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All Journal Jurnal Teknologi Dan Industri Pangan Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya El-Hayah : Jurnal Biologi Alchemy : Journal of Chemistry Agrointek Prosiding SNATIF Jurnal Pangan dan Agroindustri Jurnal Teknologi Pertanian agriTECH Jurnal Penelitian Pendidikan IPA (JPPIPA) Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) Jurnal Ilmu Peternakan Terapan Berkala Penelitian Hayati Jurnal Ilmiah Agritas
Dr.Ir. Yunianta, DEA
Department Of Food Science And Technology, Faculty Of Agricultural Technology, Brawijaya University, Malang, Indonesia, 65145
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Physics Veterinary

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Potential Use of Compounds from Neem Leaves (Azadirachta indica Juss) as PPARg and ERa Inhibitors to Control Breast Cancer Cell Growth In Silico Model Supriyanto, Supriyanto; Rifa'i, Muhaimin; Yunianta, Yunianta; Widjanarko, Simon Bambang
ALCHEMY Vol 8, No 1 (2020): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (430.121 KB) | DOI: 10.18860/al.v8i1.9863

Abstract

Treatment using herbs is currently growing rapidly. Compounds in herbal plants can cure various degenerative diseases. The study aims to analyze the potency of nimbin, deacetylnimbin, salanin, and deacetylsalanin compounds in the neem leaves extract to inhibit target proteins namely PPARg and ERa. PPARg is the main regulator of the function of adipose tissue microvascular endothelial cells (aMVECs) while ERa is a protein that mediates all estrogen effects and it is important in the growth of prostate and breast cancer. Inhibition of ERa can prevent the proliferation and growth of breast cancer cells by affecting the performance of estrogen which binds to hormonal receptors and causes inhibition of breast cancer cell proliferation. The results of in silico analysis show that deacetylnimbin can inhibit ERa protein. The docking analysis shows that deacetylnimbin has the potential to replace tamoxifen as a breast cancer drug. The other studies such in vitro and in vivo are needed to validate in silico study.
PEMBUATAN PATI TINGGI AMILOSA SECARA ENZIMATIS DARI PATI UBI KAYU (Manihot esculenta) DAN APLIKASINYA UNTUK PEMBUATAN MALTOSA DEA, Dr.Ir. Yunianta,
El-Hayah : Jurnal Biologi Vol 1, No 1 (2009): EL-HAYAH (VOL 1, NO 1,September 2009)
Publisher : Department of Biology Science and Technology Faculty UIN Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/elha.v1i1.1683

