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All Journal JURNAL BISNIS STRATEGI JDM (Jurnal Dinamika Manajemen) JBTI : Jurnal Bisnis : Teori dan Implementasi Anterior Jurnal Indonesian Journal of Community Services Munaddhomah: Jurnal Manajemen Pendidikan Islam Sibatik Journal : Jurnal Ilmiah Bidang Sosial, Ekonomi, Budaya, Teknologi, Dan Pendidikan eCo-Fin AKADEMIK: Jurnal Mahasiswa Ekonomi & Bisnis Borobudur Management Review Journal of Accounting and Finance Management (JAFM) Cerdika: Jurnal Ilmiah Indonesia Jurnal Ilmiah Sultan Agung Journal of Innovative and Creativity PESHUM Al-Hayat: Journal of Islamic Education Folia Medica Indonesiana
Heru Sulistyo
Faculty of Economic, Sultan Agung Islamic University, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Examination of Micro Vascular Density on Metastatic Colorectal Cancer of RAS Mutant-Type as Anti Vegf Therapy Predictor Sulistyo, Heru; Budipramana, Vicky Sumarki
Folia Medica Indonesiana Vol. 57, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

According to the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) on Colon Cancer Version 2.2019, mCRC patients with mutant type RAS were treated with anti-VEGF. However, the use of the targeting therapy still had inconsistent results. Neoangiogenesis studies had been used as a basis to assess the prognosis of mCRC. Microvascular density (MVD) had become the morphological gold standard to assess neovascularization in human tumors. This study proved the existence of low microvascular density (MVD) in mCRC patients with mutant type RAS status as a predictor of failure of anti-VEGF therapy. There were 29 patients at Dr. Soetomo Academic Hospital from 2015-2018 who had their RAS status checked and tested for microvascular density (MVD). The results of this study were analyzed using SPSS 23.0. In the Mutant-type of RAS group, this study examined microvascular density (MVD). 11 (73%) research subjects with high MVD scores and 4 (27%) research subjects had low MVD scores. Besides, 27% microvascular density (MVD) was low, in the mutant-type of RAS mCRC patient which could be a predictor factor for the failure of anti-VEGF therapy.
Peran Ukuran Perusahaan Dalam Memoderasi Pengaruh Likuiditas Terhadap Financial Distress Khikmah, Febrianti Nur; Sulistyo, Heru
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.5830

Abstract

Penelitian ini dilatarbelakangi oleh ketidakstabilan ekonomi pasca-pandemi yang meningkatkan risiko financial distress pada perusahaan manufaktur di Bursa Efek Indonesia (BEI). Tujuan penelitian adalah menguji pengaruh likuiditas terhadap financial distress dan peran moderasi ukuran perusahaan pada 46 perusahaan manufaktur BEI periode 2023-2024. Jenis penelitian kuantitatif explanatory menggunakan metode Partial Least Squares Structural Equation Modeling (PLS-SEM) dan Moderated Regression Analysis (MRA). Populasi penelitian seluruh perusahaan manufaktur di BEI dengan sampel purposive berdasarkan kriteria keuangan dan risiko distress. Data sekunder diolah menggunakan SmartPLS 4.0 dan SPSS 26 dengan validasi model melalui bootstrapping. Hasil menunjukkan likuiditas berpengaruh negatif signifikan terhadap financial distress. Ukuran perusahaan juga berperan sebagai moderator yang memperlemah hubungan antara likuiditas dan financial distress, menandakan perusahaan besar lebih tahan tekanan keuangan. Penelitian menyimpulkan bahwa pengelolaan likuiditas harus disesuaikan dengan ukuran perusahaan untuk memitigasi risiko financial distress. Temuan ini memberikan panduan bagi manajer dan investor dalam pengambilan keputusan keuangan.
Co-Authors ., Nurhidayati Aniek, Sri Anita Rahayuningsih, Anita Ayuni, Sri Ayuni, Sri Azhar, Syafrudin Aulia Budhi Cahyono Budipramana, Vicky Sumarki Fibriantoro, Dedy Gunarto Gunarto Henny Pratiwi Adi Ibnu Khajar Ikke Oktavianti, Renita Khikmah, Febrianti Nur Kirana, Putricia Lutfi Nurcholis Marno Nugroho Mulya Noviana, Nana Mulyana Mulyana Nunung Ghoniyah Nurdin, Muh. Nur Islam Oetami, Elok Retno Pamungkas, Gufa Bagus Puspitaningrum, Putri Febiana Rushami Zien Yusoff Sahni, Sahni Saputri, Pungky Lela Setiyarti, Tettie Solikhin, Muhammad Sri Anik, Sri Subiyantoro Sundari, Pipit Suparman Suparman Uttami, Regitasari Setyaning Zainal Alim Adiwijaya, Zainal Alim