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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Majalah Kedokteran Bandung Althea Medical Journal Indonesian Journal of Urology Majalah Patologi Indonesia Jurnal Ilmu Bedah Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Locus Penelitian dan Pengabdian Eduvest - Journal of Universal Studies
Anglita Yantisetiasti
Department Of Anatomical Pathology, Faculty Of Medicine/Padjadjaran University, Hasan Sadikin Hospital, Bandung.
Aerospace Engineering Automotive Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Electrical & Electronics Engineering Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Perbandingan Gambaran Histopatologi Mukosa Kolon Tikus Putih (Rattus Norvegicus) Galur Wistar setelah Dilakukan Washout antara yang Menggunakan Nacl 0,9% dan Larutan Garam Meja 1% Lindayanti Tanzil; Rizki Diposarosa; Anglita Yantisetiasti
Jurnal llmu Bedah Indonesia Vol. 43 No. 1 (2014): September 2014
Publisher : Ikatan Ahli Bedah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46800/jibi-ikabi.v43i1.68

Abstract

Pendahuluan. Irigasi usus melalui rektum atau washout merupakan suatu prosedur menggunakan sebuah pipa yang dimasukkan melalui anus dan sejumlah cairan dimasukkan melalui pipa tersebut dengan tujuan untuk membersikan usus. NaCl 0,9% sering digunakan pada pasien–pasien penderita penyakit Hirschsprung sebagai cairan washout. Ada berbagai jenis cairan washout yang digunakan, beberapa diantaranya berupa cairan siap pakai yang dapat dibeli di apotek atau toko obat, cairan lainnya dapat dibuat di rumah yaitu larutan garam. Larutan garam ini dianggap sama dengan NaCl 0,9%. Larutan ini selain mudah dibuat dengan biaya yang relatif lebih rendah, tentu saja diharapkan efektivitasnya sama dengan NaCl 0,9%. Namun, garam yang beredar di Indonesia sebagian besar telah mengalami fortifikasi iodium.Tujuan penelitian ini untuk melihat perubahan histopatologi setelah dilakukan washout menggunakan larutan garam meja 1% dibandingkan dengan NaCl 0,9%. Metode. Penelitian ini merupakan penelitian eksperimental menggunakan 12 tikus Wistar yang terbagi dalam 2 kelompok yaitu kelompok yang dilakukan washout menggunakan NaCl 0,9% dan kelompok yang dilakukan washout menggunakan larutan garam meja 1%. Setelah kedua kelompok dilakukan washout, sampel jaringan diambil dari kolon kemudian dilakukan pemeriksaan histopatologi untuk melihat gambaran kongesti, edema dan inflamasi pada mukosa kolon tikus. Analisis statistik menggunakan Mann whitney dan Independent–T test, signifikan jika p<0,05. Hasil. Variabel kongesti, edema dan inflamasi pada kelompok NaCl 0,9% mempunyai skor rata–rata yang lebih tinggi dibandingkan kelompok larutan garam meja 1%. Berdasarkan hasil uji statistik tidak terdapat perbedaan yang bermakna antara kedua kelompok (kongesti p=0,065, edema p=0,306, inflamasi p=0,296. Kesimpulan. Tidak terdapat perbedaan histopatologi yang bermakna antara penggunaan NaCl 0,9% dan larutan garam meja 1% sebagai cairan washout
CLINICOHISTOPATHOLOGICAL STUDY OF TESTICULAR TUMOURS IN DR. HASAN SADIKIN GENERAL HOSPITAL BANDUNG Rindra Rizqyahya Retossa; Yantisetiasti, Anglita; Gita Tiara Dewi Nasution; Ahmad Agil; Muhammad Hasan Bashari
Indonesian Journal of Urology Vol 31 No 3 (2024)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v31i3.888

