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All Journal Journal Of Vocational Health Studies Vitek : Bidang Kedokteran Hewan Darmabakti Cendekia: Journal of Community Service and Engagements Jurnal Layanan Masyarakat (Journal of Public Service) Journal of Applied Veterinary Science and Technology Jurnal Kedokteran Hewan
Agung Budianto Achmad, Agung Budianto
Departemen Kedokteran Dasar, Fakultas Kedokteran Hewan, Universitas Airlangga
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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EFEKTIVITAS TERAPI RAT BONE MARROW MESENCHYMAL STEM CELL PADA TIKUS (Rattus norvegicus) MODEL TERATOGENIK PARTICULATE MATTER TERHADAP EKSPRESI TNF- , BAX, DAN BCL-2 PLASENTA Pantja Madyawati, Sri; R, Rimayanti; W, Widjiati; Achmad, Agung Budianto
Jurnal Kedokteran Hewan Vol 9, No 1 (2015): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v9i1.2774

Abstract

Tujuan penelitian ini adalah membuktikan potensi dan efektivitas rat bone marrow mesenchymal stem cell (rbmmsc) sebagai terapi pada kasus teratogenik selama kebuntingan dengan melihat ekspresi tumor necrosis factor (TNF-), Bax, dan Bcl-2. Dua puluh empat ekor tikus bunting model teratogenik dibagi menjadi empat kelompok perlakuan yang berbeda yaitu P1-Kontrol (dipapar carbon black dosis 532 mg/m3 selama 4 jam pada umur kebuntingan ke-6 s/d ke-11 + Injeksi MEM 0,1 ml), P1-Terapi (dipapar carbon black dosis 532 mg/m3 selama 4 jam pada umur kebuntingan ke-6 s/d ke-11 + rbmmsc dengan dosis 1x106 sel/0,1 ml), P2-Kontrol (dipapar carbon black dosis 532 mg/m3 selama 4 jam pada umur kebuntingan ke-6 s/d ke-17 + Injeksi MEM 0,1 ml), P2-Terapi (dipapar carbon black dosis 532 mg/m3 selama 4 jam pada umurkebuntingan ke-6 s/d ke-11 + rbmmsc dengan dosis 1x106 sel/0,1 ml). Data yang didapatkan kemudian dianalisis menggunakan uji MannWhitney. Hasil penelitian ini menunjukkan bahwa pemberian terapi rat bone marrow mesenchymal stem cell pada tikus model teratogenikparticulate matter tidak berpengaruh dalam menurunkan parameter ekspresi TNF- dan Bax, serta meningkatkan ekspresi Bcl-2 pada plasenta.
Procedurs of Pizzle Rot Treatment in Etawa Goats Benardin Ariani Nurvijayanti; Dony Chrismanto; Herry Agoes Hermadi; Siti Eliana Rochmi; Agung Budianto Achmad
Journal of Applied Veterinary Science And Technology Vol. 7 No. 1 (2026): April 2026
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/javest.V7.I1.2026.127-131

Abstract

Background: Goats are widely raised due to their lower maintenance costs compared to cattle. The Etawa crossbreed is one of the most common goat breeds in Indonesia. Pizzle rot is a reproductive disorder in bucks characterized by inflammation and swelling of the penis and prepuce, often associated with dietary factors and secondary bacterial infection. Purpose: To describe the surgical treatment and postoperative management of pizzle rot in a buck. Case(s): A 1.5-year-old Etawa crossbreed buck was presented to the Veterinary Clinic with a history of anorexia and penile swelling. Clinical examination of the reproductive system revealed marked swelling of the penis and prepuce consistent with pizzle rot. Case Management: Surgical treatment was performed by excising the abscessed tissue and removing the urethral obstruction. The affected preputial area was opened, the abscess tissue was removed, and the urethral passage was cleared. Postoperative care included routine wound cleaning, medication administration, and regular monitoring of wound healing. Clinical improvement was observed within a few days after surgery, indicated by reduced swelling and improved urination. The healing process progressed well, and complete restoration of normal penile function was achieved within eight weeks. The buck regained the ability to protrude the penis and urinate normally without recurrence of swelling. Conclusion: Surgical excision of abscessed tissue combined with appropriate postoperative wound care was effective in treating pizzle rot in this buck. Early surgical intervention and proper postoperative management contributed to rapid clinical improvement and complete recovery of penile function.
Co-Authors Anwar Ma'ruf Aulia Nur Afifah Benardin Ariani Nurvijayanti Chrismanto, Dony Dio Yudistira Diyantoro Diyantoro, Diyantoro Gandul Atik Yuliani Herinda Pertiwi Herry Agoes Hermadi Iwan Syahrial Hamid Meilinia, Shafina Meilinia Mirni Lamid Nidia Yulanda Nove Hidajati Oriza Cahya Rahmadiati Ratna Damayanti Retno Sri Wahjuni Rimayanti . Rimayanti R Rimayanti R, Rimayanti Rochmi, Siti Eliana Sofyan, Miyayu Soneta Sri Pantja Madyawati Tri Bhawono Dadi Tri Wahyu Suprayogi Widjiati . Widjiati Widjiati, Widjiati Yolifia Rahma Milenia