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All Journal JURNAL KIMIA SAINS DAN APLIKASI Jurnal Penelitian Kesehatan Suara Forikes Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas Indonesian Journal of Global Health research Jurnal Ilmu Kesehatan Indonesia (JIKSI)

Adrial Adrial

Andalas University

Author-ID : 4165718

Agriculture, Biological Sciences & Forestry Humanities Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Veterinary Other

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Articles

Hubungan Kecemasan dengan Kualitas Hidup pada Wanita Menopause Amatulqaiyum Idri Sari; Ariadi Ariadi; Adrial Adrial
Jurnal Ilmu Kesehatan Indonesia Vol 1 No 2 (2020): Juli 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

Latar Belakang. Angka harapan hidup di Sumatera Barat semakin tinggi, tingginya angka harapan hidup meningkatkan kualitas kesehatan dan jumlah wanita menopause. Gejala menopause akan mempengaruhi kualitas hidup seorang wanita, semakin berat gejala yang dialami dapat terganggunya kualitas hidup. Salah satu gejala yang dialami adalah kecemasan. Objektif. Mengetahui hubungan kecemasan dengan kualitas hidup pada wanita menopause di Posyandu Lansia Puskesmas Nanggalo Kota Padang. Metode. Penelitian ini merupakan penelitian analitik observasional dengan desain cross sectional pada 30 wanita menopause di Posyandu Lansia Puskesmas Nanggalo Kota Padang yang dipilih melalui purposive sampling dengan teknik wawancara menggunakan kuesioner HARS untuk mengukur kecemasan dan WHO-QOL BREF untuk mengukur kualitas hidup. Analisis data dilakukan dengan uji korelasi pearson dan uji regresi linear. asil. Hasil penelitian didapatkan nilai korelasi pada setiap domain fisik, psikologis, sosial, lingkungan (r= -0,744, -0,781, -0,667, -0,660) dengan arah korelasi negatif. Kontribusi (r2) kecemasan terhadap kualitas hidup setiap domain fisik, psikologis, sosial, lingkungan (55,4%, 61%, 44,5%, 43,5%) dengan persamaan regresi WHO-QOL BREF = a+(-b) HARS. Simpulan. Ada hubungan negatif yang signifikan antara kecemasan dengan kualitas hidup. Kata kunci : kecemasan, kualitas hidup, menopause Background. Life expectancy in West Sumatra is getting higher, higher life expectancy increases the quality of health and the number of menopausal women. The symptoms of menopause will affect a woman's quality of life, the more severe the symptoms experienced can interfere with the quality of life. One of the symptoms experienced is anxiety. Objective. Knowing the relationship between anxiety and quality of life in menopausal women at Elderly Posyandu Nanggalo Public Health Center Padang. Method. This research is an observational analytic study with cross sectional design on 30 menopausal women at Elderly Posyandu Nangglo Public Health Center Padang who were selected through purposive sampling with interview techniques using the HARS questionnaire to measure anxiety and WHO-QOL BREF to measure quality of life. Data analysis was performed using Pearson correlation test and linear regression test. Result. The results showed that the correlation value in each physical, psychological, social, environmental domain (r = -0,744, -0,781, -0,667, -0,660) with a negative correlation direction. Contribution (r2) of anxiety to the quality of life of each physical, psychological, social, environmental domain (55.4%, 61%, 44.5%, 43.5%) with the WHO-QOL regression equation BREF = a + (- b) HARS . Conclusion. There is a significant negative relationship between anxiety and quality of life. Key words: anxiety, quality of life, menopause