Abstract

Objective: The purpose of this research was to describe the clinical and histopathological characteristics of testicular tumours at Hasan Sadikin General Hospital (RSHS) between 2017-2021. Material & Methods: This research was a cross-sectional descriptive study examining the clinical and histopathological profiles of testicular tumours. The secondary data sources included medical records from the Department of Urology, Anatomic Pathology, Medical Records, and Hospital Information System (SIRS). The collected data covered age, ethnicity, clinical symptoms, site, stage, annual prevalence rate, and analyzed using Microsoft Excel. Results: There were 42 patients who had primary testicular tumour. The highest prevalence of testicular tumours at RSHS was in 2019 consist of 12(29%) patients and the lowest in 2020 were 6(14%) patients. Most patients were >35 years old amounting 19(45%) patients, Sundanese ethnicity were 29(69%) patients, and testicular enlargement revealed in 27(64%) patients. Majority patients were in stage 0/IB 36(86%) patients and occurred in unilateral testis which 34(80%) patients, with 3(7%) patients metastasized. The most common histopathological type was seminoma 18(43%) cases followed by prepubertal-type yolk sac tumour 9(21%) patients. Seminomas, and the fibroma-thecoma group were mostly in patients over 35 years old, while prepubertal-type yolk sac tumour was more commonly in children under 15 years old. Conclusion: Prevalence of testicular tumours increased from 2017 to 2019, then started to decrease in 2020. Histopathologically, seminoma was the most common type. These tumours were most commonly found in older individuals (>35 YO) and unilateral, diagnosed in stage 0/IB, and were mostly presented with enlargement of testis. Keywords: Testicular tumours, clinical features, histopathology
Clinicopathological Characteristics of Cervical Carcinoma with Pelvic Lymph Node Metastases in Dr. Hasan Sadikin General Hospital, Bandung 2013-2021 Sri Rejeki, Henny; Suryanti, Sri; Yantisetiasti, Anglita; Mantilidewi, Kemala I.; Winarno, Gatot Nyarumenteng Adhipurnawan
Althea Medical Journal Vol 10, No 2 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n2.2776

Abstract

Background: Carcinoma of the cervix is the most common gynecological malignancy, which ranks first among carcinomas in Indonesia. Lymph node metastasis is a risk of recurrence, affecting survival and therapy. The purpose of this study was to determine the clinicopathological characteristics of cervical carcinoma with pelvic lymph node metastasis that had undergone radical hysterectomy and lymphadenectomy at Dr. Hasan Sadikin General Hospital, Bandung.Methods: This study used a cross-sectional retrospective descriptive study. Data on the clinical stage I-II cervical cancer patients with pelvic lymph node metastasis were collected  from the archives of the pathological anatomy  laboratory during period from 2013 to 2021. Data were presented in percentage.Results: There were 64 data patients, and the most common age of cervical carcinoma ranged from 40 to 50 years old (52%), the most common stage was stage II (66%), and the most frequent histopathological type was squamous cell carcinoma (70%). The highest degree of differentiation was moderate differentiation (50%). There was no difference in tumor size between sizes <4 cm and ≥4 cm.Conclusion: The cases of cervical carcinoma at Dr. Hasan Sadikin General Hospital Bandung are treated with radical hysterectomy and lymphadenectomy. The patients generally aged between 41–50 years old, stage II, and squamous cell carcinoma with a moderate degree of differentiation.
Effectiveness of Short-Term Use Denosumab and Risedronate Using β-Crosslaps and Histopathology as a Parameter in Osteoporotic Rat Model Siwendro, Afrisya Bimo; Ramdan, Ahmad; Ismiarto, Yoyos Dias; Yantisetiasti, Anglita; fachri, Dliyauddin
Majalah Kedokteran Bandung Vol 56, No 3 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3016

