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All Journal Medicina Sport and Fitness Journal Buletin Udayana Mengabdi E-Jurnal Medika Udayana Bali Journal of Anesthesiology Indonesian Journal of Medicine ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Keperawatan dan Fisioterapi (JKF) International Journal of Economic Research and Financial Accounting
I Ketut Suyasa
Departemen Ortopedi Dan Traumatologi, Universitas Udayana, Denpasar
Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Public Health Social Sciences Other

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Hubungan dan titik potong skor Caprini terhadap D-dimer sebagai parameter resiko trombosis vena dalam pada pasien paska fiksasi internal fraktur tulang panjang ekstremitas bawah Made Wirabhawa; Ketut Siki Kawiyana; I Ketut Suyasa; Putu Astawa; Ketut Gede Mulyadi Ridia; I Wayan Suryanto Dusak; I Gede Eka Wiratnaya; Anak Agung Wiradewi Lestari
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (265.291 KB) | DOI: 10.15562/ism.v11i1.555

Abstract

Background: Fractures contribute to a substantial proportion of the emergency department cases. Surgical procedures such as internal fixation of lower limb fractures posed a risk to develop deep vein thrombosis (DVT). The current diagnosis of DVT is still a challenge, as the current main parameter, the D-dimer, requires additional laboratory time and cost. Threrefore, an easier and faster alternative should be used in clinical decision making. Caprini score is among a simple method to assess the risk of a DVT, but validation is still needed before it can be implemented.Methods: This is an cross-sectional analytic study aimed to determine the relationship between Caprini scores and D-dimer level in patients with post-internal fixation of long bone fractures in lower extrimities at Sanglah Hospital Denpasar. Caprini scores were determined before surgery then D-dimer measurements were taken postoperatively. Statistical analysis was performed using the Pearson correlation method and ROC curve were generated to determine the cut-off point of Caprini Score equivalent of high risk DVT with the D-dimer as the predictor.Result: The average Caprini score was 9.37 (7-13). Mean preoperative D-dimer was 6.59 µg/ml (2.50-13.20 µg/ml), postoperatively 11.50 µg / ml (3.71-19.89 µg/ml) and mean delta D -Dimer 5.23 µg/ml (0.56-12.28 µg/ml). Pearson correlation test obtained a strong positive relationship (r = 0.726 and p≤0,0001). Analysis of the ROC curve to determine the cut-off point for Caprini score which equivalent to the high risk of DVT from D-dimer prediction (> 7.2 µg / ml) resulted in AUC of 0.824 (95% CI 0.669-0.979, p= 0.024) with the optimal cut-off point for Caprini score was 8.Conclusion: Caprini and D-dimer scores show a strong positive correlation.  Caprini scores can be considered to estimate the risk of DVT in post-internal fixation patients of lower extremities long bone fractures. Latar Belakang. Kejadian fraktur memiliki proporsi yang substansial dari total pasien yang datang ke unit gawat darurat rumah sakit. Prosedur operasi seperti pemasangan fiksasi internal pada fraktur ekstremitas bawah memiliki resiko untuk terjadinya trombosis vena dalam (DVT). Penegakan diagnosis DVT saat ini masih merupakan suatu tantangan salah satunya karena pemeriksaan laboratorium D-dimer membutuhkan waktu dan biaya tambahan, sehingga dibutuhkan alternatif yang lebih mudah dan cepat digunakan dalam pengambilan keputusan klinis. Skor Caprini merupakan salah satu cara untuk menilai resiko terjadinya suatu DVT, akan tetapi masih diperlukan validasi sebelum dapat diimplementasikan. Metode: Penelitian cross-sectional analitik dilakukan untuk mengetahui hubungan Skor Caprini dengan kadar D-dimer pada pasien paska operasi fiksasi internal fraktur tulang panjang ekstremitas bawah di RSUP Sanglah Denpasar. Skor Caprini ditentuakan sebelum operasi kemudian pengukuran D-dimer dilakukan paska operasi. Analisis statistik dilakukan dengan metode korelasi Pearson dan penentan titik potong risiko DVT dengan prediktor D-dimer menggunakan metode kurva ROC.Hasil: Rerata Skor Caprini adalah 9,37 dengan rentang skor 7-13. Rerata D-dimer sebelum operasi sebesar 6,59 µg/ml (2,50-13,20 µg/ml), paska operasi 11,50 µg/ml (3,71-19,89 µg/ml) dan rerata delta D-Dimer 5,23µg/ml (0,56-12,28 µg/ml). Uji korelasi Pearson diperoleh hubungan positif kuat antara Skor Caprini dengan kadar D-dimer (nilai r=0,726 dan nilai p≤0,0001). Analisis kurva ROC untuk menentukan itik potong  Skor Caprini yang setara dengan resiko tinggi terjadinya DVT dari prediksi D-dimer (>7,2 µg/ml) memperoleh Area Under Curve 0,824 (95% CI 0,669-0,979, p = 0,024) dengan titik potong optimal skor Caprini 8.Kesimpulan: Skor Caprini dan D-dimer menunjukkan korelasi positif yang kuat pada pasien paska fiksasi internal fraktur tulang panjang ekstremitas bawah. Skor Caprini dapat dipertimbangkan sebagai acuan dalam menentukan resiko terjadinya  DVT.
Hemiartroplasti Bipolar menghasilkan luaran C-Reactive Protein dan Harris Hip Score yang lebih tinggi dibandingkan Cephalomedulary Nailing Komang Septian Sandiwidayat; Putu Astawa; Ketut Gede Mulyadi Ridia; Ketut Siki Kawiyana; I Wayan Suryanto Dusak; I Ketut Suyasa; I Gede Eka Wiratnaya; Anak Agung Wiradewi Lestari
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (264.283 KB) | DOI: 10.15562/ism.v11i1.556

