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Journal : Microbiology Indonesia

Sub-Acute Toxicity of Pigment Derived from Penicillium resticulosum in Mice TATANG SOPANDI; WARDAH WARDAH
Microbiology Indonesia Vol. 6 No. 1 (2012): March 2012
Publisher : Indonesian Society for microbiology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1106.196 KB) | DOI: 10.5454/mi.6.1.6

Abstract

Pigments derived from Penicillium have different toxicities depending on the pigment components. This study was intended to evaluate the sub-acute toxicity of oral exposure of Balb/c mice to Penicillium resticulosum pigment. A total of 50 healthy adult male and female mice were divided into 5 treatment groups and different doses of pigment (0, 125, 250, 500, and 1000 mg kg-1 weight) were orally administered. Oral feeding of pigment with doses 125 to 1000 mg kg-1 body weight daily to adult mice did not cause mortality nor any clinical abnormalities. There were no significant differences in body, liver and kidney weights, nor liver and kidney functions of mice when pigment was given orally with intake doses of 125 to 1000 mg/kg body weight daily for 28 d in comparison to mice without pigment intake (control groups). There is a slight difference in liver histopathology of mice exposed to 500and 1000 mg/kg body weight of pigment for 28 d in comparison to mice control groups, although there were no differences in kidney histopathology. Thus, we can conclude that the pigment of P. resticulosum can be cathegorized as low toxic pigment and well tolerated at dose below 500 mg kg-1 body weight daily for 28 d.
Co-Authors Agus Trisna, Erliya Alvitasari, Fida Amalia, Sri Hidayati Amelia Putri, Santi Andarwulan, Setiana Andriani, Vivin Arbiatur, Fitria Arbiatur, Fitria Ardithasari, Bunga Arif Yachya Astini Astini Astini, Astini Astini, Astini D.A. Trifatmawati Dewi, N.W. Dewi, N.W. Diah Karunia Binawati Dyah Hariani Elhany, N.A. Elhany, N.A. Ellyana, Siska Erliya Agus Trisna F.R. Wirandasari Fahreza Helmi Isnaini Fatmawati Fatmawati Ferdia Windarti Fida Alvitasari Fitria Arbiatur Framono, Indra Dwi H.Nur Fauziyah Hasanah Hafidz Malik Zulkarnaen, Syifa Hardani, Prisma Trida Hasanah, H.Nur Fauziyah Hasanah, H.Nur Fauziyah Hoiri Hoiri Hoiri, Hoiri Hoiri, Hoiri I Dian Kinasih Iftakhur Roziqin Intan Ayu Kusuma Pramushinta Kafil Irsalina Mirza Ludin Karunia Binawati, Diah Kinasih, I Dian Kinasih, I Dian M. Nushron Ali Mukhtar Maria Paolina Grazzia Maulidiyah, Zahro Al Miftahul, Siti Miftahul, Siti Mufidah, Rofikatul Mukti, Asri Wido Mukti, Ria Andriani N. Winarsih N.L. Nurfi N.W. Dewi Nadya Ambarwati Ngadiani, Ngadiani Nurfi, N.L. Nurfi, N.L. Nurul Avidhah Elhany Paolina Grazzia, Maria Prasmita Dian Wijayati Pungky Slamet Wisnu Kusuma Pungky Slamet WK Purbosari, Ira Purity Sabila Ajiningrum Puspita, Veronica Angga Puspita, Veronica Angga Putri Hanifah, Riza Rahayu, Asti S. Widayati Samudera, Shokimun Mega Sari, Dewi Perwito Sinulingga, Amanda Safithri Siti Miftahul Slamet Wisnu Kusuma, Pungky Sukarjati Sukarjati Sukarjati Sukarjati, Sukarjati Ta'inidari, Y. Tainidari, Y. Trifatmawati, D.A. Trifatmawati, D.A. Veronica Angga Puspita Vivin Andriani Wardah Wardah Wardah Wardah Widayati, S. Widayati, S. Winarsih, N. Winarsih, N. Windarti, Ferdia Windarti, Ferdia Wirandasari, F.R. Wirandasari, F.R. WK, Pungky Slamet Y. Ta'inidari Yitno Utomo Yoga Cahya Mahardika