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All Journal Darussalam Nutrition Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Farmasains : Jurnal Ilmiah Ilmu Kefarmasian JMM (Jurnal Masyarakat Mandiri) Jurnal Pengabdian Masyarakat AbdiMas NUSANTARA : Jurnal Ilmu Pengetahuan Sosial FITOFARMAKA: Jurnal Ilmiah Farmasi Unnes Journal of Public Health Majalah Farmasetika Pharmacoscript Jurnal Ekonomi Manajemen Sistem Informasi PREPOTIF : Jurnal Kesehatan Masyarakat Journal of Nursing and Public Health (JNPH) Jurnal Ilmu Manajemen Terapan (JIMT) Community Empowerment Jurnal Pengabdian Masyarakat Indonesia International Journal of Engineering, Science and Information Technology Jurnal Pengabdian kepada Masyarakat Archives Pharmacia Action Research Literate (ARL) Pharmaceutical Sciences and Research (PSR) EJOIN : Jurnal Pengabdian Masyarakat Ranah Research : Journal of Multidisciplinary Research and Development Borneo Journal of Pharmacy Epaper Bisnis: International Journal Entrepreneurship and Management
Aprilita Rina Yanti
Universitas Esa Unggul
Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Transportation Other

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UJI SITOTOKSIK EKSTRAK ETANOL 50% DAUN KITOLOD (Isotoma longiflora (L.) Presl.) TERHADAP SEL KANKER SERVIKS (Ca Ski Cell Line) SECARA IN- VITRO yanti, Aprilita rina
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol 3 No 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (318.748 KB)

Abstract

Kitolod (Isotoma longiflora (L.) Presl.) Is a traditional medicinal plant which is efficacious as anticancer. Empirically kitolod had been used  by Indonesian people for the treatment of cancer, but this remains to be proven scientifically through research. The objective of this research was to determine the cytotoxic activity of 50% Ethanol Extract of Kitolod leaves (Isotoma longiflora (L.) Presl) at a concentration of 25 mg / mL, 50 mg / mL, 75 mg / mL, and 125 mg / mL against cervical cancer cells (Ca Ski Cell Line) in vitro assay using red natural methods.Results of Cytotoxic assay  shows that  IC50 values 50% Ethanol Extract of Kitolod leaves (Isotoma longiflora (L.) Presl) in Ca Ski Cell Line  is  55.78 ug / mL. Ethanol extract  at  concentration of 25 mg / mL, 50 mg / mL, 75 mg / mL, and 125 mg / mL have cytotoxic effecst against cervical cancer cells (Ca Ski Cell Line) and extract at a concentration of 125 ug / mL indicates the largest percentage of cell death.
SARS-Cov-2: Virologi dan Target Obat Yanti Eff, Aprilita Rina
Archives Pharmacia Vol 3, No 2 (2021): ARCHIVES PHARMACIA
Publisher : Lembaga Penerbitan Universitas Esa Unggul

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Abstract

Pandemi COVID-19 yang disebabkan oleh coronavirus 2 (SARS-CoV-2) menimbulkan tantangan bagi para peneliti dalam mengidentifikasi obat yang efektif untuk pencegahan maupun pengobatan Covid-19. Pengetahuan yang berkembang pesat mengenai virologi SARS-CoV-2 memberikan informasi sejumlah besar target obat yang potensial. Banyak terapi telah dilaporkan efektif menghambat replikasi SARS-CoV-2 sejak merebaknya pandemi ini. Target utama pada obat-obat ini adalah protein esensial dalam siklus hidup virus. Beberapa obat saat ini direkomendasikan untuk pasien COVID-19 yang memiliki gejala sedang hingga berat, termasuk obat antivirus Favipiravir, Remdesivir, Baricitinib dan Kortikosteroid. Pendekatan saat ini untuk terapi COVID-19 umumnya terbagi dalam dua kategori: antivirus yang mencegah virus bereplikasi dan imunomodulator yang membantu sistem kekebalan untuk melawan virus. Pandemi Covid-19 merupakan tantangan dan krisis kesehatan global. Oleh karena itu sangat dibutuhkan kecepatan dan jumlah uji klinis obat-obat yang potensial untuk Covid-19.  Sampai saat ini belum ada terapi yang terbukti efektif dalam mengobati covid-19.
Efektivitas Repelan Losion Minyak Atsiri Daun Zodia (Evodia Suaveolens) Terhadap Nyamuk Aedes aegypti Linnaeus Aprilita Rina Yanti Eff; Ratih Dyah Lestari Ayu Pertiwi; Tyas Putri Utami
Majalah Farmasetika Vol. 4, Supl. 1, Tahun 2019
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v4i0.25868

