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DEVELOPMENT OF STEM CELL-BASED CANCER THERAPY STRATEGIES Sumadi; Warda, Rizki Zeillatul
Journal of Stem Cell Research and Tissue Engineering Vol. 8 No. 2 (2024): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v8i2.67760

Abstract

Cancer remains one of the leading causes of death worldwide, with various treatment options available depending on the type and stage of the disease. Traditional therapies, such as surgery, radiotherapy, chemotherapy, and immunotherapy, have shown varying degrees of success, but each has its limitations. Recently, stem cell therapies have emerged as a promising alternative, offering more targeted treatments with fewer side effects. Stem cells, including mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), and cancer stem cells (CSCs), have demonstrated potential in cancer therapy through mechanisms like tumor site targeting, paracrine signaling, and gene delivery. MSCs, in particular, are of interest due to their ability to migrate to tumor sites and release exosomes that can influence tumor growth, angiogenesis, and metastasis. Modified MSCs have been engineered to deliver anticancer agents or "suicide" genes, providing a more focused approach to tumor treatment. Moreover, MSCs have shown promise in addressing challenges like drug resistance and recurrence in cancer. However, their effectiveness depends on factors such as exosome composition and the tumor microenvironment. Despite the challenges, stem cell-based therapies, including MSC-derived exosomes, represent a novel strategy to enhance the specificity and efficacy of cancer treatments. This review explores current advances in stem cell-based cancer therapies, highlighting their potential, ongoing research, and the need for further studies to optimize these approaches for clinical application.
DOING DRAMA IN ACTION: STUDENTS’ INQUIRY PROCESS INVESTIGATION Hendi Hidayat; Rina Nursabrina; Sumadi
Language and Education Journal Vol. 7 No. 1 (2022): Language and Education Journal
Publisher : Language and Education Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52237/pxcbqh98

Abstract

This study was intended to investigate the students’ inquiry process reflected in doing drama activity. The study applied classroom ethnography. The writer spent seven weeks making ethnographic observations and field notes related to doing drama activity, noting what the students do before, during and after the activity. An in depth interview was conducted to 3 participants. The criteria of chosen participants was their performance during the project. They were considered to have more information. The interview aims to know how each phases fit into the overall context of the inquiry process. The findings show that the inquiry process in doing drama activities are reflected in group formation, selection of drama’s title, making synopsis, devision of roles, rehearsal, costume and propery preparation, and drama performance
UTILIZATION OF STEM CELL THERAPY AS A NEW APPROACH TO OVERCOME REPRODUCTIVE DISEASES IN WOMEN Warda, Rizki Zeillatul; Sumadi
Journal of Stem Cell Research and Tissue Engineering Vol. 8 No. 2 (2024): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v8i2.67758

Abstract

The human body contains approximately 37.2 trillion cells, each specialized to perform specific functions within tissues and organs. Stem cells, particularly mesenchymal stem cells (MSCs), have emerged as a promising therapeutic option for various medical conditions due to their regenerative and differentiation capabilities. Female infertility, which significantly impacts quality of life, often results from reproductive disorders such as premature ovarian failure (POF), polycystic ovary syndrome (PCOS), endometriosis, Asherman syndrome, and preeclampsia. Conventional treatments like hormone therapy are limited by long-term risks, including heart disease and cancer, while assisted reproductive technologies are hindered by ethical, safety, and financial concerns. This review explores MSC-based therapies as innovative alternatives for addressing female reproductive disorders. MSCs demonstrate potential in regenerating ovarian cells, restoring hormonal balance, and repairing uterine tissue. For POF, MSC therapy replenishes ovarian cells, improves hormone levels, and restores function. In PCOS, MSCs reduce inflammation and fibrosis while enhancing ovarian function. Endometriosis management benefits from MSCs' ability to repair endometrial damage and improve uterine receptivity. MSCs also show efficacy in reducing fibrosis and increasing vascularization in Asherman syndrome and repairing placental damage in preeclampsia by mitigating oxidative stress and inflammation. This review synthesizes findings from recent studies to highlight MSCs' role in advancing gynecological medicine, presenting them as a safe, effective, and sustainable therapeutic approach for treating infertility and enhancing reproductive health.
Gender Identification and Population Detection in a Room Using YOLOv8 Zulfi, M.Ridho; Sumadi; Murdika, Umi; Ulya Darajat, Anisa
Emitor: Jurnal Teknik Elektro Vol 25, No 1: March 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/emitor.v24i3.5734

