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All Journal Majalah Kedokteran Bandung Berkala Kedokteran Universa Medicina Jurnal Berkala Kesehatan Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Manuju : Malahayati Nursing Journal Jurnal Ners An-Nadaa: Jurnal Kesehatan Masyarakat Journal Orthopaedi and Traumatology Surabaya (JOINTS) MAHESA : Malahayati Health Student Journal Homeostasis: Jurnal Mahasiswa Pendidikan Dokter Cermin Dunia Kedokteran
Zairin Noor
Departemen Bedah Orthopaedi RSU Ulin-Fakultas Kedokteran Universitas Lambung Mangkurat Banjarmasin
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Perbedaan Kadar Kalsium Femur Tikus Setelah Paparan Akut Dan Subkronik Debu Batubara Nurmalita, Karina Solikha; Noor, Zairin; Setiawan, Bambang
Jurnal Berkala Kedokteran Vol 9, No 2 (2013): September 2013
Publisher : Pendidikan Dokter Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v9i2.946

Abstract

Abstract: Coal dust is a byproduct of coal processing and pollutants in coal mining area and transportation as well. After inhalation of coal dust, the particles will settle in alveoli of the lungs and spread through the vascular system by inflammatory process. The particles contain various minerals that increased substitution or incorporation process of bone mineral in hydroxyapatite lattice, include calcium. The aimed of this research was to determine the difference of Ca2+ levels in femur wistar rats caused by acute and subchronic coal dust exposure. This research was an observational analytic research. Subjects were male wistar rat bone samples taken from Bank Jaringan PEROSI Banjarmasin. Research subjects divided into seven groups: control, acute exposure (14 days) and subchronic exposure (28 days) each with an exposure dose at 6.25 mg/m3, 12.5 mg/m3, and 25 mg/m3. There were four samples femur in each group. Data were analyzed using Kruskal-Wallis test. The result did not show any significant differences of calcium levels in femoral bone wistar rats after acute (p=0,739) and subchronic exposure (p= 0,123). The conclusion, there were no significant differences of calcium levels in femur rats after exposure to coal dust with various dosage. Keywords: Calcium levels, coal dust, wistar rats, acute, subchronic. ABSTRAK: Debu batubara merupakan produk samping pengolahan batubara sekaligus polutan di area pertambangan dan transportasi batubara. Partikel tersebut mengandung berbagai macam mineral yang dapat memicu proses substitusi atau inkorporasi mineral tulang dalam kristal hidroksiapatit, salah satunya mineral kalsium. Penelitian bertujuan untuk mengetahui perbedaan kadar Ca2+ femur tikus wistar jantan akibat paparan debu batubara yang diberikan pada wakru berbeda. Penelitian ini merupakan penelitian observasional analitik menggunakan sampel tulang tikus wistar jantan yang diambil dari Bank Jaringan PEROSI Banjarmasin. Subjek penelitian dibagi dalam tujuh kelompok yaitu, kontrol, BB1 = dosis batubara 6,25 mg/m3, BB2 = dosis batubara 12,5 mg/m3, dan BB3 = dosis batubara 25 mg/m3, yang masing-masing diberi paparan akut (14 hari) dan paparan subkronik (28 hari). Berdasarkan hasil uji Kruskal-Wallis, disimpulkan bahwa tidak terdapat perbedaan bermakna apabila didapatkan nilai p<0,05. Hasil penelitian menunjukkan perbedaan kadar kalsium tulang femur tikus wistar jantan yang tidak bermakna setelah paparan akut (p=0,739) dan subkronik (p= 0,123). Tidak terdapat perbedaan bermakna dari kadar kalsium femur tikus setelah paparan debu batubara. Kata-kata kunci: Kadar kalsium, debu batubara, tikus wistar, akut, subkronik.
Perbedaan Efektivitas antara Cilostazol dan Aspirin terhadap Peningkatan Suhu Sela Jari: Tinjauan terhadap Kaki Diabetik Wagner Derajat II dan III Noor, Zairin; Al Audhah, Nelly
Jurnal Berkala Kedokteran Vol 10, No 1 (2014): Februari 2014
Publisher : Pendidikan Dokter Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v10i1.932

