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All Journal Medical Journal of Indonesia Journal of Dentistry Indonesia Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Penyakit Dalam Indonesia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)

Bambang Sutrisna

Faculty of Public Health, Universitas Indonesia

Author-ID : 397475

Dentistry Health Professions Medicine & Pharmacology Public Health

Published : 24 Documents Claim Missing Document

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Articles

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Survival rate and prognostic factors in advanced cervical cancer patients accompanied by renal impairment Rasjidi, Imam; Nuranna, Laila; Aziz, M. F.; Andrijono, Andrijono; Purbadi, Sigit; Rochani, Rochani; Supriana, Nana; Dharmeizar, Dharmeizar; Sutrisna, Bambang
Medical Journal of Indonesia Vol 14, No 3 (2005): July-September
Publisher : Faculty of Medicine Universitas Indonesia

The objective of this study was to obtain information on theÂ survival rateÂ of advanced cervical cancer patients withÂ renal impairment (ACCRI) and its prognostic factors. In addition, it is hoped that by this method the scoring system for predicting the death ofÂ ACCRI patients hopetullyÂ could be obtained.Â Design of the study used was retrospective cohort study. Data collectedÂ were retrieved fromÂ medicalÂ records ofÂ ACCRI patients from 1 January 1998 toÂ 31 December 2003 at Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, with a total sample of 70 cases. The results of the study showed that mean survival ofÂ all ACCRI patientsÂ was 8.2 months,Â mean survival at sixth month was 39%, and mean survivalÂ at one year was 3.2%. Median survival wasÂ 5.3 months. Prognostic factors affecting the survival of ACCRI patients includedÂ histopathological type (adenosquamous cell and cell differentiation), cortical thickness of the kidney less than 1 cm, and nephrostomy. (Med J Indones 2005; 14: 173-8)Keywords:Â Advance cervical cancer, renal impairment, nephrostomy, survival prognostic factor, scoring system

Clinical-pathologic factors, as predictor of lymph nodes metastasis in cervical cancer stage IB and IIA Aziz, M. F.; Andrijono, Andrijono; Nuranna, Laila; Purbadi, Sigit; Mangunkusumo, Rukmini T.; Siregar, Budiningsih; Cornain, Santoso; Saifuddin, Abdul B.; Tjarta, Achmad; Sutrisna, Bambang
Medical Journal of Indonesia Vol 13, No 2 (2004): April-June
Publisher : Faculty of Medicine Universitas Indonesia

The aim of this study was to identify possible predictor factors of lymph node metastases in patients with cervical cancer stage IB and IIA. Study was conducted between May 1996 and December 2001. There were 183 patients of cervical cancer with FIGO Stage IB and IIA who were underwent radical hysterectomy and lymphadenectomy. From those 158 patients could be evaluated, consisting 43 patients with node metastases 115 patients without metastases. Research design was case control study. Case was patients with node metastases and control was those without node metastases. Multivariate analysis was made after bivariate analysis. On bivariate analysis age < 39 years, diameter of lesion > 4 cm, stage IIA > 4 cm, histopathology moderate and poor differentiation, blood and lymphatic vessel invasion were independent variables for node metastases with p value â¤ 0.05. However, on multivariate analysis younger age, parity â¥ 4, diameter of lesion, histopathology adenosquamous, and lymph vascular invasion (+) as independent factors for node metastases with p value â¤ 0.05. Conclusion: Younger age, parity â¥ 4, stage IIA > 4 cm, diameter of lesion, histopathology adenosquamous, and lymph vascular invasion (+) were risk factors for node metastases and can be used as predictors. (Med J Indones 2004; 13: 113-8)Keywords: cervical cancer, radical hysterectomy, node metastases, case control study, predictor

