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All Journal Jurnal MIPA PHARMACON Jurnal Bios Logos Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Agritrop : Jurnal Ilmu-Ilmu Pertanian (Journal of Agricultural Science) The Studies of Social Sciences Journal of Tropical Ethnobiology Jurnal Ilmiah Sains Malacca Pharmaceutics Jurnal Lentera Farma
Herny E.I. Simbala
Faculty Of Mathematics And Basic Science, University Of Sam Ratulangi Manado
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Environmental Science Immunology & microbiology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences

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Journal : Malacca Pharmaceutics

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In Vitro Antioxidant Activity of Chrysanthemum indicum Flowers Extract and Its Fraction Dolongtelide, Jeclin Inebel; Fatimawali, Fatimawali; Tallei, Trina Ekawati; Suoth, Elly Juliana; Simbala, Herny Emma Inonta; Antasionasti, Irma; Kalalo, Marko Jeremia
Malacca Pharmaceutics Vol. 1 No. 2 (2023): October 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v1i2.26

Abstract

Chrysanthemum indicum L., commonly known as Chrysanthemum flower, is an herbaceous plant that has a long-established history of medicinal usage. There has been extensive research about C. indicium L, especially about its antioxidant activities, but not much has been done on its fraction. This study aimed to explore the efficacy of the ethanol extract and its fraction derived from Chrysanthemum flowers in scavenging free radicals. The antioxidant potential of the ethanol extract, as well as its aqueous and n-hexane fractions, was evaluated using the 2,2-diphenyl-1-picrilhidrazine (DPPH) method in vitro. The degree of antioxidant activity was quantified by determining the IC50 value, which corresponds to the concentration of the extract or fractions required to inhibit 50% of DPPH free radicals. The results obtained from this investigation provide strong evidence that the ethanolic extract, as well as its aqueous and n-hexane fractions, exhibited significant antioxidant activity. The measured IC50 values for the ethanolic extract, aqueous fraction, and n-hexane fraction were 1.350 µg/mL, 1.109 µg/mL, and 7.588 µg/mL, respectively.
A Comprehensive Network Pharmacology Study on the Diabetes-Fighting Capabilities of Yacon Leaf Extract Wawo, Arsianita Ester; Simbala, Herny Emma Inonta; Fatimawali, Fatimawali; Tallei, Trina Ekawati
Malacca Pharmaceutics Vol. 2 No. 2 (2024): September 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v2i2.161

Abstract

Indonesia ranks fourth in the world for the number of diabetes mellitus (DM) sufferers. DM is a group of metabolic disorders characterized by hyperglycemia due to insulin abnormalities. This research employs Network Pharmacology analysis to examine the target proteins and pharmacological network profiles predicted to be influenced by compounds in the leaves of Smallanthus sonchifolius (yacon) for their anti-diabetic effects. Gas chromatography-mass spectrometry (GC-MS) identified 41 secondary metabolite compounds in yacon leaves, seven of which have a Pa value > 0.5. Compound C28 has the highest Pa value as an insulin promoter, at 0.662. A total of 129 target proteins were found for the secondary metabolite compounds in yacon leaves, and 5,112 target proteins were identified for Type 2 Diabetes Mellitus (T2DM). The intersection analysis between yacon leaves and T2DM revealed 32 common proteins. Network analysis highlighted 10 top proteins: ESR1, PPAR-α, HMGCR, CYP19A1, PPARD, PTP1N, GRIN2B, FYN, AR, and SHBG. Among these, PPAR-α shows great potential and promising prospects as a target for further exploration. Considering several parameters, it can be concluded that PPAR-α is a promising protein and a potential target for new drug candidates for T2DM.
Co-Authors Agustinus Mokoginta Ahmad Sugandi Altini O. Kosegeran Altini O. Kosegeran, Altini O. Anggraini Toar Antasionasti, Irma Bakti, Andi Ikhtiar Defny Silvia Wewengkang Dolongtelide, Jeclin Inebel Edi, Hosea Jaya Edwin de Queljoe Eka Julianti Elly Suoth ERLADYS MELINDAH RUMONDOR, ERLADYS MELINDAH Erladys Rumondor Fatimawali . Feky R Mantiri Feky R. Mantiri Gayatri Citraningtyas Gerald Rundengan Grafland Langkay Hariyanto, Yuanita Amalia Henki Rotinsulu, Henki Hermelina Yosephina Burdam Hosea Jaya Edy Irma Antasionasti Jayanto, Imam Johanis Pelealu Juliana Mabe -, Juliana Mabe Julianri Lebang Kalalo, Marko Jeremia Karlah L. R. Mansauda Karundeng, Glorya Khairunnisa Mutiara Thaib Kotel, Marcelinda Kotel, Marcelinda N. Kristiani Walesasi Kumakauw, Vanesa Vebiola Lawani, Vaneza C. Lawani, Vaneza Christine Ludong, Raynaldo M. Marampung, Wahyuni Marhaenus Rumondor Marhaenus Rumondor Marhaenus Rumondor Mayor, Troce Meilani Jayanti Mende, Rivaldo Mokalu, Ribka G. Mokodongan, Triswa Mokodongan, Triswa A. Mokoginta, Rizkah V. Mongi, Rifo Nadine Natari Ngantung, Yunike Ngantung, Yunike E. Oeiyano, Walen Oeiyano, Walen E. Olvie Syenni Datu Pabundu, Daniel Pristian Sibua Purwoko, Agus Putri, Rafi’a Adinda Rambi, Christani Rante, Trian Rizki Kala’ Ratu, Kartini Redwik, Danni U. W. Redwik, Danni Umbu Wira Ribka G. Mokalu Rondonuwu, Greifen Triky Roni Koneri Roring, Tirza Rumondor, Erladys Rundengan, Gerald Sagay, Steleynes Sakul, Glorya Sarai Raehilda Febriansi Korban Sartje J. Rondonuwu Sendy Rondonuwu Sendy Rondonuwu, Sendy Sharon Colin Tangkere Sitti Tasya Putri Ibrahim Toding, Serly D. S. TRINA EKAWATI TALLEI Tunggali, Sitti Tunggali, Sitti N Valensia J. Takapaha Waas, Riviani Angela Walesasi, Kristiani Wawo, Arsianita Ester Wiranatika Jhonatan Sangkoy Yulien C. Sambode