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All Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan JFL : Jurnal Farmasi Lampung JFM (Jurnal Farmasi Malahayati) Jurnal Ilmiah Farmasi Farmasyifa Jurnal Riset Kefarmasian Indonesia Borneo Journal Of Pharmascientech Bivalen: Chemical Studies Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Abdi Masyarakat Kita Journal Prima Health Science Jurnal Pengabdian Masyarakat Bangsa Media Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
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Antibacterial Activity of N-Hexan and Ethyl Asetet Fraction of Ethanol Extract of Red Atai (Plagiogyria pycnophylla (Kunze) Mett.) Leaves on Propionibacterium acnes Bacteria Reksi Sundu; Nurul Fatimah; Andi Mismawati
Journal Prima Health Science Vol 1 No 1 (2019): Oktober
Publisher : LPPM STIKes Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Ferns are cormophyte plants with spore, which can live anywhere.The number of ferns and their spread is high, especially in tropicalrain areas. The purpose of this study was to determine theantibacterial activity of the n-hexane and ethyl acetate fraction ofethanol extract of the red atai fern (Plagiogyria pycnophylla (Kunze)Mett.) leaves against Propionibacterium acnes bacteria. The stages ofthe study were sample collection, extraction, fractionation,phytochemical screening and antibacterial activity testing using theKirby-Bauer disc diffusion method. The results showed that the nhexanefraction each of 2,5%; 5%; 10% and 20% concentrations hada medium category with successive inhibition zone diameter values of7,20 mm ± 0,60; 7,55 mm ± 0,07; 7,56 mm ± 0,48 and 7,73 mm ±0,88. The ethyl acetate fraction at a concentration of 2.5%, 5% and10% had medium category inhibition with diameter of inhibitionzones respectively 7,97 mm ± 0,81; 8,55 mm ± 0,49 and 9,12 mm ±0,35, while at a concentration of 20% have strong category (13,73mm ± 0,75). From the results of the above study, it can be concludedthat the n-hexane and ethyl acetate fraction of the ethanol extract ofthe red atai fern (Plagiogyria pycnophylla (Kunze) Mett.) leaves haveantibacterial activity against Propionibacterium acnes.
Gambaran Pengelolaan Obat di Instalasi Farmasi Rumah Sakit X Sangatta Tahun 2020 Rena Handayani Alfian; Reksi Sundu; Nurul Fatimah
BORNEO JOURNAL OF PHARMASCIENTECH Vol 6 No 2 (2022): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v6i2.401

Abstract

Drug management at the Hospital Pharmacy Installation is very important to ensure the quality of drugs, in addition to maintaining the availability of pharmaceuticals to keep them in good condition, storage of pharmaceutical reparations is also important because to keep drugs from being damaged, not expired, avoiding dead stock and drug turnover. within 1 year running at maximum. This research is a descriptive non-experimental research. Qualitative data was obtained from observations using a check list form based on Permenkes number 72 of 2016. Quantitative data was based on tracking drug storage indicators, namely drug compatibility with stock cards, Turn Over Ratio (TOR), percentage of ED or damaged drug values. The results of the re-search at RS X Sangatta there were several storages that were not in accordance with predetermined standards. This can be seen from the results of the research conducted, the percentage is 33%, the results storage method is 80%, the storage component is obtained a percentage of 100%, 100% storage settings, 100% emergency medicine management, and 100% storage equipment. The results ofthe evaluation of drug stor-age at RS X Sangatta with drug storage indicators showed TOR results of 1.89 times/period, the percentage of expired or damaged drugs was 5.2%, the percentage of dead stock was 9.03% and the percentage of matched drugs with stock cards was 100%.
AKTIVITAS ANTIBAKTERI FRAKSI AKTIF DAUN SELUTUI PUKA (Tabernaemontana macrocarpa Jack.) TERHADAP Staphylococcus aureus Rismaul Wahdah; Fitri Handayani; Reksi Sundu
Jurnal Ilmiah Farmasi Farmasyifa Vol 6, No 2 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v6i2.11694