Gambaran Histopatologi Hepar Mencit (Mus musculus Balb/C) yang Diinfeksi dengan Plasmodium berghei Hanifah Putri Dwiridal; Adrial Adrial; Eryati Darwin
Jurnal Ilmu Kesehatan Indonesia Vol 2 No 2 (2021): Juni 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Background: The most common cause of death by malaria in Indonesia is Plasmodium falciparum, which is analogous to Plasmodium berghei, which lives as a parasite in the liver of mice. The damage caused is seen in severe hepatocyte cell damage, which can be prevented by immunization, but the right type of immunization has not been found. Objective: This study aims to see whether immunization with Anopheles sundaicus salivary gland extract in mice can reduce liver damage in mice that have been infected with Plasmodium berghei. Methods: This research was conducted at the Anatomical Pathology Laboratory, Faculty of Medicine, Andalas University, from May - September 2020. The research method was descriptive with a quantitative approach. View and compare the histopathological picture of the liver of mice, which were infected with Plasmodium berghei after being immunized with Anopheles sundaicus salivary gland extract, in the pellet extract and supernatant extract groups, and the control group who were not immunized. The preparations were viewed using a microscope (Binocular Olympus BX 51 DIC), the number of hepatocytes was counted using the Image J application and the percentage of damage was calculated using the formula by Baldatina (2008). Results: The percentage of hepatocyte cell damage in the mencit control group was 96.27%, pellet extract 88.88% and supernatan extract 85.93%. Conclusion: The highest percentage of hepatocyte cell damage was found in the mencit control group and the lowest damage percentage in the supernatan extract group.

Gambaran Histopatologi Ginjal Mencit (Mus musculus Balb/C) yang Diinfeksi dengan Plasmodium berghei Miftah Ar Rahmah; Adrial Adrial; Yenita Yenita
Jurnal Ilmu Kesehatan Indonesia Vol 2 No 1 (2021): Maret 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Background: P. berghei is a parasite that causes malaria in small rodents. This parasite is analogous to P. falciparum which causes severe malaria in humans with the highest risk of death compared to 4 other plasmodium species. Complications of falciparum malaria in renal microcirculation is AKI (Acute Kidney Injury). AKI is preceded by the incidence of ATN (Acute Tubular Necrosis) and MPGN (Mesangioproliferative Glomerulonephritis) with ATN being the highest prevalence. Objective: This study aims to determine the histopathological appearance of renal tubules of white mice Mus musculus Balb/C which are infected with P. berghei. Methods: Descriptive analysis method with quantitative approach is used in this study. The study was conducted at the Anatomical Pathology Laboratory of the Faculty of Medicine, Andalas University. The study was conducted since February to October 2020. The sample size was determined by the Federer formula (2008). Results: Percentage of renal tubular cell damage which were 8.42% for the control group, 4.52% for the pellet extract group, and 2.74% for supernatant extract group. Conclusion: The study concluded that highest percentage of kidney tubular cell damage was found in the kidney of mice immunization with the control group, and the lowest percentage of kidney tubular cell damage was found in the kidney of mice immunization with supernatant extract.

Gambaran Pengetahuan, Sikap, dan Tindakan Mahasiswa Kesehatan di Kota Padang Mengenai Vaksin COVID-19 Gustia Anugrahwati; Dwitya Elvira; Yulistini Yulistini; Adrial Adrial; Hendriati Hendriati; Cimi Ilmiawati
Jurnal Ilmu Kesehatan Indonesia Vol 3 No 2 (2022): Juni 2022
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v3i2.887

Latar Belakang: Keraguan terhadap vaksin COVID-19 dan kurangnya pengetahuan mahasiswa kesehatan dapat mempengaruhi keberhasilan herd immunity sehingga dibutuhkan berbagai upaya untuk meningkatkan pengetahuan dan kesadaran akan pentingnya vaksinasi COVID-19. Objektif: Penelitian ini bertujuan untuk mengetahui gambaran pengetahuan, sikap dan tindakan mengenai vaksin COVID-19 pada mahasiswa kesehatan di Padang, Indonesia. Metode: Penelitian ini merupakan penelitian deskriptif dengan desain cross-sectional menggunakan teknik consecutive sampling pada bulan Maret-April 2022 dan didapatkan sebanyak 350 responden yang berpartisipasi dalam penelitian ini. Data diperoleh dari kuesioner yang dibagikan melalui tautan Google form kemudian dianalisis menggunakan analisis univariat. Hasil: Hasil penelitian menunjukkan sebanyak 58,6% responden memiliki pengetahuan yang baik, sebanyak 66,6% responden menunjukkan sikap positif dan sebanyak 52,9% responden menunjukkan tindakan yang cukup baik mengenai vaksin COVID-19. Kesimpulan: Mayoritas mahasiswa kesehatan menunjukkan tingkat pengetahuan baik, sikap positif dan tindakan cukup baik terhadap vaksin COVID-19.