Abstract

ABSTRACT: Diabetes mellitus is a multisystem disease characterized by hyperglycemia due to abnormalities in insulin secretion, insulin mechanism, or both. Hyperglycemia in diabetes will lead to long-term complications, such as, several organs failure or disfunction, especially the eyes, kidneys, nerves, heart and blood vessels. One of the diabetic complications is diabetic foot. The appearance of diabetic foot mainly occurs due to repetitive trauma to the foot. After the appearance of ulcers, diabetic foot was compounded with decreased vascular in the patients, making it more difficult to recover. The poor vascularization for diabetic foot patients implicates falling temperatures of the toes. Cilostazol and aspirin are antithrombotic medicines that cause inhibition activation and aggregation trombosit, and vasodilatation. This study aimed to examine the effect of cilostazol and aspirin on toes temperature of the feet of diabetic patients. This research is an experimental research by calculating the average temperature of the toes of diabetic foot patients before and after the administration of cilostazol and aspirin . The results showed the average temperature of the subject toes before giving cilostazol and aspirin is 33.340C and 33.970C, and after administration is 33.540C and 34.720C. From this research it can be concluded that there is an increase in the temperature of the toes after administration of cilostazol and aspirin on the toes of diabetic foot patients. Keywords : Aspirin, Cilostazol, Diabetes Mellitus, Diabetic Foot ABSTRAK: Diabetes mellitus merupakan suatu penyakit multisistem dengan ciri hiperglikemia akibat kelainan sekresi insulin, kerja insulin, atau kedua-duanya. Hiperglikemia pada diabetes akan mengakibatkan komplikasi jangka panjang seperti, disfungsi atau kegagalan beberapa organ tubuh, terutama mata, ginjal, saraf, jantung dan pembuluh darah. Salah satu komplikasinya adalah kaki diabetik. Kemunculan kaki diabetik terutama terjadi karena adanya trauma berulang pada kaki. Setelah munculnya ulkus, kaki diabetik diperparah dengan daya vaskuler pasien yang menurun, sehingga sulit untuk sembuh. Buruknya vaskularisasi pasien kaki diabetik berimplikasi pada turunnya suhu sela jari kaki. Cilostazol dan aspirin adalah obat antitrombotik yang menyebabkan terjadinya inhibisi aktivasi dan agregasi trombosit, serta vasodilatasi. Penelitian ini bertujuan untuk melihat pengaruh cilostazol dan aspirin terhadap suhu sela jari kaki pada pasien kaki diabetik. Penelitian ini bersifat eksperimental dengan menghitung rata-rata suhu sela jari kaki pasien kaki diabetik sebelum dan setelah pemberian cilostazol dan aspirin. Hasil penelitian menunjukkan rata-rata suhu sela jari kaki subyek sebelum pemberian cilostazol dan aspirin adalah 33,340C dan 33,970C, dan setelah pemberian adalah 33,540C dan 34,720C. Dari hasil penelitian dapat disimpulkan bahwa terdapat peningkatan suhu sela jari kaki setelah pemberian cilostazol dan aspirin pada sela jari kaki pasien kaki diabetik. Kata-kata Kunci : Aspirin, Cilostazol, Diabetes Mellitus, Kaki Diabetik.
Assessment of microarchitecture and crystal structure of hydroxyapatite in osteoporosis Noor, Zairin; Sumitro, Sutiman B; Hidayat, Mohammad; Rahim, Agus Hadian; Taufiq, Ahmad
Universa Medicina Vol 30, No 1 (2011)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2011.v30.29-35

