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Antihypertensive and Antioxidant Activity of Herbal Medicine (Jamu) B on Rats Induced by 10% Fructose Eff, Aprilita Rina Yanti; Ayu Pertiwi, Reza; Ehe Hurit, Hermanus; Rahayu, Sri Teguh; Eden, Yonatan
Pharmaceutical Sciences and Research Vol. 9, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Prolonged fructose intake can activate the renin-angiotensin-aldosterone system and enhance oxidative stress conditions, causing hypertension and hyperuricemia. This study aimed to determine the antihypertensive and antioxidant activity of Jamu B on the activity of superoxide dismutase (SOD), glutathione (GSH), and malondialdehyde (MDA) in the kidneys of Sprague Dawley rats induced by 10% fructose. Thirty rats were divided into six groups. Groups B1-B3 were Jamu groups at a dose of 0.12 g/kg BW (B1), 0.24 g/kg BW (B2), and 0.36 g/kg BW (B3); group C (positive control) was given captopril 0.1 g/kg BW, group D (negative control) was given only 10% fructose, and group E (normal control) was healthy rats. The 10% fructose was induced for eight weeks and the treatment was given at the week 9th and 10th. Jamu B reduced systolic and diastolic blood pressure at all doses, but not significantly different from the normal control group (p>0.05). The SOD activity in groups B1, B2, B3, and C was significantly different from the negative control group (pJamu B at dose of 0.12 g/kg BW; 0.24 g/kg BW; and 0.36 g/kg BW have antihypertensive and antioxidant activity in the kidneys of rats induced by 10% fructose. Nevertheless, Jamu B at a dose of 0.36 g/kg BW was the most effective as an antihypertensive and antioxidant.
PENGARUH PENGETAHUAN, KEPATUHAN, DAN PROSEDUR TERHADAP IMPLEMENTASI KLAIM INACBG’S DENGAN KOMUNIKASI TERBUKA TENTANG KENDALI MUTU DAN BIAYA SEBAGAI VARIABEL MODERASI DI RUMAH SAKIT X SERANG Rekha Rakhma Hidayah; Fresley Hutapea; Aprilita Rina Yanti Eff
NUSANTARA : Jurnal Ilmu Pengetahuan Sosial Vol 10, No 8 (2023): NUSANTARA : Jurnal Ilmu Pengetahuan Sosial
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jips.v10i8.2023.4131-4148

Abstract

Implementasi BPJS RS X Serang masih terdapat masalah-masalah terutama terkait klaim INACBG’s seperti adanya missed komunikasi, pengetahuan yang masih kurang, SOP (birokrasi) yang tidak berjalan dengan baik, kurangnya kepatuhan (disposisi) petugas dalam menjalankan peraturan sehingga berdampak pada besaran klaim yang dapat merugikan rumah sakit. Penelitian ini bertujuan untuk menganalisis pengaruh pengetahuan, kepatuhan, dan prosedur terhadap implementasi klaim INACBG’s dengan komunikasi terbuka tentang kendali mutu dan biaya sebagai variabel moderasi di rumah sakit X Serang. Jenis Penelitian ini adalah penelitian survei yang bersifat analitik kuantitatif pendekatan cross sectional dengan jumlah sampel 70 orang yang di ambil menggunakan stratified random sampling. Data di peroleh dengan menggunkan kuesioner dan analisis dengan uji jalur pada α=5%. Hasil penelitian menunjukkan bahwa pengetahuan, kepatuhan, dan prosedur terhadap implementasi klaim inacbg’s dengan komunikasi terbuka tentang kendali mutu dan biaya sebagai variabel moderasi berpengaruh signifikan terhadap implementasi klaim INA CBG’s. R square sebesar 0,925, artinya variabel tersebut dapat menjelaskan pengaruh terhadap variabel implementasi kebijakan JKN tentang klaim INA CBG’s sebesar 92.5% %. Disarankan kepada pihak manajemen meningkatkan kualitas, sumber daya dan profesionalisme pegawai agar dapat menjalankan implementasi kebijakan JKN tentang klaim INA CBG’s dengan lebih baik sehingga dapat meningkatkan mutu pelayanan dan pendapatan rumah sakit.
Waste management education for the community of Duri Kepa Village, West Jakarta Aprilita Rina Yanti Eff; Mellisa Resmiati; Mayang Ayu Purborini; Devi Angeliana Kusumaningtiar
Community Empowerment Vol 8 No 12 (2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ce.10393