Abstract

Background: Bipolar Hemiarthroplasty and Cephalomedullary Nailing (PFNA) are operative procedures for the management of proximal femoral fractures. Both of these surgical techniques have their respective advantages and disadvantages. This study aims to determine the differences in biological and functional outcomes. C-Reactive Protein (CRP) used to measure inflammation due to tissue damage and Harris Hip Score (HHS) used to measure functional output. This study hoped to facilitate the selection of appropriate techniques for the treatment of proximal femoral fractures.Methods: Prospective cohort study conducted among patient with proximal femoral fractures who underwent Bipolar Hemiarthroplasty and PFNA surgery. CRP levels were examined before surgery and 12 hours postoperatively. The HHS assessment was performed at weeks 4, 6, and 8 postoperatively.Results: In general, the preoperative CRP levels of the groups undergoing Bipolar Hemiarthroplasty and PFNA were not significantly different (32.4±16.7 and 33.7±17.1; p> 0.05), whereas postoperatively, Bipolar Hemiarthroplasty shown significantly higher CRP (76.5±27.3 and 42.6±17.6; p <0.0001). Similar results were also shown from the ∆CRP analysis (45.1±22.1 and 8.9±3.2; p<0.0001). The mean HHS score was higher in the Bipolar Hemiarthroplasty group than in PFNA group at each measurement. At the 4th week, the mean HHS score did not show a significant difference (52.3±4.2 vs 52.2±5.4; p>0.05). The 6th week evaluation showed Bipolar Hemiarthroplasty had a mean HHS of 76.5±4.6 while PFNA 61.4±5.4 (p <0.0001). At week 8, HHS in Bipolar Hemiarthroplasty was consistently higher than PFNA (89.43±4.5 and 74.95±4.9; p <0.0001). The Bipolar Hemiarthroplasty group was hospitalized 56% longer (6.1±1.3 and 3.9±1.3 days; p<0.0001) and the Bipolar Hemiarthroplasty had an average bleeding volume of 4.5 times more (407.4±122.8 and 90±13 ml; p <0.0001).Conclusion: Bipolar Hemiarthroplasty and PFNA procedures have significantly different functional and biological outcomes. The postoperative HHS score in Bipolar Hemiarthroplasty is better but with a higher delta CRP. Latar Belakang: Hemiarthroplasti bipolar dan Cephalomedullary Nailing (PFNA) merupakan prosedur operatif penatalaksanaan fraktur proksimal femur. Kedua prosedur tersebut menggunakan pendekatan yang berbeda utamanya pada upaya preservasi bagian proksimal femur. Kedua teknik bedah ini memiliki keuntungan dan kerugian masing-masing. Penelitian ini bertujuan untuk mengetahui perbedaan luaran biologis dan fungsional kedua teknik tersebut. C-Reactive Protein (CRP) digunakan sebagai parameter terkait inflamasi akibat kerusakan jaringan dan Harris Hip Score (HHS) digunakan mengukur luaran fungsional. Studi ini diharapkan dapat mempermudah pemilihan teknik yang tepat untuk penanganan fraktur proksimal femur.Metode: Penelitian ini adalah penelitian kohort prospektif pada pasien dengan fraktur proksimal femur yang menjalani operasi Hemiartroplasti Bipolar dan PFNA. Kadar CRP diperiksa sebelum operasi dan 12 jam paska operasi. Penilaian HHS dilakukan pada minggu ke-4, 6, dan 8 paska operasi.Hasil: Secara umum kadar CRP preoperasi kelompok yang menjalani Hemiarthroplasti Bipolar dan PFNA tidak berbeda signifikan (32,4±16,7 dan 33,7±17,1; p>0,05), sedangkan pada paska operasi kadar CRP Hemiarthroplasti Bipolar secara signifikan lebih tinggi (76,5±27,3 dan 42,6±17,6; p<0,0001). Hasil yang sama juga ditunjukan dari analisis ∆CRP (45,1±22,1 dan 8,9±3,2; p < 0,0001). Rerata skor HHS lebih tinggi pada kelompok Hemiarthroplasti Bipolar daripada PFNA pada setiap kali pengukuran. Pada minggu ke-4 nilai rerata HHS tidak menunjukan perbedaan yang signifikan (52,3±4,2 vs 52,2±5,4, p>0,05). Evaluasi minggu ke-6 menunjukan Hemiarthroplasti Bipolar memiliki rerata HHS 76,5±4,6 sementara PFNA 61,4±5,4 (p<0,0001). Pada minggu ke-8, HHS pada Hemiarthroplasti Bipolar konsisten lebih tinggi daripada PFNA (89,43±4,5 dan 74,95±4,9; p<0,0001). Kelompok Hemiarthroplasti Bipolar menjalani rawat inap 56% lebih lama (6,1±1,3 dan 3,9±1,3 hari; p < 0,0001) serta Hemiarthroplasti Bipolar memiliki rerata volume perdarahan 4,5 kali lebih banyak (407,4±122,8 dan 90±13 ml; p < 0,0001).Kesimpulan: Prosedur Hemiarthroplasti Bipolar dan PFNA memiliki luaran fungsional dan biologis yang berbeda secara signifikan. Skor HHS pada Hemiarthroplasti Bipolar lebih baik tetapi selisih CRP yang lebih tinggi.
Skor Patient Rated Wrist Examination (PRWE) dan Radius Union Scoring System (RUSS) lebih baik dengan pemberian Platelet Rich Plasma pada kasus fraktur distal radius dengan terapi konservatif I Gusti Ngurah Pramartha Wijaya Putra; I Ketut Siki Kawiyana; I Wayan Suryanto Dusak; Putu Astawa; I Ketut Suyasa; Ketut Gede Mulyadi Ridia; I Gede Eka Wiratnaya
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (272.553 KB) | DOI: 10.15562/ism.v11i3.776