Abstract

Osteoporosis is characterized by lower bone mineral density (BMD) and microarchitectural degeneration, which tends to increase bone fragility and fracture risk. Bone microstructure depends on interactions between the mineral atoms, which may perform substitution or incorporation into bone crystals, and may dynamically take over the function of calcium or may become a complementary part. The mineral atoms may also become a composite in the hydroxyapatite crystals. The aim of this study was to find an association between the bone microstructure and hydoxyapatite crystal structure in osteoporosis, in comparison to normal bone. The subjects of this study were surgery patients at the Department of Orthopedics of Ulin General Hospital in Banjarmasin and other centers. Inclusion criteria consisted of the presence of fracture of trabecular bone, normal or osteoporotic BMD values, and no past history of chronic disease. Bone was obtained from fracture patients during surgery. The characteristics of the hydroxyapatite crystals were analyzed by X-ray diffraction (XRD) and the microarchitecture by scanning electron microscopy (SEM). SEM showed degeneration of the microarchitecture of osteoporotic bone, in comparison with normal bone. On XRD there was a peak of hydoxyapatite crystals only and no other crystal phases. Diffraction patterns showed a larger crystal size in osteoporotic bone as compared to normal bone, indicating higher porosity. It may be concluded that there is a difference in crystal size and morphologic distribution of hydoxyapatite in osteoporotic bone, determining bone microarchitecture.
DESCRIPTION OF EFFECTIVENESS OF CILOSTAZOL AND ASPIRIN AS ADJUVANT OF DIABETIC FOOT WAGNER GRADE II AND III Nurikhwan, Pandji Winata; Noor, Zairin; Al Audhah, Nelly
Berkala Kedokteran Vol 10, No 2 (2014): September 2014
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v10i12.961

Abstract

Abstract: Inflammation in patients with diabetic foot will activate platelets and cause aggregation and lead to stasis of blood flow. This inflammation is caused by infection of the diabetic foot. Management of diabetic foot infections in patients is the use of antibiotics. However, the presence of vascularization disorders causing antibiotic delivery to the site of infection to be disrupted so that the process of eradication of infection would be inhibited. One of inflamation markers on patient with diabetic foot is increasing of ESRs.The general objective of this study was to determine the efficacy difference between cilostazol and aspirin as an adjuvant to accelerate tissue healing of diabetic foot care Wagner Grade II – III based on erythrocyte sedimentation rate. This study is a descriptive study using the double-blind and randomized pretest-posttest design. A total of 14 samples is obtained by consecutive sampling. The results showed that four patients given cilostazol showed a 35% reduction in ESR and ten patients were given aspirin showed a 35% reduction in ESR. It can be concluded giving cilostazol and aspirin as adjuvant diabetic foot Wagner II and III showed a decrease in ESR. Key words: erythrocyte sedimentation rate, diabetic foot, cilostazol, aspirin. Listen 
Pengaruh Insuflasi terhadap Jumlah Sel Mast Peritoneum Tikus Fathoni, Muhammad Halim; Noor, Zairin; Poerwosusanto, Hery
Berkala Kedokteran Vol 12, No 1 (2016): Februari 2016
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v12i1.355

Abstract

Abstract:Peritoneal insufflation is swelling process to perform laparoscopic surgery, the choice of gas for insufflation in laparoscopic surgery, namely CO2. because it is not flammable bleak N2O, so it can be used safely for diathermy in mice. This study aims to determine whether there is influence insufflation in an increased number of mast cells in rats (Rattus norvegicus). This study is pure experimental research with posttest-only control group design, which consists of the control and treatment of pressure 8 mmHg and 10 mmHg, with the results obtained p0 control = 0.52 p1 8 mmHg = 7.84  p2 10 mmHg = 11.94. ANOVA test showed that the increase in the number of mast cells was significantly occurred in the group with a pressure of 10 mmHg as compared to the pressure of 8 mmHg. Based on research carried out can be concluded that the higher the CO2 gas in the insufflation pressure significantly increases the number of mast cells.Keywords: insuflation, peritoneal, cell Mast Abstrak: Insuflasi adalah proses penggembugan peritoneum untuk melakukan pembedahan laparoskopi, pilihan gas untuk insuflasi pada bedah laparoskopi yaitu CO2. karena tidak mudah terbakar seprti N2O, sehingga dapat digunakan secara aman untuk diatermi pada tikus. Penelitian ini bertujuan untuk mengetahui apakah ada pengaruh insuflasi dalam peningkatan jumlah sel mast pada tikus putih (Rattus norvegicus). penelitian ini merupakan penelitian experimental murni dengan posttest-only with control group design, yang terdiri dari kontrol dan perlakuan dengan tekanan 8 mmHg dan 10 mmHg, dengan hasil yang didapatkan p0 kontrol = 0,52 p1 8 mmHg = 7,84 p2 10 mmHg=11,94. Uji anova menunjukan bahwa peningkatan jumlah sel mast secara bermakna terjadi pada kelompok dengan tekanan 10 mmHg dibandingkan dengan tekanan 8 mmHg. Berdasarkan penelitian yang dilakukan dapat diambil kesimpulan bahwa semakin tinggi tekanan gas CO2 pada insuflasi secara bermakna dapat meningkatkan jumlah sel mast. Kata-kata Kunci :Insuflasi, sel mast, peritoneum
POTENSI EKSTRAK BAWANG DAYAK (Eleutherine sp) SEBAGAI OBAT HERBAL TERSTANDAR (OHT) PADA PENGOBATAN MEDIS Poerwosusanta, Hery; Ali, Mulyohadi; Noor, Zairin; Mintaroem, Karyono; Widjajanto, Edi
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 3, No 2 (2018)
Publisher : Akademi Farmasi ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (8.262 KB)