Gambaran Perlukaan Jenazah di Bagian Forensik RSUP Dr. M. Djamil Padang Periode 2019-2021 Samantha Samantha; Rika Susanti; Adrial Adrial
Jurnal Ilmu Kesehatan Indonesia Vol 3 No 4 (2022): Desember 2022
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v3i4.1038

Latar Belakang: Kekerasan merupakan salah satu penyebab kematian terbesar di dunia. Kekerasan dapat dibuktikan dengan menemukan tanda-tanda kekerasan pada jenazah yang tergambarkan dari jenis luka yang ditemukan. Jenis kekerasan dapat berupa kekerasan mekanik, fisika, maupun kimia. Berbagai data terkait usia, jenis kelamin, sampai pendapatan negara juga berhubungan dengan kejadian luka dan kekerasan. Objektif: Untuk mengetahui gambaran perlukaan jenazah di Bagian Forensik RSUP Dr. M. Djamil Padang Periode 2019– 2021. Metode: Penelitian ini menggunakan desain deskriptif retrospektif. Pengambilan sampel menggunakan teknik total sampling. Sampel berupa Visum et Repertum jenazah dengan perlukaan yang tercatat di Bagian Forensik RSUP M.Djamil Padang periode 2019– 2021. Analisis data secara univariat. Hasil: Hasil penelitian pada 77 VeR jenazah dengan perlukaan mendapatkan total luka sebanyak 1.463 buah dan jenis kekerasan sebanyak 83 buah. Kelompok usia terbanyak yaitu kelompok usia 30–59 tahun (42,9%), jenis kelamin terbanyak adalah laki-laki (77,9%), agama terbanyak adalah islam (96,1%), jenazah paling banyak merupakan golongan pelajar (19,5%), alamat terbanyak berasal dari Kota Padang (28,6%) dengan jenis kedatangan terbanyak merupakan rujukan dari fasilitas kesehatan lain (71,4%). Jenis luka terbanyak adalah luka lecet (58,2%), luka memar (19,2%), dan luka terbuka tepi tidak rata (11,6%). Jenis kekerasan terbanyak adalah kekerasan tumpul (92,8%). Kesimpulan: Jenazah dengan perlukaan terbanyak berada pada kelompok usia 30–59 tahun, lebih banyak laki-laki daripada perempuan, mayoritas jenazah menganut agama Islam, paling banyak merupakan golongan pelajar, dan alamat terbanyak berasal dari Kota Padang dengan jenis kedatangan paling banyak adalah rujukan dari fasilitas kesehatan lain. Jenis luka terbanyak adalah luka lecet, diikuti luka memar, dan luka terbuka tepi tidak rata dengan penyebab luka terbanyak adalah kekerasan tumpul.

Hubungan Askariasis Terhadap Derajat Keparahan Stunting Pada Balita di Kota Padang Adrial Adrial
Majalah Kedokteran Andalas Vol 46, No 6 (2023): Online Oktober
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i6.p919-929.2023

Tujuan: Menganalisis hubungan askariasis terhadap derajat keparahan stunting pada balita di Kota Padang. Metode: Penelitian ini merupakan penilitian analitik observasional dengan pendekatan cross sectional. Sampel penelitian ini merupakan balita stunting yang dipilih dengan teknik purposive sampling dengan jumlah sampel sebanyak 116 orang. Penelitian ini menggunakan data sekunder dari penelitian induk dan dianalisis dengan menggunakan uji statistic chi-square. Hasil: Hasil penelitian ini menemukan 5,2% balita stunting positif terinfeksi Ascaris lumbricoides yang terdiri dari 4 balita (3,4%) dengan kategori pendek dan 2 balita (1,7%) dengan kategori sangat pendek. Hasil analisis secara statistik menemukan tidak ada hubungan yang bermakna antara kejadian askariasis dan intensitas infestasinya dengan derajat keparahan stunting pada balita. (p>0,05) Kesimpulan: Tidak tidak terdapat hubungan antara status infestasi askariasis dan intensitas infestasinya terhadap derajat keparahan stunting pada balita di Kota Padang.