Abstract

Introduction: Platelet Rich Plasma (PRP) is one of the supporting therapies that can increase the rate of tissue regeneration. In orthopedics, PRP is generally considered a therapy to accelerate bone regeneration, especially when combined with bone allografts. This study was conducted to determine whether the administration of platelet rich plasma (PRP) in conservative therapy of distal radius fractures resulted in a functional outcome (Patient Related Wrist Examination / PRWE score) and increased callus formation (Radius Union Scoring System / RUSS score) was better when compared to conservative therapy without PRP administration.Methods: A total of 22 patients with distal radius fracture were divided into two groups, the intervention group who underwent closed reduction, immobilization with short arm cast and PRP injection at the fracture site, and the control group who received a placebo injection of 0.9% NaCl. After 8 weeks, the evaluation was carried out with the PRWE form and radiologic examination to assess RUSS. The research data were then analyzed to determine the difference in mean scores between groups.Results: The mean PRWE score was lower in the conservative + PRP treatment group (73.18 ± 5.96) than in the control group (79.55 ± 3.30), p value = 0.007. In addition, the mean RUSS score was higher in the conservative + PRP treatment group (5.27 ± 1.10) than in the control group (4.00 ± 1.18),  p value = 0.017.Conclusion: Administration of PRP in conservative therapy of distal radius fractures resulted in a lower PRWE score and a higher RUSS score at 8 weeks. It can be used as a basis for administering PRP in adjunct therapy to conservative therapy of distal radius fractures. Pendahuluan: Platelet Rich Plasma (PRP) merupakan salah satu terapi penunjang yang dapat meningkatkan kecepatan regenerasi jaringan. Dalam bidang orthopaedi, PRP umumnya dianggap sebagai terapi untuk mempercepat regenerasi tulang, terutama ketika dikombinasikan dengan allografts tulang. Penelitian ini dilakukan untuk menentukan apakah pemberian platelet rich plasma (PRP) pada terapi konservatif fraktur distal radius menghasilkan luaran fungsional (skor Patient Related Wrist Examination / PRWE) dan peningkatan pembentukan kalus (skor Radius Union Scoring System / RUSS) yang lebih baik apabila dibandingkan dengan terapi konservaif tanpa pemberian PRP.Metode:  Sebanyak total 22 pasien dengan fraktur distal radius dibagi ke dalam dua kelompok, yakni kelompok intervensi yang menjalani reduksi tertutup, imobilisasi dengan short arm cast dan injeksi PRP di lokasi fraktur, serta kelompok kontrol yang mendapat injeksi plasebo berupa NaCl 0,9%. Setelah 8 minggu, evaluasi dilakukan dengan formulir PRWE dan pemeriksaan radiologik untuk menilai RUSS. Data penelitian kemudian dianalisis untuk mengetahui perbedaan rerata skor antar kelompok.Hasil: Didapatkan rerata skor PRWE yang lebih rendah pada kelompok perlakuan konservatif + PRP (73,18 ± 5,96) dibanding pada kelompok kontrol (79,55 ± 3,30) dengan nilai p < 0,05. Selain itu, didapatkan pula rerata skor RUSS yang lebih tinggi pada kelompok perlakuan konservatif + PRP (5,27 ± 1,10) dibanding pada kelompok kontrol (4,00 ± 1,18) dengan nilai p < 0,05.Simpulan: Pemberian PRP pada terapi konservatif fraktur distal radius menghasilkan skor PRWE yang lebih rendah dan skor RUSS yang lebih tinggi dalam waktu 8 minggu. Hal ini dapat digunakan sebagai dasar pemberian PRP dalam terapi tambahan pada terapi konservatif fraktur distal radius. 
Konfigurasi fraktur Schatzker VI dan malalignment merupakan faktor risiko terjadinya joint narrowing pada fraktur tibia plateau di RSUP Sanglah, Bali, Indonesia Herryanto Agustriadi Simanjuntak; Ketut Siki Kawiyana; I Ketut Suyasa; Putu Astawa; Ketut Gede Mulyadi Ridia; I Wayan Suryanto Dusak; I Gede Eka Wiratnaya; I Wayan Subawa
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (322.672 KB) | DOI: 10.15562/ism.v11i3.783

