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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Presipitasi : Media Komunikasi dan Pengembangan Teknik Lingkungan Berkala Kedokteran The Indonesian Biomedical Journal Jurnal Berkala Kesehatan JPKMI (Jurnal Publikasi Kesehatan Masyarakat Indonesia) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Indonesian Journal of Perinatology Jurnal Pengabdian Ilung (Inovasi Lahan Basah Unggul) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Iskandar Iskandar
Public Health Study Program, Faculty Of Medicine And Health Sciences, Lambung Mangkurat University
Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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STUDY OF INTERACTION BETWEEN LEAD AND GASTRIC MUCOSAL PROTEIN OF RATS WITH FORENSIC TOXICOLOGY APPROACH Aflanie, Iwan; Thalib, Iskandar; Suhartono, Eko
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v13i2.4065

Abstract

Abstract: Recently, forensic toxicology has been an interesting concern, especially in exposing the phenomena associated with the law. Using the forensic toxicology approach, several cases of lead (Pb) poisoning have been widely revealed. In this present study will be investigate the interaction between Pb and amino acid gastric mucosal constituent proteins, especially cysteine and tyrosine groups. This research is a pure experimental research with posttest control group design, which is divided into 4 groups with 6 rats (Rattus novergicus) in each group. Treatment in each group as follows; P0 was control group were given 2 ml of distilled water; P1 = administration of Pb 0.1 g/L; P2 = Pb administration of 1 mg/L; and P3 = Pb administration of 10 g/L for 4 weeks repectively. According to the results, it can be concluded that Pb-Protein interaction tends to binding of Pb-Cysteine rather than Pb-Tyrosine Keywords: Gastric Mucosa, Lead, Protein
EFFECT OF CADMIUM EXPOSURE ON INCREASING RISK OF DIABETES MELITUS THROUGH THE MEASUREMENT OF BLOOD GLUCOSE LEVEL AND LIVER GLUCOKINASE ACTIVITY IN RATS Thalib, Iskandar; Budianto, Windy Yuliana; Suhartono, Eko
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v13i2.4068

Abstract

Abstract: This present study was undertaken to investigate the effect of cadmium (Cd) exposure on an increasing risk of Diabetes Melitus (DM), through the measurement of blood glucose level and liver glucokinase activity in rats. The subjects that used in this study are 15 male rats (Rattus novergicus) with normal activity, 2-3 months old, and weighing 300±10 gram. The research subjects the divided into 3 groups; P0 group are given commercial fed rats diets only; P1 are given commercial fed rats + Cd with a concentration of 3 mg/l in drinking water for 1 day (acute); and P2 are given commercial fed rats+Cd with a concentration of 3 mg/l in drinking water for 4 weeks (subacute). The results of this present study shows that treatment with Cd significantly increase the levels of blood glucose (P < 0,05). The result also showed that treatment with Cd can increase the Km value of liver glucokinase, and it means Cd exposure can decrease the affinity between glucose and glucokinase. The present study demonstrated that Cd exposure could increase the risk of DM through increased the blood glucose and decrease the activity of liver glucokinase. Keywords: Cadmium, glucose metabolism, glucose, glucokinase
Prevention of Dengue Hemorrhagic Fever (DHF) Associated with the Aedes aegypti Larvae Presence based on the Type of Water Source Hidayah, Nurul; Iskandar, Iskandar; Abidin, Zainal
Journal of Tropical Life Science Vol 7, No 2 (2017)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.07.02.05

Abstract

Aedes aegypti is the vector of Dengue Hemorrhagic Fever (DHF) disease. Containers are breeding places for DHF vector and the most commonly found larvae in the bath water containers. The presence of Aedes aegypti larvae in a container could be affected by the type of water source besides the container’s color, material, location, lid existence and the container’s drain frequency. This study was conducted to determine the associate of water source type with larvae presence and the additional factors. This study used observational analytic with case control design. The case group consisted of households using well water and the control group consisted of households using tap water with a sample size of 130 households for each group. The sample was collected by proportional random sampling in five villages. The data was analyzed using a regression logistic test. The significant variables associated with the presence of larvae were the water source type (OR=1.923), container’s color (OR=2.345), container’s location (OR=2.241), container’s lid existence (OR=2.122) and the container’s drain frequency (OR=2.260). This study did not consider the significant association of the container’s material. The dominant variable associated with the presence of larvae was the container’s drain frequency which was controlled by the water source type, container’s color and container’s location.
STUDY OF INTERACTION BETWEEN LEAD AND GASTRIC MUCOSAL PROTEIN OF RATS WITH FORENSIC TOXICOLOGY APPROACH Iwan Aflanie; Iskandar Thalib; Eko Suhartono
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (714.156 KB) | DOI: 10.20527/jbk.v13i2.4065