The prevalence of orthostatic hypotension and its risk factors among 40 years and above adult population in Indonesia Setiati, Siti; Sutrisna, Bambang; Prodjosudjadi, Wiguno
Medical Journal of Indonesia Vol 13, No 3 (2004): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Factors associated with orthostatic hypotension such as age, drug induced hypotension, hypertension and diabetes mellitus have still been debatable. Most of previous studies were conducted in subjects 65 years or older, only a few were done in subjects from younger to older adults. The purpose of this study is to find the prevalence and predictor factors of orthostatic hypotension among adult population aged 40 years and above in Indonesia. This study is a part of Indonesian Hypertension Epidemiologic Survey. A random sample of 4436 subjects aged 40â94 years was obtained from various municipalities in every big island in Indonesia. Orthostatic testing, assesment of history of medical conditions (diabetes mellitus, stroke, and hypertension), blood pressure measurement and use of anti-hypertensive medications were performed. A stepwise logistic regression was used to determine the significant predictor of orthostatic hypotension. A total of 561 persons (12.6%) experienced orthostatic hypotension. Central Î±2-agonist and other centrally acting drug is the only anti hypertension medicine which influences orthostatic hypotension. Multivariate analysis showed that high systolic and diastolic blood pressures were predictor factors of orthostatic hypotension. The use of anti-hypertensive medicine was a protective factor for orthostatic hypotension. This study confirms the conclusion that age is not a predictor factor for orthostatic hypotension. In fact, the existence of comorbidities in the subjects such as hypertension (high systolic and diastolic blood pressure) is a predictor factor, while the use of anti-hypertensive medication is a protective factor. (Med J Indones 2004; 13: 180-9) Keywords: adult, orthostatic hypotension, prevalence, risk factor

Survival of borderline tumors of the ovary and its prognostic factors at Dr. Cipto Mangunkusumo hospital from 1990 to 1999 Sanif, Rizal; Nuranna, Laila; Sutrisna, Bambang
Medical Journal of Indonesia Vol 11, No 4 (2002): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Sixty-two patients with borderline tumors of ovary were historical cohort analyzed for survival characteristics. There were 9 patients with FIGO stage IA, 9 with stage IC, 3 with stage IIIA, 2 with stage IIIB, 4 with stage IIIC, 1 with stage IV and 34 with inadequate stage tumors. Twenty one patients had surgical staging with radical surgery, 10 patient had at least a total abdominal hysterectomy and bilateral salpingo-oophorectomy, 6 patient had surgical staging with conservative surgery, 24 patient had at least a unilateral salphingo-oophorectomy or ovarian cystectomy and 1 patient had biopsy. Sixteen patients received cisplatin-based combination chemotherapy, that were 8 with inadequate stage tumors, 7 with stage III tumors and 1 with stage IV tumor. Follow-up range from 0.02 to 10.48 years, with a median of 3.5 years. Fifty nine patient were alive. Three patients died, all of disease. Recurrence were found in 4 patients. The overall 2-years survival rate was 96% and 10-years survival rate was 94%. In log rank test, residual disease and histology type were significant predictor of survival. (Med J Indones 2002; 11:222-9)Keywords: borderline tumors of ovary, survival

Demographic characteristics, risk factors and immunocytochemistry of p16INK4a, Ki-67, MCM5, and survivin as predictors for the progress of cervical precancer lesion Indarti, Junita; Aziz, Mohammad F.; Sutrisna, Bambang; Siregar, Nuryati C.; Suryawati, Bethy; Harahap, Alida
Medical Journal of Indonesia Vol 19, No 3 (2010): August
Publisher : Faculty of Medicine Universitas Indonesia