Abstract

In today's digital era, lectures and higher education have experienced rapid development, especially in theuse of technology. Technology has opened up various opportunities to improve efficiency and effectiveness in variousaspects of education. One aspect that needs to be improved is the presence of students in lectures. Through this thesis,the author aims to develop a tool that can overcome the problem of recapitulation of student attendance using imageprocessing technology and the YOLOv8 algorithm, then adding male and female face training data to identifygender. By combining the latest technology and this innovative approach, it is hoped that an efficient and accuratesolution can be created to record student attendance in lectures. In this study, the implementation of population countand gender identification within a room using YOLOv8 achieved a precision value of 100%, a recall value of 100%,an accuracy value of 100%, and an F1-score value of 100%.
Minat Beli Sepeda Motor Vespa Melalui Faktor Intervening Sikap Daffa, Muhammad; Sumadi
Indonesian Journal of Economics, Business, Accounting, and Management (IJEBAM) Vol 1 No 5 (2023): Volume 1, No. 5, 2023
Publisher : PT SOLUSI EDUKASI BERDIKARI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63901/ijebam.v1i5.26

Abstract

Penelitian ini bertujuan untuk mengetahui hubungan antara kualitas produk, brand image, negara asal, dan harga melalui sikap sebagai variabel mediasi terhadap minat beli pada pengguna sepeda motor merek vespa di Daerah Istimewa Yogyakarta. Penelitian ini dilakukan menggunakan desain TRA (theory of reasoned action) yang melibatkan survei pada 224 pengguna sepeda motor merek vespa di Daerah Istimewa Yogyakarta melalui skala likert dengan rentang usia 18 sampai 60 tahun. Metode analisis yang digunakan pada penelitian ini adalah uji regresi linear sederhana, uji regresi linear berganda, uji koefisien determinan (R2), uji signifikansi individual (Uji statistik T), uji signifikansi simultan (Uji statistik F) dan uji mediasi menggunakan software IBM SPSS Statistics 25. Hasil penelitian menunjukkan terdapat hubungan antara sikap dengan kualitas produk, brand image, negara asal dan harga berpengaruh positif dan signifikan terhadap minat beli. Selain itu variabel mediasi yaitu sikap mampu memediasi hubungan antara kualitas produk, brand image, negara asal, dan harga terhadap minat beli.
Niat Menggunakan Bank Syariah Indonesia: Studi pada Perguruan Tinggi Islam di Yogyakarta Pratama, Yogi; Sumadi
Indonesian Journal of Economics, Business, Accounting, and Management (IJEBAM) Vol 1 No 6 (2023): Volume 1, No. 6, 2023
Publisher : PT SOLUSI EDUKASI BERDIKARI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63901/ijebam.v1i6.39

Abstract

Penelitian ini bertujuan untuk mengetahui faktor-faktor mahasiswa/pelajar terhadap niat menggunakan Bank Syariah Indonesia. sampel dalam responden ini dipilih menggunakan teknik purposive sampling dengan kriteria responden mahasiswa. Teknik analisis data yang digunakan dalam penelitian ini adalah PLS-SEM dengan alat bantu software Smart-PLS. Adapun hasil dari penelitian ini menunjukkan bahwa literasi keuangan berpengaruh positif terhadap sikap pada Bank Syariah Indonesia, literasi keuangan berpengaruh positif terhadap Niat menggunakan pada Bank Syariah Indonesia, kesadaran berpengaruh positif terhadap sikap pada Bank Syariah Indonesia, kesadaran berpengaruh positif terhadap niat menggunakan pada Bank Syariah Indonesia, sikap berpengaruh positif terhadap niat menggunakan pada Bank Syariah Indonesia. Hasil penelitian ini diharapkan dapat membantu pihak yang bersangkutan untuk mengetahui faktor-faktor yang memengaruhi niat seseorang untuk menggunakan Bank Syariah Indonesia.
Pengenalan aksara lampung berbasis pencocokan template menggunakan metode sum of absolute differences (SAD) FX Arinto Setyawan; Afri Yudamson; Emir Nasrullah; Sumadi; Gigih Forda Nama
Prosiding Seminar Nasional Ilmu Teknik Dan Aplikasi Industri Fakultas Teknik Universitas Lampung Vol. 7 (2024): Prosiding Seminar Nasional Ilmu Teknik dan Aplikasi Industi (SINTA) 2024
Publisher : Fakultas Teknik Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pengajaran dan pelestarian aksara Lampung menjadi semakin penting seiring dengan perkembangan era digital dan globalisasi. Bahasa dan aksara menjadi fondasi utama yang membawa nilai-nilai budaya, sejarah, dan identitas suatu masyarakat. Dalam konteks ini, pengajaran aksara Lampung bukan hanya menjadi upaya pelestarian, tetapi juga sebagai langkah strategis untuk menjaga keberlanjutan bahasa dan budaya lokal di tengah arus globalisasi. Penelitian ini mengusulkan pengembangan metode pengenalan aksara Lampung ke aksara Latin menggunakan teknik Template Matching (pencocokkan template) dengan Metode Sum of Absolute Differences (SAD) untuk mengukur tingkat akurasi metode Template Matching dengan SAD, serta menghasilkan metode pengenalan. Pada penelitian ini akan digunakan 50 data tulisan tangan aksara lampung. Citra-citra tulisan tangan tersebut diproses menggunakan dua ukuran template, yaitu 80x80 piksel dan 40x40 piksel. Hasil pengujian menunjukkan bahwa untuk ukuran template 80x80 piksel, metode SAD mencapai persentase akurasi sebesar 78%, sementara untuk ukuran template 40x40 piksel, persentase akurasi terbesar adalah 77%. Selain akurasi, waktu pemrosesan juga diukur, dengan waktu rata-rata untuk template 80x80 berkisar di angka 0.0282 detik, dan untuk template 40x40 sekitar 0.0264 detik. Meskipun ukuran template yang lebih besar memberikan akurasi yang lebih tinggi, penggunaan ukuran template yang lebih kecil memiliki keunggulan dalam hal waktu pemrosesan yang lebih cepat. Metode SAD secara keseluruhan menunjukkan performa yang baik dalam tugas pengenalan aksara Lampung. Persentase kesalahan dalam mengenali huruf antara 21,54% hingga 29,46%. Penelitian ini memberikan kontribusi penting bagi pengembangan teknologi pelestarian aksara Lampung di era digital dan membuka peluang untuk pengembangan lebih lanjut.
PENGARUH PERMAINAN TRADISIONAL GAPYAK TERHADAP KECERDASAN KINESTETIK ANAK KELOMPOK B TK AISYIYAH BUSTANUL ATHFAL 28 JOMPONG BRONDONG LAMONGAN Efendi, Dwi Imam; Sumadi; Firdausi Nuzula Apriliyana
GCEJ (Golden Childhood Education Journal) Vol 6 No 1 (2025): Vol. 6 No. 1 Tahun 2025
Publisher : Program Studi PG PAUD Universitas PGRI Ronggolawe

