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All Journal Dentika Dental Journal STOMATOGNATIC- Jurnal Kedokteran Gigi ODONTO Dental Journal Dentino: Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Odonto dental journal
Iin Eliana Triwahyuni
Faculty Of Dentistry, University Of Jember, Jember, Indonesia
Dentistry Health Professions Medicine & Pharmacology

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Journal : ODONTO Dental Journal

 1 
Bay Leaf Extract Aggravated Fungal Infections in The Rat Model of Oral Candidiasis. Sulistyani, Erna; Triwahyuni, Iin Eliana; Dewi, Leni Rokhma; Futaihana, Hasna' Garaniva; Andriani, Hilma; Agustin, Merry Ayu Ayu; Khairunnisa, Luthfitah Zahra
Odonto : Dental Journal Vol 12, No 2 (2025): August 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.2.136-142

Abstract

Background: The prevalence of oral candidiasis has been increasing in recent years due to various factors, such as diseases that weaken the immune system, medication, xerostomia, and chemotherapy. The types of antifungal drugs are still very limited, and those that can be given systemically have significant side effects. Numerous in-vitro studies have demonstrated that bay leaves have antifungal properties. This study aimed to evaluate the effect of bay leaf extract in vivo on the oral candidiasis rat model.Method: The rat model for oral candidiasis was created by adding Tetracycline HCl 500 mg/L to the rats' drinking water. Then, the rats were injected with methylprednisolone one day before and after inoculating 0.3 ml of Candida albicans (9.4 x 107 cells/ml) into the oral cavity of the rats. The bay leaf extract was given to two groups of the oral candidiasis rat model by intragastric tube at 250 mg/kgBW/day (P1) and 500 mg/kgBW/day (P2)  doses for 5 days.  Oral candidiasis infection was evaluated on the last day by counting the number of colonies from swabs of the oral mucosa cultured on SDA-C. Result: After 5 days of treatment, the number of fungal colonies of group P2 was surprisingly higher than P1, positive and negative control. Conclusion: This study revealed that bay leaf extract aggravated oral candidiasis in vivo. The flavonoids in bay leaves may inhibit the production of pro-inflammatory cytokines, which could diminish the rats' immune response.
Evaluation of rat model oral candidiasis mucosal response immune Sulistyani, Erna; Triwahyuni, Iin Eliana; Harmono, Happy; Sholehah, Almaratus; Prameswari, Syefira Putri; Mayangsari, Zahra; Perwitasuci, Brigitta Damai; Wulandari, Widya Nurfitriastuti
Odonto : Dental Journal Vol 10, No 2 (2023): December 2023
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.10.2.172-179

Abstract

Background: The choice of antifungal drugs is limited and has not yet made significant progress. The animal model of oral candidiasis is a crucial factor in exploring antifungals. In our previous study's oral candidiasis rat model, we found an increase in the sedimentation rate and a decrease in infection microbiologically and histologically on day 8 compared to day five after inoculation. On the other hand, blood plasma levels of IL-17, as the main cytokine in fungal infections, keep at a low level. The study aims to prove the increase in the immune response in the oral mucosa of an oral candidiasis rat model on the 8th day after inoculation of C. albicans. Methods: The sample consisted of 2 groups; healthy Wistar rats as a control and Wistar Rat rats treated as an oral candidiasis rat model. Eight days after inoculating C. albicans,The immune response was evaluated by counting the number of visual field inflammatory cells on the dorsum of the rat dorsum tongue.Results: The number of inflammatory cells, including macrophages in the dorsal tongue mucosa of oral candidiasis rats, was higher than that of healthy rats. Conclusion: There was an increase in the number of inflammatory cells in the dorsum of the tongue mucosa of the oral candidiasis rat model on day 8, which is a sign of an increased immune response in the experimental animal model.
THE CYTOTOXIC AND PROLIFERATIVE ACTIVITY OF COCOA POD HUSK EXTRACT (THEOBROMA CACAO L.) ON PERIODONTAL LIGAMENT FIBROBLASTS Rahayu, Yani Corvianindya; Triwahyuni, Iin Eliana; Kusumawardani, Banun; Sari, Dewi Yunita
Odonto : Dental Journal Vol 9, No 1 (2022): July 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.9.1.46-52

