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All Journal 2-TRIK: TUNAS-TUNAS RISET KESEHATAN JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Jurnal Kesehatan Amanah Jurnal Sains dan Kesehatan
Aulia Debby Pelu
STIKes Maluku Husada
Environmental Science Health Professions Nursing Public Health

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Uji Aktivitas Antidiabetes Ekstrak Etanol Daun Pala (Myiristica Fragrans) Terhadap Tikus(Rattus Norvegicust) Galur Wistar Jantan Yang Diinduksi Aloksan Aulia Debby Pelu; Pia Batmomolin; Salama Nurlette
Jurnal Kesehatan Amanah Vol. 5 No. 2 (2021): Oktober : Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (181.732 KB) | DOI: 10.57214/jka.v5i2.142

Abstract

Nutmeg is known as a spice plant that has economic value and multipurpose because every part of the plant can be used in various industries. Compounds contained in nutmeg leaves include alkaloids, triterpenoids, tannins and 2 flavonoids. The purpose of this study was to determine the antidiabetic effect of ethanolic extract of nutmeg leaf (myristica frangrans) against male wistar white rats (Rattusnorvegicus) induced by alloxan administered intraperitoneally and compare its effectiveness with glibenclamide. This study used five treatment groups, namely the administration of aquadest as a negative control, glibenclamide as a positive control and ethanol extract of nutmeg leaves at a dose of 100 mg/kg BW, 200 mg/kg BW and 300 mg/kg BW as control treatments. Blood glucose measurements were carried out on day 0 (three days after induction), day 3, day 7 and day 10. The results showed that the ethanol extract of nutmeg leaf (myristica frangrans) TEST ACTIVITY can reduce blood glucose levels. At a dose of 300 mg/kg but not exceeding the decrease in blood sugar in the administration of glibenclamide. Giving ethanol extract of nutmeg leaves (myristica frangrans) also has activity to repair damage to pancreatic -cells in white rats (Rattus norvegicus) induced by alloxan.
SKRINING FITOKIMIA DAN UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL BULU BABI (Diadema setosum) TERHADAP PERTUMBUHAN Staphylococcus aureus DI PERAIRAN DESA PELAUW Aulia Debby Pelu; Risman Tunny; Bilkis Latuconsina
Jurnal Sains dan Kesehatan Vol. 4 No. 2 (2020): Desember : Jurnal Sains dan Kesehatan (JUSIKA)
Publisher : Universitas Muhamadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.701 KB)

Abstract

Sea urchin (Diadema setosum) is an aquatic biota that has high nutritional value. Bioactive compounds produced by sea urchins have the potential to be used as natural antibacterial compounds. This study aims to identify chemical compounds and determine the antibacterial activity of ethanol extract of sea urchins (Diadema setosum) against the growth of Staphylococcus aureus bacteria. The research method used is the agar diffusion method. The results of phytochemical screening of sea urchin extract (Diadema setosum) showed the presence of alkaloids and saponins. By using variations in the concentration of ethanol extract of sea urchin (Diadema setosum) at a concentration of 80% it had an inhibitory power of 18 mm, a concentration of 90% had an inhibitory power of 23 mm, a concentration of 100% had an inhibitory power of 28 mm and for a concentration of 110% had an inhibitory power of 35 mm. The positive control has a resistance of 30 mm and the negative control is 0 mm. The results showed that the ethanol extract of sea urchins (Diadema setosum) had a strong bacterial inhibitory activity against Staphylococcus aureus bacteria.
FORMULASI DAN UJI SIFAT FISIK SEDIAAN KRIM EKSTRAK ETANOL BUAH PALA (MYRISTICA FRAGRANS) SEBAGAI ANTI AGING Jayanti Djarami; Aulia Debby Pelu; Sisilia W. Marjuni
Jurnal Sains dan Kesehatan Vol. 4 No. 2 (2020): Desember : Jurnal Sains dan Kesehatan (JUSIKA)
Publisher : Universitas Muhamadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (104.906 KB)