Abstract

Background: Tibia plateau fracture is a fracture that involves the joint surface and dramatically contributes to the early development of knee osteoarthritis, which can lead to disability. The joint narrowing is one of the most initial signs of knee osteoarthritis. Until now, the mechanism of joint narrowing is not known with certainty but is thought to be related to the configuration of the patient's fracture, malalignment, and BMI. This study aims to determine and analyze the effect of Schatzker VI fracture configuration, malalignment, and BMI > 25 kg/m2 on joint narrowing in post-operative tibia plateau fracture patients.Methods: This research is an observational study with a case-control design. Thirty-eight patients with tibia plateau fractures who had surgery with acceptable reduction were followed-up within 12-15 months post-operatively. The control group consisted of patients who did not experience joint narrowing post-operatively, while the case group are patients with joint narrowing. Schatzker classification, malalignment, and BMI were compared and statistically analyzed for significance. Data were analyzed using SPSS version 21 for Windows.Results: Sixteen patients (84,0%) had Schatzker VI with a risk of 11.56 times to experience joint narrowing (p=0.003). Malalignment were 18 samples (47,0%), with a risk of 11,56 times becoming joint narrowing (p=0.003); and 8 samples with BMI > 25 kg/m2 had a risk of 0.802 times to develop joint narrowing (p=1.000).Conclusion: Schatzker VI configuration and malalignment are risk factors for joint narrowing in patients following tibial plateau surgery, while a BMI is not a risk factor for joint narrowing. Latar Belakang: Fraktur tibia plateau merupakan fraktur yang melibatkan permukaan sendi dan sangat berkontribusi terhadap perkembangan dini osteoartritis lutut yang dapat berujung pada timbulnya disabilitas. Joint narrowing merupakan salah satu tanda awal terjadinya osteoartritis lutut. Sampai saat ini mekanisme terjadinya joint narrowing belum diketahui secara pasti namun diduga terkait dengan konfigurasi fraktur, malalignment, dan BMI pasien. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh konfigurasi fraktur Schatzker VI, malalignment, dan BMI > 25 kg/m2 terhadap terjadinya joint narrowing pada pasien pasca operasi fraktur tibia plateau.Metode: Penelitian ini merupakan studi observasional dengan desain case control. Tiga puluh delapan pasien yang menjalani operasi fraktur tibia plateau diamati dalam 12-15 bulan pasca operasi. Kelompok kontrol terdiri dari pasien yang tidak mengalami joint narrowing pasca operasi sedangkan kelompok kasus terdiri dari pasien yang mengalami joint narrowing. Klasifikasi Schatzker, malalignment, dan BMI dibandingkan dan dianalisis secara statistik untuk signifikansi.Hasil: Enam belas pasien (84,0%) memiliki konfigurasi fraktur Schatzker VI berisiko 11,56 kali mengalami joint narrowing (p=0,003); malalignment dengan 18 sampel (47%), berisiko 11,56 kali menjadi joint narrowing (p=0,003); dan sampel dengan BMI> 25 kg/m2 adalah 8 sampel dan berisiko 0,802 kali untuk mengalami joint narrowing (p=1.000). Simpulan: Konfigurasi Schatzker VI fraktur tibia plateau dan malalignment adalah faktor risiko untuk terjadinya joint narrowing pada pasien yang pasca operasi fraktur tibia plateau, sementara BMI > 25kg/m2 bukan merupakan faktor risiko terjadinya joint narrowing.
Lactate Dehydrogenase (LDH) dan prokalsitonin merupakan parameter pembeda yang lebih spesifik dan sensitif dibandingkan dengan Laju Endap Darah (LED), C-Reactive Protein (CRP), dan Alkaline Phosphatase (ALP) antara osteosarkoma dan osteomielitis di RSUP S Ivander Purvance; Putu Astawa; Made Bramantya Karna; I Ketut Siki Kawiyana; Ketut Gede Mulyadi Ridia; I Ketut Suyasa; I Wayan Suryanto Dusak; I Gede Eka Wiratnaya
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (353.331 KB) | DOI: 10.15562/ism.v11i3.784

