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UJI AKTIVITAS ANTIDIABETES EKSTRAK TEPUNG OTOT (Borreria laevis (Lamk) Griseb) TERHADAP MENCIT (Mus musculus) YANG DIINDUKSI ALOKSAN Wahyuni; Yaya Sulthon Aziz; Mujtahid Bin Abd Khadir; Datin Annisa Sukmawati
CERATA Jurnal Ilmu Farmasi Vol 13 No 2 (2022)
Publisher : UNIVRSITAS MUHAMMADIYAH KLATEN

Show Abstract | Download Original | Original Source | Check in Google Scholar

Diabetes melitus merupakan suatu penyakit pada saat kadar glukosa dalam darah mengalami hiperglikemia. Penanganan umum penyakit diabetes melitus umumnya menggunakan obat diabetes oral dan obat herbal sebagai alternatif untuk mempercepat penurunan glukosa darah. Masyarakat di Suku Tengger Kabupaten Probolinggo mengunakan Borreria laevis Lamk Griseb sebagai pengobatan herbal untuk menurunkan kadar glukosa darah. Penelitian ini bertujuan untuk mengetahui potensi aktivitas antidiabetes dan dosis konsentrasi yang efektif pada tanaman herba Borreria laevis Lamk Griseb dengan cara menginduksi mencit menggunakan aloksan dosis 168 mg/KgBB secara intraperitoneal.Mencit dibagi menjadi 5 kelompok yaitu kontrol negatif (Na-CMC), kontrol positif (Glibenklamid), dosis konsentrasi ekstrak 100 mg/KgBB, 150 mg/KgBB dan 200 mg/KgBB. Pengamatan terhadap penurunan kadar glukosa darah masing-masing kelompok di lakukan setelah 3 hari penyuntikan. Berdasarkan analisis ANOVA penurunan kadar glukosa darah setelah 3 hari perlakuan menunjukkan bahwa dosis konsentrasi 100 mg/KgBB, 150 mg/KgBB dan 200 mg/KgBB berbeda signifikan terhadap kontrol negatif dan kontrol positif. Dosis efektif yang dapat menurunkan kadar glukosa darah pada mencit yaitu pada dosis konsentrasi 200 mg/KgBB dengan penurunan kadar glukosa darah 181±26,01 mg/dl.

UJI AKTIVITAS ANTIDIABETES EKSTRAK TEPUNG OTOT (Borreria laevis (Lamk) Griseb) TERHADAP MENCIT (Mus musculus) YANG DIINDUKSI ALOKSAN Wahyuni; Yaya Sulthon Aziz; Mujtahid Bin Abd Khadir; Datin Annisa Sukmawati
CERATA Jurnal Ilmu Farmasi Vol 13 No 2 (2022): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v13i2.606

Diabetes melitus merupakan suatu penyakit pada saat kadar glukosa dalam darah mengalami hiperglikemia. Penanganan umum penyakit diabetes melitus umumnya menggunakan obat diabetes oral dan obat herbal sebagai alternatif untuk mempercepat penurunan glukosa darah. Masyarakat di Suku Tengger Kabupaten Probolinggo mengunakan Borreria laevis Lamk Griseb sebagai pengobatan herbal untuk menurunkan kadar glukosa darah. Penelitian ini bertujuan untuk mengetahui potensi aktivitas antidiabetes dan dosis konsentrasi yang efektif pada tanaman herba Borreria laevis Lamk Griseb dengan cara menginduksi mencit menggunakan aloksan dosis 168 mg/KgBB secara intraperitoneal.Mencit dibagi menjadi 5 kelompok yaitu kontrol negatif (Na-CMC), kontrol positif (Glibenklamid), dosis konsentrasi ekstrak 100 mg/KgBB, 150 mg/KgBB dan 200 mg/KgBB. Pengamatan terhadap penurunan kadar glukosa darah masing-masing kelompok di lakukan setelah 3 hari penyuntikan. Berdasarkan analisis ANOVA penurunan kadar glukosa darah setelah 3 hari perlakuan menunjukkan bahwa dosis konsentrasi 100 mg/KgBB, 150 mg/KgBB dan 200 mg/KgBB berbeda signifikan terhadap kontrol negatif dan kontrol positif. Dosis efektif yang dapat menurunkan kadar glukosa darah pada mencit yaitu pada dosis konsentrasi 200 mg/KgBB dengan penurunan kadar glukosa darah 181±26,01 mg/dl.