Abstract

Bawang Dayak (Eleutherine sp) merupakan salah satu tanaman yang tumbuh liar di hutan Kalimantan yang berpotensi dikembangkan menjadi Obat Herbal Terstandard. Berdasarkan studi etnofarmakologi, tanaman ini dimanfaatkan masyarakat suku Dayak sebagai obat diabetes, stroke, kanker payudara, antihipertensi, mempercepat penutupan luka, dan pengobatan jantung. Meski sudah digunakan turun temurun dan riset yang berkelanjutan, bawang Dayak belum dimanfaatkan dokter formal untuk pengobatan klinis. Hal ini disebabkan belum adanya uji y akurat dan terstandar yang dapat digunakan sebagai bukti ilmiah. Pada sisi lain, masyarakat berpendapat bahwa penggunaan bawang Dayak sebagai jamu dapat berbahaya karena komplikasi akibat bercampur dengan Bahan Kimia Obat (BKO). Dengan demikian, bawang Dayak perlu diupayakan dalam Program Saintifikasi Jamu untuk mewujudkan jamu, obat herbal terstandar, dan fitofarmaka yang berkualitas, bermutu serta aman. Oleh karena itu, pada artikel ini akan dibahas beberapa riset tentang bioaktifitas bawang Dayak mulai fitokimia hingga tahapan uji praklinik
Karakteristik Atom Mineral pada Osteoporosis dengan Arsitektur Porosis dan Nonporosis Noor, Zairin; Sumitro, Sutiman B.; Hidayat, Mohammad; Rahim, Agus Hadian
Majalah Kedokteran Bandung Vol 45, No 1 (2013)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (651.505 KB)

Abstract

Terdapat hasil yang bervariasi dalam peningkatan bone mineral density (BMD) akibat asupan kalsium mengindikasikan keterlibatan atom mineral lain dalam perkembangan struktur tulang. Kuantitas atom mineral tulang yaitu kadar atom mineral dalam struktur tulang. Penelitian ini bertujuan untuk membandingkan karakteristik atom mineral pada gambaran arsitektur (scanning electron microscope/SEM) porosis dibandingkan dengan nonporosis. Sepuluh penderita osteoporosis dengan gambaran SEM porosis dan tujuh penderita gambaran SEM nonporosis terlibat dalam penelitian ini. Tulang yang diambil ketika operasi fraktur dianalisis mikrostruktur dengan SEM dan karakter atom mineral tulang dengan X-ray fluorescence (XRF). Pemeriksaan SEM dan XRF dilaksanakan di Laboratorium Fisika Universitas Negeri Malang. Penelitian dilakukan mulai Agustus 2010 sampai Januari 2011. Uji t dilakukan untuk menentukan perbedaan kadar mineral tulang. Hasil SEM menunjukkan perbedaan porositas dan integritas trabekular antara SEM porosis dan SEM nonporosis. Analisis XRF didapatkan komposisi atom yang lebih tinggi pada tulang SEM nonporosis yaitu P, S, Fe, Ni, Cr, Pb, dan Si. Sebaliknya, komposisi atom yang lebih tinggi pada tulang SEM porosis adalah Cu, Zn, Ca, dan Mo. Perbedaan komposisi atom tersebut tidak berbeda secara bermakna (p>0,05). Simpulan, perkembangan porositas pada osteoporosis tidak didasari oleh kuantitas atom mineral tulang. [MKB. 2013;45(1):23–7]Kata kunci: Arsitektur, atom mineral, komposit, osteoporosisMineral Atomic Characteristic on Porotic and Non Porotic Architecture  of OsteoporosisThere was variance result in increased bone mineral density (BMD) due to calcium intake which indicates involvement of another mineral atomic in bone structure development. Bone mineral atomic quantity is the level or concentration of mineral atomic in bone structure. Aim of this study was to compare mineral atomic characteristic in architecture (scanning electron microscope/SEM) porotic and non porotic figure. Ten osteoporosis patients with porotic SEM and seven non porotic SEM patients were involved in this study. Bone which was obtained from fracture surgery was analyzed for microstructure by SEM and for bone atomic mineral characteristic by X-ray fluorescence (XRF). Analysis of SEM and XRF were done in Physics Laboratory State University of Malang. This study was done from August 2010 to January 2011. t-test was done to analyse the difference of atomic mineral level. Scanning electron microscope result showed the difference in porosity and trabecular integrity between porotic and non porotic SEM. Analysis of XRF showed atomic composition was higher in porotic SEM such as P, S, Fe, Ni, Cr, Pb and Si. Conversely atomic composition such as Cu, Zn, Ca, and Mo, was higher in non porotic SEM. There was no significant difference between each groups (p>0.05). In conclusion, the development of porocity in osteoporosis is not depend on bone mineral atomic quantity. [MKB. 2013;45(1):23–7]Key words: Architecture, composite, mineral atomic, osteoporosis DOI: http://dx.doi.org/10.15395/mkb.v45n1.96
HUBUNGAN INDEKS MASSA TUBUH DENGAN KECEPATAN BERJALAN PADA LANSIA DI PPRSLU BUDI SEJAHTERA BANJARBARU Firdaus, Muhammad Rizqi; Cahyawati, Wiwit Agung Sri Nur; Yasmina, Alfi; Noor, Zairin; Wahyuni, Wahyuni
Homeostasis Vol 7, No 1 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i1.12401