Abstract

Zodia (Evodia suaveolens) merupakan salah satu tanaman yang mempunyai aroma yang tajam pada bagian bunga dan daunnya dan dipercaya dapat mengusir nyamuk. Daun Zodia mengandung minyak atsiri evodiamine dan rutaecarpine yang tidak disukai oleh nyamuk. Tujuan penelitian ini untuk menilai efektivitas repelen losion mengandung minyak atsiri daun Zodia pada konsentrasi 1%, 1.5% dan 2%. Metodenya dengan iosion yang dibuat dengan mencampurkan minyak atsiri hasil isolasi dari daun Zodia pada konsentrasi 1%, 1,5% dan 2% ke dalam formulasi sediaan losion yang terdiri dari asam stearat, setil alkohol, parafin cair, dimetikon, vaselin kuning, trietanolamin dan asam sitrat. Pengujian dilakukan dengan cara memasukkan lengan secara bergantian antara lengan yang diberi perlakuan (losion) dan kontrol (tidak diberi perlakuan) ke dalam kurungan nyamuk yang berisi 25 ekor nyamuk Aedes aegypti, kemudian  dihitung jumlah nyamuk yang hinggap setiap jam selama enam jam. Efikasi repelan ditentukan berdasarkan daya proteksi yang dihitung dengan rumus : Daya proteksi (DP) =( K - R)/K x 100%; K = banyaknya hinggapan pada lengan control; R = banyaknya hinggapan pada lengan pelakuan.  Hasil penelitian losion mengandung minyak atsiri daun zodia pada konsentrasi 1%, 1,5% dan 2% berpotensi sebagai pengusir nyamuk  (repelan) Aedes aegypti dengan daya proteksi rata-rata selama enam jam berturut-turut  adalah sebesar 74,50%, 75,39% dan 82,45%. Tidak terdapat perbedaan yang signifikan pada daya proteksi antara ke 3 konsentrasi losion  (p>0.05) Losion mengandung minyak atsiri daun zodiac pada konsetrasi 1%, 1,5% dan 2% memiliki efektivitas sebagai repelen. Daya proteksi tertinggi ditunjukkan oleh losion yang mengandung minyak atsiri daun Zodia 2% yaitu sebesar 82.45%.
Pengaruh pemberian aminofusin hepar terhadap kadar albumin dan status gizi pasien sirosis di RSUD Cengkareng Anugrah Novianti; Della Mahdalia; Aprilita Rina Yanti
Darussalam Nutrition Journal Vol 3, No 1 (2019): Darussalam Nutrition Journal
Publisher : University of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/dnj.v3i1.3029

Abstract

Latar belakang : Sirosis hati dapat dijumpai di seluruh negara termasuk Indonesia. Menurut data Perhimpunan Peneliti Hati Indonesia (PPHI) pada tahun 2013, rata-rata prevalensi sirosis hati sebesar 47,4% dari seluruh pasien penyakit hati yang dirawat. Data di RSUD Cengkareng, pada periode tahun 2015 - 2017 terdapat 146 pasien sirosis hati yang dirawat inap. Sirosis hati dapat menyebabkan gangguan sintesis albumin. Seringkali pasien dengan penyakit berat tidak memungkinkan untuk pemberian zat gizi secara oral karena adanya gangguan pencernaan, maka pemberian terapi gizi enteral atau parenteral dapat menjadi solusi guna mencegah terjadinya malnutrisi. Tujuan : Mengetahui pengaruh pemberian terapi gizi parenteral (Aminofusin Hepar) terhadap kadar albumin dan status gizi pada pasien penyakit sirosis hati kronis. Metode :Penelitian ini menggunakan desain penelitian retrospektif, total populasi 146 orang, total sampel 21 orang. Pengambilan sampel menggunakan teknik purposive sampling. Jenis data merupakan data sekunder, kemudian dianalisis menggunakan uji t berpasangan dan uji Wilcoxon jika data berdistribusi tidak normal. Hasil : Hasil penelitian menunjukkan bahwa responden terbanyak yaitu pria, dengan rata-rata responden berada pada kategori pra lansia, kadar albumin seluruh responden rendah, status gizi terbanyak berada di kategori normal. Ada pengaruh pemberian terapi gizi parenteral aminofusin hepar terhadap kadar albumin (p=0,002), tetapi tidak ada pengaruh dengan status gizi berdasarkan IMT (p=0,109). Kesimpulan : Pemberian terapi gizi parenteral aminofusin hepar berpengaruh terhadap kadar albumin tetapi tidak berpengaruh pada IMT. 
UJI SITOTOKSIK EKSTRAK ETANOL 50% DAUN KITOLOD (Isotoma longiflora (L.) Presl.) TERHADAP SEL KANKER SERVIKS (Ca Ski Cell Line) SECARA IN- VITRO Aprilita rina yanti
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 3 No. 1 (2016)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (318.748 KB)

