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All Journal JURNAL PENDIDIKAN KEPERAWATAN INDONESIA Jurnal Kesehatan Medika Saintika Jurnal Ilmiah PANNMED (Pharmacist, Analyst, Nurse, Nutrition, Midwivery, Environment, Dentist) Jurnal Ners Journal of Telenursing (JOTING) Journal of Nursing and Public Health (JNPH) Jurnal Kesehatan Tambusai Jurnal Kesehatan Saintika Meditory Journal of Sciences and Health (JSH) Jurnal Pengabdian kepada Masyarakat Wahana Usada COVIT Jurnal Sains dan Teknologi Sehat Rakyat: Jurnal Kesehatan Masyarakat Journal of Artificial Intelligence and Digital Business KOLONI Jurnal Masyarakat Madani Indonesia Jurnal Ilmiah Kesehatan Mandira Cendikia
Rahmadani, Elsi
Program Studi Ilmu Keperawatan, STIKES Tri Mandiri Sakti Bengkulu
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Tinjauan Farmakogenomik dan Variasi Genetik Yang Mempengaruhi Respons Terapi Tuberkulosis Di Indonesia Rahmadani, Elsi Fitri; Aini, Putri Nur; Jayanti, Rena Dwi
RIGGS: Journal of Artificial Intelligence and Digital Business Vol. 4 No. 4 (2026): November - January
Publisher : Prodi Bisnis Digital Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/riggs.v4i4.3954

Abstract

Tuberkulosis (TB) masih menjadi salah satu masalah kesehatan masyarakat terbesar di Indonesia, terutama dengan tingginya beban kasus dan meningkatnya kejadian resistensi obat yang mengancam efektivitas terapi standar. Respons terhadap obat anti-tuberkulosis (OAT) dipengaruhi oleh interaksi kompleks antara faktor klinis, status imun pasien, kepatuhan pengobatan, serta variasi genetik baik pada host maupun Mycobacterium tuberculosis. Dalam beberapa tahun terakhir, farmakogenomik muncul sebagai pendekatan penting untuk memahami bagaimana polimorfisme genetik memengaruhi metabolisme obat, efektivitas terapi, serta potensi terjadinya toksisitas. Pada sisi patogen, mutasi pada gen katG, inhA, rpoB, embB, dan pncA telah diketahui berperan dalam mekanisme resistensi terhadap isoniazid, rifampisin, etambutol, dan pirazinamid, yang menjadi komponen utama regimen lini pertama. Di sisi host, variasi genetik seperti NAT2, SLCO1B1, CYP2E1, dan UGT1A1 berkontribusi terhadap perbedaan kecepatan metabolisme obat, distribusi farmakokinetik, dan kerentanan terhadap hepatotoksisitas yang sering menjadi penyebab penghentian terapi. Pemahaman yang lebih dalam terhadap kedua aspek genetik ini tidak hanya mendukung optimalisasi terapi yang lebih personal, tetapi juga berperan dalam strategi pencegahan resistensi lanjutan. Kemajuan teknologi, termasuk terapi gen dan gene editing, turut membuka peluang pengembangan pendekatan presisi dalam penatalaksanaan TB di masa depan. Dengan mengintegrasikan farmakogenomik, data genomik bakteri, serta informasi klinis pasien, pengobatan TB di Indonesia berpotensi menjadi lebih efektif, aman, dan berkelanjutan, sehingga memperkuat upaya nasional dalam menurunkan morbiditas, mortalitas, dan resistensi obat secara signifikan.
HUBUNGAN AKTIFITAS FISIK, RIWAYAT ORANG TUA DAN POLA MAKAN DENGAN KEJADIAN OBESITAS PADA ANAK DI SEKOLAH DASAR Elsi Rahmadani; Pawiliyah Pawiliyah; Novi Ade Suryani; Suryani Suryani
KOLONI Vol. 1 No. 1 (2022): MARET 2022
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/koloni.v1i1.437

Abstract

The number of overweight children aged 5-19 years has increased on every continent from 1990-2016, the highest was in the United States with a prevalence in 2016 of 41.86% (UNICEF, 2019). The purpose of this study was to determine the relationship between physical activity, and diets with the cases of obesity in children. The method used was an analytical research design with a cross sectional approach. The sample in this study was 52 school-age children in grades 4 and 5 at the State Elementary Islamic 2 in Bengkulu using a total sampling technique. This study used SPSS with a chi-square bivariate statistical test with a value of =<0.05. The results of univariate analysis that more than half of the respondents 51.9% or 27 respondents have moderate physical activity, more than half of the respondents 65.4% or 34 respondents have a pattern eat well, most of the respondents 71.2% or 37 respondents are not obese. The results of the bivariate analysis showed that there was a relationship between physical activity, and diets with the incidence of obesity in children at the State Elementary Islamic 2 in Bengkulu (p : 0.000). There is a relationship between physical activity, and diets with the cases of obesity in children at State Elementary Islamic 2 in Bengkulu (p: 0.000. The researcher suggests for schools to be more active in conducting counseling or education about childhood obesity. Keywords: physical activity, parental history, diet, obesity
PENINGKATAN PENGETAHUAN ANAK TENTANG KESEHATAN GIGI DAN MULUT MENGGUNAKAN MEDIA VIDEO ANIMASI Elsi Rahmadani; Siti Zulva; Melani Sri Cahyani; Yunisa Putri Damayani; Lesa Aprina Putri
Jurnal Kesehatan Medika Saintika Vol 17, No 1 (2026): Juni 2026
Publisher : Stikes Syedza Saintika Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jkms.v17i1.30830

