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All Journal MEDIA MEDIKA INDONESIANA JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Journal of Biomedicine and Translational Research Sari Pediatri Paediatrica Indonesiana Media Medika Muda Jurnal Health Sains
Noor Wijayahadi
Department Of Pharmacology, Faculty Of Medicine, Universitas Diponegoro, Semarang, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : Jurnal Health Sains

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Adjuvant Therapy Effect of Curcuma Longa Rhizome Extract On TGF-β Serum Levels in Leprosy Ulcer Patients Alfarizi, Rizki; Yuniati, Renni; Mundhofir, Farmaditya Eka Putra; Wijayahadi, Noor; Nindita, Yora
Jurnal Health Sains Vol. 5 No. 6 (2024): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v5i6.1300

Abstract

Leprosy ulcer is one of the worsening manifestations of leprosy that often causes disability if not appropriately handled. Healing of ulcers requires a long enough duration so that a good immunological response is needed to encourage the wound healing process, one of which is transforming growth factor-  (TGF-), which is necessary of the plants that plays a role in the expression of TGF-  to spur wound healing is Curcuma longa rhizome or turmeric rhizome. This study is expected to prove that administering Curcuma longa rhizome extract can increase serum TGF-β levels in leprosy ulcer patients. This study is an experimental study with a pre and post-randomised single-blind controlled trial design involving 22 subjects with leprosy ulcers. The control group obtained standard therapy for leprosy ulcers, and the treatment group received standard therapy and adjuvant Curcuma longa rhizome extract at a dose of 1 g per day for 30 days. TGF-β levels were measured by the ELISA method. Data analysis used the Wilcoxon test and the Mann-Whitney test. The results showed no significant difference in TGF-β levels after and before the intervention in the control group (p=0.79) and the treatment group (p=0.14). However, there was a significant difference in TGF-β levels after the intervention in the control group and treatment (p=0.01). Curcuma longa rhizome extract did not show an important role in changes in serum TGF-β levels in leprosy ulcer patients. This study showed that administering Curcuma longa rhizome extract for 1 month did not show a potential role as an adjuvant therapy. Leprosy ulcer is one of the worsening manifestations of leprosy that often causes disability if not appropriately handled. Healing of ulcers requires a long enough duration so that a good immunological response is needed to encourage the wound healing process, one of which is transforming growth factor-  (TGF-), which is necessary of the plants that plays a role in the expression of TGF-  to spur wound healing is Curcuma longa rhizome or turmeric rhizome. This study is expected to prove that administering Curcuma longa rhizome extract can increase serum TGF-β levels in leprosy ulcer patients. This study is an experimental study with a pre and post-randomised single-blind controlled trial design involving 22 subjects with leprosy ulcers. The control group obtained standard therapy for leprosy ulcers, and the treatment group received standard therapy and adjuvant Curcuma longa rhizome extract at a dose of 1 g per day for 30 days. TGF-β levels were measured by the ELISA method. Data analysis used the Wilcoxon test and the Mann-Whitney test. The results showed no significant difference in TGF-β levels after and before the intervention in the control group (p=0.79) and the treatment group (p=0.14). However, there was a significant difference in TGF-β levels after the intervention in the control group and treatment (p=0.01). Curcuma longa rhizome extract did not show an important role in changes in serum TGF-β levels in leprosy ulcer patients. This study showed that administering Curcuma longa rhizome extract for 1 month did not show a potential role as an adjuvant therapy.
Effect of Curcuma longa Extract as Adjuvant Therapy on IL-6 Serum Levels in Leprosy Type 1 Reaction Patients Putri, Syifa Nurisma; Mundhofir, Farmaditya Eka Putra; Yuniati, Renni; Wijayahadi, Noor; Nindita, Yora
Jurnal Health Sains Vol. 5 No. 6 (2024): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v5i6.1301

Abstract

Type 1 leprosy reaction / Reversal reaction (RR) is an inflammatory episode in existing leprosy lesions and aggravates the pain rate. Long-term therapy with steroids causes a variety of side effects, so an adjuvant therapy alternative is needed to alleviate steroid use. Curcuma longa rhizome extract has become an anti-inflammatory therapy choice in various previous inflammatory diseases. This study aims to determine the anti-inflammatory effect of Curcuma longa rhizome extract as an adjuvant therapy for reversal reaction patients by analyzing serum levels of IL-6 as a marker of inflammation. The pre and post-test randomized single-blinded controlled trial was conducted on two groups, namely control (RR patients with steroid therapy & placebo) and treatment (steroid therapy & Curcuma longa rhizome extract 1 gram/day). IL-6 serum levels were analyzed from sampling before and after the intervention for one month. The serum levels of IL-6 post-test in the control group were significantly higher than those of the pre-test. The treatment group showed lower serum levels of IL-6 post-test compared to pre-test, although there was no significant difference. Curcuma longa rhizome extract 1 gram/day for one month as adjuvant therapy for patients with type 1 leprosy reaction did not significantly reduce serum IL-6 levels.
Co-Authors Abdul Khanis Agus Priyatno Alfarizi, Rizki Anang M Legowo Andreas Arie Setiawan Andreas Arie Setiawan, Andreas Arie Andrew Johan Ardiansyah, Revi Diniafelsa Wola Edwin Tohaga Elvi Suryati Endang Mahati Erwin Kresnoadi Fairuz Azmila Purnomo Fathur Nur Kholis Fuadi Fuadi Hartantyo Hartantyo Ika Pawitra Miranti Indra Wijaya Iva-Yuana Iva-Yuana Kamilah Budhi Kamilah Budhi R Kamilah Budhi Rahardjani Ken Shinta Kis - Djamiatun Kusdalinah Kusdalinah Kusmadewi Eka Damayanti Meira Dewi Mochamad Ali Sobirin Muhammad Sholeh Kosim Mundhofir, Farmaditya Eka Putra Niken Puruhita Novi Angriyani Perdana, Evangga Yudha Putri, Syifa Nurisma Rachmatu Bill M Rahmi - Wirman Rahmi Isma Asmara Putri Raya, Maxianus Kopong Renni Yuniati Rifki Agung Rina Pratiwi Rudy Handoyo Satrio Adi W Sulistiyati Bayu U Tjahjono Tjahjono Tjipta Bahtera Tjipta Bahtera Tjipta Bahtera Tun Paksi Sareharto Vega Karlowee Yora Nindita