Abstract

Kitolod (Isotoma longiflora (L.) Presl.) Is a traditional medicinal plant which is efficacious as anticancer. Empirically kitolod had been used  by Indonesian people for the treatment of cancer, but this remains to be proven scientifically through research. The objective of this research was to determine the cytotoxic activity of 50% Ethanol Extract of Kitolod leaves (Isotoma longiflora (L.) Presl) at a concentration of 25 mg / mL, 50 mg / mL, 75 mg / mL, and 125 mg / mL against cervical cancer cells (Ca Ski Cell Line) in vitro assay using red natural methods.Results of Cytotoxic assay  shows that  IC50 values 50% Ethanol Extract of Kitolod leaves (Isotoma longiflora (L.) Presl) in Ca Ski Cell Line  is  55.78 ug / mL. Ethanol extract  at  concentration of 25 mg / mL, 50 mg / mL, 75 mg / mL, and 125 mg / mL have cytotoxic effecst against cervical cancer cells (Ca Ski Cell Line) and extract at a concentration of 125 ug / mL indicates the largest percentage of cell death.
THE ACTIVITY OF GEL EXTRACT MAHKOTA DEWA FRUITS [(Phaleria macrocarpa (Scheff.) Boerl] THROUGH TYROSINASE ENZYME INHIBITOR Aprilita Rina Yanti Eff; Erika Noviyanti; Ratih Dyah Pertiwi
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 12, No 1 (2022): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v12i1.4874

Abstract

Mahkota dewa fruit [(Phaleria macrocarpa (Scheff.) Boerl] contains benzophenone derivatives which have sun protection activity and flavonoid compounds which can act as tyrosinase inhibitors.  This study aimed to determine the tyrosinase inhibitor activity of 70% ethanol extract of Mahkota Dewa fruit and gel extract of Mahkota Dewa fruits with variations in concentrations of 1.25% (F1), 2.5% (F2), and 5% (F3). Assay of tyrosinase inhibitor activity against ethanol extract of Mahkota Dewa fruit and ethanol extract was done with various concentrations (31.25, 62.5, 125, 250, and 500 µg/ml), using a positive control of Kojic acid and L-DOPA as a substrate. Absorbance measurement was carried out using UV-vis microplate reader with a wavelength of 480 nm. The results showed that the ethanolic extract Mahkota Dewa had an IC50 value of 6668.06 µg/ml while kojic acid as a positive control possessed an IC50 value of 4.22 µg/ml. Gel preparation of the ethanol extract has inhibitor activity of the enzyme tyrosinase represent moderate values of the IC50each, i.e., F1 (1.25%) amounted to 285.03 µg/ml, F2 (2.5%) amounted to 373.25µg/ml, and F3 (5%) of 397.40 µg/ml. The tyrosinase inhibitor activity of the 70% ethanol extract of Mahkota Dewa fruit was lower with a relative potency of 5.167 x 10-3 times compared to that of kojic acid.
Upaya Pencegahan Penyakit Sindrom Metabolik Sejak Remaja Aprilita Rina Yanti Eff; Sri Teguh Rahayu; Ayu Puspita Lena
Jurnal Pengabdian Masyarakat Indonesia Vol 2 No 3 (2022): JPMI - Juni 2022
Publisher : CV Infinite Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52436/1.jpmi.612

