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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Mandala Pharmacon Indonesia Rambideun : Jurnal Pengabdian Kepada Masyarakat Jurnal Abdi Masyarakat Indonesia Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Jurnal Pengabdian Kefarmasian JAMU : Jurnal Abdi Masyarakat UMUS Nanggroe: Journal Of Scholarly Service Gema Kesehatan Jurnal Mahasiswa Ilmu Kesehatan Nanggroe: Journal of Scholarly Service Jurnal Farmasindo: Jurnal Penelitian dan Pengabdian Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan
Muthmainah Tuldjanah
Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu
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GAMBARAN PENGGUNAAN OBAT ANTIHIPERTENSI DI RUANGAN ICCU RUMAH SAKIT UMUM ANUTAPURA PALU TAHUN 2020 Muthmainah Tuldjanah
Jurnal Farmasindo Vol 5 No 1 (2021): Juni
Publisher : Program Studi D3 Farmasi Politeknik Indonusa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hipertensi merupakan salah satu mortalitas dan morbalitas di indonesia. Penelitian ini bertujuan untuk mengetahui pengobatan penggunaan obat antihipertensi di Ruang ICCU Rumah Sakit Umum Anutapura Palu dan melihat kesesuaian terapi obat antihipertensi di Ruang ICCU Rumah Sakit Umum Anutapura Palu sudah sesuai standar pengobatan. Pengumpulan data dilakukan pada bulan juli- agustus 2020. Penelitian ini merupakan penelitian deskriptif secara cross sectional dengan pengambilanan data secara retrospektif pada data rekam medik pasien hipertensi periode januari 2017- desember 2019. Teknik pengambilan sampel secara total sampling dan diperoleh sampel sebanyak 50 pasien yang memenuhi kriteria inklusi. Hasil penelitian menunjukan hasil obat antihipertensi yang paling banyak furosemide sebanyak (23%) dan untuk obat pendamping yang paling banyak digunakan golongan antiplatelet sebayak (25%). Evaluasi kerasional penggunaan obat antihipertensi berdasarkan tepat indikasi sebanyak 100%, tepat pasien sebanyak 100%, tepat obat sebanyak 100% dan tepat dosis sebanyak 94%.
EVALUATION OF APHRODISIAC ACTIVITY OF ETHYL ACETATE FRACTION OF CLOVE LEAVES (Syzygium aromaticum L.) IN MALE WHITE RATS (Rattus norvegicus) Muthmainah Tuldjanah; Rezky Yanuarty; Agung; Ayu Wulandari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.918

Abstract

Clove leaves contain antioxidant compounds such as saponins, flavonoids, tannins, sterols, and essential oils. Among those chemical constituents, eugenol, eugenol acetate, caryophyllene, and sesquiterpenes were believed to have aphrodisiac activity. This study aims to investigate the potential aphrodisiac effects of the ethyl acetate fraction of clove leaves (Syzygium aromaticum L) administered at a dose of 250 mg/kg BW. The research employed an experimental method with a modified post-test randomized controlled group design and utilized a total of 45 white rats, consisting of 15 males and 30 females, divided into three treatment groups in a 1:2 ratio. Each group consisted of 5 male rats and 10 female rats. The three groups included the healthy control group (Na-CMC 0.5%), the positive control group (treated with X-Gra 52.5 mg/kg body weight) and the treatment group receiving clove leaf extract samples at a dosage of 250 mg/kg BW. The results indicate that the ethyl acetate fraction of clove leaves contains steroids and alkaloids with mount latency (ML), intromission latency (IL) ejaculation latency (EL), mount frequency (MF), intromission frequency (IF) and ejaculation frequency (EF) of 11.40 s, 15.80 s, 6.228 s, 23.60, 14.60, and 1.60 s, respectively. Based on these findings, it can be concluded that it has the potential to be used as an aphrodisiac agent. Keywords: Aphrodisiac, Syzygium Aromaticum L., ethyl acetate fraction, clove leaves, ejaculation frequency
POLA PENGGUNAAN OBAT PASIEN ISPA (PNEUMONIA) RUANG RAWAT INAP RUMAH SAKIT ANUTAPURA PALU TAHUN 2021 Tuldjanah, Muthmainah; Andriawan; Erick Budiawan
Jurnal Mahasiswa Ilmu Kesehatan Vol. 1 No. 3 (2023): Juli : Jurnal Mahasiswa Ilmu Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/jumkes.v1i3.30