Abstract

Staphylococcus aureius meirupakan bakteiri yang dapat meinyeibabkan peinyakit infeiksi, seipeirti infeiksi pada kulit. Masyarakat deisa Karangan Mook Manar Bulant, Kutai Barat, Kalimantan Timur meinggunakan daun seilutui puka (Tabeirnaeimontana macrocarpa Jack.) seibagai obat tradisional untuk meingobati peinyakit kulit, seipeirti kulit yang gatal. Tujuan peineilitian untuk meingeitahui kandungan meitabolit seikundeir pada fraksi aktif dan aktivitas antibakteiri fraksi aktif daun seilutui puka. Peineilitian beirsifat eikspeirimeintal. Obyeik yang diteiliti adalah zona hambat fraksi aktif daun seilutui puka teirhadap bakteiri Staphylococcus aureius. Tahapan peineilitian yaitu peingumpulan bahan baku, deiteirminasi tumbuhan, peimbuatan simplisia dan eikstrak, fraksinasi, uji skrining fitokimia fraksi aktif, uji aktivitas antibakteiri fraksi aktif (eitanol-air, eitil aseitat dan n-heiksana) daun seilutui puka teirhadap bakteiri Staphylococcus aureius deingan meitodei difusi cakram pada konseintrasi 5%, 10% dan 15%, kontrol positif klindamisin 0,1% dan kontrol neigatif DMSO 1%. Data dianalisis seicara kualitatif dan kuantitatif. Hasil skrining fitokimia  meinunjukkan bahwa fraksi eitanol-air meimiliki kandungan seinyawa meitabolit seikundeir beirupa flavonoid dan saponin, fraksi eitil aseitat meingandung flavonoid, tanin dan steiroid, fraksi n-heiksana meingandung alkaloid dan steiroid. Aktivitas antibakteiri pada fraksi aktif meinunjukkan bahwa fraksi eitanol-air meinghasilkan zona hambat seibeisar 2,88 mm (5%), 5,33 mm (10%) dan 6,06 mm (15%). Fraksi eitil aseitat seibeisar 2,54 mm (5%), 6,81 mm (10%)  dan 7,81 mm (15%). Fraksi n-heiksana seibeisar  6,50 mm (5%), 8,35 mm (10%), dan 5,83 mm (15%). Zona hambat kontrol positif pada klindamisin 0,1% seibeisar 35,45 mm dan kontrol neigatif DMSO 1% adalah 0 mm.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL UMBI PAKU ATAI MERAH ( Angiopteris ferox Copel) TERHADAP Propionibacterium acnes Reksi Sundu; Sapri .; Fitri Handayani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 2 No 2 (2018)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v2i2.50