Abstract

The RW. 02 in Duri Kepa Village, Kebon Jeruk District, West Jakarta, is a densely populated region situated close to the market, where frequent floods occur. The market area is marred by indiscriminate rubbish disposal, and it has been used as a temporary landfill, leading to a buildup of waste, unpleasant odors, and triggering floods. Community service activities aim to enhance residents' awareness and knowledge of waste management. These activities involve outreach and education conducted for RW residents in Duri Kepa Village. Posters and brochures are distributed from house to house, complemented by lectures and discussions. Analysis of pre-test and post-test results on 70 participants reveals that the socialization and education efforts successfully increased knowledge about waste management by 24.99 points.
Assessment of Drug Therapy Problems Among Type 2 Diabetes Patients with Hypertension Comorbidity in Indonesia Julaeha Julaeha; Ery Fudjiati; Aprilita Rina Yanti Eff
Borneo Journal of Pharmacy Vol. 3 No. 3 (2020): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3i3.1359

Abstract

Type 2 diabetes mellitus (T2DM) is a major chronic disease that affects a large number of people worldwide. Hypertension is a common disease comorbidity among T2DM patients, and often those patients received polypharmacy and complex treatment in long term duration. This condition may lead to an increased risk of drug therapy problems (DTPs). This study aimed to assess and determine potential drug therapy problems in type 2 diabetic patients with hypertension comorbidity. Retrospective cross-sectional design was conducted in a hospital setting, especially data sources from the prescription of ambulatory T2DM patients with hypertension. A total of 190 patients were studied. More than half of the participants were female (53.68%). The majority age range of participants was 50-59 years (46.84%). Almost all antidiabetic agents were prescribed as polypharmacy (73.16%). Metformin was the most antidiabetic agent prescribed as monotherapy and combination therapy (63.16%). Almost all antihypertensive agents were prescribed as polypharmacy (63.26%). Amlodipine was the most antihypertensive agent prescribed as monotherapy and combination therapy (34.74%). Among the study participants, 56.84% have at least one of DTPs. Adverse drug reaction was the most frequent (47.22%), followed by ineffective drug therapy (29.63%). Since the potential of DTPs in T2DM patients with hypertension comorbidity is relatively high, early identifying, resolving, and preventing drug therapy problems by the pharmacist is needed to achieve goals of treatment.
Formulasi Pasta Gigi Herbal Ekstrak Etanol Daun Rosemary (Rosmarinus officinalis Linn.) Yanti Eff, Aprilita Rina; Ramadhani, Rizki Dwi; Hurit, Hermanus Ehe
Archives Pharmacia Vol 6, No 1 (2024): ARCHIVES PHARMACIA
Publisher : Lembaga Penerbitan Universitas Esa Unggul

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47007/ap.v6i1.7462

Abstract

Kesehatan mulut dan gigi tidak kalah pentingnya dengan kesehatan bagian tubuh yang lainnya karena mulut dan gigi merupakan bagian penting dalam melakukan aktivitas sehari-hari. Salah satu bahan alam yang ada di sekitar yang memiliki manfaat dalam bidang kesehatan mulut adalah daun rosemary (Rosmarinus officinalis Linn.). Rosmarinus officinalis Linn. merupakan salah satu spesies dari famili Lamiaceae yang kaya akan senyawa fenolik. Daun rosemary dapat digunakan untuk mengobati gangguan pada gigi seperti plak pada gigi. Penelitian ini bertujuan mendapatkan formulasi pasta gigi herbal ekstrak etanol daun rosemary yang sesuai dengan persyaratan sediaan pasta gigi. Penelitian ini menggunakan 3 formula ekstrak dengan variasi konsentrasi,  yaitu formula I, II dan III masing-masing dengan konsentarsi 15%, 20%, dan 25%. Selanjutnya dilakukan uji sifat fisik sediaan pasta gigi hasil formulasi. Hasil uji sifat fisik  menunjukkan bahwa ketiga formula tersebut memenuhi persyaratan dan sesuai standar sediaan pasta gigi berdasarkan parameter organoleptis, homogenitas, pH, viskositas, daya sebar, stabilitas dipercepat, dan daya busa.  Berdasarkan hasil uji sifat fisik sediaan pasta gigi herbal, ekstrak etanol 15%, 20%, dan 25% dapat diformulasikan menjadi pasta gigi herbal yang memenuhi persyaratan sediaan pasta gigi. 
Pharmacovigilance and Adverse Drug Reaction Reporting by Nurses to Improve Patient Safety Goals at Hospital in Bekasi, West Java Eff, Aprilita Rina Yanti; Utami, Luciana Mery; Indrawati, Ratna
Unnes Journal of Public Health Vol 13 No 1 (2024): Unnes Journal of Public Health
Publisher : Universitas Negeri Semarang (UNNES) in cooperation with Association of Indonesian Public Health Experts (Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ujph.v13i1.72297

