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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Presipitasi : Media Komunikasi dan Pengembangan Teknik Lingkungan Berkala Kedokteran The Indonesian Biomedical Journal Jurnal Berkala Kesehatan JPKMI (Jurnal Publikasi Kesehatan Masyarakat Indonesia) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Manuju : Malahayati Nursing Journal Jurnal Abdimas Mahakam Indonesian Journal of Perinatology Jurnal Pengabdian Ilung (Inovasi Lahan Basah Unggul) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Gema Lingkungan Kesehatan An Najah (Jurnal Pendidikan Islam dan Sosial Keagamaan)
Iskandar Iskandar
Public Health Study Program, Faculty Of Medicine And Health Sciences, Lambung Mangkurat University
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Berkala Kedokteran

 1 
STUDY OF INTERACTION BETWEEN LEAD AND GASTRIC MUCOSAL PROTEIN OF RATS WITH FORENSIC TOXICOLOGY APPROACH Aflanie, Iwan; Thalib, Iskandar; Suhartono, Eko
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v13i2.4065

Abstract

Abstract: Recently, forensic toxicology has been an interesting concern, especially in exposing the phenomena associated with the law. Using the forensic toxicology approach, several cases of lead (Pb) poisoning have been widely revealed. In this present study will be investigate the interaction between Pb and amino acid gastric mucosal constituent proteins, especially cysteine and tyrosine groups. This research is a pure experimental research with posttest control group design, which is divided into 4 groups with 6 rats (Rattus novergicus) in each group. Treatment in each group as follows; P0 was control group were given 2 ml of distilled water; P1 = administration of Pb 0.1 g/L; P2 = Pb administration of 1 mg/L; and P3 = Pb administration of 10 g/L for 4 weeks repectively. According to the results, it can be concluded that Pb-Protein interaction tends to binding of Pb-Cysteine rather than Pb-Tyrosine Keywords: Gastric Mucosa, Lead, Protein
EFFECT OF CADMIUM EXPOSURE ON INCREASING RISK OF DIABETES MELITUS THROUGH THE MEASUREMENT OF BLOOD GLUCOSE LEVEL AND LIVER GLUCOKINASE ACTIVITY IN RATS Thalib, Iskandar; Budianto, Windy Yuliana; Suhartono, Eko
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v13i2.4068

Abstract

Abstract: This present study was undertaken to investigate the effect of cadmium (Cd) exposure on an increasing risk of Diabetes Melitus (DM), through the measurement of blood glucose level and liver glucokinase activity in rats. The subjects that used in this study are 15 male rats (Rattus novergicus) with normal activity, 2-3 months old, and weighing 300±10 gram. The research subjects the divided into 3 groups; P0 group are given commercial fed rats diets only; P1 are given commercial fed rats + Cd with a concentration of 3 mg/l in drinking water for 1 day (acute); and P2 are given commercial fed rats+Cd with a concentration of 3 mg/l in drinking water for 4 weeks (subacute). The results of this present study shows that treatment with Cd significantly increase the levels of blood glucose (P < 0,05). The result also showed that treatment with Cd can increase the Km value of liver glucokinase, and it means Cd exposure can decrease the affinity between glucose and glucokinase. The present study demonstrated that Cd exposure could increase the risk of DM through increased the blood glucose and decrease the activity of liver glucokinase. Keywords: Cadmium, glucose metabolism, glucose, glucokinase
STUDY OF INTERACTION BETWEEN LEAD AND GASTRIC MUCOSAL PROTEIN OF RATS WITH FORENSIC TOXICOLOGY APPROACH Iwan Aflanie; Iskandar Thalib; Eko Suhartono
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (714.156 KB) | DOI: 10.20527/jbk.v13i2.4065

Abstract

Abstract: Recently, forensic toxicology has been an interesting concern, especially in exposing the phenomena associated with the law. Using the forensic toxicology approach, several cases of lead (Pb) poisoning have been widely revealed. In this present study will be investigate the interaction between Pb and amino acid gastric mucosal constituent proteins, especially cysteine and tyrosine groups. This research is a pure experimental research with posttest control group design, which is divided into 4 groups with 6 rats (Rattus novergicus) in each group. Treatment in each group as follows; P0 was control group were given 2 ml of distilled water; P1 = administration of Pb 0.1 g/L; P2 = Pb administration of 1 mg/L; and P3 = Pb administration of 10 g/L for 4 weeks repectively. According to the results, it can be concluded that Pb-Protein interaction tends to binding of Pb-Cysteine rather than Pb-Tyrosine Keywords: Gastric Mucosa, Lead, Protein
EFFECT OF CADMIUM EXPOSURE ON INCREASING RISK OF DIABETES MELITUS THROUGH THE MEASUREMENT OF BLOOD GLUCOSE LEVEL AND LIVER GLUCOKINASE ACTIVITY IN RATS Iskandar Thalib; Windy Yuliana Budianto; Eko Suhartono
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (589.562 KB) | DOI: 10.20527/jbk.v13i2.4068

