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All Journal Reaktor SAINS DAN MATEMATIKA JURNAL KIMIA SAINS DAN APLIKASI Jurnal Ilmu Lingkungan Alchemy : Journal of Chemistry Indonesian Journal of Cancer Chemoprevention Alchemy Jurnal Penelitian Kimia Indonesian Journal of Chemical Science Akta Kimia Indonesia Indonesia Journal of Halal Molekul: Jurnal Ilmiah Kimia Journal of Telenursing (JOTING) International Journal Of Science, Technology & Management (IJSTM) Greensphere: Journal of Environmental Chemistry Prosiding Seminar Nasional Universitas Serambi Mekkah Jurnal Riptek International Journal of Cell and Biomedical Science
Meiny Suzery
Department Of Chemistry, Diponegoro University, Jl. Prof. Soedarto, Kampus Undip Tembalang, Semarang 50275
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Journal : International Journal of Cell and Biomedical Science

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Application of Bioinformatics Analysis to Identify Important Pathways and Hub Genes in Breast Cancer Affected by HER-2 Tjipta, Arya; Hermansyah, Dedy; Suzery, Meiny; Cahyono, Bambang; Amalina, Nur Dina
International Journal of Cell and Biomedical Science Vol 1 No 1 (2022)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v1i1.11

Abstract

Human epidermal growth factor receptor 2 (HER-2) is used as a marker for the diagnosis and prognosis of breast cancer. However, the molecular mechanisms involving HER2 in breast cancer require further study. Herein, we used the bioinformatics approaches to identify important pathways and hub genes in breast cancer affected by HER-2. The results showed that HER-2 is highly expressed in ovarian cancer and is closely related to the overall survival and progression-free survival of breast cancer. A total of 3014 downregulated genes and 4121 upregulated genes were identified under Gene Expression Omnibus (GEO) database with the GEO2R tool. Among them, the top 10 hub genes including CCNB1, KIF11, BUB1B, TOP2A, ASPM, MAD2L1, BUB1, RRM2, EGFR, and FN1 demonstrated by connectivity degree in the protein-protein interaction (PPI) network were screened out. In Kaplan–Meier plotter survival analysis, the overexpression of CCNB1, EGFR, MAD2L1, ASPM, and RRM2 were shown to be associated with an unfavourable prognosis in HER-2 positive breast cancer patients. In conclusion, we have identified important signalling pathways involving HER-2 that affect breast cancer. These findings could provide new insights outlining mechanisms involving HER-2 gene expression in breast cancer and provides a rationale for the novel treatment of breast cancer.
Co-Authors . Widayat A.A. Ketut Agung Cahyawan W Agustini, Dewi Meliati Ahmad Ni’matullah, Albaari Al-Baarri, Ahmad Ni'matullah Al-Baarri, Ahmad Ni’matullah Amalina, Nur Dina Aminin, Agustin L.N. Bambang Cahyono Budianto, Irawan Arief Burhan Nudin Christiana Suci Prihatini Citra Agustina Isnaning Damar Nurwahyu Bima Dedy Hermansyah Dwi Hudiyanti Elvira Yunita Ely Kusniawati H Hadiyanto Hadiyanto Hadiyanto Hantoro Satriadi Hendarko, Sriani Hendra Try Ardianto Iqbal Mubarak Irawan Arif Budianto Ismiyarto Ismitarto Kurdianto Kurdianto M Cholid Djunaidi, M Cholid M. Cholid Djunaidi Maria Eka Patri Y Marini . Merry Gultom Nazli, Nazli Neni Susilaningsih Nike Rizky Prahesti, Nike Rizky Priyosetyoko Priyosetyoko, Priyosetyoko Pusaka, Semerdanta Putri Pratiwi Putri, Adhina Choiri Raisi Aga Oktavi Sestri Bela Pratiwi Suhartono, Suhartono Sulistyowati Sulistyowati Suradi, Agus Sylvia Rahmi Putri Tjipta, Arya Tri Winarni Agustini Tri Winarni, Agustini Widayadi, Eko YS Darmanto Yuliyandjaja, John Philia Yusi Luluk, Rahmania Zainal Arifin Zhafran Hafizhki