Abstract

Kalimantan adalah pulau yang memiliki keanekaragaman hayati dan potensi yang sangat melimpah sebagai tumbuhan berkhasiat obat. Masyarakat suku dayak daerah Kutai Barat di Kecamatan Linggang Bigung Kalimantan Timur menggunakan paku atai merah sebagai obat dengan cara umbi paku atai merah diparut dan dicampur dengan beras kemudian diolah menjadi bedak dingin untuk kulit yang berjerawat. Tujuan penelitian untuk mengetahui aktivitas antibakteri pada ekstrak etanol umbi paku atai merah terhadap Propionibacterium acnes . Penelitian diawali dengan skrining fitokimia yaitu pemeriksaan senyawa golongan alkaloid, flavanoid, saponin, tanin dan steroid/terpenoid selanjutnya dilakukan pengujian aktivitas antibakteri terhadap Propionibacterium acnes dengan metode difusi cakram. Larutan uji dibuat dengan konsentrasi yang berbeda yaitu ekstrak etanol umbi paku atai merah 20%, 40%, 60% dan 80%, kontrol positif clindamycin 0,1%, kontrol negatif DMSO 0,1%. Metode analisis data adalah metode deskriptif yaitu berupa data kualitatif dan kuantitatif. Data disajikan dalam bentuk tabel dan gambar. Hasil skrining fitokimia menunjukkan positif mengandung golongan alkoloid, flavonoid, tanin, saponin dan steroid. Hasil pengujian aktivitas antibakteri menunjukkan bahwa ekstrak etanol umbi paku atai merah memiliki aktvitas antibakteri terhadap Propionibacterium acne dengan diameter zona hambat sebesar 6,83mm ± 0,27 (20%); 8,33 mm ± 0,36 (40%) dan 8,25 mm ± 0,31 (80%) yaitu zona hambat kategori sedang. Ekstrak etanol 60% menunjukkan zona hambat bakteri 11,05 mm ± 1,99 yaitu zona hambat kategori kuat. Clindamycin 0,1 % memiliki zona hambat bakteri 24,10 mm ± 0.61 yaitu zona hambat kategori sangat kuat. Dimetil sulfoksida 0,1% tidak memiliki daya hambat bakteri.
Perbandingan Efek Antihipertensi Ekstrak Etanol White Tea, Yellow Tea, Black Dragon Tea dan Green Tea Susilowati, Agustina; Qarriy ‘Aina Urfiyya; Andi Wijaya; Reksi Sundu; Risa Supriningrum
Media Farmasi Vol 20 No 1 (2024): Media Farmasi Edisi April 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i1.236

Abstract

Comparison Of Antihypertension Effects Of White Tea, Yellow Tea, Black Dragon Tea And Green Tea Ethanol Extracts In Indonesia, hypertension is still a significant health issue. Every year, Indonesia sees a rise in the prevalence of hypertension. Green tea, black dragon tea, white tea, and yellow tea all contain flavonoid antioxidants that may be used to treat hypertension by acting through the antioxidant route. The comparison of the antihypertensive effects of various ethanol extracts of white tea, yellow tea, blackdragon tea, and premium green tea (Camellia sinensis L.) is the main goal of this study. Pretest-Posttest Control Group Design research is this kind of experimental study. White tea, yellow tea, black dragon tea, and premium green tea (Camellia sinensis L.) were all subjected to antihypertensive tests using various ethanol extracts. Thirty Wistar rats were placed into six groups for the antihypertension test, each group comprising are group I (CMC. Na 1%), Group II (Captopril 2.25 mg/kgW), Groups III, IV, V and VI were the treatment groups. which consists of administering ethanol extracts of White Tea, Yellow Tea, Black Dragon Tea and Green Tea Premium at a dose of 500 mg/kgW. Blood pressure checks were carried out 3 times, namely before induction (TD I), after induction (TD II), and after being given the test solution (TD III). The results of the blood measurements then calculate the antihypertensive activity. In this study, it was discovered that captopril had a 40.0% antihypertensive action, compared to 33.3% for white tea ethanol extract, 37.2% for yellow tea, 37.7% for black dragon tea, and 38.0% for green tea. The results of this study indicate that the four ethanol extracts of tea, when administered at a dose of 500 mg/kgBB, can have an antihypertensive effect. However, only yellow tea, black dragon tea, and green tea are not substantially different from captopril (p>0.05).  Hipertensi masih menjadi suatu masalah kesehatan yang cukup besar di Indonesia. Prevalensi hipertensi di Indonesia terus meningkat setiap tahunnya. White tea, yellow tea, black dragon tea dan green tea mengandung senyawa flavonoid sebagai antioksidan yang dapat berpotensi sebagai antihipertensi dengan melalui jalur antioksidan. Tujuan dari penelitian ini yaitu mengetahui perbandingan efek antihipertensi berbagai ekstrak etanol white tea, yellow tea, blackdragon tea dan green tea premium (Camellia sinensis L.). Jenis penelitian ini yaitu penelitian eksperimental Pretest-Posttest Control Group Design. Uji antihipertensi berbagai ekstrak etanol berbagai produk teh yaitu white tea, yellow tea, black dragon tea dan green tea premium (Camellia sinensis L.). Pada uji antihipertensi, 30 ekor tikus galur wistar di bagi menjadi 6 kelompok yang terdiri dari kelompok I (CMC. Na 1%), Kelompok II (Captopril 2,25 mg/kgBB), Kelompok III, IV, V dan VI merupakan kelompok perlakuan yang terdiri dari pemberian ekstrak etanol White Tea, Yellow Tea, Black Dragon Tea dan Green Tea Premium dengan dosis 500 mg/kgBB. Pengecekan tekanan darah dilakukan sebanyak 3 kali yaitu pada sebelum penginduksian (TD I), setelah penginduksian (TD II), dan setelah diberikan larutan uji (TD III). Hasil Pengukuran darah tersebut kemudian dihitung aktivitas antihipertensinya. Pada penelitian ini dapat diperoleh data bahwa aktivitas antihipertensi Captopril 40,0%, ekstrak etanol white tea 33,3%, yellow tea 37,2%, black dragon tea 37,7% dan green tea 38,0%. Melalui penelitian ini dapat disimpulkan bahwa keempat ekstrak etanol teh tersebut dengan dosis 500mg/kgBB dapat berefek sebagai antihipertensi, namun hanya yellow tea, black dragon tea dan green tea yang tidak berbeda bermakna (p>0,05) dibandingkan dengan captopril.
Formulasi dan Uji Aktivitas Antibakteri Streptococcus mutans dari Sediaan Mouthwash Ekstrak Daun Jambu Biji (Psidium guajava L.) Fitri Handayani; Reksi Sundu; Ria Mareta Sari
Jurnal Sains dan Kesehatan Vol. 1 No. 8 (2017): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v1i8.62

