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All Journal Indonesian Journal of Tropical and Infectious Disease Jurnal Respirasi (JR) Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indian Journal of Forensic Medicine & Toxicology Jurnal Locus Penelitian dan Pengabdian Journal of Diverse Medical Research: Medicosphere Folia Medica Indonesiana
Kusmiati, Tutik
Departemen Pulmonologi Dan Ilmu Kedokteran Respirasi, Fakultas Kedokteran Universitas Airlangga
Aerospace Engineering Automotive Engineering Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Earth & Planetary Sciences Electrical & Electronics Engineering Health Professions Immunology & microbiology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Case Report: Survival of A Coronavirus Disease-2019 (Covid-19) Patient with Acute Respiratory Distress Syndrome (ARDS) in Dr. Soetomo Hospital, Surabaya, Indonesia Soedarsono, Soedarsono; Semedi, Bambang Pudjo; Setiawati, Rosy; Meliana, Resti Yudhawati; Kusmiati, Tutik; Permatasari, Ariani; Bakhtiar, Arief; Syafa'ah, Irmi; Indrawanto, Dwi Wahyu
Folia Medica Indonesiana Vol. 56, No. 3
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

An outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that began in Wuhan, China has spread rapidly in multiple countries of the world and has become a pandemic. Currently, there is no vaccine or specific antiviral for COVID-19. A study reported 7.3% of critical patients admitted to ICU, 71% of them required mechanical ventilation, and 38.5% of them were survived. Herein, we reported a 54 year old man with Acute Respiratory Distress Syndrome (ARDS) of COVID-19 who survived the disease. Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay of nasopharyngeal and oropharingeal swabs were positive for SARS-CoV-2. Diagnosis of ARDS was also according to clinical symptoms, laboratory, chest radiograph, and chest CT scan. Alcaligenes faecalis and Candida albicans were also identified from sputum culture. Treatment for this patient was causal and supportive therapy, including antibiotic, antiviral, and antifungal therapy according to the culture results, fluid resuscitation, and oxygen supply from the mechanical ventilator. This patient was survived and discharged on hospital day-29. A fibrosis in parenchyma pulmonary and sensory peripheral neuropathy occurred after survived from ARDS. Monitoring of clinical, laboratory, and chest radiograph were continued after the patient discharged from the hospital. This case highlights the importance of early diagnosis and effective treatment to the care of COVID-19 patient.
Effectiveness of Black Cumin (Nigella Sativa) Seed Extract as an Antibacterial Agent Against Mycobacterium Tuberculosis Using The Resazurin Microtiter Assay (REMA) Method Laura Freitas Silva Ferreira; Nurul Wiqoyah; Tutik Kusmiati; Eko Budi Koendhori
Jurnal Locus Penelitian dan Pengabdian Vol. 5 No. 7 (2026): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v5i7.5941

Abstract

Tuberculosis remains a major global health problem caused by Mycobacterium tuberculosis. The rising prevalence of multidrug-resistant tuberculosis and the adverse effects associated with prolonged first-line therapy like rifampicin, highlight the need for alternative or adjunctive treatments. Nigella sativa, a medicinal plant rich in bioactive compounds, has attracted considerable attention because of its antimicrobial, antioxidant, anti-inflammatory, and immunomodulatory properties, which are primarily attributed to its major active compound, thymoquinone. This study aimed to determine the antimicrobial activity and minimum inhibitory concentration of Nigella sativa seed extract against Mycobacterium tuberculosis using the resazurin microtiter assay method. A true experimental study was conducted using the H37Rv strain of Mycobacterium tuberculosis. A methanolic extract of Nigella sativa seeds was prepared using the maceration method. Antibacterial activity was assessed using the resazurin microtiter assay (REMA) after 10 days of incubation. Bacterial growth inhibition was determined through visual observation of resazurin color change and confirmed using a microplate reader at 630 nm. Wells remaining blue indicated inhibition, whereas pink indicated growth. Rifampicin and sterile water were included as positive and negative controls respectively to validate experimental conditions and assay performance consistency throughout the study. Nigella sativa seed extract demonstrated antimicrobial activity with a minimum inhibitory concentration of approximately 0.125 mg/mL (31-62 µg/mL), indicated by the absence of color change and supported by lower absorbance values at 630 nm. Rifampicin showed inhibitory activity at significantly lower concentrations 0.125µg/mL, confirming its higher antimicrobial potency. Nigella sativa seed extract exhibits measurable antibacterial activity against Mycobacterium tuberculosis.
First Line and Second Line Anti-Tuberculosis Drugs Resistance Patterns in Drug Resistance Tuberculosis Patients at Dr. Soetomo General Academic Hospital Surabaya Period 2019-2022 R. Mochammad Naufal Affan Hakim; Abdul Khairul Rizki Purba; Tutik Kusmiati; Ni Made Mertaniasih
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 17 No. 2 (2026): IN-PROGRESS ISSUE (AUGUST 2026)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V17I22026.100-104