Abstract

School-aged children, especially elementary school children, are vulnerable to dental and oral health problems, especially dental caries and cavities, and other oral problems. This is based on a lack of knowledge about the importance of dental and oral care. Animated video media is an educational tool that can be heard and seen, can help students in the teaching and learning process, and serves to clarify or facilitate understanding of the language being studied. This study aims to improve dental and oral knowledge using animated video media. This type of research is an experiment using a pretest and posttest group design on fourth-grade students at SDN X Bengkulu. Sampling was done by random sampling. The sample in this study was 33 fourth-grade students of SDN X Bengkulu. The data analysis technique used the Wilcoxon Sign Rank Test. The results of the study showed that there was an educational effect on knowledge about teeth and mouth using animated video media. The conclusion is that there was an educational effect on knowledge about teeth and mouth using animated video media at SDN Bengkulu. Keywords: Knowledge, Animated Video, Dental and Oral Health
Barriers and Facilitators to Inclusive Healthcare for Children with Developmental Disabilities: A Qualitative Study of Caregiver and Healthcare Provider Perspectives Rahmadani, Elsi; Miniharianti, Miniharianti; Ningsih, Dewi Aprilia
Jurnal Pendidikan Keperawatan Indonesia Vol 12, No 1 (2026): Volume 12, Nomor 1, Juni 2026
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/jpki.v12i1.97969

Abstract

Introduction: Children with developmental disabilities frequently require long-term, multidisciplinary, and family-centered healthcare services. However, caregivers often encounter structural, logistical, communication, and professional barriers when accessing healthcare services for their children. Understanding both barriers and facilitators from caregiver and healthcare provider perspectives is essential for improving inclusive healthcare.Objective: This study aimed to explore barriers and facilitators to inclusive healthcare for children with developmental disabilities from the perspectives of caregivers and healthcare providers.Methods: A qualitative descriptive study was conducted using individual semi-structured interviews with 36 participants, consisting of 20 caregivers and 16 healthcare providers. Participants were recruited purposively from hospitals, rehabilitation centers, and community health facilities. Interviews were conducted individually, audio-recorded, transcribed verbatim, and analyzed using inductive thematic analysis. Recruitment continued until thematic saturation was achieved, defined as the point at which no new codes, categories, or themes emerged across consecutive interviews.Results: Six themes were identified: structural constraints within healthcare systems, accessibility and logistical barriers, communication dynamics between caregivers and healthcare providers, professional competency and training gaps, caregiver resilience and advocacy, and collaborative community-based support systems. Key barriers included limited specialized services, long waiting times, transportation difficulties, complex referral pathways, and insufficient provider training. Facilitators included caregiver advocacy, interdisciplinary collaboration, peer support networks, and community-based support systems.Conclusion: Inclusive healthcare for children with developmental disabilities requires system-level improvements in healthcare infrastructure, referral coordination, provider training, family-centered communication, and community-based support. Strengthening these areas may improve equitable healthcare access, particularly in resource-constrained settings
HUBUNGAN DUKUNGAN KELUARGA DENGAN KEMANDIRIAN PERAWATAN DIRI ANAK RETARDASI MENTAL elsi rahmadani; Gita Maya Sari; Ariyus Popsi Gito
Jurnal Kesehatan Saintika Meditory Vol 7, No 2 (2024): November 2024
Publisher : STIKES Syedza Saintika Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jsm.v7i2.2835

Abstract

Children with mental retardation are children with below average IQ with the inability to carry out daily activities and maintain self-care and need family support. The purpose of this study was to analyze the relationship between family support and self-care independence in children with mental retardation at SLB Negeri in Bengkulu. This study is a type of quantitative correlation research with a cross-sectional analysis design. The sample in this study was 43 respondents from parents of children with mental retardation at SLB Negeri Bengkulu with a purposive sampling technique. Data collection using a questionnaire on family support and self-care independence and data analysis using the Chi-Square test. The results showed that 51.2% of respondents had less family support and (51.2%) had good self-care independence in children with mental retardation at SLB Negeri Bengkulu. The results of the Chi-Square statistical test showed p = 0.022 <0.05. The conclusion is that there is a relationship between family support and self-care independence in children with mental retardation at SLB Negeri Bengkulu. It is hoped that families can provide and improve good support for children with mental retardation by providing informational, emotional, assessment and instrumental support.Key Word : Family Support, Self-Care Independence, Mental Retardation
Co-Authors ., Midiawati Aini, Putri Nur Ariyus Popsi Gito Buyung Keraman Colin, Vellyza damayanti, meitha DEWI APRILIA NINGSIH. I Dian Dwiana Maydinar Dwi Wulandari Fahriani, Metha Faridah, Euis Nur Fatima Nuraini Sasmita Gita Maya Sari Handi Rustandi Hanifah Hanifah Ida Rahmawati Jayanti, Rena Dwi Lesa Aprina Putri Listiana, Devi mardhiyah, wiwi maydinar, dian dwiana Melani Sri Cahyani Miniharianti, Miniharianti Nasuha, Ahmad Riadin neni triana Novi Ade Suryani Novi Ade Suryani pawiliyah Pawiliyah Pawiliyah PURI, CHANDRAINY Ravika Ramlis Siska Lestari Siti Zulva Suryani Suryani Sutrisna, Marlin Vellyza Colin VIVIYANI, TIARA Wulan, Susilo Yunisa Putri Damayani