Antibacterial Activity of Endophytic Bacterial Isolates from Kaempferia galanga Leaves Rafifa Ridha; Dira Hefni; Zetryana Puteri Tachrim; Gian Primahana; Jepri Agung Priyanto; Linosefa Linosefa; Adrial Adrial; Endrinaldi Endrinaldi; Muhammad Eka Prastya
Jurnal Kimia Sains dan Aplikasi Vol 27, No 11 (2024): Volume 27 Issue 11 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.11.538-548

Indonesia has a high biodiversity, which can be relied upon as a potential source of medicinal materials. One of the medicinal plants in Indonesia is Kaempferia galanga, which demonstrates various pharmacological properties, including antibacterial, anti-inflammatory, antioxidant, anticancer, and antiangiogenic effects. However, directly extracting active compounds from plants requires a considerable amount of biomass. To address this challenge, utilizing endophytic bacteria associated with these plants presents a promising alternative. Consequently, the antibacterial activity of endophytic bacterial isolates from K. galanga leaves needs to be investigated. This study is an experimental laboratory investigation conducted in vitro. Two isolates demonstrated antibacterial activity: isolate code DR4 inhibited the growth of Escherichia coli (3 ± 0.5 mm), while isolate DR10 inhibited the growth of four bacteria: Bacillus subtilis (5 ± 0 mm), Staphylococcus aureus (1.5 ± 0.5 mm), Escherichia coli (1 ± 0 mm), and Pseudomonas aeruginosa (1 ± 0 mm). Disc diffusion tests using ethyl acetate extracts of isolate DR10 showed the highest antibacterial activity at a concentration of 10,000 ppm. The Minimum Inhibitory Concentration (MIC) was determined to be 156.2 ppm against B. subtilis, while the Minimum Bactericidal Concentration (MBC) was >625 ppm. Molecular identification showed that isolate DR 10 had 100% similarity to Bacillus sp. TS8. The active compound suspected to have antibacterial properties is pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl)-, with the highest abundance.

PENYULUHAN PENYAKIT INFEKSI KECACINGAN DAN GIARDIASIS TERHADAP ANAK BALITA STUNTING DI KELURAHAN KAMPUNG BARU NAN XX KECAMATAN LUBUK BEGALUNG KOTA PADANG Adrial Adrial; Nuzulia Irawati; Hasmiwati Hasmiwati; Nurhayati Nurhayati; Selfi Renita Rusjdi; Eka Nofita; Husnil Wardiyah
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 7 No. 4 (2024)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v7i4.615

Stunting is a condition of growth failure in toddlers due to chronic malnutrition and chronic infections, including worm infections and giardiasis. Kampung Baru Nan XX Village, Lubuk Begalung District, Padang City, is one of the areas with a high stunting rate. Education related to the prevention and treatment of this infectious disease is needed to improve public understanding in order to break the chain of causes of stunting. This counseling activity aims to improve public knowledge, especially mothers of toddlers, about the relationship between worm infections and giardiasis with stunting and preventive measures. The methods used are interactive lectures and discussions. The counseling involved mothers of toddlers and integrated health post cadres in the area. From the examination of 20 feces samples of toddlers in this area, no positive cases of worm infections and giardiasis were found. The results of this activity showed a good understanding of the participants regarding the importance of environmental sanitation, personal hygiene, and providing nutritious food to children. This counseling is effective in increasing public awareness regarding worm infections and giardiasis as risk factors for stunting. Follow-up activities can be carried out in the form of monitoring and providing nutritional interventions to support sustainable stunting prevention in this region.

