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All Journal Jurnal Sains Dasar Pendas : Jurnah Ilmiah Pendidikan Dasar Jurnal Farmasi Indonesia Jurnal Biomedika Jurnal Kefarmasian AKFARINDO Berkala Ilmiah Mahasiswa Farmasi Open Access Indonesian Journal of Medical Reviews Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Multidisiplin Madani (MUDIMA) Jurnal Ventilator: Jurnal Riset Ilmu Kesehatan dan Keperawatan Strada Jurnal Ilmiah Kesehatan (SJIK)
Ismi Rahmawati
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Evaluation of Drug Management at the Pharmacy Installation of "X" Regency Health Office Indonesian in 2021 Naha Ndjurumbaha, Echa Malinda; Gunawan Pamudji Widodo; Ismi Rahmawati
Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 5 (2023): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v3i5.357

Abstract

Improving public health status can be influenced by the drug management process, one of the components of which is the availability of good drugs. This study aimed to find out the overall process description of drug management, which includes the planning, procurement, storage, and distribution stages, as well as to know the evaluation of drug management related to compliance with the indicators of the Ministry of Health of the Republic of Indonesia & JICA 2010. This study used a type of research descriptive data collection with retrospective and concurrent. Data analysis was carried out by explaining the drug management process at the "X" Regency Health Office, measuring the value of each drug management indicator, and then making a problem-solving based on the Hanlon method. The results of the evaluation of drug management at the Pharmacy Installation of the "X" Regency Health Office were the suitability of the available drug items with the Fornas of 54%; percentage of fund allocation procurement drugs by 93%; percentage suitability of drug planning and procurement by 73%; the percentage of drug planning accuracy is 84%; percentage and value of expired drugs by 8% worth Rp. 39,888,756; The accuracy of drug distribution is 94%; drug availability12-18 months of 94%; and the percentage of drug blanks is 2%. Some indicators are not up to standard, so improvements are made using the Hanlon method.
The Potential of Parijoto Fruit Extract Fraction (Medinilla speciosa Blume) as Antibiofilm against Staphylococcus aureus Bacteria Nafi’ah, Luthfiana Nurulin; Ismi Rahmawati; Titik Sunarni
Open Access Indonesian Journal of Medical Reviews Vol. 4 No. 2 (2024): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v4i2.547

Abstract

Parijoto fruit extract (Medinilla speciosa Blume) contains flavonoids, saponins, tannins, and terpenoids and has antibacterial potential in inhibiting the growth of Staphylococcus aureus bacteria. S. aureus bacteria are bacteria that are capable of forming biofilms. This research aims to determine the potential of extracts and fractions (water, ethyl acetate, and n-hexane) in inhibiting the formation and degradation of S. aureus biofilms. Parijoto fruit was extracted using the maceration method with 96% ethanol solvent. The extract was fractionated using a liquid-liquid partition technique with water, ethyl acetate, and n-hexane as solvents. The antibiofilm activity test against the S. aureus bacteria ATCC 25923 was carried out by treatment inhibiting biofilm formation and biofilm degradation. The method is to read absorbance using a microplate reader with a wavelength of 595 nm. Optical density results to calculate IC50 and EC50 values. The results showed that the extract and fractions (water, ethyl acetate, and n-hexane) had the potential to inhibit the formation and degradation of S. aureus bacterial biofilms. The IC50 of biofilm inhibition in the extract, water fraction, ethyl acetate, and n-hexane against S. aureus bacteria was 2.51; 1.03; 1.10; 1.52 mg/ml. The EC50 value of the biofilm degradation test on the extract, water fraction, ethyl acetate, and n-hexane against S. aureus bacteria was 1.03; 1.17; 1.37; 1.88 mg/ml. The most active fraction of parijoto fruit (Medinilla specosa Blume) in inhibiting and degrading S. aureus bacterial biofilms is the water fraction.
UJI AKTIVITAS ANTIBAKTERI KOMBINASI EKSTRAK BIJI JINTAN HITAM (Nigella sativa L.) DAN DAUN CENGKEH (Syzygium aromaticum) TERHADAP BAKTERI Pseudomonas aeruginosa ATCC 27853 Tria Agustina; Ismi Rahmawati; Fitri Kurniasari
Jurnal Kefarmasian Akfarindo Vol 11 No 1 (2026)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.1191

Abstract

Pseudomonas secara intrinsik resisten terhadap antimikroba dan dapat mengembangkan resistensi selama kemoterapi antipseudomonal yang keduanya membahayakan pengobatan infeksi. Biji jintan hitam mengandung thymoquinone yang telah terbukti menghambat Pseudomonas, sementara daun cengkeh kaya eugenol yang memiliki aktivitas antibakteri signifikan. Penelitian ini bertujuan untuk mengevaluasi aktivitas antibakteri kombinasi ekstrak etanol biji jintan hitam dan daun cengkeh terhadap Pseudomonas, serta mengidentifikasi kombinasi tersebut menghasilkan efek sinergis atau antagonis. Penelitian ini menggunakan metode True Experimental Design dengan metode uji difusi cakram dan pita kertas. Uji dilusi digunakan untuk menetapkan nilai KHM dan KBM berdasarkan perbandingan yang paling efektif dalam membunuh bakteri dengan seri pengenceran mulai dari konsentrasi 50%; 25%; 12,5%; 6,25%; 3,12%; 1,56%; 0,78%; 0,39%; 0,19%; 0,09%. Uji difusi dengan kertas cakram menggunakan perbandingan antara (1:1); (1:2); (2:1). Aktivitas antibakteri kombinasi dilakukan uji pola interaksi menggunakan metode pita kertas. Analisis data menggunakan SPSS dengan nilai signifikansi (p> 0,05). Penelitian menunjukkan bahwa ekstrak tidak dapat ditentukan nilai KHM karena ekstrak berwarna gelap. Ekstrak biji jintan hitam memiliki KBM 50% dan daun cengkeh memiliki KBM 50%. Hasil uji difusi pada ekstrak tunggal biji jintan hitam memiliki diameter 20 mm dan daun cengkeh 17,7 mm. Kombinasi (1:1) memiliki diameter daya hambat 14,43 mm, kombinasi (1:2) 17,1 mm dan kombinasi (2:1) 20,43 mm. Aktivitas antibakteri kombinasi biji jintan hitam dan daun cengkeh yang efektif adalah perbandingan (2:1). Pada uji pita kertas hasil yang didapatkan adalah bersifat sinergis.
Co-Authors Ana Indrayati Aprilia rina wati Daryono Hadi Tjahjono Dwiningsih Dwiningsih Fradine, Chossy Frans Aditia Wiguna Gunawan Pamudji Widodo Ika Purwidyaningrum Inaratul Rizkhy Hanifah Iswandi Iswandi Kukuh Andri Aka Kurniasari, Fitri Marlia Singgih Wibowo Mustika Wati Nafi’ah, Luthfiana Nurulin Naha Ndjurumbaha, Echa Malinda Opstaria saptarini Patricius Prima Dimas Putranto Putri, Luluk Aniqoh Meliana Ratna Ika Yusuf Ratno Agung Samsumaharto Sancka Stella G. Sihura Sardjiman Sardjiman Siti Kamillah Titik Sunarni Tria Agustina Vivin Nopiyanti