Abstract

Abstract: This present study was undertaken to investigate the effect of cadmium (Cd) exposure on an increasing risk of Diabetes Melitus (DM), through the measurement of blood glucose level and liver glucokinase activity in rats. The subjects that used in this study are 15 male rats (Rattus novergicus) with normal activity, 2-3 months old, and weighing 300±10 gram. The research subjects the divided into 3 groups; P0 group are given commercial fed rats diets only; P1 are given commercial fed rats + Cd with a concentration of 3 mg/l in drinking water for 1 day (acute); and P2 are given commercial fed rats+Cd with a concentration of 3 mg/l in drinking water for 4 weeks (subacute). The results of this present study shows that treatment with Cd significantly increase the levels of blood glucose (P < 0,05). The result also showed that treatment with Cd can increase the Km value of liver glucokinase, and it means Cd exposure can decrease the affinity between glucose and glucokinase. The present study demonstrated that Cd exposure could increase the risk of DM through increased the blood glucose and decrease the activity of liver glucokinase. Keywords: Cadmium, glucose metabolism, glucose, glucokinase
Biotoxic of Gemor (Nothaphoebe coriacea) Leaves from Peat Swamp Tumbang Nusa Research Forest, Central Kalimantan, Indonesia Iskandar Thalib; Purwanto Budi Santosa; Eko Suhartono
Berkala Kedokteran Vol 14, No 2 (2018)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (185.259 KB) | DOI: 10.20527/jbk.v14i2.5329

Abstract

Abstract: The study aimed to evaluate the sub-acute toxicity effect of aqueous N. coriacea leaves extract to kidney and liver function. The biotoxic study was conducted using male rats. In this study, the experimental animals received five different doses of aqueous N. coriacea leaves extract (0.1 mg, 1 mg, 10 mg, 100 mg, and 1000 mg per day) for 4 weeks via oral route. After treatment, the level of plasma ureum, creatinine, Aspartate Transaminase (AST) and Alanine Transaminase (ALT) level were measured. The results show that most of dose treatments of aqueous extract of N. coriacea leaves had not statistically effect on the level of the plasma ureum and creatinine except for dosage of 1000 mg. Similarly, the dose treatments of that extract did not statistically change the plasma AST and ALT, except on 100 and 1000 mg/kg of b.w extract dose. In conclusion, a short-term intake of N. coriacea leaves extract via oral route was not toxic to kidney and liver. Keywords: N. coriacea, Kidney, Liver, Toxicity.
Bibliometric Analysis of Lead's Effects on the Nervous System Sekartaji, Hapsari Lintang; Hartoyo, Edi; Febriana, Silvia Kristanti Tri; Noor, Zairin; Sanyoto, Didik Dwi; Iskandar, Iskandar
Berkala Kedokteran Vol 20, No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v20i2.20536

Abstract

Lead (Pb) is a heavy metal that is proven to cause various health problems. In its development, research trends on the effects of Pb on the nervous system are still a topic of research. This study aims to identify trends, research focus, and research contributions to understanding the impact of Pb on the nervous system. The method used, namely bibliometric analysis with the help of Publish or Perish (POP) with the keyword Pb on autism and VOS Viewer software and Scopus database. Keyword analysis was conducted on 131 documents from 2013-2024. The results concluded that there are 4 keywords, namely child, lead, effect, and metal and have a great opportunity for future research. This analysis also found that the article entitled "Mechanisms of lead and manganese neurotoxicity" was the most cited article, with 153 citations.
Co-Authors Adelia Anggraini Utama Alin, Dhemes Amelia, Aisya Angga Praditya Ari Yunanto Ari Yunanto Buhari Luneto Cynthia Maharani Puspita Sari Dona Marisa, Dona Edi Hartoyo Edi Hartoyo Efrilia Tanjung Eko Suhartono Eko Suhartono Eko Suhartono Eriana, Nisa Nur Agistni Erlena, Erlena Ermina Istiqomah, Ermina Gusti Muhammad Perdana Putera Hafifah, Ifa Hapsari Lintang Sekartaji Haryati Haryati Isna Syauqiah Iwan Aflanie Muhammad Hafidz MS Muthaminah, Noor Nadjamuddin, Asriyati Nasution, Annio Indah Lestari Nia Kania Niarsari Anugrahing Putri Niarsari Anugrahing Putri Nila Nirmalasari Nurul Hidayah Prastricia, Meily Andini Pratiwi, Destisa Denti Seiza Pricilia Gunawan Halim Purwakaning Agung Purwanto Budi Santosa Putera, Gusti Muhammad Perdana Ratih Kumala Sari Salan, Yosef Dwi Cahyadi Salmon Siahaan Sanyoto, Didik Dwi Sekartaji, Hapsari Lintang Silvia Kristanti Tri Febriana Susantu, Susantu Syauqia, Ahla Trang, Ha Thi Thu Utama, Adelia Anggraini Windy Budianto Windy Yuliana Budianto, Windy Yuliana Yakwan, Beny Acah Yaliza, Nella Yusanto Nugroho Zainal Abidin Zainal Abidin Zairin Noor Zuhrufa Wanna Yolanda