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All Journal Mutiara Medika: Jurnal Kedokteran dan Kesehatan Biomedika The Indonesian Journal of Public Health YARSI Medical Journal Jurnal Informatika dan Rekayasa Perangkat Lunak Didaktik : Jurnal Ilmiah PGSD STKIP Subang Jurnal Keperawatan Galuh International Islamic Medical Journal Jurnal Sosial dan Teknologi Jurnal EduHealth Info Abdi Cendekia Junior Medical Journal Journal of Innovative and Creativity Indonesian Journal of Global Health Research
Dian Widiyanti
Fakultas Kedokteran Universitas YARSI
Religion Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Peran Biomarker IL-1β, IL-6, TNF-α, MMP-9, dan SOD dalam Patogenesis Acne Vulgaris: Suatu Tinjauan Literatur Angelica Vanini Winata Taufiq; Pratiwi Pujilestari Sudarmono; Dian Widiyanti; Harliansyah
Didaktik : Jurnal Ilmiah PGSD STKIP Subang Vol. 12 No. 02 (2026): Volume 12 No. 02, Juni 2026 Produce
Publisher : STKIP Subang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36989/didaktik.v12i02.13412

Abstract

Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit involving follicular hyperkeratinization, excessive sebum production, Cutibacterium acnes colonization, inflammation, and oxidative stress. The activation of the nuclear factor kappa B (NF-κB) pathway and the inflammasome by C. acnes triggers the release of proinflammatory mediators, such as IL-1β, IL-6, and TNF-α, which contribute to the formation of comedones, papules, pustules, and severe inflammatory lesions. Furthermore, matrix metalloproteinase-9 (MMP-9) plays a role in extracellular matrix degradation, tissue damage, and scarring, while superoxide dismutase (SOD) reflects endogenous antioxidant capacity in response to increased reactive oxygen species (ROS). This review aims to examine the roles of IL-1β, IL-6, TNF-α, MMP-9, and SOD biomarkers in the pathogenesis of acne vulgaris. The method employed is a narrative review conducted through literature searches across PubMed, Scopus, and Google Scholar databases. The findings indicate that IL-1β, IL-6, and TNF-α serve as the primary mediators of acne inflammation. MMP-9 is associated with inflammatory severity, tissue destruction, and scar formation, whereas decreased SOD activity reflects elevated oxidative stress that exacerbates acne lesions. These findings confirm that IL-1β, IL-6, TNF-α, MMP-9, and SOD are critical biomarkers in the pathogenesis of acne vulgaris and possess the potential to be used as parameters for diagnosis, prognosis, and therapeutic evaluation of the condition.
Co-Authors A.A. Ketut Agung Cahyawan W Afrizal Tw Alifa Syifa Salsabilah Prastowo Angelica Vanini Winata Taufiq Basuki, Sucipto Budiman, Dicky Citra Fitri Agustina Darmawan, Dwiky Dedi Hadian Dwi Maharani, Clara Fachry Abda El Rahman Fatmah Apriani Ferizal Al Rasyid Harliansyah Harliansyah, Harliansyah Indra Kusuma Irmawati Purbo Astuti, Ike Jumiran, Jumiran Kalila Nisya Ramadhan Karimulloh, Karimulloh Muhammad Arsyad Muhammad Arsyad Muslimin Budiman Neil Author Nisa, Dhea Nurasiah Nurasiah Nury Nur Melati Tanjung Pratiwi Pujilestari Sudarmono Pratiwi Pujilestari Sudarmono Putri Medita Rachmayanti Rahim Pane, Abdul Ramdesima Kasmir Rufi'i Satryanto, Muslimin Budiman Sa’adah, Fitria Septian, Indra Sri Wuryanti Suci Rahayu Syifa Melati Putri T Rochani, Jekti T Rochani, Jekti Tama, Ardy Riyantai Taufiq, Angelica Vanini Winata Titiek Djannatun Titiek Djannatun TITIEK DJANNATUN Titiek Djannatun Wikaningrum, Riyani Wikaningrum, Riyani WINANTI, WINANTI Yasmin, Intan Farida Yusuf Yusuf