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Journal : The Journal of Pure and Applied Chemistry Research

Effect of Dexamethasone Administration toward Hematopoietic Stem Cells and Blood Progenitor Cells Expression on BALB/c Mice Wira Eka Putra; Aris Soewondo; Muhaimin Rifa'i
The Journal of Pure and Applied Chemistry Research Vol 4, No 3 (2015)
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (815.457 KB) | DOI: 10.21776/ub.jpacr.2015.004.03.221

Abstract

Hematopoiesis play important roles on maintaining body homeostasis. Dexamethasone (Dex) known as synthetic glucocorticoids and widely affect many regulations i.e. immune system, inflammation, reproduction and all aspects of metabolism. Generally Dex were used as therapeutic agentsto ameliorate many kind of diseases including cancer and auto-immune diseases. The aims of this research were to investigate the effect of Dex administration toward expression of hematopoietic stem cells and blood progenitor cells. Two weeks old BALB/c mice were used and treated with 3 groups of Dex administration i.e. untreated-mice, 0.5 mg/kg BW, and 10 mg/kg BW. Mice were sacrificed on day-7 after administration of Dex. The bone marrow stromal cells were isolated, then followed by flow cytometry analysis. The result showed that, Dex administration with dose 0.5 mg/kg BW significantly increase the expression of hematopoietic stem cells, CD34+, chemokines, SDF-1+, erythroid progenitor cells, Gr-1-TER-119+, granulocytes, Gr-1+, and B progenitor cells, B220+.
Co-Authors Agung Pramana W. M. Agung Pramana W.M Agung Pramana W.M Agung Pramana W.M Agung Pramana Warih Marhendra Agung Pramana Warih Marhendra Ahmad Shobrun Jamil Al Faizah, Belinda Nabiila Anaqoh Roudhotul Jannah Winarso Andista Firstiantono Anzila, Ivakhul Ardiansyah, Esha Asyhari, Firda Nuri Atho'illah, Mochammad Fitri Dian Siswanto Dliyauddin, Moh Fadlilah, Dawama Nur Farida Rachmawati, Farida fatchiyah . Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fikriya Novita Sari Fitria Eka Aprilia Ivakhul Anzila Izati, Rahmi Kavitarna, Septhyanti Aprilia Khairatul Insani Febrianti Khairatul Insani Febrianti Laili Nur Zaidah Mansur Ibrahim Moch Sasmito Djati Muhaimin Rifa'i Muhaimin Rifa'i Muhaimin Rifa'i Muhaimin Rifa’i Muhaimin Rifa’i Muhammad Halim Natsir Muhammad Halim Natsir Nashi Widodo Nurul Shafa Paramita Putri, Nenis Try Melani Rifa'i, Muhaimin Rifa’i, Muhaimin Rike Wahyuningroom Rike Wahyuningroom Ririn Dwi Prasetiani Ririn Dwi Prasetiani, Ririn Dwi Rivqi Rifa Bia Rizky Senna Samoedra Robitoh Desi Kurniasari Sa'adah, Nur Alfi Maghfirotus Sakti, Muhammad Wisam Wira Sakti, Sefihara Paramitha Sari, Fikriya Novita Serafinah Indriyani Setyaki Kevin Pratama Shinta Dwi Riestanti Shinta Dwi Riestanti, Shinta Dwi Shinta Oktya Wardhani, Shinta Oktya Siti Nur Arifah, Siti Nur Sofy Permana Sri Rahayu Sri Rahayu SRI RAHAYU Sri Rahayu Sri Widyarti Syamsul Arifin W. M., Agung Pramana Wira Eka Putra Wisnu Barlianto YOGA DWI JATMIKO Yuyun Indriani Kartiko Santi Zulfatim, Heni Sukma