Abstract

Masa remaja merupakan fase kritis dimana terjadi beberapa perubahan, seperti perubahan fisik, perkembangan otak, maturasi organ seksual, dan perkembangan psikososial yang mempengaruhi perilaku terkait kesehatan. Remaja rentan mengalami permasalahan kesehatan, terutama pada penyakit sindrom metabolik. Hal ini juga didukung apabila gaya hidup masa remaja tidak diperhatikan terutama di masa pandemi seperti sekarang ini, dimana makan yang tidak terkontrol dan jarang melakukan aktivitas fisik sehingga penyakit sindrom metabolik ini semakin rentan terjadi pada usia remaja. Kegiatan Pengabdian Masyarakat dilakukan dengan memberikan edukasi mengenai sindrom metabolik pada 30 siswa siswi kelas IX SMP 264 Jakarat berupa pemberian materi mengenai bagaimana mencegah sindrom metabolik dengan menerapkan pola makan yang sehat, dan aktivitas fisik yang teratur, agar dapat diterapkan dalam kehidupan sehari-hari.  Selain itu dilakukan pula pengukuran berat badan, tinggi badan, tekanan darah, dan lingkar pinggang untuk melihat gambaran kesehatan siswa-siswi SMPN 264 Jakarta. Hasil pengukuran tekanan darah menunjukkan 5 orang siswa memiliki tekanan darah ?130/85 mmHg. Pemberian Edukasi pada 30 siswa siswi kelas IX SMPN 264 Jakarta mengenai bagaimana mencegah sindrom metabolik dengan menerapkan pola makan yang sehat, dan aktivitas fisik yang teratur   sangat penting untuk terus dilakukan sehingga remaja memiliki pengetahuan tentang pentingnya menerapkan pola hidup sehat untuk mencegah sindrom metabolik.
Efek Anti-tifoid Minyak Atsiri Temu Putih (Curcuma zedoria Rosc.) pada Tikus (Rattus norvegicus L) yang Terinfeksi Salmonella typhi Rina Yanti Eff, Aprilita
Pharmaceutical Sciences and Research Vol. 5, No. 3
Publisher : UI Scholars Hub

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Abstract

Temu putih (Curcuma zedoria Rosc.) contains essential oils that have antibacterial effects, in which one of the example is against Salmonella typhi. The aim of this study is to find out the anti-typhoid effect of essential oil from temu putih in rat infected by Salmonella typhi using widal test. The study was conducted experimentally. Rats were divided into six groups, i.e., normal control group, negative control group which was given PGA 10%, positive control group, which was administered chloramphenicol suspension 20 mg / 250 g BB, experiment group 1, 2 and 3 which were administerd emulsion essential oil at a dose of 14 mg / mL, 28 mg / mL, 42 mg / mL, respectively. Antibody titer was measured on day 1 (Widal test I), day 8 (Widal test II) and on day 14 (Widal test III). After the Widal test I, rats were induced Salmonella typhi bacterial suspension for 7 days orally, except for normal control group, and followed by administration of treatment 3 times daily for 7 consecutive days according to the group. The result of Widal test I shows negative value on all groups of animal test, whereas Widal test II result shows an increase of titer antigen Salmonella typhi O and H ranging from 1/80 up to 1/320 in rats induced by Salmonella typhi bacteria. Essential oil from Curcuma zedoria Rosc at doses of 14 mg / mL, 28 mg / mL and 42 mg / mL decreased the Salmonella typhi O and H antigen titer in rats infected by Salmonella typhi and has anti-typhoid effect.
Uji Aktivitas Penghambatan Xantin Oksidase secara In-Vitro oleh Isolat 6,4’-Dihidroksi-4-Metoksibenzofenon-2-O-β-D Glukopiranosida(C20H22O10) yang Diisolasi dari Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl) Rina Yanti Eff, Aprilita; Rahayu, Sri Teguh; Syachfitri, Resta Dwi
Pharmaceutical Sciences and Research Vol. 3, No. 1
Publisher : UI Scholars Hub

