Article Per Year (5 Year)
p-Index From 2021 - 2026
2.59
P-Index
This Author published in this journals
All Journal ACTA VETERINARIA INDONESIANA BALI MEDICAL JOURNAL (BMJ) Medicina Buletin Udayana Mengabdi E-Jurnal Medika Udayana Jurnal Veteriner Indonesian Journal of Tropical and Infectious Disease The Indonesian Biomedical Journal Syntax Literate: Jurnal Ilmiah Indonesia ISM (Intisari Sains Medis) : Jurnal Kedokteran Indonesian Community Empowerment Journal Jurnal Ilmu Multidisplin
I Kadek Swastika
Departemen Parasitologi, Fakultas Kedokteran Universitas Udayana
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Veterinary Other

Published : 44 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : The Indonesian Biomedical Journal

 1 
Ethanol Extract of Spondias pinnata Leaves Reduce Parasite Number and Increase Macrophage Phagocytosis Capacity of Mice Infected by Plasmodium berghei Dewa Ayu Agus Sri Laksemi; I Gusti Kamasan Arijana; I Made Sudarmaja; Ni Luh Ariwati; Ketut Tunas; Putu Ayu Asri Damayanti; Ni Luh Putu Eka Diarthini; I Kadek Swastika; Ida Ayu Dewi Wiryantini
The Indonesian Biomedical Journal Vol 13, No 1 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i1.1286

Abstract

BACKGROUND: Currently, there is no vaccine against malaria in humans, the development of resistance to anti-malarial drugs, causing the need to find new alternatives to overcome malaria infections. This study aimed to determine effect of Spondias pinnata in increasing cellular immunity, especially phagocytosis activity of peritoneal macrophages against Plasmodium berghei infection.METHODS: This was an experimental study with two stages of research, each stage requires 36 Balb/c mice, aged 2 months and weight 20-25 grams. After one week of acclimatization, the mice were put into 6 different groups, each group consisted of 6 mice. The negative control was a group of mice given distilled water for 14 days then infected by P. berghei in the 15th day. Meanwhile, T1, T2, T3, T4 and T5 groups were given S. pinnata leaves ethanol extract with dose of 25, 50, 100, 200 and 400 mg/kg body weight (BW)/day, respectively, and then infected by P. berghei in the 15th day.RESULTS: The results showed that the lowest parasitemia and the highest capacity of macrophage to phagocytose latex was found in treatment group T3 that received 50 mg/kg BW of S. pinnata leaves ethanol extract. Based on analysis of the Pearson correlation test, there was a significant correlation between percent phagocytosis and parasitemia (p<0.05).CONCLUSION: Ethanol extract of S. pinnata leaves lower the parasite number of P. berghei in Balb/c mice and increase the capacity of macrophage to phagocytose latex. However, the mechanisms of how S. pinnata leaves extract in activating phagocytosis capacity and reducing parasitemia still need further investigation.KEYWORDS: phagocytosis, Plasmodium berghei, parasite number, Spondias pinnata
Co-Authors Abdul Karim Abdulhadi FA Adiputra, I Komang Hotra Akira Ito Anak Agung Ayu Mirah Adi Ariwati, Luh Ariwati, Ni Luh Cokorda Agung Wahyu Purnamasidhi Damayanti, Putu Asri Daondy Friarsa Soeharto Dewa Ayu Agus Sri Laksmi Divya Nirmala, Putu Ayu Fitri N, Moh. Yasin Fuad Adi Rosyadi Hartanto, Erlin Veronica Hidajati, Sri I Gede Mahardika I Gusti Agung Ayu Chintya Cahyarini I Gusti Agung Dwi Putri Anjani I Gusti Kamasan Arijana I Ketut Tunas I Made Damriyasa I Made Dwinata I Made Putra I Made Sudarmaja I NYOMAN MANTIK ASTAWA I Putu Dodik Supartha Ida Ayu Dewi Wiryantini Ida Ayu Ide Larassanthi Pratiwi Ida Bagus Made Oka Ida Bagus Putra Adyatma Isyaputri, Rahmadany Ivy Cerelia Valerie Jevon Indra Susanto Jiriadana, Teenu Chandra Kadek Karang Agustina kumara, i made bagus bayu L. Ariwati Latifa, Kurnia Dwi Luh Ariwati Luh Dewi Anggreni Maretta Rosabella Purnamasari Maretta Rosabella Purnamasari Maria Krishnandita Munehiro Okamoto N.L Ariwati N.L.P.E. Diarthini Ni Luh Ariwati Ni Luh Ariwati Ni Luh Komang Sumi Arcani Ni Luh Putu Eka Diarthini Ni Luh Putu Eka Diarthini, Ni Luh Putu Eka Ni Made Pasmiati Setyaningsih Ni Nyoman Agustianingsih Ni Putu Akopita Devi Ni Putu Ayu Elistya Ning Purwani Ni Putu Tamara Bidari Suweta Nyoman Sadra Dharmawan P.A.A. Damayanti Pratisthita Sukadana, I Made Ananda Prajna Purantara, Anak Agung Gede Wiweka Winahya Putu Ari Paramitha Widiani Putu Ayu Asri Damayanti Putu Ayu Larasati Putu Bagus Onicha Baskaranatha Putu Sutisna Sari, Komang Ayu Kartika Shabrina Inderjit Stan ley Sukmawati Basuki Toni Wandra Upik Mutiara Wulanyani Wulanyani