Potential of Bioactive Compounds from Gambier (Uncaria Gambir Roxb.) in Modulating Cognitive Function: A Scoping Review Rahmi Novita Yusuf; Adrial Adrial; Desmawati Desmawati; Nur Indrawaty Lipoeto
Indonesian Journal of Global Health Research Vol 7 No 4 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i4.5936

Aging is a process of diminishing tissue capacity for self-repair and maintenance of normal structure and function, leading to vulnerability to injury and damage. The high incidence of neurodegenerative diseases coincides with increased life expectancy in the elderly. An unavoidable negative effect of neurodegenerative diseases is the potential to cause cognitive decline. Gambier (Uncaria gambir Roxb.), containing 90% catechin, is a traditional plant with potential to enhance cognitive function. This scoping review aims to map existing research on the potential of bioactive compounds from gambier in modulating cognitive function, based on research articles in journals from the last 10 years in the PubMed, PMC, Google Scholar, and Google Scholar databases (2014-2024). The research was conducted by collecting research data from the last 10 years, totaling 12 articles. Among these, 4 articles met the inclusion criteria, focusing on the potential of bioactive compounds from gambier in modulating cognitive function. The article screening was conducted systematically using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) as 1 a guideline, followed by screening based on inclusion and exclusion criteria. This scoping review found potential for bioactive compounds from gambier in modulating cognitive function, as evidenced by increased Montreal Cognitive Assessment (MoCA) scores, decreased levels of Beta Amyloid (Aβ), Microtubule-Associated Protein Tau (MAPT), Malondialdehyde (MDA) levels, and increased Brain-Derived Neurotrophic Factor (BDNF). The potential of catechin, the primary bioactive compound in gambier, which possesses antioxidant, anti-inflammatory, and neuroprotective effects, yields beneficial results in enhancing cognitive function in the elderly.

APC-Pengaruh Pemberian Blastocystis sp. Terhadap Jumlah Leukosit Pada Tikus Febriyanti, Rizka; Nofita, Eka; Afriani, Nita; Adrial, Adrial; Asri, Aswiyanti; Almurdi, Almurdi
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 16, No 2 (2025): April-Juni 2025 (up coming)
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf.v16i2.3590

Blastocystis sp. are the most common intestinal protists in human and animal faeces. Blastocystis sp infection associated with inhibition of celluler immunity due to an increase in cytokines resulting in an increase in the number of leukocytes. This study was conducted to determine the correlation between Blastocystis sp infection and leukocyte count. This experimental study with a post test only control group design, used male Wistar white rats (Rattus norvegicus). Blastocystis sp infection in rats assessed by performing microscopic examination of rat faeces and culture. Leukocytes count examination was carried out using a counting chamber. Data analysis was carried out using the One Way Anova Test. The final results obtained were the mean number of leukocytes in treatment group 1 (P1), treatment 2 (P2) negative control (K-) respectively, 6171.43 cells/mm3, 6866.67 cells/mm3 , and 7742.86 cells/mm3 mm3. The p value of One Way Anova p = 0.7 (p > 0.05). The conclusion is the administration of Blastocystis sp. did not significantly influence the number of rat leukocytes.Keywords: blastocystis sp; leukocyte count; rattus norvegicus

Co-Authors Afriani, Nita Almurdi Almurdi Amatulqaiyum Idri Sari Ariadi Ariadi Aswiyanti Asri Desmawati Desmawati Dira Hefni Dwitya Elvira, Dwitya Eka Nofita Endrinaldi Eryati Darwin Febriyanti, Rizka Gian Primahana Gustia Anugrahwati Hanifah Putri Dwiridal Hasmiwati Hendriati, Hendriati Husnil Wardiyah Ilmiawati, Ilmiawati Jepri Agung Priyanto Linosefa Linosefa Miftah Ar Rahmah Muhammad Eka Prastya Nur Indrawaty Lipoeto Nurhayati Nurhayati Nuzulia Irawati Rafifa Ridha Rahmi Novita Yusuf Rika Susanti Samantha Samantha Selfi Renita Rusjdi Yenita Afriyeni Yulistini, Yulistini Zetryana Puteri Tachrim

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