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Abstract

Hyperuricemia is a condition in which an increasing in uric acid levels abovenormal. Hyperuricemia is a major factor in the development of gout. Gout is adisease caused by the accumulation of monosodium urate crystals in the tissues dueto elevated levels of uric acid. Crown gods (Phaleria macrocarpa (Scheff.) Boerl) is Indonesia native medicinal that has effect such as lowering blood pressure, diabetes mellitus drugand lowering uric acid levels. One of the chemical constituents of this plant is abenzopheneon compound that is 6,4’-dihydroxy-4-metoksi benzofenon-2-O-β-D-glukopiranosida (C20H22O10). Research was conducted to determine the activity of 6,4’-dihydroxy -4-metoksi benzofenon-2-O-β-D-glukopiranosida (C20H22O10) that isolated from Crown gods in inhibiting xanthine oxidase by in-vitro method using spechtrofotometer with allopurinol as a positive control.The results showed that isolates 6,4’-dihydroxy-4-metoksi benzofenon-2-O-β-D-glukopiranosida (C20H22O10) has inhibitory activity against xanthine oxidase with IC50 values 15.705 mg / mL. However, allopurinol has xanthine oxidase inhibitory activity higher than isolates with IC50value of 0.091 mg/mL. Lineweaver-Burk plot showed that isolates 6,4’-dihydroxy-4-metoksi benzofenon-2-O-β-D-glukopiranosida(C20H22O10) has a competitive inhibitory activity.
Uji Efek Antiinflamasi Fraksi Air Daun Mahkota Dewa (Phaleria macrocarpa (Shecff.) Boerl.) terhadap Tikus Putih (Rattus norvegicus L.) Eff, Aprilita Rina Yanti; Dewanti, Ema; Adelina H, Melisha
Pharmaceutical Sciences and Research Vol. 1, No. 2
Publisher : UI Scholars Hub

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Abstract

Inflammation occurs as the attempt of body to inactivate organisms that attack the body, removing irritants and regulate tissue repair. One of the medicinal plants used empirically as antiinflammation is the leaf of Mahkota Dewa (Phaleria macrocarpa (Schecff.) Boerl). This study investigated the effect of anti-inflammatory water fraction of leaf Mahkota Dewa using oedema induction method with caragenin in rat. Water fraction of Mahkota Dewa was given at the dose 0.5 g/kg BW ,1 g/kg BW and 2 g/kg BW. Sodium diclofenac was used as a positive control and CMC as negative control. The result showed water fractions of three doses can inhibit inflammation at 27.35%, 18.58%, and 20.17%, respectively. The water fraction at the dose 0.5 g/kgBW showed the largest percentage of oedema inhibition compared to other treatment groups.
Co-Authors . Juriana . Widayanti Abdurrasyid Abna, Inherni Marti Adelina H, Melisha Andry Andry Anna Yuliana, Anna Anton Bahtiar Anugrah Novianti Ayu Pertiwi, Reza Ayu Puspita Lena Ayu Puspitalena Christine Verina Della Mahdalia Devi Angeliana Kusumaningtiar Dian, Wahyuni Diman Wahyudin Duan Elnastio Eden, Yonatan Ehe Hurit, Hermanus Ema Dewanti Erika Noviyanti Ery Fudjiati Fresley Hutapea Harfia Mudahar hasyim, hasyim Helmi Geisfarad Hermanus Ehe Hurit Hurit, Hermanus Ehe Ibnu Irawan Intan Silviana Mustikawati Julaeha Julaeha Jus'at, Idrus Maksum Radji Mayang Ayu Purborini Melliany Rosna, Hendari Mellisa Resmiati Mohamad Reza Hilmy Mury Kuswari Mustikawati, Intan Silviana Nadiya Nurul Afifah Novianti, Anugrah Nudianti, Retna Mutiara Pertiwi, Ratih Dyah Putri Batenia Rachmanida Nuzrina Ramadhani, Rizki Dwi RATNA INDRAWATI Reinaldo Pradana Rekha Rakhma Hidayah Resta Dwi Syachfitri, Resta Dwi Rian Adi Pamungkas Rian Adi Pamungkas Ridwan Kurniawan Rina Anindita Rini, Tjipto Rosya, Ernalinda Sari Putri Utami Sri Teguh Rahayu Sri Teguh Rahayu, Sri Teguh Tantri Yanuar Rahmat Syah Taufik, Hidayat Tyas Putri Utami Uli, Syahdani Utami, Luciana Mery Victor S Ringoringo Victor Sahat Siringoringo Widjaya, Teriany