Positive Effect of Konjac Glucomannan on Lowering Blood Pressure in Hypertensive Wistar Rats Bryan Anggara Putra; Sugeng Mashudi; Alfia Pradita Sari; Fany Risma Afriani; Yaya Sulthon Aziz; Tukimin bin Sansuwito
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 02 (2024): Qanun Medika Vol 08 No 02 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i02.21297

Hypertension is a non-communicable disease that is currently a top priority for global health. Commonly offered anti-hypertensive pharmacological therapies such as ACE-inhibitors are known to have side effects in long-term use, unlike herbal glucomannan, which has been used as a treatment for patients with type 2 diabetes. The purpose of this study was to see what effect applying glucomannan supplements for 6 hours had on blood pressure parameters obtained from the wistar rat subjects who had hypertension. Twenty five male Wistar rats with normal systolic blood pressure (sBP) ± 110 mmHg were involved in the study; they received a 10% high salt diet for 14 days. They were divided into 4 groups: the positive control group G1 received captopril at 25 mg/kg of body weight and the treatment groups G2 50 mg KGM. Blood pressure measurement using sphygmonanometers with diastolic blood pressure (dBP) is the exclusion criterion of the study. Data analysis is done with a paired sample t-test. Blood pressure in each group decreased after 6 hours of intervention, but the most significant results were obtained in the G5 group that received glucomannan 100 mg/kg bb. In conclusion, Glucomannan can lower blood pressure; this potential is the same as that of red ginger, which modulates the production of angiotensin-corventing enzymes.

Kajian Etnomedicine Tumbuhan Obat Antiinflamasi Pada Masyarakat Samin Kecamatan Margomulyo Bojonegoro Yaya Sulthon Aziz; Nadia Hasna
Jurnal Farmasi & Sains Indonesia Vol 4 No 2 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol4no2p12-18

The use of medicinal plants is mostly done by tribes in Indonesia, one of them is the Samin tribe. Information on the use of medicinal plants can be done using ethnopharmaceutical methods. This research was conducted to determine the use of plants as anti-inflammatory drugs, how to manufacture, how to use plants as anti-inflammatory drug ingredients in the tribe of Samin, and to obtain UV and ICF values based on bioprospective analysis. Determination of the informants in the Samin tribe with the Snowball sampling method, followed by semi-structured interviews. Bioprospective analysis of plants that have the potential to be anti-inflammatory. Bioprospective parameters tested were UV, ICF. ICF values are used to identify the most important disease categories and are used as parameters in plant species for further research. UV value which is the most widely used plant and high level of confidence for treatment. Obtained 11 types of anti-inflammatory diseases, 28 anti-inflammatory plants. There were 6 anti-inflammatory diseases including broken bones with a value of 1, stung by bees 1, mumps 0.75, scratch wounds 0.75, uric acid 0.33, and toothache 0.33. The results of the ICF values above, then obtained plants used for anti-inflammatory treatment with the highest UV values are betel 0.91, bitter 0.83, black taro 0.83, breadfruit 0.5, and greetings 0.5. The five plants that need further research are the black taro plant, for which there is no research that discusses more deeply, so the black taro plant is a potential source of new anti-inflammatory.,

Membangun Kesadaran Masyarakat tentang Penggunaan Obat Analgesik melalui Edukasi Berbasis Leaflet dan Media Sosial Aziz, Yaya Sulthon; Widyaningsih, Linda; Rahmawati, Widhia Alfi
Lumbung Inovasi: Jurnal Pengabdian kepada Masyarakat Vol. 9 No. 3 (2024): September
Publisher : Lembaga Penelitian dan Pemberdayaan Masyarakat (LITPAM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/linov.v9i3.2110