Abstract

Nutmeg (Myristica fragrans) is a spice plant that produces essential oils of economic value. Especially the myristicin compounds contained in nutmeg oil have potential as antioxidants and also anti-aging. The content of nutmeg which shows antifungal activity is flavonoids, saponins and alkaloids. Flavonoids as antifungal compounds work by interfering with the permeability of fungal cell membranes and changing organic components and nutrient transport which ultimately results in toxic effects on fungi. This study aims to determine the chemical content and whether the nutmeg extract can be formulated in cream preparations as well as the results of the physical properties test on the preparation of the nutmeg (Myristica fragrans) ethanol extract of cream. The type of research used in this study was experimental research in the laboratory. Nutmeg (Myristica Fragrans), phytochemical screening test on nutmeg extract, cream preparation formulation, cream physical properties test (organoleptic test, pH test, homogeneity test, cream type test). Nutmeg extraction was carried out using the maceration method using 70% ethanol. The results of phytochemical screening of the ethanol extract of nutmeg (Myristica fragrans) indicated the presence of alkaloids, flavonoids, and saponins. The preparation of cream of ethanol extract of nutmeg (Myristica fragrans) using a Vaseline album base ratio of F1 (10%), F2 (15%) and F3 (20%) had stable physical properties.
SKRINING FITOKIMIA DAN UJI AKTIVITAS EKSTRAK ETANOL BIJI LABU KUNING (Curcubita Moschata) TERHADAP DAYA HAMBAT BAKTERI Staphylococcus aureus Aulia Debby Pelu; Ira P. Ely; Lukman La Bassy
Jurnal Sains dan Kesehatan Vol. 4 No. 1 (2020): Juni : Jurnal Sains dan Kesehatan (JUSIKA)
Publisher : Universitas Muhamadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (896.518 KB) | DOI: 10.57214/jusika.v4i1.151

Abstract

Labu kuning (Cucurbita moschata) merupakan sayuran penting karena nilai nutrisinya dan manfaat kesehatannya. Tanaman ini adalah sumber karotenoid yang kaya akan vitamin larut air, fenolat, flavonoid polisakarida, garam mineral, dan vitamin yang semuanya bermanfaat bagi kesehatan. Buah labu kuning mempunyai kulit yang sangat tebal dan keras, sehingga dapat bertindak sebagai penghalang laju respirasi, keluarnya air melalui proses penguapan, maupun masuknya udara penyebab proses oksidasi.. Tujuan dari pada penelitian ini adalah untuk mengetahui aktivitas antibakteri ekstrak biji labu kuning (curcubita moschata) terhadap daya hambat bakteri staphylococcus aureus dengan metode Difusi sumuran. Jenis penelitian ini adalah True Eksperimental laboratorium dengan menggunakan metode difusi sumuran. Sebagai control positif yang di ganakan adalah kloramfenikol. Selanjutnya diinkubasi pada temperatur 37o selama 24 jam yang kemudian zona hambat yang terbentuk selanjutnya diukur. Hasil dari penelitian ini adalah ekstrak biji labu kuning (curcubita moschata) memiliki aktivitas antibakteri dengan adanya daya hambat disekitar sumuran dari masing-masing konsentrasi ekstrak. Pada konsentrasi ekstrak 10% diameter daya hambat 19 mm, konsentrasi 15% diameter daya hambat 20 mm, konsentrasi 20% diameter daya hambat 21 mm dan untuk konsentrasi 15% dengan diameter daya hambat 24 mm, sehingga dapat disimpulkan bahwa ekstrak biji labu kuning (curcubita moschata.) memiliki aktivitas antibakteri terhadap bakteri staphylococcus aureus.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN NANGKA (Atrocarpus heterophyllus Lam) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus Aulia Debby Pelu; Hamka Sangkala; Akbar Mahfudz Ismail
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2022): Juni : Jurnal Sains dan Kesehatan (JUSIKA)
Publisher : Universitas Muhamadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jusika.v6i1.221

Abstract

Jackfruit leaves are one of the medical plants that have many benefits. In general, jackfruit leaves are known as animal feed, but behind their function as animal feed, jackfruit leaves have health benefits because jackfruit leaves contain antimicrobials including flavonoids, tannins, saponins that can dissolve in water and can work to damage cytoplasmic membranes and denature cell proteins bacteria. Staphylococcus aureus is a gram-positive bacterium and is arranged in clusters (like grapes). Some infectious diseases caused by these bacteria are impetigo, boils, acne, wound infections, toxic shock syndrome, and other types of pathogenic. This study was conducted to determine the effect of jackfruit leaf extract dissolved using 70% ethanol as a solvent on the growth of staphylococcus aureus bacteria. The method used is the maceration method for the phytochemical screening test, and the disc diffusion method for the antibacterial activity test. The results of the phytochemical screening contained secondary metabolite compounds in jackfruit leaves and for the results of the antibacterial activity test of jackfruit leaf ethanol extract against the growth of staphylococcus aureus bacteria there was antibacterial activity inhibition with high inhibition at 80% concentration with a diameter of 13mm.
Co-Authors Ainun Pamana Akbar Mahfudz Ismail Alice Martha Luhulima Amelia Niwele Bilkis Latuconsina Cut Bidara Panita Umar Dewi Amalia Salenussa Hamka Sangkala Hasni Pulhehe Ira P. Ely Jayanti Djarami Jayanti Djarami Kasmawati Kasmawati Laitupa Hardiyanti L Lukman La Bassy Naba Naba Nahdiyanti Ias Pia Batmomolin Rati Pramudita Salama Nurlette Sisilia W. Marjuni Tunny, Risman Wiwi Rumaolat