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All Journal BIOMA : Jurnal Biologi Makassar Jurnal Surya Medika Meditory : The Journal of Medical Laboratory Martabe : Jurnal Pengabdian Kepada Masyarakat CARADDE: Jurnal Pengabdian Kepada Masyarakat Klinikal Sains (Jurnal Analis Kesehatan) JURNAL ANALIS LABORATORIUM MEDIK Bali Medika Jurnal Jurnal Kesehatan Tambusai Indonesian Journal of Health Community Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Jurnal TLM Blood Smear
I GUSTI AGUNG AYU SATWIKHA DEWI -
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Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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PROFIL HEMATOLOGI PADA PENDERITA TUBERKULOSIS SEBELUM DAN SESUDAH PENGOBATAN OAT DI PUSKESMAS KOTA DENPASAR I Gusti Agung Ayu Satwikha Dewi; Ida Ayu Manik Partha Sutema; Ni Putu Widiantari; Ni Putu Diah Monica Yanti; Ni Ketut Sari Merta Dewi
Klinikal Sains : Jurnal Analis Kesehatan Vol. 13 No. 1 (2025): Juni
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikalsains.v13i1.5447

Abstract

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis that attacks the lungs as well as several systems such as gastrointestinal, central nervous, and liver. TB cases have become a global issue, in 2022 Bali has 3,040 cases and Denpasar City has the highest number reaching 1,063 cases. TB treatment is crucial to be handled effectively and efficiently. Examination of hematologic profiles provides important information about the impact of TB and response to treatment. Currently, there is little information on the relationship between hematology profile and OAT treatment of TB patients at the primary health care level such as puskesmas. The purpose of this study was to examine the hematological profile of TB patients before and after OAT treatment at the Denpasar City Health Center. The sampling technique in this study was accidental sampling conducted at the Denpasar City Health Center in January-September 2024. This study was a prospective cohort study supported by literature review. Hematology profile examination of 32 EDTA blood samples was examined using a hematology analyzer including hemoglobin, erythrocyte, leukocyte, platelet, and ESR profiles. Paired T-test results showed that the four hematological profiles had a sig. value smaller than 0.05 (p<0.05), indicating that there was a significant difference between the hematological profiles of TB patients before and after OAT treatment at the Denpasar City Health Center.
Analisis Nilai NLR, MLR, dan PLR Penderita Tuberkulosis Sebelum dan Sesudah Pengobatan Oat I Gusti Agung Ayu Satwikha Dewi; I Putu Riska Ardinata; Ni Luh Eka Kartiningsih; Dewa Ayu Trisna Dewi; I Nyoman Jirna; I Gusti Ngurah Dwija Putra; Dewa Gede Eka Prayoga
Bali Medika Jurnal Vol 13 No 1 (2026): Bali Medika Jurnal July 2026
Publisher : Stikes Wira Medika Bali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36376/bmj.v13i1.542

Abstract

Tuberculosis (TB) is an infectious disease that remains a global health challenge, including in Bali Province. Denpasar City was recorded as the region with the highest number of TB cases in 2022. The long duration of TB treatment often causes side effects such as nausea, vomiting, and liver dysfunction, which impacts low patient compliance. Assessment of immunological conditions through hematological parameters such as the Neutrophil Lymphocyte Ratio (NLR), Monocyte Lymphocyte Ratio (MLR), and Platelet Lymphocyte Ratio (PLR) is considered potential as an indicator of the effectiveness of ATD (anti-tuberculosis drug) therapy. This study aims to analyze changes in NLR, MLR, and PLR values before and after ATD therapy in TB patients at Denpasar City Community Health Centers. This study is a prospective cohort study using the Accidental Sampling method in 11 Community Health Centers. EDTA blood samples were analyzed using an automated hematology analyzer, and data were tested using normality tests and Pearson correlation. The results showed that the pre-ATD NLR values (mean 2.29) and post-ATD remained normally distributed with a weak and insignificant positive correlation (p = 0.294). The pre-ATD MLR values (mean 0.35) and post-ATD had a weak and insignificant negative correlation (p = 0.412). Similarly, the pre-ATD PLR (mean 12.82) and post-ATD showed a weak and insignificant negative correlation (p = 0.315). The conclusion of this study is that ATD treatment for two months has not provided significant changes in the NLR, MLR, and PLR values. Continued monitoring until the end of therapy is still needed to comprehensively assess the effectiveness of ATD.   Tuberkulosis (TB) merupakan salah satu penyakit menular yang masih menjadi tantangan kesehatan global, termasuk di Provinsi Bali. Kota Denpasar tercatat sebagai wilayah dengan jumlah kasus TBC tertinggi pada tahun 2022. Durasi pengobatan TBC yang panjang sering menimbulkan efek samping seperti mual, muntah, dan gangguan fungsi hati, yang berdampak pada rendahnya pemenuhan pasien. Penilaian kondisi imunologis melalui parameter hematologi seperti Rasio Limfosit Neutrofil (NLR), Rasio Limfosit Monosit (MLR), dan Rasio Limfosit Trombosit (PLR) dinilai berpotensi sebagai indikator efektivitas terapi OAT (obat anti tuberkulosis). Tujuan: menganalisis perubahan nilai NLR, MLR, dan PLR sebelum dan sesudah terapi OAT pada pasien TB di Puskesmas Kota Denpasar. Metode: Studi kohort prospektif pre-post pada 32 pasien TB baru. Sampel darah diambil sebelum OAT dan hari ke-56 metode Accidental Sampling di 11 Puskesmas. Analisis menggunakan uji t berpasangan. Hasil: Rata-rata pre-OAT: NLR=2.29±0.78, MLR=0.35±0.15, PLR=12.82±4.04. Pasca-OAT: NLR=2.34±0.81 (p=0.63), MLR=0.33±0.14 (p=0.27), PLR=12.50±4.20 (p=0.53). Tidak ada perubahan signifikan pada ketiganya. Simpulan penelitian ini adalah pengobatan OAT selama dua bulan belum mengubah biomarker inflamasi hematologis (NLR, MLR, PLR). Pemantauan hingga 6 bulan diperlukan untuk evaluasi respons terapi.
Co-Authors Andi Harmawati Novriani HS Ayu Dyahsavira Setyartini Ayu Saka Laksmita W Ayu Trisna Dewi, Dewa Da Costa, Sandra Dewa Ayu Trisna Dewi Dewa Gede Eka Prayoga Dwijastuti, Ni Made Sri I Gusti Agung Haryawan I Gusti Ngurah Dwija Putra I Nyoman Jirna I Putu Riska Ardinata I Wayan Tanjung Aryasa Intan Kurniawati Pramitaningrum Made Adhyatma Prawira Natha Kusuma Made Sri Dwijastuti, Ni Ni Ketut Sari Merta Dewi Ni Ketut Sari Mertadewi Ni Luh Eka Kartiningsih Ni Luh Putu Agustini, Ni Luh Putu Ni Putu Diah Monica Yanti Ni Putu Puniari Eka Putri, Ni Putu Puniari Eka Ni Putu Rahayu Artini Ni Putu Widayanti Ni Putu Widiantari Octifani , Amellya Puniari Eka Putri, Ni Putu Putri Ni Putu Putu Puniari Eka Putri, Ni Putu Widiantari, Ni Rajdev Dhillon Reganata, Gde Palguna Risky Vidika A Septiasari, Ni Putu Senshi Sutema, Ida Ayu Manik Partha Widiantari, Ni Putu Yulidia Iriani