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55719/gcej.v6i1.1690

Abstract

Studi ini bertujuan untuk menentukan seberapa besar pengaruh permainan tradisional gapyak terhadap kecerdasan kinestetik anak usia dini setelah anak-anak dari Kelompok B TK Aisyiyah Bustanul Athfal 28 Jompong Brondong Lamongan bermain permaminan tersebut. Studi ini menggunakan pendekatan kuantitatif dan menggunakan desain pre-experimental menggunakan model pre-test dan post-test pengaruh 8,36%, hipotesis menunjukkam bahwa permainan gapyak berdampak pada kecerdasan kinestetik anak Kelompok B TK Aisyiyah Bustanul Athfal 28 Jompong Brondong Lamongan
DOING DRAMA IN ACTION: STUDENTS’ INQUIRY PROCESS INVESTIGATION Hendi Hidayat; Rina Nursabrina; Sumadi
Language and Education Journal Vol. 7 No. 1 (2022): Language and Education Journal
Publisher : Universitas Islam Ogan Komering Ilir Kayuagung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52237/88c1p607

Abstract

This study was intended to investigate the students’ inquiry process reflected in doing drama activity. The study applied classroom ethnography. The writer spent seven weeks making ethnographic observations and field notes related to doing drama activity, noting what the students do before, during and after the activity. An in depth interview was conducted to 3 participants. The criteria of chosen participants was their performance during the project. They were considered to have more information. The interview aims to know how each phases fit into the overall context of the inquiry process. The findings show that the inquiry process in doing drama activities are reflected in group formation, selection of drama’s title, making synopsis, devision of roles, rehearsal, costume and propery preparation, and drama performance
ANALISIS KEPRAKTISAN MEDIA PEMBELAJARAN BERBASIS ISPRING UNTUK MATA PELAJARAN IPAS DI SEKOLAH DASAR Siti Muliatul Afifah; Sumadi
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 10 No. 02 (2025): Volume 10, Nomor 02 Juni 2025 publish
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v10i02.28403

Abstract

This study aims to analyse the practicality of iSpring-based interactive learning media in Natural and Social Sciences (IPAS) learning in primary schools. Interactive media is considered an innovative learning solution that can provide a more engaging and meaningful learning experience. This study was conducted using a quantitative descriptive approach. The instrument used was a practicality questionnaire distributed to teachers and students. The results of the data analysis indicate that iSpring media received very high ratings in terms of ease of use, time efficiency, visual appeal, and support for achieving learning objectives. The average practicality percentage reached 99%, categorised as ‘very practical.’ This media was also found to assist teachers in presenting material more clearly and facilitate students' understanding of IPAS learning concepts.