Abstract

Abstract: The walking speed is one of the indicators of the fitness in the elderly. One of the factors that influence walking speed is the Body Mass Index (BMI). This study aimed to determine the relationship between BMI and walking speed in the elderly. This cross-sectional study involved 40 elderly individuals living in PPRSLU Budi Sejahtera Banjarbaru who met the inclusion criteria. Data on walking speed were collected using the 4 Meters Walk Test. The relationship between BMI and walking speed was analyzed using Pearson correlation. The mean BMI was 23.4±4.6 kg/m2, the average walking speed was 0.44±0.18 m/s, and no elderlies with normal walking speed were found. There was a negative, moderate, and significant relationship between BMI and walking speed in elderly individuals with normal BMI (r = -0.528; p = 0.014), but no significant relationships were found in underweight and overweight-obese BMI categories (underweight: r = 0.387; p = 0.520; overweight-obese: r = -0.342; p = 0.231). In conclusion, there is a significant relationship between normal BMI and walking speed in the elderly living in PPRSLU Budi Sejahtera. Keywords: walking speed, body mass index, 4 Meters Walk Test, elderly Abstrak: Kecepatan berjalan merupakan salah satu tolok ukur kebugaran lansia. Salah satu faktor yang mempengaruhi kecepatan berjalan adalah indeks massa tubuh (IMT). Penelitian ini bertujuan mengetahui hubungan IMT dengan kecepatan berjalan lansia. Penelitian cross sectional ini melibatkan 40 lansia di PPRSLU Budi Sejahtera Banjarbaru sesuai kriteria inklusi. Pengambilan data kecepatan berjalan menggunakan 4 Meters Walk Test. Hubungan IMT dan kecepatan berjalan dianalisis dengan uji Pearson correlation. Didapatkan rerata IMT sebesar 23,4±4,6 kg/m2, sedangkan kecepatan berjalan adalah 0,44±0,18 m/s dan tidak ada yang mempunyai kecepatan berjalan normal. Terdapat hubungan negatif, moderat, dan bermakna antara IMT dengan kecepatan berjalan lansia dengan IMT normal (r = -0,528; p = 0,014), tetapi tidak terdapat pada IMT underweight dan overweight-obese (underweight: r = 0,387; p = 0,520; overweight-obese: r = -0,342; p = 0,231). Dapat disimpulkan bahwa terdapat hubungan bermakna antara IMT normal dengan kecepatan berjalan pada lansia di PPRSLU Budi Sejahtera. Kata-kata kunci: kecepatan berjalan, indeks massa tubuh, 4 meters walk test, lansia
HUBUNGAN INDEKS MASSA TUBUH DENGAN FRAILTY PADA LANSIA DI PPRSLU BUDI SEJAHTERA BANJARBARU Ansharullah, M Rifky; Cahyawati, Wiwit Agung Sri Nur; Yasmina, Alfi; Noor, Zairin; Wahyuni, Wahyuni
Homeostasis Vol 7, No 1 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i1.12380