Abstract

Background: It is often difficult to distinguish between the clinical presentation of osteosarcoma and osteomyelitis in the early stages. Histopathological review, requiring planning, delaying early treatment, is the golden standard diagnosis for this disorder. This research aimed to find out if it is possible to use simple laboratory examinations to distinguish these diseases. Early treatment can also be carried out, which can lead to a stronger prognosis.Methods: A medical database of patients with reported osteosarcoma and osteomyelitis was used to collect data. Initial laboratory test results, including erythrocyte sedimentation rate, C-reactive protein, dehydrogenase lactate, alkaline phosphatase, and procalcitonin, were obtained. Statistical analysis was then conducted to determine the most useful laboratory parameter for distinguishing these two diseases. SPSS version 21 for Windows analyzed the results.Results: The results showed that there was a significant difference between osteosarcoma and osteomyelitis patients' age and body mass index (BMI) (p <0.05). Important variations between all test parameters were found, but the lactate dehydrogenase and procalcitonin parameters were considered to be the most sensitive and specific parameters for the distinction between the two diseases (p<0.05). A sensitivity level of 92.5 % and a specificity of 100% with an AUC value of 0.963 (P = 0.05) were shown to have cut points of 840 U/L for LDH and 0.465 ng/mL for PCT.Conclusion: Lactate dehydrogenase and procalcitonin have been shown to distinguish between early-stage osteomyelitis and osteosarcoma, making early treatment possible.  Latar Belakang: Gambaran klinis osteosarkoma dan osteomielitis seringkali sulit dibedakan pada fase-fase awal. Pemeriksaan gold standard untuk kedua penyakit ini adalah dengan pemeriksaan histopatologi, namun pemeriksaan ini memerlukan persiapan yang cukup lama, sedangkan tatalaksana kedua penyakit ini optimal bila dilakukan seawal mungkin. Penelitian ini bertujuan untuk melihat apakah pemeriksaan laboratorium sederhana dapat membedakan kedua penyakit ini, sehingga terapi dapat dilakukan sedini mungkin, dan menghasilkan prognosis sebaik mungkin.Metode: Dilakukan pengambilan data pasien sesuai desain cross sectional analytics, yaitu pasien yang telah terkonfirmasi osteosarkoma dan osteomielitis dari rekam medis. Kemudian dilakukan penelusuran data laboratorium saat awal pasien masuk, yaitu laju endap darah, C-reactive protein, lactate dehydrogenase, alkaline phosphatase, dan prokalsitonin. Kemudian dilakukan analisis statistik untuk menentukan parameter manakah yang paling berperan membedakan kedua penyakit ini. Data dianalisis dengan SPSS versi 21 untuk Windows.Hasil: Hasil penelitian menunjukkan terdapat perbedaan yang bermakna antara usia dan Indeks Masa Tubuh (IMT) pasien kelompok osteosarkoma dengan osteomielitis (p<0,05). Didapatkan perbedaan yang bermakna dari semua parameter yang diuji, namun parameter lactate dehydrogenase dan prokalsitonin dinilai yang paling sensitif dan spesifik dalam membedakan kedua penyakit tersebut (p<0,05). Titik potong 840 U/L untuk LDH dan 0.465 ng/mL untuk PCT terbukti memiliki tingkat sensitivitas sebesar 92.5% dan spesifisitas 100% dengan nilai AUC 0,963 (P=0,05).Kesimpulan: Pemeriksaan kadar lactate dehydrogenase dan prokalsitonin terbukti dapat membedakan osteomielitis dan osteosarkoma pada awal proses penyakitnya, sehingga terapi dapat dilakukan lebih dini.
Pemberian kombinasi kalsium dengan asam askorbat meningkatkan kadar bone alkaline phosphatase dan osteocalcin serum dibandingkan kombinasi kalsium dengan vitamin D3 pada patah tulang panjang paska fiksasi internal di RSUP Sanglah, Bali, Indonesia Ni Made Puspa Dewi Astawa; I Ketut Siki Kawiyana; Ketut Gede Mulyadi Ridia; Putu Astawa; I Ketut Suyasa; I Wayan Suryanto Dusak; I Gede Eka Wiratnaya
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (289.243 KB) | DOI: 10.15562/ism.v11i3.785