Abstract

Guava leaves have been used as antidiarrhea, antioxidant, aniinflamation, and antimicrobial. The results of its preliminary phytochemical analysis showed the presence of tannins, flavonoids, steroids and saponins. This leaves also contain essential oil such as sineol. Utilization of guava leaves as a mouthwash preparation is an alternative to replace the mouthwash preparations which generally contain antiseptic form of alcohol that can lead to oral cancer. This experiment formulated the extract of guava leaves into mouthwash that fulfill the physical requirements and determine the differences of antimicrobial activity against the growth of Streptococcus mutans with concentration of extract : 2,5 %; 3% and 3,5 %. Antibacterial acivity test was using MHA media with agar diffusion method. Physical requirement test included organoleptic, pH and viscosity test. The result showed that the mouthwash preparation of guava leaves extract has a pH value outside the range of the optimum growth of bacteria (pH=5). The viscosity of the mouthwash was 1,328-1,347 cP. The antibacterial activity of Streptococcus mutans on F1 has inhibition zone of 3,15 mm, F2 (3,83 mm) and F3 (4,32 mm). It was concluded that the extract of guava leaves on concentrations of 2,5%; 3% and 3,5% can be formulated as mouthwashes. The mouthwash fulfilled the physical requirement test such as pH, viscosity and organoleptic test and can inhibit the growth of Streptococcus mutans.
UJI AKTIVITAS EKSTRAK ETANOL BIJI PINANG (Areca catechu L.) TERHADAP PENYEMBUHAN LUKA BAKAR PADA KULIT PUNGGUNG MENCIT PUTIH JANTAN (Mus musculus) Fitri Handayani; Reksi Sundu; Henriko Nober Karapa
Jurnal Ilmiah Manuntung Vol 2 No 2 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v2i2.60

