkan dengan monoterapi.
PEMBUATAN DESINFEKTAN SEDERHANA MELALUI PEMANFATAAN BAHAN KARBOL DAN CAIRAN PEMUTIH PAKAIAN BAGI MASYARAKAT DI BALAI BARU KECAMATAN KURANJI KOTA PADANG Fitri Rachmaini; Dian Ayu Juwita; Rahmad Abdillah
Jurnal Hilirisasi IPTEKS Vol 6 No 2 (2023)
Publisher : LPPM Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jhi.v6i2.657

Abstract

One of the efforts to break the chain of transmission of Covid-19 is to maintain cleanliness using an antiseptic to wash hands and body parts, as well as disinfectants that are sprayed or rubbed on various inanimate objects that may be exposed to the virus. However, there are still many people who are mistaken about using antiseptics and disinfectants, such as using antiseptics to clean items and the phenomenon of massive spraying of disinfectants in various places, even directly on humans. Apart from that, the lack of skills in making simple disinfectant fluids independently is also one of the triggering factors for the low level of concern in protecting the surrounding environment. The purpose of this activity is to educate the public about the correct use of antiseptics and disinfectants and to be able to utilize carbolic acid and liquid bleach to become simple disinfectants. This activity was carried out in Balai Baru Village, Kuranji District, Padang City. The method used in this activity is the presentation of the principles of the proper use of disinfectants and antiseptics as well as direct demonstrations of making simple disinfectants. The results of the activity are increased public understanding of the proper use of disinfectants and antiseptics as well as increased community skills in utilizing carbolic acid and clothing bleach into simple disinfectants. This activity is expected to be a reference in making simple disinfectants that are economical, environmentally friendly, and can be made by anyone. It is hoped that the chain of transmission of Covid-19 can be minimized.
Peningkatan Pengetahuan Masyarakat tentang Penggunaan Obat yang Rasional melalui Edukasi Pengenalan Obat Dian Ayu Juwita; Elsa Badriyya; Lailaturrahmi Lailaturrahmi
Warta Pengabdian Andalas Vol 30 No 3 (2023)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.30.3.423-428.2023

Abstract

One of the factors influencing the level of drug usage is the level of knowledge. Knowledge is an essential aspect in shaping concrete actions. In society, various issues related to drug usage often arise due to a lack of understanding and incorrect behaviours regarding drug usage. Educating the public about the selection and rational use of drugs is compulsary cause of that. This activity was carried out on May 7, 2023, at Jondul Housing, Padang City. The education method employed was a lecture delivered to 35 participating mothers. This method has proven effective for all segments of society, regardless of their educational background. The general public showed high enthusiasm in participating and actively engaged in interactions, asking questions, and discussing with the speaker. The conclusion drawn from this activity is that education and outreach enhanced the public knowledge about the rational use of drugs.
Education on the Benefits of Drinking Milk as a Source of Protein and Calcium for Elementary School Students Dian Ayu Juwita; Nadila Oktavia; Rahmah Rahmah
Warta Pengabdian Andalas Vol 31 No 3 (2024)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.31.3.492-497.2024

Abstract

Optimal nutrition plays a crucial role in supporting the growth and development processes of children. One abundant and easily accessible source of nutrition is milk. The protein and calcium content in milk support bone formation, brain development, and various bodily functions. This community service activity aims to provide education to elementary school students about the benefits of milk as a nutritional source and to enhance milk consumption habits. Education is conducted through face-to-face interactions using lecture and discussion methods. The material is presented through PowerPoint presentations, videos, and the distribution of leaflets to the participants. To assess the success of the educational activities, pretests and posttests are conducted on the participants. The results of the educational activities show an increase in the average posttest scores compared to the pretest scores regarding the benefits of drinking milk. This indicates that the educational activities have successfully improved the participants' understanding of the importance of including milk in a healthy diet.
Interaction between Fluoxetine and Risperidone and Its Association with Clinical Outcomes in Schizophrenic Patients Rachmaini, Fitri; Ayu Juwita, Dian; Abdillah, Rahmad; Dwi Afrianti, Rezy; Sri Wahyuni, Fatma
Pharmaceutical Sciences and Research Vol. 10, No. 1
Publisher : UI Scholars Hub

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Abstract

The concurrent use of fluoxetine and risperidone to treat schizophrenia may result in drug interactions. This study aims to analyse the clinical outcomes of fluoxetine-risperidone therapy and the possibility of their interaction in schizophrenic patients. The clinical outcomes are patient status at the time of hospital discharge, the length of hospitalisation and the Positive and Negative Syndrome Scale- Excitement Component (PANSS-EC). This study was conducted prospectively in psychiatric ward of HB Saanin Mental Hospital from May to October 2021 and study subjects were selected using consecutive sampling technique with inclusion criteria. Forty-three patients were eligible for this study. Research data were collected from direct observation and notes from medical records. To provide an overview of the frequency distribution and percentage of the variables evaluated, the data were analysed through descriptive statistics and a chi-square test using SPSS v.22. Symptoms due to risperidone-fluoxetine interaction were found in four patients (10%). The symptoms experienced are categorised as extrapyramidal syndrome (EPS). The results of the clinical outcomes showed that 38 patients (88%) having recovered and five patients (12%) were in remission. The PANSS-EC in male patient (6.24±1.12) was higher than female (5.88±1.12). The length of hospitalization was higher in patient with age 36-45 years (23.72). This study showed no significant relationship between fluoxetine-risperidone interaction on the outcome of therapy (p>0.05). It can be concluded that EPS was found in 10% of schizophrenic patients. However, there was no significant association between EPS due to fluoxetine-risperidone interaction with clinical outcomes.
Co-Authors Abdillah, Rahmad Ahmadin, Almahdy Al Rizka, Nabila Almahdy A Almahdy Almahdy Almahdy Almahdy Angelica, Sundari Anisa Annisadillah, Dwi Deni Noviza Desri, Nurul Qalbi DINI HANIFA, DINI Dita Permatasari Dita Permatasari Dolly Martha Dwi Afrianti, Rezy Dwisari Dillasamola Elsa Badriyya Fatma Sri Wahyuni Fatma, Rosalia Medisa Fitri Rachmaini Fitri, Maharani Reskia Hansen Nasif Helmi Arifin Heni Pujiastuti Hesti Rachmawati Putri Husni Muchtar Jaka Perdana Julio Fajar Rahmat Illahi Lailaturrahmi Lailaturrahmi Machlaurin, Afifah Meliani Meliani Meliani, Meliani Melvi Auliya Rifqi Nadila Oktavia Nadila Oktavia Najmiatul Fitria Nelfa Yulianti Netty Suharti Nguyen, Thang Nurul Qalbi Desri Octy Aisyahharma Pratiwi, Rasika Indri Putri, Hesti Rachmawati Putri, Wiwing Nadia Rachmaini , Fitri Rachmaini, Fitri Rahmad Abdillah Rahmah Rahmah Rahmah Rahmah Rahmi Yosmar Rifqi, Melvi Auliya Risa Hestia Rizka Afdhila Rizka Afdila Roslinda Rasyid Sabarita, Najah Suhatri Suhatri Syofyan Tesa Inmerka Alwi Viviani, Ivana Regita Wira Sanjaya Yolanda Mayestika Wati