Abstract

Abstract: Frailty is a sign of physiological and functional vulnerability in the elderly. One of the risk factors for frailty is BMI. This study aimed to determine the relationship between BMI and frailty in the elderly, using cross-sectional method. The research subjects were elderliesliving in PPRSLU Budi Sejahtera Banjarbaru, using total sampling method according to the inclusion and exclusion criteria. The independent variable was BMI and the dependent variable was frailty. Frailty was measured by physical frailty phenotype. The relationship between BMI and frailty was analyzed using the logistic regression test. A total of 40 elderlies were included; most were women with an average age of 69.8 ± 8.6 years and an average BMI of 23.4 ± 4.6 kg/m2. There were no robust/fit elderlies. Elderlies with underweight and normal BMI tended to be frail, while elderlies with overweight and obese BMI tended to be pre-frail. Increasing BMI was associated with a lower incidence of frailty compared with the pre-frail incidence, but this relationship was not significant (OR 0.53, 95%CI = 0.24-1.17). The conclusion of this research is that there is no significant relationship between BMI and frailty in the elderlies living in PPRSLU Budi Sejahtera Banjarbaru. Keywords: frailty, body mass index, elderly, physical frailty phenotype. Abstrak: Frailty merupakan tanda kerentanan fisiologis dan fungsional pada lansia. Salah satu faktor risiko frailty adalah IMT. Penelitian ini bertujuan mengetahui hubungan IMT dengan frailty pada lansia, dengan metode cross-sectional. Subjek penelitian yaitu lansia di PPRSLU Budi Sejahtera Banjarbaru, menggunakan metode total sampling sesuai kriteria inklusi dan eksklusi. Variabel bebas adalah IMT dan variabel terikatnya frailty. Frailty diukur dengan physical frailty phenotype. Hubungan IMT dan frailty dianalisis dengan uji logistic regression. Sebanyak 40 lansia diinklusi; sebagian besar perempuan dengan rerata usia 69,8±8,6 tahun dan rerata IMT 23,4±4,6 kg/m2. Tidak didapatkan lansia yang robust/fit. Lansia dengan IMT underweight dan normal cenderung frail, sedangkan lansia IMT overweight dan obesitas cenderung pre-frail. Peningkatan IMT berhubungan dengan kejadian frailty yang lebih rendah dibanding kejadian pre-frail, namun hubungan ini tidak bermakna (OR 0,53, 95%CI = 0,24-1,17). Simpulan penelitian ini adalah tidak terdapat hubungan yang signifikan antara IMT dan frailty pada lansia di PPRSLU Budi Sejahtera Banjarbaru. Kata-kata kunci: frailty, indeks massa tubuh, lansia, physical frailty phenotype
PERBANDINGAN EFEKTIVITAS NATRIUM DIKLOFENAK DAN MELOKSIKAM PADA DERAJAT KEPARAHAN PASIEN PEREMPUAN DENGAN OSTEOARTRITIS LUTUT Aulia, Ahmad Candra; Pambudi, Pagan; Nur’amin, Hendra Wana; Noor, Zairin; Qamariah, Nur
Homeostasis Vol 7, No 2 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i2.13176