Swamedikasi atau pengobatan mandiri, sering dilakukan oleh masyarakat untuk mengatasi penyakit dengan gejala ringan hingga sedang menggunakan obat yang dapat dibeli tanpa resep dokter. Namun, kurangnya pengetahuan tentang penggunaan obat yang tepat dapat menimbulkan risiko kesehatan. Pengabdian menyoroti pentingnya edukasi kesehatan dalam meningkatkan pemahaman masyarakat tentang penggunaan analgesik yang aman dan rasional. Edukasi yang efektif dapat mengurangi risiko efek samping dan kesalahan penggunaan obat, serta meningkatkan kualitas pelayanan apotek. Pengabdian ini bertujuan untuk memberikan pengaruh edukasi terhadap pengetahuan masyarakat mengenai penggunaan analgesik dalam swamedikasi di Kecamatan Slahung, Ponorogo. Pengabdian dilakukan dengan participant education dan observasional yang dilakukan kepada responden yaitu Masyarakat Slahung, yang diambil sebagai subjek pengabdian. Metode yang digunakan adalah deskriptif. Subjek dalam pengabdian ini adalah pasien yang melakukan swamedikasi dan memenuhi kriteria inklusi. Tempat pengabdian berada di Apotek Wilayah Slahung Ponorogo. Waktu pengabdian dilaksanakan pada bulan Maret 2024. Hasil dari pengabdian ini menunjukkan bahwa perolehan rata-rata dari nilai pre test responden sebesar 62,37% sedangkan rata-rata nilai Post test responden sebesar 84,88%, pada nilai rata-rata pre test dan post test tersebut mengalami peningkatan sebesar 22,51% dari sebelum edukasi dan sesudah edukasi. Sedangkan hasil dari nilai N-Gain sebesar 0,57 masuk kategori sedang, hal ini menunjukkan bahwa edukasi dengan menggunakan leaflet dan media social mempunyai pengarug sedang terhadap peningkatan pengetahuan responden. Building Public Awareness About the Use of Analgesic Drugs Through Leaflet-Based Education and Social Media Abstract Self-medication or self-medication is often done by people to treat illnesses with mild to moderate symptoms using drugs that can be purchased without a doctor's prescription. However, lack of knowledge about proper use of medication can pose health risks. The service highlights the importance of health education in increasing public understanding about the safe and rational use of analgesics. Effective education can reduce the risk of side effects and medication errors, as well as improve the quality of pharmacy services. This service aims to provide an educational influence on public knowledge regarding the use of analgesics in self-medication in Slahung District, Ponorogo. Service was carried out with participant education and observation carried out on respondents, namely the Slahung Community, which was taken as the subject of service. The method used is descriptive. The subjects in this service are patients who carry out self-medication and meet the inclusion criteria. The place of service is at the Slahung Ponorogo Regional Pharmacy. The time of service was carried out in March 2024. The results of this service showed that the average score of respondents' pre-test was 62.37%, while the average post-test score of respondents was 84.88%, the average score of pre-test and The post test experienced an increase of 22.51% from before education and after education. Meanwhile, the results of the N-Gain value of 0.57 are in the medium category, this shows that education using leaflets and social media has a moderate effect on increasing respondents' knowledge.

Formulation And Test Effectiveness Of Antifungal Cream Of Mugwort Ethanol Extract (Artemisia vulgaris L) On Candida Albicans ATCC 10231 Yaya Sulthon Aziz; Naila Matsna Assyifa; Amalia Rahma Pratiwi; Siska Tri Wahyuni
Berkala Ilmiah Kimia Farmasi Vol. 11 No. 2 (2024): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v11i2.56171

According to the people of the Tengger Tribe for generations, a Mugwort plant (Artemisia vulgaris L.) was believed to be useful as a treatment for fungal infections. Based on research reports, the Mugwort plant (Artemisia vulgaris L.) contained bioactive compounds such as flavonoids, tannins, saponins, steroids, and alkaloids. These active compounds had activity as an antifungal. This study aimed to formulate, evaluate, and test the activity of a cream preparation with type m/a ethanol extract of Mugwort (Artemisia vulgaris L.) in inhibiting the growth of the fungus Candida albicans ATCC 10231. This type of research was laboratory experimental research. Samples were taken by simple random sampling to test the inhibition of Candida albicans ATCC 10231. The results of the physical quality test of Mugwort leaf extract (Artemisia vulgaris L.) cream from the 4 formulation with test parameters including organoleptic, pH, spreadability, adhesion, and viscosity test, were in accordance with the established quality standards. The results of the physical evaluation of the antifungal cream showed organoleptic properties, homogeneity, pH 6, spreadability test F1 5.2, FII 5.1, FIII 5.3, and FIV 5.4 cm, FI adhesion test 5.3, FII 5.3, FIII 5.4, and FIV 5.5 seconds. Meanwhile, in the viscosity test the results were FI 24,606, FII 30,836, FIII 40,198 cP, and FIV 38,695 cP. The inhibition test results were analyzed by calculating the average for each concentration, performed three times. The results showed that the ethanol extract of Mugwort leaf (Artemisia vulgaris L.) cream had antifungal effectiveness with an average value of 8.6 mm at a concentration of 2.5% (moderate category), 10.3 mm at a concentration of 5% (medium category), 11 mm at a concentration of 10% (strong category) and 12 mm at a concentration of 20% (strong category). The study concluded that the ethanol extract of Mugwort Leaf (Artemisia vulgaris L.) cream was effective in inhibiting the growth of Candida albicans ATCC 10231. Keywords: Mugwort (Artemisisa Vulgaris L), Antifungal, Candida Albicans ATCC 10231

Formulasi Sediaan Krim Ekstrak Etanol Lobak Tengger (Raphanus Raphanistrum L.) Dan Uji Aktivitas Antijamur Terhadap Candida Albicans ATCC 10231 Aziz, Yaya Sulthon; Novitasari, Heni; Wulandari, Septiana Indah Ayu
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p105-111