Abstract

Nurses are frontline healthcare providers who spend much time with patients and can help avoid, mitigate, promote public health, and determine and maintain medicine safety. To ensure patient and medication safety, nurses need knowledge and experience in Pharmacovigilance. This study aims to assess Pharmacovigilance and adverse drug reaction reporting by nurses to implement Patient Safety Goals with Patient Safety Culture as intervening variables at X Hospital in Bekasi. This research is a quantitative causality study with a cross-sectional design to see the effect of pharmacovigilance knowledge on implementing patient safety goals mediated by patient safety culture. The study was conducted on 130 nurses at X Bekasi Hospital who met the inclusion and exclusion criteria. The data collection technique uses a closed questionnaire instrument; the answers to the questionnaire questions have been determined. Data were analyzed using the Smart PLS program's Structural Equation Modeling technique. The study's results found that knowledge of Pharmacovigilance and adverse drug reactions significantly affected the implementation of patient safety goals (F count is greater than F table / 64.5> 2.67; (R²) = 0.667). There is a significant influence of pharmacovigilance knowledge on improving patient safety culture (p-value = 0.000). The estimated value of the influence of pharmacovigilance knowledge on patient safety culture is 60.9%. Knowledge, attitude, and practice of Pharmacovigilance is the dominant variable in influencing patient safety culture and positively influences the implementation of patient safety goals. However, knowledge, attitude, and practice significantly impact patient safety culture, so efforts to implement consistent and continuous Pharmacovigilance can improve patient safety culture, which will continue with implementing patient safety goals.
PENGARUH KECERDASAN EMOSIONAL DAN KUALITAS KEHIDUPAN KERJA TERHADAP KOMITMEN ORGANISASIONAL DENGAN BUDAYA ORGANISASI SEBAGAI VARIABEL MODERASI PADA TENAGA KESEHATAN DI RS XYZ Nudianti, Retna Mutiara; Yanti Eff, Aprilita Rina; Jus'at, Idrus
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 3 (2024): DESEMBER 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i3.34718

Abstract

Penelitian ini dilandaskan hasil observasi awal yang menginformasikan tingginya tingkat turnover di kalangan tenaga kesehatan yang berdampak pada stabilitas dan kualitas pelayanan kesehatan. Tujuan penelitian ini adalah untuk mengungkap secara empiris pengaruh kecerdasan emosional dan kualitas kehidupan kerja terhadap komitmen organisasional dengan budaya organisasi sebagai variabel moderasi. Jenis penelitian termasuk dalam kuantitatif dengan desain cross sectional study. Populasi yang digunakan adalah tenaga kesehatan di unit rawat inap. Teknik sampling menggunakan purposive sampling sehingga ditemukan responden sebanyak 77 tenaga kesehatan dengan status karyawan tetap. Teknik pengumpulan data menggunakan kuesioner, dan metode analisa menggunakan analisa three-box method serta PLS-SEM dengan bantuan program Smart-PLS dan SPSS sebagai perbandingan. Hasil analisa membuktikan bahwa secara simultan dan parsial, kecerdasan emosional, kualitas kehidupan kerja dan budaya organisasi berpengaruh terhadap komitmen organisasional Budaya organisasi mampu memperkuat pengaruh kecerdasan emosional terhadap komitmen organisasional, sedangkan budaya organisasi tidak mampu memoderasi pengaruh kualitas kehidupan kerja terhadap komitmen organisasional. Budaya organisasi merupakan variabel dominan yang mampu meningkatkan komitmen organisasional.
Pengaruh Perilaku Caring dan Pengalaman Pasien Terhadap Kualitas Pelayanan Rawat Inap dengan Kepercayaan Pasien Sebagai Variabel Intervening Widjaya, Teriany; Yanti, Aprilita Rina; Dian, Wahyuni
Action Research Literate Vol. 8 No. 11 (2024): Action Research Literate
Publisher : Ridwan Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/arl.v8i11.2523