Abstract

Abstract: Recently, forensic toxicology has been an interesting concern, especially in exposing the phenomena associated with the law. Using the forensic toxicology approach, several cases of lead (Pb) poisoning have been widely revealed. In this present study will be investigate the interaction between Pb and amino acid gastric mucosal constituent proteins, especially cysteine and tyrosine groups. This research is a pure experimental research with posttest control group design, which is divided into 4 groups with 6 rats (Rattus novergicus) in each group. Treatment in each group as follows; P0 was control group were given 2 ml of distilled water; P1 = administration of Pb 0.1 g/L; P2 = Pb administration of 1 mg/L; and P3 = Pb administration of 10 g/L for 4 weeks repectively. According to the results, it can be concluded that Pb-Protein interaction tends to binding of Pb-Cysteine rather than Pb-Tyrosine Keywords: Gastric Mucosa, Lead, Protein
EFFECT OF CADMIUM EXPOSURE ON INCREASING RISK OF DIABETES MELITUS THROUGH THE MEASUREMENT OF BLOOD GLUCOSE LEVEL AND LIVER GLUCOKINASE ACTIVITY IN RATS Iskandar Thalib; Windy Yuliana Budianto; Eko Suhartono
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (589.562 KB) | DOI: 10.20527/jbk.v13i2.4068

Abstract

Abstract: This present study was undertaken to investigate the effect of cadmium (Cd) exposure on an increasing risk of Diabetes Melitus (DM), through the measurement of blood glucose level and liver glucokinase activity in rats. The subjects that used in this study are 15 male rats (Rattus novergicus) with normal activity, 2-3 months old, and weighing 300±10 gram. The research subjects the divided into 3 groups; P0 group are given commercial fed rats diets only; P1 are given commercial fed rats + Cd with a concentration of 3 mg/l in drinking water for 1 day (acute); and P2 are given commercial fed rats+Cd with a concentration of 3 mg/l in drinking water for 4 weeks (subacute). The results of this present study shows that treatment with Cd significantly increase the levels of blood glucose (P < 0,05). The result also showed that treatment with Cd can increase the Km value of liver glucokinase, and it means Cd exposure can decrease the affinity between glucose and glucokinase. The present study demonstrated that Cd exposure could increase the risk of DM through increased the blood glucose and decrease the activity of liver glucokinase. Keywords: Cadmium, glucose metabolism, glucose, glucokinase
Biotoxic of Gemor (Nothaphoebe coriacea) Leaves from Peat Swamp Tumbang Nusa Research Forest, Central Kalimantan, Indonesia Iskandar Thalib; Purwanto Budi Santosa; Eko Suhartono
Berkala Kedokteran Vol 14, No 2 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (185.259 KB) | DOI: 10.20527/jbk.v14i2.5329

Abstract

Abstract: The study aimed to evaluate the sub-acute toxicity effect of aqueous N. coriacea leaves extract to kidney and liver function. The biotoxic study was conducted using male rats. In this study, the experimental animals received five different doses of aqueous N. coriacea leaves extract (0.1 mg, 1 mg, 10 mg, 100 mg, and 1000 mg per day) for 4 weeks via oral route. After treatment, the level of plasma ureum, creatinine, Aspartate Transaminase (AST) and Alanine Transaminase (ALT) level were measured. The results show that most of dose treatments of aqueous extract of N. coriacea leaves had not statistically effect on the level of the plasma ureum and creatinine except for dosage of 1000 mg. Similarly, the dose treatments of that extract did not statistically change the plasma AST and ALT, except on 100 and 1000 mg/kg of b.w extract dose. In conclusion, a short-term intake of N. coriacea leaves extract via oral route was not toxic to kidney and liver. Keywords: N. coriacea, Kidney, Liver, Toxicity.
UV-Visible Spectrophotometric as a Prospective Tool in Neonatal Sepsis Eko Suhartono; Ari Yunanto; Edi Hartoyo; Nia Kania; Adelia Anggraini Utama; Ratih Kumala Sari; Niarsari Anugrahing Putri; Iskandar Thalib
The Indonesian Biomedical Journal Vol 10, No 1 (2018)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v10i1.360

Abstract

BACKGROUND: This study was aimed to employ the UV-Visible (UV-Vis) spectrophotometry techniques to detect the changes in the blood of neonatal sepsis (NS) subject for a deeper understanding in the pathomechanism of NS.METHODS: The cross-sectional study was conducted from February to May 2017 in the Neonatology Division, Department of Pediatric, Ulin General Hospital/Faculty of Medicine, Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia. Blood specimens were taken from newborns, of which 15 each of newborns at risk of sepsis and without risk of sepsis. Data were analyzed by using Mann-Whitney U test.RESULTS: The result of this study suggested that there is a significant difference in the average of absorbance ratio parameter using UV-Vis spectrophotometric methods on the case group compared to the control group. Also, there is a significant difference between advanced oxidation protein products (AOPPs) and thiocyanate (SCN) level in newborn at risk of sepsis.CONCLUSION: The present study demonstrated there were significant differences between the average of absorbance ratio parameter for protein and oxy-hemoglobin region using UV-Vis spectrophotometric methods in healthy subjects and newborn at risk of sepsis.KEYWORDS: spectrophotometric, neonatal sepsis, oxidative stress
The effect of antibiotic therapy on Salivary Catalase kinetic parameters in neonatal at risk of Sepsis Ari Yunanto; Pricilia Gunawan Halim; Iskandar Iskandar; Eko Suhartono
Indonesian Journal of Perinatology Vol. 1 No. 1 (2020): Available Online: 1 December 2020
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (467.688 KB) | DOI: 10.51559/inajperinatol.v1i1.5