Abstract

Highlights: This study covers the prevalent pattern of first-line and second-line anti-TB drugs. High-dose INH was the most prevalent pattern among DR-TB patients.   Abstract Introduction: Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), with drug-resistant TB (DR-TB) posing a significant global health challenge. Drug-resistant TB is characterized by complex resistance patterns, leading to high morbidity and mortality rates. The lack of understanding regarding resistance to both primary and secondary anti-TB drugs contributed to the persistence of resistance. Methods: This was a retrospective, descriptive, observational study that used secondary data from the medical records of patients with DR-TB resistant to Rifampicin at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, from 2019 to 2022. A total of 199 patient samples were included, selected using the total sampling technique and based on specific inclusion and exclusion criteria. Data analysis was performed using Microsoft Excel software. Results: The most prevalent resistance pattern observed was high-dose Isoniazid (30.7%). A case of cross-resistance between Bedaquiline and Clofazimine was found in a single DR-TB patient. Among patients with a history of diabetes mellitus (DM), 41% of those with DM and 39.8% without DM showed high-dose Isoniazid (INH) resistance. One case of extensively drug-resistant TB occurred in a patient without DM. Conclusion: Drug-resistant TB remained a major health issue due to its high prevalence and complex treatment. Understanding resistance patterns and managing comorbidities, such as DM, was crucial for improving treatment outcomes.
Factors That Reduce The Incidence of Lung Tuberculosis Other Than Isoniazid Preventive Therapy (IPT) in Latent Igra Positive HIV-TB Patients Shinta Karina Yuniati; Tutik Kusmiati; Erwin Astha Triyono; Aryati
Journal of Diverse Medical Research : Medicosphere Vol. 1 No. 4 (2024): J Divers Med Res 2024
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v1i4.20

Abstract

Background. One crucial public health measure to stop persons living with HIV (PLWHA) from developing active TB is isoniazid preventative therapy (IPT). Only few hospitals in Indonesia continue to offer IPT. Aim. The purpose of this study was to assess how IPT affected the incidence of TB in patients with latent HIV infection. Method. This study uses a prospective cohort design and is quasi-experimental in design. Samples for the study were obtained by convenience sampling and the study was carried out in the inpatient and outpatient departments of UPIPI Dr. Soetomo Hospital. Latent IGRA positive HIV-TB patients who satisfied the inclusion requirements made up the samples. Result. Of the 59 patients who finished the screening exam, 23 fulfilled the inclusion requirements for this study. Using the ELISPOT method, the IGRA T-SPOT.TB test yields 36 (64.29%) negative findings and 23 (35.18%) positive results. After six months of IPT administration, analysis of the data revealed that the incidence of active pulmonary TB in latent HIV-TB patients was 0% in the IPT group and 0% in the non-IPT group. Antiretroviral medication used for more than four years and a CD4+ T lymphocyte count of more than 200 cells/μL were factors that contributed to the lack of pulmonary tuberculosis in both groups. Conclusion. ARV used for more than four years and CD4+ lymphocyte count more than 200 cells/L contributing significantly in pulmonary tuberculosis incidence.
Co-Authors Abdul Khairul Rizki Purba Abdul Rahman Bahmid Aryati Aryati Aryati Aryati Aryati Aryati Aryati Bakhtiar, Arief Budi Suprapti Deny Perdana Putra Eko Budi Koendhori, Eko Budi Erwin Astha Triyono Gemilang Khusnurrokhman Hapsari Paramita Narendrani Ida Bagus Ngurah Rai Ika Yunita Sari Indrawanto, Dwi Wahyu Isnin Anang Marhana Kadek Widianiti Koesoemoprodjo, Winariani Laura Freitas Silva Ferreira Made Agustya Darmaputra Wesnawa Marsha Maritsa, Olivia Mega Rizkya Arfiana Mohammad Yamin Sunaryo Suwandi Nabil Salim Ambar Naomi Rahmasena Ni Made Mertaniasih Ni Made Mertaniasih Notrisia Rachmayanti Novita Maulidiyah Nur Prasetyo Nugroho Nurul Wiqoyah Permatasari, Ariani Pradnyandari, Anak Agung Sagung Putri Prayitno, Jongky Hendro Putranto, J.Nugroho Eko R. Mochammad Naufal Affan Hakim Resti Yudhawati S. Soedarsono Semedi, Bambang Pudjo Setiawati, Rosy Soedarsono Soedarsono Syafa'ah, Irmi Tuksin Jearanaiwitayakul Umi Fatmawati Wahyu Agung Purnomo Widjaja, Stella Agatha Yuniati, Shinta Karina Zahra, Nadhifa Az