Abstract

Pneumonia is a respiratory tract infection that causes coughing, difficulty breathing, sore throat, runny nose, earache, and fever, that caused by various kinds of bacteria, viruses, and fungi. This study aims to determine the accuracy of drug use in pneumonia patients based on indicators of the right dose, the right frequency and the right indication of the drug in the Inpatient Room of Anutapura Hospital Palu. This study was carried out using a cross sectional where data were collected retrospectively based on medical record data of ARI (Pneumonia) patients using a minimized sampling technique namely 30 samples based on the inclusion criteria. The results of this study showed that the most pneumonia patients were male, as many as 20 patients (67%). Meanwhile, based on the age range, the most age group affected namely the age of 1- 5 years, as many as 21 patients (70%). The results also showed that the most widely pneumonia drug used were antibiotics (32%), analgesics antipyretics (22%), corticosteroids (17%), and mucolytics (13%). This is in accordance with the recommendation of therapy from the Director General of Community and Clinical Bimfar 2005.
Antioxidant Activity Test of Effervescent Granules Morinda citrifolia L Leaf Extract with DPPH Free Radical Absorption Method Muthmainah Tuldjanah; Niluh Puspita Dewi; Dian Rahmawati
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 4 (2021): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i4.285

Abstract

Morinda citrifolia. L leaf is a plant that has the potential as an antioxidant due to the presence of compounds in the form of flavonoids and other phenolic compounds that can function as natural antioxidants. In connection with this, research was carried out to Morinda citrifolia. L formulate leaf extract in the form of effervescent granules. Morinda citrifolia leaf extract was macerated with ethanol 96% as solvent. Phytochemical screening showsthat the extract contains flavonoids, tannins, saponins and alkaloids. The extract was formulated with various concentrations of F1 (20%), F2 (25%), F3 (4%). Determination of antioxidant activity using the DPPH free radical immersion method. The results showed that the concentration in the granules influenced antioxidant activity with IC50 values of 109.05 ppm, 101.33 ppm and 73.28 ppm, respectively
Uji Efek Ekstrak Etanol Daun Afrika (Gymnanthemum amygdalinum (delile) Sch. Bip. Ex Walp) terhadap Kadar Glukosa Darah Tikus Putih Rattus norvegicus) Muthmainah Tuldjanah; Wayan Wirawan; Ni Putu Setiawati
Jurnal Sains dan Kesehatan Vol. 2 No. 4 (2020): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v2i4.162

Abstract

Penelitian ini bertujuan untuk menguji kandungan senyawa metabolit sekunder pada ekstrak etanol daun afrika, efek pemberian ekstrak etanol daun afrika dan perbedaan efek ekstrak etanol daun afrika dosis bertingkat yang efektif untuk menurunkan kadar glukosa darah tikus putih jantan yang diinduksi streptozotocin dan pakan tinggi lemak.Penelitian ini menggunakan metode dengan rancangan modifikasi pretest-posttest randomized controlled group design, dengan menggunakan 30 ekor hewan uji yang dikelompokkan dalam 6 kelompok perlakuan, tiap kelompok terdiri dari 5 ekor tikus yaitu 1 kelompok diberi pakan standar dan 5 kelompok diberi pakan tinggi lemak dan diinduksi streptozotocin 30 mg/kg BB tikus i.p selanjutnya kelompok kontrol negatif diberi Na CMC, kontrol positif diberi metformin dan 3 kelompok diberi ekstrak etanol daun afrika dengan dosis masing-masing 50 mg/kg BB, 100 mg/kg BB dan 150 mg/kg BB. Data hasil pengujian kadar glukosa darah dianalisis dengan one way ANOVA kemudian dilanjutkan dengan uji lanjut Least Significant Differene (LSD) untuk melihat perbedaan antar perlakuan.Hasil penelitian menunjukkan bahwa terdapat senyawa metabolit sekunder pada ekstrak etanol daun afrika yaitu alkaloid, flavonoid, saponin dan tanin: pemberian ekstrak etanol daun afrika memberikan efek menurunkan kadar glukosa darah pada tikus putih jantan yang diinduksi streptozotocin dan pakan tinggi lemak: pemberian ekstrak etanol daun afrika dengan dosis 150 mg/kg BB merupakan dosis yang efektif terhadap kadar glukosa darah tikus putih jantan yang diinduksi streptozotocin dan pakan tinggi lemak.
Edukasi Pemanfaatan Potensi Daun Kelor Sebagai Upaya Pencegahan Stunting Pada Masyarakat Desa Powelua Kabupaten Donggala Sulawesi Tengah Muthmainah Tuldjanah; Erick Budiawan; Sasdila; Putri Natalia; Leligrafela Tudaan
RAMBIDEUN : Jurnal Pengabdian Kepada Masyarakat Vol. 7 No. 3 (2024): Rambideun: Jurnal Pengabdian Kepada Masyarakat
Publisher : LPPM Universitas Al Muslim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51179/pkm.v7i3.2730