Abstract

Introduction: This study describes the effect of antibiotic therapy on salivary catalase kinetic parameters (CAT) at neonatal at risk of sepsis. Methods: Study is conducted from February – June 2015. Salivary samples are obtained from 20 neonates (5 normal-healthy neonates and 15 neonates at risk of sepsis) at Ulin General Hospital, Banjarmasin, Indonesia. The samples were placed in four different groups: P0 as control group (saliva + hydrogen peroxide/H2O2), P1 (saliva + 2 mg Ampicillin + H2O2), P2 (saliva + 0.2 mg Gentamicin + H2O2), P3 (saliva + 2 mg Ampicillin + 0.2 mg Gentamicin + H2O2). The solution is incubated at 37oC and 40oC before catalase (CAT) activity is measured. Catalase activity is measured by using a spectrophotometer at 240 nm. Kinetic parameters are measured at different concentrations of H2O2 and temperature. Kinetic parameters are represented by the Michaelis-Menten constant (Km) and the maximum reaction speed (Vmax) obtained through the Lineweaver-Burk curve plot. Results: The Km of Catalase on the saliva of neonates at risk of sepsis treated with antibiotics (4.37, 1.84, 0.12, and 0.23, 3.74, 1.5, for P1, P2, P3 respectively) was lower than the control group (17.61 and 12.54), both at 37ºC and 40ºC. Similarly, Vmax of the neonates at risk of sepsis treated with antibiotics (0.46, 0.34, 0.04 and 0.07, 0.20, 0.24) was lower than the control group (1.47 and 0.53) at 37ºC and 40ºC. Conclusion: The study shows that the Catalase activity at the saliva of newborns at risk of sepsis treated with antibiotic was lower than the control group.
Fourier transformation infrared (FTIR) spectroscopy of human saliva as a novel approach for detection dengue virus infection in children Eko Suhartono; Iskandar Iskandar; Edi Hartoyo
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 1, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss1.art1

Abstract

No abstract
Evaluation of Antioxidant Activity of Some Selected Tropical Fruits in South Kalimantan, Indonesia Efrilia Tanjung; Muhammad Hafidz MS; Iskandar Thalib; Eko Suhartono
Journal of Tropical Life Science Vol. 4 No. 3 (2014)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.04.03.09

Abstract

In the present study antioxidant and antioxidant activity of some tropical fruits was evaluated. Antioxidants are compounds or molecules that can scavenging and prevent free radicals and reactive oxygen species that can caused a cell damage. Fruit was known as a source of antioxidant. South Kalimantan Indonesia, has a variety of fruit such as mentega, nangka, timun suri and kuranji. Study for evaluating the antioxidant levels and activity of those fruit were never been investigated. Thus, our study aim to measure the antioxidant levels and antioxidant activtity of those selected fruits. Ascorbic acid, lycopene, b-carotene levels and antioxidant activtity of four selected tropical fruits was evaluated using spectrophotometer. The result of this studied suggest that the four selected tropical fruits is potential antioxidant because it contained ascorbic acid, b-carotene, lycopene and had effect of scavenging radical hydroxyl, hydrogen peroxide and chellating ferrous iron.
Co-Authors Adelia Anggraini Utama Alin, Dhemes Angga Praditya Ari Yunanto Ari Yunanto Cynthia Maharani Puspita Sari Edi Hartoyo Edi Hartoyo Efrilia Tanjung Eko Suhartono Eko Suhartono Eko Suhartono Erlena, Erlena Hafifah, Ifa Haryatie, Haryatie Iskandar Iskandar Isna Syauqiah Iwan Aflanie Muhammad Hafidz MS Nasution, Annio Indah Lestari Nia Kania Niarsari Anugrahing Putri Nila Nirmalasari, Nila Nurul Hidayah Prastricia, Meily Andini Pricilia Gunawan Halim Purwakaning Agung Purwanto Budi Santosa Putera, Gusti Muhammad Perdana Ratih Kumala Sari Salmon Siahaan Sanyoto, Didik Dwi Sekartaji, Hapsari Lintang Silvia Kristanti Tri Febriana Trang, Ha Thi Thu Windy Budianto Windy Yuliana Budianto, Windy Yuliana Yaliza, Nella Yusanto Nugroho Zainal Abidin Zainal Abidin Zairin Noor Zuhrufa Wanna Yolanda