Abstract

Areca seeds contain flavonoid, tannin, and alkaloid which can help the healing process of burn wounds on the back skin of mice. Areca seeds are used for treatment because it has  antimicrobial activity. Areca Seeds are one of Indonesian plants which the fruit in tranditional way is used as burn medicine. The objective of this study was to know theeffect of ethanol extract of areca seeds against burn wound healing on the back skin of mice. Fifteen mices were used in this experiment and were divided into 5 groups : vaseline flavum as a control negative, branded ointment as a control positive , ethanol extract of areca seeds in vaseline flavum with consentration 20%, 40 % and 60 %. Each group consisted of 3 mices. The back skin of mice was induced using hot iron size 1×1 cm for 2 seconds then given a treatment for 14 days. The percentage of healing of burns  by calculating the surface area of wound. The results of its preliminary phytochemical analysis showed the presence of alkaloids, flavonoids, tannins and saponins. The percentage of burn wound healing of ethanol extract in concentration 20 % was 84,33 %, 40 % was 87,67%; and 60% was 89,67%. Data was analyzed using one-way Analysis of Variance (ANOVA) which showed that data has significant differences (P < 0,05) was 0,000. LSD test showed that each treatment group had siginicant differences with significant value < 0,05.  
IDENTIFIKASI BAKTERI Escherichia coli PADA MINUMAN TEH KEMASAN INDUSTRI RUMAH TANGGA DI KELURAHAN SUNGAI DAMA DAN SELILI MENGGUNAKAN METODE MOST PROBABLE NUMBER (MPN) Fitri Handayani; Reksi Sundu; Dawia Dawia
Jurnal Ilmiah Manuntung Vol 3 No 1 (2017): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v3i1.91

Abstract

Tea beverage packaging is a popular fast food beverage because it has a variety of flavors that are in great demand by the public. Presentation of packaged tea beverages is mostly found in roads that may be contaminated by Escherichia coli bacteria. This study aims to identify Escherichia coli bacteria in packaged tea drinks circulating in the rivers of Kelurahan Selili. This research is a descriptive research. The sample used is packaged tea drink taken in two subdistricts of Samarinda ilir namely Selili urban village and Sungai Dama by using Purposive Sampling method of 10 samples. Sample tests include presumtive test, confirmative test and completed test. The LB (Lactose Broth) assay test was used to detect early presence of Coliform bacteria, BGLBB (Brillian Green Lactose Bile Broth) as a detector of the specification of the presence of Coliform bacteria and completed test using EMBA (Eosin Methylene Blue Agar) as Escherichia coli. The results of this study were 7 samples of 10 samples tested containing Escherichia coli.
Kandungan total senyawa fenol, total senyawa flavonoid dan aktivitas antioksidan ektsrak etanol kulit batang sekilang (Embelia borneensis Scheff.) Sundu, Reksi; Supriningrum, Risa; Fatimah, Nurul
Bivalen: Chemical Studies Journal Vol. 5 No. 2 (2022)
Publisher : Bachelor Degree Program of Chemical Education - Mulawarman University | Program Studi S-1 Pendidikan Kimia - Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/bcsj.v5i2.1388