The seaweed plant (Rhapanus raphanistrum L) has been used as a traditional medicine due to its many pharmacological effects. The tree is known to have benefits for treating fever, typhoid, syphilis, and diarrhea due to its important contents, including saponins, flavonoids, and polyphenols. The aim of this study is to standardize the extracts and make a cream preparation with a type M/A ethanol extract of the Tengger Shell (Rhapanus raphanistrum L), which can stop the development of the fungus Candida albicans. Laboratory experiments are this kind of research. The sample was taken by random sampling to test the resistance to Candida Albicans ATCC 10231. The results of this study showed that the ethanol extract of Tengger Rye (Rhapanus raphanistrum L) was obtained from the dried tengger rye bulbs using a method of maseration with 96% ethanol. The extract is thick, brownish, characteristic smell, and bitter taste, and has chemical content like flavonoids, saponins, and tannins. The resulting randomness was 13.57%. Non-specific parameters resulting from a drying suspension of 2.03%, extract type weight of 0.27%, water content of 3.26%, total ash of 14.28%, and acid insoluble ash of 2.67% meet the established quality standards. Antifungal activity suggests that the preparation of the cream ethanol extract of Tengger (Raphanus raphanistrum L.) has the ability to inhibit the fungus Candida albicans. The average diameter of formula I is 5 mm, formula II is 5mm, formula III is 10mm, and formula IV has a maximum barrier zone of 11mm. The results of research and data analysis showed that the cream ethanol extract of Tengger Shrimp (Raphanus raphanistrum L.) inhibits the fungus Candida albicans.

Positive Effect of Konjac Glucomannan on Lowering Blood Pressure in Hypertensive Wistar Rats Putra, Bryan Anggara; Mashudi, Sugeng; Sari, Alfia Pradita; Afriani, Fany Risma; Aziz, Yaya Sulthon; Sansuwito, Tukimin bin
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 02 (2024): Qanun Medika Vol 08 No 02 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i02.21297

Hypertension is a non-communicable disease that is currently a top priority for global health. Commonly offered anti-hypertensive pharmacological therapies such as ACE-inhibitors are known to have side effects in long-term use, unlike herbal glucomannan, which has been used as a treatment for patients with type 2 diabetes. The purpose of this study was to see what effect applying glucomannan supplements for 6 hours had on blood pressure parameters obtained from the wistar rat subjects who had hypertension. Twenty five male Wistar rats with normal systolic blood pressure (sBP) ± 110 mmHg were involved in the study; they received a 10% high salt diet for 14 days. They were divided into 4 groups: the positive control group G1 received captopril at 25 mg/kg of body weight and the treatment groups G2 50 mg KGM. Blood pressure measurement using sphygmonanometers with diastolic blood pressure (dBP) is the exclusion criterion of the study. Data analysis is done with a paired sample t-test. Blood pressure in each group decreased after 6 hours of intervention, but the most significant results were obtained in the G5 group that received glucomannan 100 mg/kg bb. In conclusion, Glucomannan can lower blood pressure; this potential is the same as that of red ginger, which modulates the production of angiotensin-corventing enzymes.

Evaluasi Tingkat Kepercayaan Masyarakat Terhadap Keamanan Obat Pasca Penarikan Obat Sediaan Sirup Yuniar, Cinthya Ratna; Arifianto, Nasruhan; Qonita, Eka Wanda; Aziz, Yaya Sulthon
World Health Digital Journal Vol. 1 No. 1 (2025)
Publisher : Institute of Advanced Knowledge and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/wolgitj.v1i1.2

Kasus gagal ginjal akut anak yang terjadi pada Oktober 2022, disinyalir karena adanya cemaran Etilen Glikol (EG) dan Dietilen Glikol (DEG) dalam sediaan sirup. Pemerintah mengambil tindakan penarikan ijin edar obat sediaan sirup selama masa penyelidikan. Akibat himbauan tersebut timbul perubahan perilaku dan sikap masyarakat terhadap kepercayaan keamanan obat sirup anak terutama yang mengandung parasetamol. Tujuan penelitian ini adalah untuk mengevaluasi tingkat kepercayaan masyarakat terhadap keamanan sediaan sirup anak yang mengandung parasetamol pasca penarikan. Penelitian ini menggunakan metode deskriptif dengan pendekatan data kualitatif dengan instrumen angket dan wawancara tertulis. Populasi dalam penelitian ini adalah masyarakat Desa Madigondo Kecamatan Takeran Kabupaten Magetan. Penentuan sampel menggunakan purposive sampling yang menggunakan rumus Yamane dengan jumlah sampel sebanyak 100 orang. Hasil penelitian menunjukkan bahwa tingkat kepercayaan masyarakat di Desa Madigondo Kecamatan Takeran Kabupaten Magetan terhadap obat sirup anak yang mengandung parasetamol pasca penarikan obat sirup tinggi sebanyak 86 responden (86%) dengan rata-rata presentase tanggapan responden 79,4% dan sebanyak 14 responden (14%) dengan rata-rata presentase tanggapan responden 67,7% tergolong pada kategori sedang.

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