Abstract

Meningkatnya pengetahuan masyarakat akan pelayanan kesehatan, khususnya rumah sakit serta persaingan bisnis yang semakin ketat, maka pelayanan kesehatan di rumah sakit harus mampu memberikan kepada pasien terkait pelayanan kesehatan yang prima. Oleh karena itu, rumah sakit dituntunt selalu menjaga kepercayaan dengan meningkatkan perilaku caring dan pengalaman pasien agar kualitas pelayanan rumah sakit menjadi lebih baik. Tujuan penelitian ini untuk menganalisis mengenai pengaruh perilaku caring dan pengalaman pasien terhadap kualitas pelayanan rawat inap rumah sakit dengan kepercayaan pasien sebagai variabel intervening. Metode penelitian yang digunakan yakni metode deskriptif kuantitatif. Responden dalam penelitian ini merupakan pasien rawat inap rumah sakit. Pemilihan sampel penelitian menggunakan teknik purposive sampling sehingga responden pada penelitian ini sebanyak 250 pasien rawat inap rumah sakit. Teknik analisis yang digunakan adalah Partial Least Square – Structural Equation Modeling (PLS-SEM). Hasil penelitian menunjukkan bahwa caring dan pengalaman pasien berpengaruh terhadap kepercayaan, caring tidak berpengaruh terhadap kualitas pelayanan, namun pengalaman pasien berpengaruh terhadap kualitas pelayanan, serta caring dan pengalaman pasien berpengaruh terhadap kualitas pelayanan dengan kepercayaan sebagai variabel intervening. Hal ini berarti peningakatn kualitas pelayanan didapatkan melalui kepercayaan pasien dengan perilaku caring dan pengalaman pasien, Implikasi hasil penelitian menunjukkan bahwa manajemen rumah sakit dapat melakukan peningkatan kualitas pelayanan dengan cara perbaikan pada indikator setiap variabel. Temuan penelitian menunjukkan bahwa perilaku pengalaman pasien memberikan pengaruh terbesar terhadap kualitas pelayanan.
Organizational Culture and Leadership Affect Nurses' Use of EMR Through Work Motivation at Hospital X Tangerang Christine Verina; Aprilita Rina Yanti; Andry Andry
ePaper Bisnis : International Journal of Entrepreneurship and Management Vol. 2 No. 3 (2025): ePaper Bisnis : International Journal of Entrepreneurship and Management
Publisher : Asosiasi Riset Ilmu Manajemen Kewirausahaan dan Bisnis Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/epaperbisnis.v2i3.557

Abstract

Electronic Medical Records (EMR) are a crucial component of hospital information systems that support the effectiveness, accuracy, and continuity of patient care. However, their implementation among nurses at Hospital X remains suboptimal due to barriers related to organizational culture, leadership, and individual motivation. This study aims to analyze the effect of organizational culture (X1) and transformational leadership (X2) on the implementation of EMR (Y) through work motivation (Z) as an intervening variable. The research applied an explanatory-causal design with a quantitative approach, using a cross-sectional survey method. Data were collected through questionnaires distributed to nurses and analyzed using Structural Equation Modeling–Partial Least Squares (SEM-PLS). The findings reveal that organizational culture and transformational leadership significantly influence EMR implementation both directly and indirectly through work motivation, with p-values less than 0.05. These results indicate that strong organizational values, collaborative culture, and transformational leadership that fosters motivation and innovation can improve nurses’ willingness and effectiveness in utilizing EMR. The study concludes that enhancing organizational and leadership factors, along with maintaining high work motivation, is essential to ensure successful EMR adoption and optimize healthcare service quality in hospitals.
FUN AEROBIC DAN EDUKASI KESEHATAN MENGENAI AKTIVITAS FISIK DAN KONSUMSI MAKANAN BERGIZI DI SD LAZUARDI CORDOVA GCS, JAKARTA BARAT Mustikawati, Intan Silviana; Kuswari, Mury; Nuzrina, Rachmanida; Pamungkas, Rian Adi; Rosya, Ernalinda; Eff, Aprilita Rina Yanti; Rahayu, Sri Teguh
EJOIN : Jurnal Pengabdian Masyarakat Vol. 2 No. 2 (2024): EJOIN : Jurnal Pengabdian Masyarakat, Februari 2024
Publisher : LPPM Institut Pendidikan Nusantara Global

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/ejoin.v2i2.2233

Abstract

One of the problems of school-age children is a change in lifestyle from traditional life style to sedentary life style which is the cause of lack of physical activity that can increase the risk of obesity. The practice of regular physical activity is very important to improve body health which can have an impact on student achievement. Communication, information, and education among students about the importance of practicing regular physical activity are needed to improve knowledge, attitudes, and practices of physical activity. The purpose of this activity is to provide health education about physical activity and consumption of nutritious food, practice aerobic gymnastics together, and health examinations and consultations. The targets of this activity are students, parents, teachers, and employees of SD Lazuardi Cordova GCS, West Jakarta. These activities were carried out in the form of health education through lectures and discussions, practice aerobic gymnastics together, health checks such as height, weight, blood pressure, nutritional status, blood sugar, and uric acid, as well as health consultations. Regular health education in schools is needed to improve health knowledge, attitudes, and practices in students.