Abstract

Osteoporosis is a condition of decreased bone mass density. Pharmacological management uses drugs that decrease bone resorption or increase bone formation. The most commonly used drugs are bisphosphonates. Risedronate is one of these bisphosphonates. It inhibits osteoclasts, resulting in osteoclast apoptosis. Denosumab is a human monoclonal antibody that inhibits receptor activator kappa-B ligand, inhibiting osteoclast activation. Both drugs are widely used. Research on the efficacy of these two mechanisms has yet to obtain conclusive results. β-cross-laps is a parameter that can be used to evaluate the effectiveness of therapy through monitoring the bone resorption process. This experimental study used female rats >9 weeks old and was conducted at the Pharmacology and Therapeutic Laboratory, Universitas Padjadjaran Bandung, Indonesia, from  June to September 2021. This study utilized a simple random sampling to allocate 24 experimental animals into three groups: control, risedronate, and denosumab. β-Crosslaps expression values before ovariectomy, post ovariectomy before receiving medication, and post ovariectomy and receiving medication was recorded and statistically analyzed using the SPSS version 24.0. The analysis of 24 samples revealed a statistically significant decrease in the median value of β-Crosslaps after ovariectomy in the denosumab group (p=0.036) when compared to the control group, whereas the decrease in the risedronate group was not significant (p=0.687). Administration of denosumab in rat models is more effective in reducing bone resorption compared to risedronate.
Karakteristik klinikopatologikal Mucoepidermoid Carcinoma kelenjar liur di Rumah Sakit Umum Pusat dr Hasan Sadikin (RSHS) Bandung tahun 2013-2022: A 10 Year review Noor Fitriana, Maya; Usman, Hermin Aminah; Yantisetiasti, Anglita
Majalah Patologi Indonesia Vol. 33 No. 3, September 2024
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i2.596

Abstract

Background Primary salivary gland malignancy is rare and has limited reports. Mucoepidermoid Carcinoma (MEC) is the most common malignant tumor of the salivary glands. However, epidemiological reports on salivary gland MEC are still limited, particularly in Indonesia. This study aimed to report the clinicopathological characteristics of Salivary gland MEC in dr Hasan Sadikin Central Hospital (RSHS) from January 2013 to December 2022. Method: This study is a descriptive study with a cross-sectional method. Total cases of salivary glands MEC that were histopathologically diagnosed and recorded in the RSHS Hospital Information System (SIRS) medical records from 2013 to 2022 were collected. It is included demographic, clinical, and histopathological data. Result A total of 86 MEC cases were diagnosed histopathologically between 2013 and 2022. The cases involved 44 (51,2%) females and 42 (48,8%) males. The mean age is 46,4 years old. The most common site affected is a parotid gland (37,2%). According histopathological grade, 51,2% were high grade, 25,6% were intermediate grade, and 23,3% were low grade. The result of clinical stage is Stage III has the highest percentage (n=32, 37,2%). The majority of patients receive surgical combined with radiotherapy treatment (n=53; 61,6%). Conclusion There are 86 cases of Salivary MEC in RSHS period 2013-2022. MEC is common in females, mean age 46,4 years old. Parotid gland is the most common site. The most frequent histopathological grading and clinical staging are high grade and stage III. Keyword Mucoepidermoid carcinoma, salivary gland, clinicopathological, RSHS
Neuroendocrine Carcinoma of The Uterine Cervix: Clinicopathological Profile and Outcomes From a Tertiary Referral Center in Indonesia Permatasari, Anita; Dewayani, Birgitta Maria; Yantisetiasti , Anglita
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 9 (2025): : JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i9.4856

Abstract

Neuroendocrine carcinoma of the cervix (NECC) is a rare and aggressive cervical malignancy with poor prognosis. Data from Indonesia remain scarce. We retrospectively reviewed 55 cases of NECC diagnosed at Dr. Hasan Sadikin General Hospital, Bandung, between 2019 and 2025. Clinicopathological data included age, International Federation of Gynecology and Obstetrics (FIGO) stage, histologic subtype, lymphovascular invasion (LVI), and metastatic status. Overall survival (OS) was estimated using Kaplan–Meier analysis. Patients’ ages ranged from 24 to 82 years, with a median age of 46 years. Most cases were diagnosed at locally advanced stages (FIGO II–III, 54.5%), while 14 patients (25.5%) presented with distant metastatic disease (IVB). Small cell NECC was the predominant subtype, while large cell and admixed variants were less frequent. LVI was present in more than half of the cases. Distant metastases at diagnosis were identified in the lungs, bone, and liver. At the last follow-up, 25 patients (45.4%) had died. Kaplan–Meier analysis revealed a median OS of 14.5 months, with 1-year survival of 52% and 2-year survival of 42%. NECC in Indonesia presents mostly at locally advanced stages, with high rates of LVI and frequent metastases, leading to poor survival. These findings highlight the aggressive course of NECC and provide baseline data for future studies in Indonesia.
Quantitative Histomorphometrical Analysis in Distinguishing Non-Hodgkin Malignant Lymphoma, Large Cell Type with Nasopharyngeal Carcinoma Husain, Okky; Aminah Usman, Hermin; Yantisetiasti, Anglita; Handayani, Astri; S Hernowo, Bethy
Majalah Patologi Indonesia Vol. 33 No. 1, Januari 2024
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i1.526

