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All Journal International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Althea Medical Journal Indonesian Journal of Rheumatology Majalah Kedokteran Neurosains Medica Hospitalia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Anna Tjandrawati
Department Of Clinical Pathology, Faculty Of Medicine, Padjadjaran University/Dr. Hasan Hasan Sadikin Hospital, Bandung
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Interleukin-6 Level and Neutrophil-Lymphocytes Ratio and Severity of Coronavirus Disease 19 Latifah, Armina; Parwati, Ida; Tjandrawati, Anna; Suraya, Nida
Majalah Kedokteran Bandung Vol 56, No 1 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3039

Abstract

Interleukin-6 (IL-6) is a proinflammatory cytokine that plays an important role in hyperinflammation and cytokine storm in Coronavirus Disease 19 (COVID-19) patients. The neutrophil-lymphocyte ratio (NRL) describes the innate and adaptive immune responses. Elevated IL-6 and NLR levels usually indicate a severe clinical condition in COVID-19 patients. Aim of this study was to determine the correlation of IL-6 and NLR with the severity of illness in COVID-19 hospitalized patients. This was a descriptive correlative observational study with a cross-sectional design using secondary data from COVID-19 patients treated in Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, from November 2020 to October 2021. There were 225 subjects who were classified by the severity and analyzed for IL-6 levels and NLR. Median levels of IL-6 at moderate, severe, and critical levels were 4.1 pg/mL, 20.4 pg/mL, and 38.8 pg/mL, respectively. The median NLR at moderate, severe, and critical grades were respectively 4.41, 9.65, and 17.79. The correlation between IL-6, NLR, and severity was 0.441 (p<0.001) and 0.408 (p<0.001). Meanwhile, the correlation between IL-6 levels and NLR in COVID-19 was 0.230 (p<0.001). Thus, IL-6 and NRL levels have a moderate positive correlation with the severity of COVID-19, while IL-6 and NRL have a weak correlation because IL-6 is not the only factor that affects the NRL.
Correlation of Mac-2 Binding Protein Glycosylation Isomer (M2BPGi) with Liver Transient Elastography Results: An Evaluating Liver Fibrosis in Chronic Hepatitis B Patients Haryono, Haryono; Bestari, Muhammad Begawan; Agustanti, Nenny; Girawan, Dolvy; Wahyudi, Yudi; Abdurachman, Siti Aminah; Tjandrawati, Anna
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 1 (2023): VOLUME 24, NUMBER 1, April, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/241202312-22

Abstract

Background: Transient elastography (TE) is widely recognized as a reliable surrogate marker for grading the severity of liver fibrosis in chronic hepatitis B (CHB) patients. Mac-2 binding protein of glycosylation isomer (M2BPGi) is a novel non-invasive serum biomarker for liver fibrosis staging in various liver diseases, including CHB. This study aimed to evaluate the correlation of M2BPGi and liver stiffness (LS), as measured through TE, in predicting the degree of liver fibrosis in CHB patients.Methods: A cross-sectional study was conducted at Dr. Hasan Sadikin General Hospital, Bandung, between September 2021 and January 2022. The study included patients diagnosed with chronic hepatitis B (CHB) based on clinical and biochemical assessments. All subjects underwent TE examination using Fibroscan®, and the M2BPGi levels were determined with an automated immunoassay analyzer HISCL-800, Sysmex, Japan. Statistical analysis was conducted using the Spearman rank correlation method, with a significance value of p0.05.Results: A total of 119 patients with chronic hepatitis B (CHB) were consecutively recruited (Male:Female = 66:53; median age: 43 years). The median M2BPGi level was 1.04 COI (range: 0.74–1.59), while the median liver stiffness (LS) was 7.3 kPa (range: 5.6–12.5). A moderate and statistically significant correlation was observed between M2BPGi and LS (r = 0.525; p 0.001). Median M2BPGi values by fibrosis stage were 0.89 COI for F0–F1, 0.88 for F2, 1.61 for F3, and 2.24 for F4 (p 0.001).Conclusion: This study revealed a moderate positive correlation between serum M2BPGi level and LS in CHB patients.
Autoantibody Profile and Lung HRCT Scan in Systemic Sclerosis with Restrictive Lung Disease Saragih, Winda Agnestia Maranna; Dewi, Sumartini; Wachjudi, Rachmat Gunadi; Logito, Verina; Tjandrawati, Anna
International Journal of Integrated Health Sciences Vol 11, No 1 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v11n1.3020

Abstract

Objective: To identify auto-antibodies in systemic sclerosis with interstitial lung disease (ILD). Method: This was a descriptive categorical study on auto-antibody profile in systemic sclerosis patients visiting the Rheumatology Clinic of Dr. Hasan Sadikin General Hospital, West Java, and Bandung during the period of January 2018 to December 2019 who were registered in the West Java Systemic Sclerosis Registry. Auto-antibody identification was performed using the Euroline immunoblot assays.Results: Thirty six cases were identified during the study period with most of the cases involved women (n=35, 97.2%). The average age of patients participating in this study was 40 years, with an average duration of disease of 18 months. Diffuse cutaneous systemic sclerosis was found in 22 (61.1%) cases and limited cutaneous systemic sclerosis was observed in 14 (38.9%) cases. Specific autoantibodies were positive in 33 (91.6%) cases, with anti-topoisomerase I as the largest group, positive in 22 (52.9.3%) cases. This was followed by anti-Th/To in eight (15.7%) cases; anti-Ro52 in four (7.8%) cases; anti-centromere in three (5.9%) cases; anti-RNA polymerase in three (5.9%) cases; anti-fibrillarin in three (5.9%) cases; anti-Ku in two (3.9%) cases; and anti-PDGF in one (2.0%) case. High-resolution computed tomography of the lung showed 34 (94.4%) cases with ILD and 22 (61.1%) cases with severe lung fibrosis. Usual interstitial pneumonia was seen in 19 (52.8%) cases and non-specific interstitial pneumonia in 15 (41.7%) cases.Conclusion: Anti-topoisomerase I, anti-Th/To, and anti-Ro52 are the most common autoantibodies observed in systemic sclerosis patients with ILD as the most prevalent feature detected with lung HRCT.
Co-Authors Bethy S. Hernowo Chakrawati Hayuningsih Coriejati Rita Dewi Kartika T Dewi Kartika Turbawaty Dewi, Sumartini Dolvy Girawan Efriyani, Yuhpita Indah Elsa Yulius Emmy Hermiyanti Pranggono Erna Jupri Hartanto Bayuaji Haryono Haryono Ida Parwati Ivana Dewi Ivana Dewi Juan Achmad Yudistira Kurnia Pramono, Laila Laniyati Hamijoyo, Laniyati Latifah, Armina Leni Lismayanti Leni Lismayanti Lidya Chaidir Linda Choerunnisa Logito, Verina Maman Abdurahman Maria Enrica Mike Rezeki Muhammad Begawan Bestari Nadjwa Zamalek Dalimoenthe Nadjwa Zamalek Dalimoenthe Nenny Agustanti Nenny Gustiani Nida Suraya Nida Suraya Nida Suraya Nina Tristina Primal Sudjana Putri Vidyaniati Rachmat Gunadi Wachjudi Raja Iqbal Mulya Harahap Rizki Dumpatna Saragih, Winda Agnestia Maranna Siti Aminah Abdurachman Stefanie Yuliana Usman Sylvia Rachmayati Tiene Rostini, Tiene Toha Sapari Usman, Stefanie Yuliana Verina Logito Yudi Wahyudi Yudistira, Juan Achmad