Abstract

Background: It is expected that supplementation will be able to satisfy the needs of calcium as well as improve the process of fracture healing. The goal of this study is to show the efficacy of calcium and ascorbic acid (vitamin C) combination supplements in fracture bone healing compared to calcium and vitamin D3.Methods. This study is a randomized clinical trial involving 30 patients with long bone fractures of the lower extremity who have undergone internal fixation and are split into two classes. The calcium carbonate-ascorbic acid regiment combination was given to one group, while the calcium carbonate-vitamin D3 regiment was given to the other group. The effect of the regiment was tested on serum calcium, bone alkaline phosphatase (BAP) and osteocalcin (OC) levels. The findings were compared and interpreted statistically by SPSS version 21 for Windows.Results. Administration of calcium carbonate and ascorbic acid combination was be able to increase serum calcium significantly (p = 0.00, 95% CI = 0.59 – 0,87), but not as strong as combination of calcium carbonate with vitamin D3. An increased level of serum BAP and OC was found significantly higher in calcium carbonate and ascorbic acid supplementation group (p value = 0,033, CI -4,18 – -0,19 for BAP, p value = 0,04, CI -2,25 – -0,49 for OC).Conclusion. The administration of calcium carbonate and ascorbic acid combination supplement increases the serum calcium level, but not as strong as calcium carbonate and vitamin D3 combination.  Latar Belakang: Pemberian suplemen diharapkan mampu untuk memenuhi kebutuhan kalsium sekaligus mempercepat proses penyembuhan patah tulang. Penelitian ini bertujuan untuk mengetahui keefektifan suplemen kalsium dan asam askorbat (vitamin C) dalam penyembuhan tulang pasca patah tulang dibandingkan pemberian suplemen kalsium dan vitamin D3.Metode: Penelitian ini merupakan uji klinis terandomisasi yang melibatkan 30 pasien patah tulang panjang ekstremitas bawah pasca fiksasi internal yang kemudian dibagi menjadi dua kelompok. Satu kelompok diberikan suplemen kombinasi kalsium karbonat-asam askorbat sedangkan kelompok lainnya diberikan kombinasi kalsium karbonat-vitamin D3. Efeknya terhadap kadar serum kalsium, bone alkaline phosphatase (BAP), dan osteocalcin (OC) kemudian diperiksa dan dibandingkan antara kadar sebelum dengan setelah perlakuan. Analisis statistik dilakukan dengan SPSS versi 21 untuk Windows.Hasil: Pemberian kombinasi kalsium karbonat-asam askorbat mampu meningkatkan serum kalsium secara bermakna (p=0.00, IK 95% = 0.59 – 0,87), namun tidak lebih kuat dibandingkan kombinasi kalsium karbonat-vitamin D3. Peningkatan kadar BAP dan OC juga ditemukan lebih tinggi secara bermakna pada kelompok dengan suplementasi kalsium karbonat-asam askorbat (nilai p 0,033 IK -4,18 – -0,19 untuk BAP, nilai p = 0,04, IK -2,25 – -0,49 untuk OC) apabila dibandingkan dengan suplementasi kalsium karbonat-vitamin D3.Simpulan: Pemberian kombinasi kalsium karbonat dan asam askorbat terbukti dapat meningkatan kadar serum kalsium, namun tidak sekuat pada kombinasi kalsium dan vitamin D3.
Differences in union time, dash score and range of motion between giving bisphosphonate and without giving bisphosphonate of osteoporosis patients with distal radius fracture: a systematic review and meta-analysis Dwiwahyonokusuma Dwiwahyonokusuma; Putu Astawa; I Wayan Suryanto Dusak; I Ketut Suyasa; Made Bramantya Karna
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (457.559 KB) | DOI: 10.15562/ism.v12i1.894