Abstract

Background Non-Hodgkin’s Malignant Lymphomas (NHMLs) with large cell morphology have similar histopathological appearance with Nasopharyngeal Carcinoma, undifferentiated type therefore ancillary examination such as Immunohistochemistry (IHC) are required. Quantitative histomorphometrical analysis able to identify subtle detail. The aim of this study is to measure the accuracy of quantitative histomorphometrical analysis to distinguishing NHML, large cell type with Nasopharyngeal Carcinoma.   Methods Up to 33 Hematoxylin and Eosin (HE) slides from NHML, large cell type, and 27 cases of Nasopharyngeal Carcinoma were photographed under 400 times magnification with a total of 7131 images. Background, nuclei, and extra-nuclear components between cells are segmented as mathematical objects. Objects’ properties were measured and represented as distribution factors (minimum, quartile 1, median, quartile 3, maximum, range, and interquartile range). Significant factors that can differentiate the study groups are measured with a fisher-exact statistical test. Models to predict NHML, large cell type from nasopharyngeal carcinoma were formulated with different numbers of factors. The HE diagnosis accuracy compared to IHC was measured   Results A sum of 7131 with 3893 from NHMLs, large cell type, and 3238 images of nasopharyngeal carcinoma were collected. After features selection, up to 76 properties factors are selected. Models' accuracy are ranging from 72.67% with a single factor and up to 89.9% with the whole selected factors.   Summary Models’ accuracy are higher (72.6-89.9%) compared to HE primary diagnosis (60%) in distinguishing NHML, large cell againts nasopharyngeal carcinoma. Quantitative histomorphometry can assist pathologist for early screening to distinguishing NHML, large cell type with Nasopharyngeal Carcinoma.
A Rare Primary Breast Angiosarcoma with Bone Metastasis: A Case Report Sari , Rupita; Kiki A. Rizki; Anglita Yantisetiasti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1095