Abstract

Stunting is a disorder where the growth and development of toddlers is hampered due to malnutrition during pregnancy and this condition is known by looking at the child's body condition which is smaller than other children of the same age. Overcoming stunting is one of the programs of the Donggala Regency Government because of the large number of stunted children in the district, one of which is Powelua Village. Many factors can cause delays in the growth and development of toddlers, including toddler characteristics and socio-economic factors. The number of families at risk of stunting in Powelua Village in 2023 reached 58 children with a total of 150 Heads of Families. This community service activity aimed to educate the public that Moringa leaves have a very high nutritional content, especially their potential in preventing stunting. One way to prevent stunting is to provide education related to the potential use of Moringa leaves in preventing stunting which wass delivered in the form of lectures with material, as well in the form of leaflets, followed by a questions-and-answers session. Evaluation of achievement was carried out by providing pre-tests and post-tests to the community on the material presented with a success indicator of 74.27% of parents understanding the education provided. The results of implementing this community service activity showed an increase in knowledge of 88.67% with a very good category.
Acute Toxicity Nanoemultion of Ethanol Extract of Clove Leaves (Syzygium aromaticum L.) Muthmainah Tuldjanah; Putri Natalia Laurenza Ladjeba; Rezky Yanuarty; Ayu Wuladari; Joni Tandi; Muaadzatul Izzah Sudarman
Jurnal Penelitian Pendidikan IPA Vol 12 No 2 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i2.12783

Abstract

Clove leaves have been widely used as traditional medicine. Clove leaves are rich in saponins, flavonoids, tannins, sterols, and essential oils. To improve the function of clove leaves, one of them is by reducing the sample size into nanoemulsion form. Nanoemulsions were prepared using the sonication method and exhibited an average droplet size of 13.3 nm. The purpose of this study was to determine the toxic properties, the dose that can cause toxic effects, and the LD50 value of nanoemulsion administration of ethanol extract of clove leaves. This study used 25 male white rats which were divided into five groups, namely a control group (nanoemulsion base) and four treatment groups receiving oral doses of 5, 50, 300, and 2000 mg/kg BW. The LD50 value was calculated using AOT425 StatPgm in accordance with OECD TG 425 (Up and Down Procedure). Mortality summary: control 0/5; 5 mg/kg BW 0/5; 50 mg/kg BW 0/5; 300 mg/kg BW 0/5; 2000 mg/kg BW 5/5. The results showed an LD50 of 798.5 mg/kg BW and, based on the GHS, it falls under Acute Toxicity (Oral) Category 4 (300–2000 mg/kg BW). Clinical signs such as piloerection, grooming, and weakness appeared mainly in the early observation phase (from 30 minutes to 4/8/12 hours) in each dose group and were reversible.
Co-Authors Agung Andriawan Aprilia Ariesta Aprilia Theodora Ayu Wuladari Ayu Wulandari DIAN RAHMAWATI Erick Budiawan Erick Budiawan Erick Budiawan Erick Budiawan Joni Tandi, Joni Leligrafela Tudaan Muaadzatul Izzah Sudarman Ni Putu Setiawati Niluh Puspita Dewi Niluh Puspita Dewi Putri Natalia Putri Natalia Laurenza Ladjeba Rezky Yanuarty Rezky Yanuarty Rezky Yanuarty Rianto Tanggo Doko Sasdila Trace Chintya Letana Trivena Lois Torampe Wayan Wirawan