Abstract

Background: Osteoporosis is a common health problem. Meanwhile, the incidence of distal radius fracture increases with osteoporosis. The standard modality for osteoporosis is a combination of pharmacological therapy, one example of which is the administration of bisphosphonates. There is some disagreement about bisphosphonates' effect on the treatment of distal radius fractures in osteoporosis patients. This study aims to conclude the effect of bisphosphonates for this condition on both functional and radiological outcomesMethods: A systematic search was carried out on the PUBMED database and Google Scholar on studies comparing the timing of bone fusion, Disability of Arm, Shoulder, And Hand (DASH) scores, and wrist Range of Motion (ROM) among distal radius fracture patients with or without additional bisphosphonate therapy. A prospective or retrospective cohort study and a randomized controlled trial were included in this study during 2000-2020. Inclusion and exclusion criteria were used for sample selection. Weight Mean Difference (WMD) was used to assess the statistical results in RevMan version 5.3 for Windows.Results: A search through the PUBMED and Google Scholar databases yielded 376 studies. Scanning titles and abstracts from studies that met the inclusion and exclusion criteria resulted in 6 articles. In total, there were 973 patients with distal radius fractures who received different treatment on bisphosphonate therapy. There was a significant difference in time to union with bisphosphonates (WMD=0.56; 95% CI=-0.94-2.06). Meanwhile, there was no significant difference in the assessment of DASH and ROM scores (WMD=0.27; 95% CI= -1.01-1.55).Conclusion Bisphosphonates provide a slower time to union in osteoporotic patients with distal radius fracture.
The use of compression stockings produces lower Interleukin-6 (IL-6) levels, Higher American Orthopaedic Foot and Ankle Society Score (AOFAS), and does not produce higher alkaline phosphatase level in postoperative patients with fracture around the ankle Gede Agung Krisna Yudha; I Ketut Siki Kawiyana; Ketut Gede Mulyadi Ridia; I Ketut Suyasa; I Gede Eka Wiratnaya
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (237.333 KB) | DOI: 10.15562/ism.v12i1.895

Abstract

Background: Fractures around the ankles are common injuries. The use of compression stockings is one of the postoperative modalities that has been widely used in developing countries but is rarely used in Indonesia. This study aimed to determine the effect of using compression stockings on changes in inflammatory biomarkers level and functional outcomes in postoperative patients with fractures around the ankle.Methods: This study was a randomized clinical trial (post-operative-only design) in 26 patients with fractures around the ankle. The study subjects were divided into groups using postoperative compression stockings and groups without compression stockings. Its efficacy was assessed by measuring levels of Interleukin-6 (IL-6), Alkaline Phosphatase (ALP), and American Orthopedic Foot and Ankle Society (AOFAS) scores. Data were analyzed using SPSS version 20 for Windows.Results: Postoperative 24-hour IL-6 levels were not significantly different (p=0.200; -59.93–266.42), but they were significantly different postoperatively in 3 days (p = 0.001; 8.76-30.21), 14 days (p=0.015; 2.40-20.49), and 30 days (p=0.000; -15.49–[-5.03]). ALP was not different significantly, both at 24 hours (p=0.160; -16.0-2.80), 3 days (p=0.072; -0.65-14.19), 14 days (p=0.098; -1,310–12,54), and 30 days (p=0.419; -5.00–11.61) after surgery. The AOFAS scores was different significantly 30 days postoperatively (p=0.000; -3.915– [-1.469]).Conclusion: The use of compression stockings can be considered as postoperative therapy to lower the IL-6 levels but do not affect ALP levels in postoperative patients with fractures around the ankle. The use of compression stocking resulted in a higher AOFAS score than without wearing compression stockings in postoperative patients with fractures around the ankle.
Laminoplasty provides better functional outcomes than laminectomy in the management of cervical stenosis myelopathy: a systematic review Putu Kermawan; I Ketut Siki Kawiyana; I Gusti Ngurah Wien Aryana; I Gusti Lanang Ngurah Agung Artha Wiguna; I Gede Eka Wiratnaya; I Ketut Suyasa
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (297.207 KB) | DOI: 10.15562/ism.v12i1.896