Abstract

Abstract: Osteoarthritis is a disease characterized by degeneration of cartilage an bone underneath in the joints and excessive bone growth. This tissue damage eventually causes pain and joint stiffness. Non-Steroidal Anti-Inflamatory Drugs (NSAIDs) are usually considered the first line intreatment of osteoarthritis in the treatment of osteoarthritis. NSAIDs that are often used in the treatment are sodium dicofenac and meloxicam. This study aims to compare the effectiveness of sodium diclofenac and meloxicam in the severity of female subject with knee osteoarthritis in RSUD Dr. H. M Ansari Saleh Banjarmasin. The method used in this study is analytical observational with the cohort prospective research design. The sample in this study was chosen in a simple random sampling way with a total of 20 subject, 10 people received sodium diclofenac therapy and 10 people received meloxicam therapy, which would then be analyzed using T test. There is a significal difference in the lequesne index before and after administration of sodium diclofenac (p = 0,008) and meloxicam (p = 0,038). There is no significant difference between sodium diclofenac therapy compared to meloxicam (p = 0,55). Keywords: knee osteoartritis, sodium diclofenac, meloxicam Abstrak: Osteoartritis adalah penyakit sendi yang ditandai dengan degenerasi tulang rawan dan tulang dibawahnya di dalam sendi serta pertumbuhan tulang yang berlebihan. Kerusakan jaringan ini akhirnya menyebabkan nyeri dan kekakuan sendi. Non-Steroidal Anti-Inflamatory Drugs (NSAID) biasanya dianggap sebagai lini pertama dalam pengobatan osteoartritis. NSAID yang sering digunakan dalam pengobatan osteoartritis adalah natrium diklofenak dan meloksikam. Penelitian ini bertujuan untuk membandingkan efektivitas natrium diklofenak dan meloksikam pada derajat keparahan subyek perempuan dengan osteoartritis lutut di RSUD dr H. M. Ansari Saleh Banjarmasin. Metode yang digunakan dalam peneltian ini yaitu observasional analitik dengan desain penelitian cohort prospective. Sampel dalam penelitian ini dipilih dengan cara simple random sampling dengan total subyek sejumlah 20 orang, 10 orang mendapatkan terapi natrium diklofenak dan 10 orang mendapatkan terapi meloksikam, yang kemudian akan dianalisis dengan menggunakan uji T test. Terdapat perbedaan bermakna pada indeks lequesne sebelum dan sesudah pemberian natrium diklofenak (p = 0,008) dan meloksikam (p = 0,038). Tidak terdapat perbedaan signifikan antara terapi natrium diklofenak dibandingkan meloksikam (p = 0,55) Kata-kata kunci: osteoartritis lutut, natrium diklofenak, meloksikam
Co-Authors Adelina, I Dewa Ayu Yulia Adi Nugroho Agus Hadian Rahim Ahmad Taufiq Alfi Yasmina Ansharullah, M Rifky Asnawati Asnawati Aulia, Ahmad Candra Bahrul Ilmi Bakhiransyah, M. Bambang Setiawan Edi Hartoyo Edi Widjajanto Eko Suhartono Ermina Istiqomah, Ermina Fakhrurrazy Fakhrurrazy Fauzie Rahman Firdaus, Muhammad Nanda Firdaus, Muhammad Rizqi Hayati, Azka Herawati Herawati Hery Poerwosusanto, Hery Husaini Husaini Husna Dharma Putera, Husna Dharma imadduddin, Imadduddin Iskandar Iskandar Karina Solikha Nurmalita Karyono Mintaroem Khaliq, Rifky Nor Lenie Marlinae Meitria Syahadatina Noor Mohammad Hidayat Muhammad Abdan Shadiqi Muhammad Halim Fathoni, Muhammad Halim Mujiningtyas, Tsalsa Rohmatul Jannah Mulyohadi Ali Nelly Al Audhah Nia Kania Nur Qamariah Nur'amin, Hendra Wana Nur’amin, Hendra Wana Pagan Pambudi Pambudi, Zanuba Tarieq Ridho Pandji Winata Nurikhwan Perdias, Antonio Poerwosusanta, Hery Pratista, Muhammad Bagas Rahman, Ansari Rajib, Maulana Nur Ramadhan, Fadlan Roselina Panghiyangani Rumboko, Raihan Febri Sanyoto, Didik Dwi Savira Angelia Sekartaji, Hapsari Lintang Sembiring, Asriyani Br Siddik, Muhammad Silvia Kristanti Tri Febriana Silvia Kristanti Tri Febriana, Silvia Kristanti Soesanto, Bayu Somantri, Nizam Al Fikri Sutiman B. Sumitro Syamsul Arifin Wahyuni Wahyuni Wiwit Agung Sri Nur Cahyawati Wydiamala, Erida Yulianti Yulianti