Aim To identify the predictive factors and biomarkers in the progression of cervical precancer lesion or CervicalÂ Intraepithelial Neoplasia (CIN).Methods The study was conducted from August 2007 to September 2008. Design of the study was case-control withÂ stratifications of test dose response. The cases were patients with CIN. Control patients were non CIN patients. BivariateÂ analysis followed by multivariate analysis was conducted.Results There were 130 patients, consisting of 124 CIN patients divided into CIN 1, CIN 2 and CIN 3, with the followingÂ numbers of patients: 30, 41, and 33, respectively and 26 patients without CIN (non CIN). Bivariate analysis showedÂ that age < 41 years, education â¥ 13 years, sexual partner â¥ 2, first sexual relationship at age < 22 years, smoking, theÂ presence of sexuallly transmitted infections, positive HPV DNA, high p16INK4a, Ki-67, MCM5 and Survivin expressionÂ constituted independent variables for the occurrence of CIN with P value of < 0.05. However, on multivariate analysis,Â independent variables that emerged were age, education â¥ 13 years, sexual partner â¥ 2 persons, positive HPV DNA, andÂ over expression of p16INK4a, Ki-67 and Survivin that showed a P value of < 0.005.Conclusion Younger ages, education age â¥ 13 years, sexual partner â¥ 2 persons, positive HPV DNA, high p16INK4a,Â Ki-67 and Survivin expression constituted the risk factors for the occurrence of the progress of CIN, and was used in theÂ equation to predict the progress of cervical precancer lesion. (Med J Indones 2010;19:147-53)Key words: case control study, equation, HPV DNA

Survival of cervical cancer patients and its prognostic factors at Cipto Mangunkusumo Hospital, Jakarta Nuranna, Laila; Prastasari, Rahma; Sutrisna, Bambang
Medical Journal of Indonesia Vol 23, No 3 (2014): August
Publisher : Faculty of Medicine Universitas Indonesia

Background: Cervical cancer is the second most common cancer among Indonesian women. Information concerning survival probability is very important for the patient and institution. Our last data about cervical cancer survival was studied for more than 10 years ago. This study aimed to know the latest cervical cancer survival and its prognostic factors.Methods: This is a retrospective cohort study which enrolled cervical cancer patients treated at Cipto Mangunkusumo Hospital in 2005-2006. Subjects were followed-up for minimum of 5 years. Kaplan-Meier and Cox regression analysis was used to determine the survival probability and to assess prognostic factors.Results: A total of 447 patients who met the study criteria were selected. Stage III was the largest proportion on the study (41.6%). Most of the histopathology type was squamous cell carcinoma (71.6%). This study revealed that median survival was 63 months with the overall 5-years survival probability to be 52%. Tumor size did not influence overall survival rate. Stage III and IV had lower survival probability (HR 3.27 and 6.44). Poor differentiation and uncompleted therapy also had lower survival probability (HR 2.26 and 2.22). Histopathology of others (neuroendocrine) had lower survival probability (HR 2.85). However, it was not statistically significant on multivariate analysis.Conclusion: Median survival time for cervical cancer patients at Cipto Mangunkusumo Hospital was 63 months. There were improvement in the survival rate comparing from the study in 1997. In this study, the independent prognostic factors for survival were tumor staging, tumor differentiation, and completion of therapy.

Interleukin-10 serum level in acute coronary syndrome patients Alwi, Idrus; Santoso, Teguh; Suyono, Slamet; Sutrisna, Bambang; Kresno, Siti B.
Medical Journal of Indonesia Vol 18, No 3 (2009): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Aim To compare plasma IL-10 concentrations in patients with Acute Coronary Syndrome (ACS) with those inÂ Coronary Artery Disease (CAD).Methods ACS patients hospitalized in intensive coronary care unit (ICCU) of Cipto Mangunkusumo Hospital/FacultyÂ of Medicine University of Indonesia (CMH/FMUI), Persahabatan Hospital, MMC Hospital, and Medistra Hospital,Â Jakarta, between May 2005 and May 2006, were included in this study. The ambulatory CAD patients were takenÂ as comparator. The serum IL-10 level was measured by immunoassay method, and compared by using IndependentÂ Studentâs t-test. To investigate whether IL-10 serum level could predict ACS, the sensitivity and specificity of thisÂ parameter towards ACS in various IL-10 serum levels were calculated as well.Results In this observational study, as many as 146 subjects were analyzed, consisting of 84 ACS patients, and 62Â coronary artery disease (CAD). The IL-10 level was higher in the group of ACS patients (7.37 pg/mL + 7.81, CI 95%Â 5.68-9.07) than that in CAD patients (1.59 pg/mL + 1.55, CI 95% 1.2-1.98). The optimal cut-off point for serum IL-10level is >1.95 pg/mL, with 79.76 % sensitivity and 77.42 % specificity.Conclusion The IL-10 level was higher in the ACS patients compared to that in CAD patients. Serum IL-10Â measurement is a quite superior method to distinguish acute and stable condition, eventhough it is not as good asÂ hsCRP for the same purpose. (Med J Indones 2009;18:165-9)Key words: Interleukin-10, acute coronary syndrome