Abstract

Background: Increasing the life expectancy of an individual will be accompanied by the emergence of various degenerative diseases such as cervical stenosis myelopathy (CSM). CSM is characterized by the presence of signs and symptoms of spinal cord compression associated with narrowing the spinal canal dimensions. Decompression can be achieved by conventional methods such as laminectomy or a lamina reshaping procedure known as a laminoplasty. This study reports recent evidence regarding laminectomy and laminoplasty procedures in managing CSM in terms of functional outcomes.Methods: A systematic search was conducted on the PUBMED database to identify and find studies comparing laminoplasty and laminectomy procedures. Inclusion criteria included patients older than 65 years diagnosed with cervical myelopathy, including CSM and/or ossified posterior longitudinal ligament (OPLL). Randomized controlled studies and prospective and retrospective cohorts were included in this study, while case series and case reports were excluded. The comparison of effectiveness is based on the results of measuring functional outcomes using the Japanese Orthopedic Association (JOA) score, neck disability index (NDI), and the visual analogue scale (VAS) for pain assessment.Results: A thorough search through the PUBMED database yielded 156 citations. Scanning titles and abstracts from studies that met the inclusion and exclusion criteria resulted in 14 articles. All articles have a retrospective cohort design. In total, there were 187 patients in the laminoplasty group and 161 patients in the laminectomy group. There was no significant difference between laminoplasty and laminectomy when viewed from the JOA score in weighted mean difference (WMD) (WMD 0.28; 95% Confidence Interval [CI]:-0.34-0.91) and VAS score (WMD 0.06; 95% CI: -1.13-1.02). However, laminoplasty was shown to have a better NDI score (WMD 3.32; 95% CI: -6.50-0.14).Conclusion: Laminoplasty is superior to laminectomy for managing cervical myelopathic stenosis in terms of NDI score.
Risk factors of superficial surgical site infection post debridement and internal fixation of open fractures in long bones at Sanglah General Hospital, Bali, Indonesia Stedy Adnyana Christian; Putu Astawa; I Ketut Suyasa
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (284.878 KB) | DOI: 10.15562/ism.v12i1.897

Abstract

Background: The fracture condition exposed to the environment can damage muscle, vascular, and nerve tissue due to infection. This study aims to determine whether age, Hb, OF grade II, duration and surgery time are risk factors of superficial surgical site infection for post-debridement and internal fixation in long bone fractures.Methods: This study used cohort retrospective. Samples of patients with open long bone fractures at Sanglah Denpasar from February to July 2020 were assessed for their risk factors for infection based on secondary data from medical records, physical and laboratory examinations. Monitoring for infection incidence was performed 1-4 weeks postoperatively, based on clinical and infection markers (Procalcitonin). After that, descriptive and inferential statistical analysis was performed using the Chi-square test and Logistic Regression using SPSS version 24 for Windows.Results: Hb level < 10 g/dLwas proven to be a risk factor (p=0.027). There was a significant difference in patients with grade II  (p=0.049; RR=10.00). There was a significant difference in the risk with patients with surgery duration ? 2 hours (p=0.011; RR=15). There was a significant difference in the patients with time to operation ? 12 hours (p=0.005; RR=8). Logistic Regression Test proves that the most influencing factor for superficial surgical site infection is operation duration (RR=9.328).Conclusion: Hb, OF grade II, duration, and time to operation are risk factors of superficial surgical site infection for post-debridement and internal fixation in open fractures of the long bone. The most important risk factor for superficial surgical site infection is the duration of surgery.
Co-Authors A. Salim Aakash Aakash Adler Manurung Agus Frandes Sariaman Anak Agung Gde Yuda Asmara Anak Agung Wiradewi Lestari Aryana, I Gusti Ngurah Wien Bahtiar Usman, Bahtiar Christopher Ryalino Dharmayuda, Cokorda Gde Oka Dwiwahyonokusuma Dwiwahyonokusuma Eka Wiratnaya Febyan Gede Agung Krisna Yudha Gede Ketut Alit Satria Nugraha Gede Parta Kinandana Ghanaputri, Made Maharani Calistha Giri, Kadek Gede Bakta Gunawan, Dary Herryanto Agustriadi Simanjuntak I Gede Eka Juli Prasana I Gede Ratnaya I Gusti Lanang Ngurah Agung Artha Wiguna I Gusti Ngurah Pramartha Wijaya Putra I Gusti Ngurah Wien Aryana I Made Ady Wirawan I Made Krisna Dinata I Nyoman Adi Putra I Nyoman Mangku Karmaya I Putu Adiartha Griadhi I Wayan Subawa I Wayan Suryanto Dusak Ivander Purvance Jonathan Pratama Swannjo Ketut Gede Mulyadi Ridia Ketut Siki Kawiyana Komang Indra Teguh Wisesa Komang Septian Sandiwidayat L.G.M. Gutama Luh Putu Ratna Sundari M.R.S. Devinta Made Bramantya Karna Made Priska Arya Agustini Made Wirabhawa Mario Daniel Simatupang Muhammad Irfan Muliarta N.M. Jaya Ni Made Puspa Dewi Astawa Pradnyani, Ni Putu Novita Putu Astawa Putu Indah Budi Apsari Putu Kermawan Sitranata, Madeline Juliand Sri Maliawan Stedy Adnyana Christian Tamzil, Kezia Aurelia Vidyaputra T.A. Wahyuddin Wahyuddin, Wahyuddin Wibowo T Wiguna I G.L.N.A.A Wiratnaya, Gede Eka Yuda Asmara, Anak Agung Gde Yudhi I GN