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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Althea Medical Journal Journal on Mathematics Education (JME) Indonesian Journal of Urology Agrivet Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Kesehatan Andalas Global Medical and Health Communication Techno LPPM Planta Tropika JIPM (Jurnal Ilmiah Pendidikan Matematika) Journal of Medicine and Health Jurnal SOLMA JMM (Jurnal Masyarakat Mandiri) JTAM (Jurnal Teori dan Aplikasi Matematika) Jurnal Agrotek UMMat YARSI Medical Journal Majalah Patologi Indonesia Jurnal Agro Wiralodra Jurnal Abdi Insani JK Unila (Jurnal Kedokteran Universitas Lampung) Didaktika: Jurnal Pemikiran Pendidikan Jurnal Agro Dedikasi Masyarakat (JADM) Postulat : Jurnal Inovasi Pendidikan Matematika Jurnal Lingkar Mutu Pendidikan Kingdom (The Journal of Biological Studies) Jurnal Pendidikan MIPA Journal on Mathematics Education
Sri Suryanti
Department Of Anatomical Pathology, Faculty Of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital Bandung
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Global Medical and Health Communication

 1 
The Role of Fibroblast Growth Factor Receptor 3 (FGFR3) and Androgen Receptor (AR) in a Non-invasive Urothelial Carcinoma Recurrences Oki Meilani Dewi; Sri Suryanti; Bethy Suryawathy Hernowo
Global Medical & Health Communication (GMHC) Vol 7, No 2 (2019)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (230.702 KB) | DOI: 10.29313/gmhc.v7i2.3956

Abstract

Urothelial carcinoma is a bladder carcinoma that took place in the urinary tract. Non-invasive urothelial carcinoma patients have high recurrence rates (50–70%). The recurrences took so many years that may lead to the high-cost treatment and low survival rate. Fibroblast growth factor receptor 3 (FGFR3) and androgen receptor (AR) known to play a role in non-invasive urothelial carcinoma and potentially act as a prognostic marker to predict recurrences. This study aimed to discover the role of FGFR3 and AR in recurrences of non-invasive urothelial carcinoma. This research used a case-control study design. Samples took from patients diagnosed with non-invasive urothelial carcinoma registered at Dr. Hasan Sadikin General Hospital Bandung 1 January 2010–30 December 2015 period. Sixty samples consisted of 30 recurrent groups, and 30 non-recurrent groups individually fixated and embedded to paraffin block for FGFR3 and AR immunohistochemistry analysis. Analysis chi-square performed with a level of confidence 95% and statistical power 95%. p values<0.05 were considered to be statistically significant. Statistical analysis showed that FGFR3 immunoexpression was found significantly low on the recurrence group (p=0.002, OR=5.50). While AR immunoexpression was found insignificant (p=1.000, OR=1.00). FGFR3 immunoexpression from samples in the recurrent group with multiple tumors found to be significantly low (p=0.031, OR=6.067). This study showed that recurrences took place when FGFR3 lowly expressed within non-invasive urothelial carcinoma samples with multiple tumors. This finding may raise a candidate to early-predict the recurrence, thus will suggest early therapy.PERANAN FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) DAN RESEPTOR ANDROGEN (RA) TERHADAP KEJADIAN REKURENSI PADA KARSINOMA UROTELIAL BULI NON-INVASIFKarsinoma urotelial merupakan karsinoma buli yang sering terjadi pada saluran kemih. Karsinoma urotelial dibagi menjadi karsinoma urotelial non-invasif dan invasif. Pasien karsinoma urotelial non-invasif mempunyai kejadian rekurensi tinggi (50–70%) dan membutuhkan waktu lama untuk memantau kejadian rekurensi sehingga membutuhkan biaya tinggi dengan angka ketahanan hidup rendah. Fibroblast growth factor receptor 3 (FGFR3) dan reseptor androgen (RA) berperan dalam terjadinya karsinoma urotelial non-invasif dan berpotensi sebagai penanda prognostik yang memprediksi rekurensi secara akurat. Tujuan penelitian ini mengetahui peranan FGFR3 dan RA terhadap kejadian rekurensi pada karsinoma urotelial non-invasif. Penelitian menggunakan rancangan case-control study. Sampel berupa blok parafin yang diagnosis sebagai karsinoma urotelial non-invasif di RSUP Dr. Hasan Sadikin Bandung periode 1 Januari 2010–30 Desember 2015. Sebanyak 60 sampel dievaluasi terdiri atas 30 sampel kelompok rekurensi dan 30 kelompok tidak rekurensi. Pemeriksaan imunohistokimia menggunakan antibodi FGFR3 dan RA. Analisis menggunakan uji chi-square dengan taraf kepercayaan 95% dan kuasa uji (power test) 95%. Nilai p<0,05 dianggap signifikan secara statistik. Pada analisis statistik, imunoekspresi FGFR3 rendah signifikan pada kelompok rekurensi (p=0,002; OR=5,50) dan imunoekspresi RA tidak signifikan (p=1,000; OR=1,00). Imunoekspresi FGFR3 rendah dengan tumor multipel signifikan pada kelompok rekurensi (p=0,031;  OR=6,067). Hasil penelitian menunjukkan bahwa rekurensi terjadi ketika FGFR3 terekspresi rendah pada sampel karsinoma non-invasif dengan tumor multipel. Hal ini dapat menjadi penanda memprediksi kejadian rekurensi sehingga dapat dilakukan terapi yang lebih cepat.
Association between Chronic Inflammation of Basal Plate and Decidua Existences with Placenta Accreta Spectrum Yuktiana Kharisma; Meike Rachmawati; Abdul Hadi Hassan; Ismet Muchtar Nur; Hasrayati Agustina; Sri Suryanti
Global Medical & Health Communication (GMHC) Vol 10, No 2 (2022)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (412.693 KB) | DOI: 10.29313/gmhc.v10i2.9060