CD133, CD44, and ALDH1A1 as cancer stem cell markers and prognostic factors in epithelial ovarian cancer Andrijono, Andrijono; Sutrisna, Bambang; Harahap, Alida Roswita; Kanoko, Mpu; Nuranna, Laila; Siregar, Budiningsih; Wulandari, Dewi; Pelupessy, Nugraha Utama
Medical Journal of Indonesia Vol 28, No 1 (2019): March
Publisher : Faculty of Medicine Universitas Indonesia

BACKGROUND Ovarian cancer is a heterogeneous disease, and most patients are diagnosed at an advanced stage. Epithelial ovarian cancer type II is characterized by rapid tumor growth and is genetically more labile than type I. This study was aimed to demonstrate the prognostic value of CSC by using the markers CD133, CD44, and ALDH1A1 in EOC.METHODS Clinicopathological and demographic data were collected from medical records. The markers CD133, CD44, and ALDH1A1 were examined with flow cytometry and immunohistochemistry. Cancer stem cell (CSC) marker expression in patients with ovarian cancer types I and II were related to chemotherapy and survival. In multivariate analysis, the prognosis model was tested for ten months.RESULTS The largest demographic consisted of patients aged ≥45 years, with stage I, poor differentiation, and type II, of which there were 40 samples (72.7%), 23 samples (41.8%), 30 samples (54.5%), and 16 samples (29.1%), respectively. There is a high correlation between the 10-month chemotherapy response and the 4 variables, i.e., age ≥45 years, type II, stage III–IV, and CD44, with an ROC of 80.75% and a post-test probability of 82.5%. Using the ROC curve, the highest chemoresistance score was 0.841, based on the combination of CSCs markers and clinicopathological factors, that is stage III–IV, age ≥45 years, poor differentiation, type II, negative CD133, high CD44, and high ALDH1A1.CONCLUSIONS CSC (CD133, CD44, and ALDH1A1) markers and clinicopathological factors are prognostic of epithelial ovarian cancer.

Co-Authors A.A. Ketut Agung Cahyawan W Abdul B. Saifuddin Achmad Tjarta Alida Harahap Alida R Harahap, Alida R Andi Andi Andriansyah Andriansyah Andrijono Andrijono Bethy Suryawati Budiningsih Siregar Dewi Wulandari Dharmeizar Dharmeizar Dian Wijayanti Ediwibowo Ambari Ellen A. Gunawan Endang Susalit Ferry Armanza, Ferry Harahap, Alida Roswita Hariyono Winarto Herdiman T Pohan Idrus Alwi Imam Rasjidi Junita Indarti Kasmianto Abadi Khonsa, Oni Laila Nuranna Lukman H Makmun M. F. Aziz Marcella Erwina Rumawas Markus, Unedo H Markus, Unedo H Maruhum B.H. Marbun Miesje Karmiati Purwanegara, Miesje Karmiati Mohammad F. Aziz Mpu Kanoko Nana Supriana Nuryanto, Kartiwa H Nuryati C. Siregar Pelupessy, Nugraha Utama Pradana Soewondo Princen Princen Rahma Prastasari Rinaldy, Dino Rizal Sanif Rochani Rochani Rukmini T. Mangunkusumo Santoso Cornain Sarwono Waspadji Sigit Purbadi Siti B. Kresno Siti Setiati Slamet Suyono Suhendro Suwarto, Suhendro Susilowati, Utami Suwignyo . Sylvia D Elvira Valentinus Budi Kidarsa Vitantri, Fara Wiguno Prodjosudjadi Yohana Margarita

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