Abstract

Background: Theobroma cacao was considered agricultural wastes. Cocoa pod husk contain various bioactive compounds as natural antioxidants,antibacterial and anti-inflammatory. A good biomaterial must be non-toxic and have no detrimental effect on the biological environment. The aim of research was to determine the cytotoxicity and proliferative activity of cocoa pod husk extract on primary cells of periodontal ligament fibroblasts. Method: This experimental laboratory used primary cell culture of periodontal ligament fibroblasts. The cytotoxicity and proliferative activity were analyzed by MTT assay [2-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide]. Extraction of cacao pods were obtained using the ultrasonic homogenizer method with ethanol 70%. The cytotoxicity test was observed for 24 hours and the doubling time proliferative test was observed for 24, 48, and 72 hours. Result: Cocoa pod husk extract showed there were no cytotoxic effects with viability of primary cells of periodontal ligament fibroblasts at the concentration of 1.56 pg/ml, 3.125 pg/ml, 6.25 pg/ml, 12.5 pg/ml, 25 pg/ml, 50 pg/ml, and 100 pg/ml. The proliferation test showed increasing of fibroblasts at 24 and 48 hours. Kruskal Wallis analysis obtained a significance value (p<0.05) Conclusion: Cytotoxicity and proliferation assays of Cocoa pod husk extract increased cell viability and cell proliferation of periodontal ligament fibroblast.
Median rhomboid glossitis as a sign of undiagnosed diabetes mellitus - a case report Sulistyani, Erna; Triwahyuni, Iin Eliana; Astuti, Pudji; Swandari, Rindang
Odonto : Dental Journal Vol 10, No 1 (2023): July 2023
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.10.1.7-13

Abstract

Background: Median Rhomboid Glossitis (MRG) is included in the group of nodular-plaque-like candidiasis, a subtype of chronic hyperplastic candidiasis. A lot of literature suggests that MRG is a manifestation of Diabetes Mellitus (DM), but the association between DM and MRG is unclear until now. This article reports an MRG found in an undiagnosed diabetes mellitus patient. Case: In October 2019, A 71-year-old man came to RSGM Universitas Jember to fix his loose denture. In the oral examination, we found a well-bordering, atrophic oval area surrounded by thick- soft white plaque. In his leg, we found itchy papule, ulcer, and crust multiple lesions. The microscopic examination of the white plaque swab showed that the spore and hyphae were found to fill all fields of view. The direct sugar blood level test showed that the sugar blood level was 390 mg/dL. We diagnosed the patient as having an MRG associated with suspected DM. Case Management: The patient was given miconazole oral gel and recommended to use it after cleaning the tongue three times a day. For diabetes management, the patient was referred to the Unit Medical Center University of Jember. The patient was diagnosed with diabetes mellitus and given oral-antidiabetics. After two weeks, the atrophic area had improved, and the white plaque had disappeared. Conclusion: General practitioners must be aware if they find the MRG in their patients caused a probability of underlying undiagnosed systemic disease, particularly diabetes mellitus on them.
Co-Authors Agustin, Merry Ayu Ayu Ainunnusak Ayuningtyas Andriani, Hilma Banun Kusumawardani Dewi Yunita Sari Dewi, Leni Rokhma Dyah Indartin Setyowati Dyah Setyorini Erna Sulistyani Futaihana, Hasna' Garaniva Happy Harmono Khairunnisa, Luthfitah Zahra Leni Rokhma Dewi Leni Rokhma Dewi Lisa Miftakhul Janna Mahardiani Dwi Astanti Mayangsari, Zahra Melok Aris Wahyukundari Muchamad Ziyad Afif Nindita Cahya Mumpuni Novia Dyah Rahma Dhani Perwitasuci, Brigitta Damai Prameswari, Syefira Putri PUDJI ASTUTI Pujiana Endah Lestari Safira Zahra Marari Saikha Adila Azzah Sholehah, Almaratus Sri Hernawati Swandari, Rindang Wulandari, Widya Nurfitriastuti Yani Corvianindya Rahayu Zainul Cholid