Abstract

The placenta accreta spectrum (PAS) is an abnormal placenta condition with a high level of morbidity and mortality in both the mother and fetus. The PAS has a multifactorial etiology, one of which is a chronic inflammation of the basal plate (CIBP) and the decidual existences (DE). The study aims to analyze the association between CIBP and DE with PAS. It was an analytical observational with a cross-sectional study design on 50 placentae (25 PAS paraffin block, 25 standard placenta samples) from Dr. Hasan Sadikin General Hospital and other health centers that meet the inclusion and exclusion criteria. The data are taken from PAS patients from January 2015–December 2020. All samples will be stained with hematoxylin-eosin (HE), then undergo histopathological examination. The result of the studies analyzed statistically using Fisher's exact. CIBP in PAS was found in 21/25 cases, while in the normal placenta was found in 16/21 patients. The DE is positive in 15/25 cases of PAS, whereas the normal placenta was found in all cases. The association between CIBP and PAS is insignificant statistically (p=0.19), while the DE showed a significant relationship with PAS (p=0.00). The presence of the decidua is related to the regulation of trophoblastic invasion into the myometrium in PAS cases. CIBP can occur due to the reaction of decidua tissue to trophoblastic invasion or an infectious agent. The pathogenesis of PAS needs further understanding so that the appropriate therapy can be found for its prevention and management.
Co-Authors Aaron T Sihombing, Aaron T Aaron Tigor Aaron Tigor Sihombing Abdul H Hassan, Abdul H Abdul Hadi Hassan Abdul Hadi Hassan Abdul Hadi Hassan, Abdul Hadi Abdurrahman, Fauzan admin admin Agung Putra Wijaya, Agung Putra Agus Koesmawan Anglita Yantisetiasti Antonius Janes Ridwan, Antonius Janes Arif - Umami Azimah, Khoridatul Bethy S Hernowo Bethy S Hernowo, Bethy S Bethy S. Hernowo Bethy S. Hernowo, Bethy Bethy Suryawathy Hernowo Bethy Suryawati Hernowo Bethy Suryawati Hernowo Birgitta Maria Dewayani Deni Sutaji Dewayani, Birgitta Maria Dicky Suryana Putra Didik Indradewa Fariha Wilisiani, Fariha Fatimatul Khikmiyah Fauziyah, Nur Fennisia Wibisono Fennisia Wibisono, Fennisia Fenny Ariyanni Fenny Ariyanni, Fenny Firdaus, Ahmad Qolfathiriyus Firmansyah, Ryan Firmanto, Agung Friede Rismayanti Saragih Friska Mardianty Gatot Nyarumenteng Adhipurnawan Winarno Hasrayati Agustina Hasrayati Agustina Hikmah, Nimatul I Nengah Parta Igun, Maulana Irwani Zawawi Ismet Muchtar Nur JAKA WIDADA Jazilah, Ferina Vetty KHOLIS, SITI NUR Kurniawan, Stefanus Lestari, Adela Ayu Maf'ula, Iswatun Mantilidewi, Kemala I. Mawandha, Hangger Gahara Meike Rachmawati Mukarramah Mukarramah, Mukarramah Mulyono Mulyono Murtiyani, Sri Novian, Dwi Oki Meilani Dewi Oktavianty, Hera Perdana, Cahyo Putra Perix, Vivien Kate Putra, Dicky Suryana Putra, Zuhadur Ra’is Ariyono Raden Yohana Rahayu, Enny Rajagukgguk, Arjuna Mangaroha Reza Widyasaputra sarwo edy Setiawan, Landung Rodhy Setyastuti Purwanti, Setyastuti Setyawati, Ety Siripala, Wannaporn Siti Fauziyah Siti Nur Hidayah, Siti Nur Sofi, Maulana Sri Mulyati Sri Mulyati Sri Rejeki, Henny Standsyah, Rahmawati Erma Stephanie Victoria Gunadi Sulistijowati, Sri Handajani Teddy, Teddy Syah Putra Tiasari, Lulus Cahya Toto Nusantara Vivien Kate Perix Winarto, Bambang Yanti, Liza Puspita Yenni Wisudarma Yudhi Arifani Yuktiana Kharisma