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All Journal Medicina journal of internal medicine Buletin Udayana Mengabdi E-Jurnal Medika Udayana Jurnal Veteriner Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya ISM (Intisari Sains Medis) : Jurnal Kedokteran Bioscientia Medicina : Journal of Biomedicine and Translational Research Lumbung Farmasi : Jurnal Ilmu Kefarmasian Essential: Essence of Scientific Medical Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran
I Wayan Sumardika
Department Of Pharmacology And Therapy, Faculty Of Medicine, Universitas Udayana, Bali, Indonesia
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary

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Journal : Jurnal Veteriner

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Pencegahan Gangguan Fungsi Ginjal Karena Stres Oksidatif pada Tikus Diabetes dengan Ubi Jalar Ungu I Made Jawi; I Wayan Sumardika; Ni Made Linawati
Jurnal Veteriner Vol 15 No 2 (2014)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

Recently, anthocyanins-rich food, is believed to prevent tissue damages due to oxidative stress. This studyaimed to investigate the protective effect of water extract of Balinese purple sweet potatoes which containhigh anthocyanins to the renal tissues of diabetic rats. A total of 30 adult male rats were divided into threegroups using randomized post-test only control group design, respectivelly. Animals in group 1 (diabeticgroup) were given streptozotocin 60 mg/kg; group 2 (diabetic+extract/ treatment group) at 3 days after theanimals were given streptozotocin they were given 4 mL per day of the extract for 50, group 3 (control group)animals were given placebo. At day 50 of the treatment, the blood and renal tissue superoxidase dismutase(SOD) and malondialdehyde (MDA), creatinin and blood urea nitrogen (BUN) level of all rats were measured.The data were analyzed using analysis of variance. The results showed a significant increase of blood andrenal tissues MDA and BUN level in group 1 (p<0,05). In addition, a decrease of SOD and creatinin level(p<0,05) were also seen in this group. In comparison to animals in group 2, the increase of blood MDA andBUN level as well the decrease of SOD and, creatinin level were significantly lower (p<0,05). From thesefindings, it can be concluded that aqueous extract of Balinese purple sweet potato can prevent renalfunction disorders due to oxidative stress.
Co-Authors A.N. Mahendra A.W. Indrayani Agung Nova Mahendra Agung Wiwiek Indrayan Agung Wiwiek Indrayani Ayuti Bulaan Bagus Komang Satriyasa Desak Ketut Ernawati Dewa Ngurah Suprapta I Gde Suranaya Pandit I Made Jawi I Made Siswadi Semadi I Made Winarsa Ruma I Putu Riska Ardinata I Wayan Putu Sutirta Yasa I.A.A. Widhiartini I.G. Wiranatha I.G.A. Artini I.G.M. Aman I.G.M.G.S.C. Trapika Junior, Darren Losen Adnyan MADE RATNA SARASWATI . Made Syanindita Putri Larasati N.W. Tianing N.W.S. Dewi Ni Luh Guantari Ni Luh Suriani Ni Made Linawati Ni Putu Nadia Ramayanti Pande Ayu Naya Kasih Permatananda Saktivi Harkitasari, Saktivi Sandra Sandra Sumadewi, Komang Trisna Tresnayanthi, Kadek Ayu Sri W. Riski Widya Mulyani Wangi, Yan Sista Winanti, Kadek Dinda Ayu Sri Wulandari, Putu Kintan Yan Sista Wangi