Article Per Year (5 Year)
p-Index From 2020 - 2025
1.325
P-Index
This Author published in this journals
All Journal Pustakaloka: Jurnal Kajian Informasi dan Perpustakaan TIK ILMEU : Jurnal Ilmu Perpustakaan dan Informasi Diponegoro International Medical Journal (DIMJ) Al-MIKRAJ: Jurnal studi Islam dan Humaniora IPTEK: Jurnal Hasil Pengabdian kepada Masyarakat International Journal of Education Research and Development Indonesian Journal of Library and Information Science (IJLIS)
SUTRIONO SUTRIONO
Jurusan Peternakan Fakultas Pertanian Universitas Bengkulu Jalan Raya Kandang Limun, Bengkulu. Telp. (0736) 2170 pst.219.
Agriculture, Biological Sciences & Forestry Arts Humanities Computer Science & IT Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

Published : 8 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Diponegoro International Medical Journal (DIMJ)

 1 
THE EFFECT OF COMBINATION FOSFOMYCIN AND SAMBILOTO (Andrographis paniculata) LEAF EXTRACT ON THE LEUKOCYTES COUNT, NITRITE LEVELS, AND LACTOFERRIN LEVELS IN WISTAR RATS (Rattus norvegicus) URINARY TRACT INFECTION MODEL Sutriono, Sutriono; Lestari, Endang Sri; Agung Nugroho, Eriawan; Nindita, Yora; Addin, Sofyan Rais
Diponegoro International Medical Journal Vol 5, No 2 (2024): December 2024
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/potensi.%Y.24216

Abstract

Background: Fosfomycin is the first-line of antibiotic for urinary tract infection (UTI). To prevent antibiotic resistance, antibiotics and herbal medicines combination was developed. Studies have shown that Andrographis paniculata has antimicrobial and anti-inflammatory agent.Objective: To investigate the effect of A. paniculata extract for treating UTI in animal modelMethods: Using post test only control group design, thirty females Rattus norvegicus rats were induced by 1 cc transurethral inoculation of E. coli and then randomly grouped into negative control (NC) received no treatment, positive control (PC) that had 54 mg fosfomycin, and treatment groups which were divided into T1 (A. paniculata 100 mg/kgBW), T2 (A. paniculata 200 mg/kgBW), T3 (fosfomycin 54 mg with A. paniculata 100 mg/kgBW), T4 (fosfomycin 54 mg with A. paniculata 200 mg/kgBW). Urinary samples were utilized to count leukocytes under microscope, nitrite levels with a dipstick, and lactoferrin using ELISA.Results: Combination of fosfomycin and A. paniculata led to a reduction in the number of leukocytes and nitrite levels compared to the single therapy group, particularly in T4 group (p<0.001). There were no significant differences in lactoferrin levels among all study groups (p>0.05).Conclusion: Combination of A. paniculata with fosfomycin resulted in a more pronounced reduction in the number of leukocytes and nitrite levels compared to single therapy, while lactoferrin levels were unaffected.TRANSLATE with x EnglishArabicHebrewPolishBulgarianHindiPortugueseCatalanHmong DawRomanianChinese SimplifiedHungarianRussianChinese TraditionalIndonesianSlovakCzechItalianSlovenianDanishJapaneseSpanishDutchKlingonSwedishEnglishKoreanThaiEstonianLatvianTurkishFinnishLithuanianUkrainianFrenchMalayUrduGermanMalteseVietnameseGreekNorwegianWelshHaitian CreolePersian //  TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster PortalBack//
Co-Authors Addin, Sofyan Rais Agung Nugroho, Eriawan Cik Zulia, Cik Dermawan, Imam Eke Wince, Eke Endang Sri Lestari Hamzah, Syukri Handayani, Turi Jurianto Juwansyah, Rizky Gilang Lubis, Ade Fipriani Nasution, Zulkarnain Siddik Ningsih, Sri Susanti Normansyah Padila, Nurul Pase, Abd. Khauf Pratama, Yogi Rumondang, Rumondang Sabina, Sahnia Sidabalok, hamidah Sinaga, Muhammad Sakha Sinaga, Saria Suriono, Hadi Syahril Syahril Syamsul Rizal Yora Nindita Yulistio, Didi Zahar, Intan