Abstract

Kulit batang sekilang (Embelia borneensis Scheff.) secara empiris oleh suku Dayak Kenyah digunakan untuk penangkapan ikan di sungai dan mengusir lintah. Flavonoid merupakan kelompok terbesar dari senyawa fenolik yang memiliki sifat sebagai antioksidan. Tujuan penelitian ini adalah untuk mengetahui kandungan total senyawa fenol, total senyawa flavonoid dan aktivitas antioksidan dari ekstrak etanol kulit batang sekilang. Metode ekstraksi yang digunakan adalah metode maserasi, penetapan kadar fenol dengan metode Folin-Ciocalteu, penetapan kadar flavonoid dengan metode AlCl3 dan pengujian aktivitas antioksidan menggunakan metode 2,2 -diphenyl-1-picrylhydrazyl (DPPH). Berdasarkan hasil penelitian, ekstrak etanol kulit batang sekilang mengandung total senyawa fenol sebesar 42,605 mg GAE/g ekstrak dan total senyawa flavonoid sebesar 6,165 mg QE/g ekstrak. Ekstrak etanol kulit batang sekilang memiliki aktivitas antioksidan dengan nilai IC50 sebesar 141,27 ppm dengan kategori aktivitas sedang. Hasil penelitian ini menunjukkan bahwa bahwa kulit batang sekilang memiliki potensi sebagai agen antioksidan alami.
Pemanfaatan kulit buah dan kulit ubi sebagai indikator asam-basa alternatif alami dengan variasi suhu pengeringan Nathalia, Nyda; Sundu, Reksi; Supriningrum, Risa
Bivalen: Chemical Studies Journal Vol. 6 No. 1 (2023)
Publisher : Bachelor Degree Program of Chemical Education - Mulawarman University | Program Studi S-1 Pendidikan Kimia - Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/bcsj.v6i1.2009

Abstract

Indikator asam basa alami dapat dibuat dengan mengesktrak bagian dari tanaman, seperti batang, daun, bunga, buah dan kulit buah atau kulit ubi. Antosianin merupakan pigmen warna yang terdapat pada berbagai jenis tumbuhan. Kadar antosianin akan menurun pada suhu 100oC karena terjadi degradasi pada antosianin. Penelitian ini bertujuan untuk mengetahui pengaruh variasi suhu pengeringan pada kulit buah dan kulit ubi terhadap pembuatan indikator asam-basa dan mengetahui potensi ekstrak kulit buah dan kulit ubi untuk dijadikan indikator asam-basa. Tahapan penelitian ini dimulai dengan persiapan sampel, mengeringkan sampel dengan variasi suhu 30, 40, 50, 60 dan 70°C selama 10 jam, pembuatan ekstrak dan pengujian indikator asam-basa. Hasil penelitian ini menunjukkan bahwa variasi suhu pengeringan berpengaruh terhadap hasil kertas indikator asam-basa alami. Kulit buah naga, kulit buah manggis dan kulit ubi ungu memiliki potensi untuk dijadikan indikator asam-basa alternatif dan ekstrak dari kulit ubi ungu yang dikeringkan dengan suhu 60 dan 70°C memiliki potensi yang paling besar untuk dijadikan kertas indikator asam-basa alternatif karena dapat memberikan hasil perbedaan warna ketika diujikan dengan larutan asam kuat, basa kuat, asam lemah dan basa lemah
Co-Authors ., Sapri Adhila, Ghina Ameliora Dwi Astani Ananda, Anugrah Andi Wijaya Aulia Rahmi Azizah Budiman, Hariyadi Daniel Happy Putra Dawia Dawia Dawia, Dawia Dhevani, Apria Audya Dwi Setyawati Eka Kumalasari Eka Siswanto Syamsul Fitri Handayani Fitri Handayani Fitri Handayani Goetie, Inayah Herman Henny Nurhasnawati Henriko Nober Karapa Inayah Herman Goetie Karapa, Henriko Nober Maulida, Mielsya Milasari, Novi Mismawati, Andi Nabila, Annisa Bela Namira, Nadine Anastasya Putri Nathalia, Nyda Nurul Fatimah Nurul Fatimah Nurul Fatimah Piya, Nor Qarriy ‘Aina Urfiyya Rachman, Nadya Rahmawati Rachmanissa, Nadya Rakhmadhan Niah Rasidah, Ananda Imroatur Rena Handayani Alfian Ria Mareta Sari Rio Adi Saputra Risa Supriningrum Rismaul Wahdah Sabatini, Sheila Dwi Sabriningsih, Nur Sapri . sapri sapri Sapri Sapri Sheila Dwi Sabatini Siti Jubaidah, Siti Susilowati, Agustina Syamsiar, Syamsiar Triswanto Sentat Wilujeng, Firdianty Lestari Yuliani, Siska Dwi