Abstract

Background: Angiosarcoma is a rare and aggressive malignant tumor originating from endothelial cells. Primary breast angiosarcoma (PBA) is exceedingly uncommon, accounting for less than 1% of all breast malignancies. Bone metastasis from PBA is even rarer, making it a unique clinical entity. Case presentation: We present the case of a 37-year-old woman who initially presented with a rapidly enlarging breast mass. A biopsy confirmed the diagnosis of PBA, and she underwent a modified radical mastectomy followed by radiotherapy. Seventeen months later, she developed progressive lower extremity weakness and urinary and bowel incontinence. Imaging revealed a spinal metastasis at the Th4-Th6 level. Biopsy and immunohistochemistry confirmed metastatic angiosarcoma. The patient underwent laminectomy and posterior stabilization. Conclusion: This case highlights the rarity and aggressive nature of PBA with bone metastasis. It emphasizes the importance of early detection, comprehensive treatment, and long-term surveillance in managing this challenging disease. Further research is needed to understand the underlying mechanisms and develop effective therapeutic strategies for PBA with bone metastasis.
Analisis Gambaran Histopatologi Gastritis Kronik dengan dan Tanpa Bakteri Helicobacter pylori Menurut Sistem Sydney Deassy Ariefiany; Abdul Hadi Hassan; Birgitta M Dewayani; Anglita Yantisetiasti
Majalah Patologi Indonesia Vol. 23 No. 2, Mei 2014
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background Histopathology definition of chronic gastritis is a chronic inflammation of the gastric mucosa that can cause glandular atrophy and intestinal metaplasia of the gastric mucosal epithelium. Chronic gastritis can be caused by many factors. The most common etiology chronic gastritis by the bacterium Helicobacter pylori (Hp). The incidence chronic gastritis causes of Hp is more common in developing country than developed country. Histopathological picture on chronic gastritis causes of Hp similar with chronic gastritis non-Hp. The aims of this study to determine the difference of histopathological picture between chronic gastritis with Hp and chronic gastritis without Hp bacteria in the Hospital Dr Hasan Sadikin Bandung. Methods The sample used in this study were 30 cases of chronic gastritis with Helicobacter pylori (Hp) and 30 cases of chronic gastritis non-Hp bacteria from the Pathology Department of the hospital Dr. Hasan Sadikin Bandung. The research start from May 1st until November 30th 2012. All sample cases histopathology is seen the image of the Sydney sistem classification, after that are staining with immunohistochemical with antibody monoclonal Hp was performed to confirm the presence of the Hp. Results Immunohistochemical staining result obtained from 42 cases of the bacteria Hp positive and 18 negative cases the bacteria Hp. Chronic inflammation in chronic gastritis with Hp with chronic gastritis without Hp bacteria are in category 3 (limfosit cell more than 20/10HPF) as much as 88,1% and 88,9%. Conclusion Histopathological picture of chronic gastritis with Hp bacteria did not differ with chronic gastritis without Hp bacteria. Key words: Chronic gastritis, Helicobacter pylori, Sydney system.
Hubungan antara HER-2/neu dan Ki-67 dengan Respons Kemo-terapi Neoadjuvan pada Karsinoma Payudara Lanjut Lokal I Made Jatiluhur; Anglita Yantisetiasti; Abdul Hadi Hassan; Bethy S Hernowo
Majalah Patologi Indonesia Vol. 23 No. 3, September 2014
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background Locally advanced breast cancer (LABC) were stage III breast carcinoma based on TNM system, with an incidence >50% of all breast cancers in developing countries , including Indonesia. The first treatment of LABC is neoadjuvant chemotherapy, most often in anthracycline base. The purpose of this study is to analyze the relationship between HER-2/neu and Ki-67 with anthracycline-based neoadjuvant chemotherapy responsse in LABC. Methods The study involved 52 LABC, each of 26 patients responsding and not responsding. Paraffin block from biopsy stained with HER-2/neu and Ki-67 immunohistochemistry. HER-2/neu expression interpreted as positive and negative, while Ki-67 were categorized as
Co-Authors Aaron Tigor Sihombing Abdul Hadi Hassan Ahmad Agil Ahmad Ramdan Anita Permatasari Bashari, Muhammad Hasan Bethy S Hernowo Bethy S Hernowo, Bethy Betthy S Hernowo, Betthy S Betthy S. Hernowo Betthy S. S. Hernowo Betty Marlina Birgitta M Dewayani Dandy Tanuwidjaja Darmadji Ismono Darmadji Ismono, Darmadji Deassy Ariefiany Desy Anggraini Desy Anggraini Dewayani, Birgitta Maria fachri, Dliyauddin Farah Farera Gatot Nyarumenteng Adhipurnawan Winarno Gita Tiara Dewi Nasution Gunasegaran, Kirtana Handayani, Astri Hasrayati Agustina Hermin Aminah Usman Husain, Okky I Made Jatiluhur Indra Jaya Irawan, M.Naseh Sajadi Budi Kiki A. Rizki Kirtana Gunasegaran Lindayanti Tanzil M.Naseh Sajadi Budi Irawan Mantilidewi, Kemala I. Mas Adi Sunardi Muhammad Rivai Muhammad Syah Misuari Sabirin Noor Fitriana, Maya Rindra Rizqyahya Retossa Rizki Diposarosa Sari , Rupita Siwendro, Afrisya Bimo Sri Rejeki, Henny Sri Suryanti Suryajaya, Bernard Santoso Suwandi Sugandi Yoyos Dias Ismiarto