Abstract

Sebagian besar pati alami seperti pati jagung, gandum, tapioka, kentang dan sagu mengandung prosentase yang tinggi dari rantai percabangan amilopektin. Tingginya komponen amilopektin dalam tapioka tersebut merupakan salah satu kendala dalam pemanfaatan tapioka secara meluas dalam berbagai industri. Agar dihasilkan pati dengan amilosa tinggi maka salah satu alternatifnya adalah memodifikasi pati secara enzimatis dengan debranching enzymes yaitu enzim yang mampu menghidrolisis ikatan α-1,6 pada pati. Aplikasi pati tinggi amilosa dalam penelitian ini adalah untuk pembuatan maltosa.Tujuan penelitian ini adalah untuk mengetahui pengaruh konsentrasi tapioka dan lama inkubasi terhadap kadar amilosa yang dihasilkan oleh enzim pullulanase dan mengetahui pengaruh penambahan enzim -amilase pada tapioka dengan amilosa tertinggi  terhadap maltosa yang dihasilkan. Rancangan percobaan yang digunakan pada tahap I adalah Rancangan Acak Kelompok yang disusun secara faktorial dengan dua faktor, faktor I adalah konsentrasi tapioka (5, 10, 15, dan 20%) dan faktor dua adalah lama inkubasi (12 dan 24 jam) pada larutan 2% enzim pullulanase. Masing-masing perlakuan diulang sebanyak 3 kali. Data yang diperoleh dianalisa dengan ANOVA yang dilanjutkan dengan uji DMRT. Sedangkan pada tahap II menggunakan metode eksperimen secara deskriptif.Hasil penelitian tahap I menunjukkan bahwa dari perlakuan kombinasi konsentrasi substrat tapioka dan lama inkubasi, kadar amilosa tertinggi diperoleh pada konsentrasi tapioka 15% dengan lama inkubasi 12 jam yaitu sebesar 41,12%, dengan kadar pati 77,46%, viskositas 358,33 cP dan kadar air 4,01%. Penelitian tahap II menunjukkan hasil hidrolisis tapioka tinggi amilosa oleh β-amilase adalah maltosa 30,84%, maltotriosa 2,90%, glukosa 0,27% dan oligosakarida 5,42%. Sedangkan untuk tapioka tanpa proses debranching menghasilkan maltosa 26,47%, maltotriosa 1,86%, glukosa 0,28% dan oligosakarida 13,83%.
Immunomodulatory Activity of Methanol Leaf Extract of Neem (Azadirachta indica Juss) Against Suppressor and Proinflammatory Molecules Supriyanto, Supriyanto; Widjanarko, Simon Bambang; Rifa'i, Muhaimin; Yunianta, Yunianta
Journal of Tropical Life Science Vol 11, No 3 (2021)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.11.03.07

Abstract

Neem plant is rich in bioactive constituents, which make it massively discussed the treatment of various diseases. A study on the immunomodulatory activities of neem is given here. This current work aimed to investigate the effects of neem leaf extract on immunocompetent cells. In vivo experiment was carried out using mice (Mus musculus)  induced with DMBA, comprising positive control, negative control, and treatments of neem leaf extracts (250, 500, and 1000 ppm). Data obtained from flow cytometric analysis were evaluated using BD Cellquest ProTM software, then statistically analyzed in SPSS version 21. Parametric analysis in one-way ANOVA was performed at a significance level of 5%. The significant difference was compared in the Duncan test. The results showed that administration of neem leaf extracts significantly affected the expression of CD4+, CD8+, CD25+, CD62L, IL-10, and IL-17 cells .Neem leaf extract has immunomodulatory activities by increasing pressure molecules and decreasing pro-inflammatory molecules
CHEMICAL CHARACTERISTIC AND ANTIOXIDANT ACTIVITY OF METHANOL EXTRACT NEEM LEAVES (AZADIRACHTA INDICA JUSS) Supriyanto, Supriyanto; Widjanarko, Simon Bambang; Rifa'i, Muhaimin; Yunianta, Yunianta
AGROINTEK Vol 15, No 2 (2021)
Publisher : Agroindustrial Technology, University of Trunojoyo Madura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21107/agrointek.v15i2.10605

Abstract

The neem plant (Azadirachta indica) is a herb with the potential as a source of antioxidants. This study aimed to identify compounds that exist in the neem leaf and determine their antioxidant activity. Neem leaf extract was collected by using 80% methanol.  Furthermore, methanol extracts from neem leaves with the highest antioxidant activity were partitioned with n-hexane, ethyl acetate, and water. This research were analyzed by partition for antioxidant activity, and DPPH (1,1-diphenyl-2-pycrilhydrazil) and the half-maximal inhibitory concentration (IC50) values were determined. The results showed that the ethyl acetate partition had the highest antioxidant activity, with IC50 values of 1.004 µg/ml. Neem leaf extract has the potential for a use as an herbal medicine in the treatment of various diseases..
PENGARUH RASIO TEPUNG BERAS DAN AIR TERHADAP KARAKTERISTIK KULIT LUMPIA BASAH [Effect of Flour to Water Ratio on Characteristics of Fresh Rice-Based Spring Rolls Wrappers] Anna Ingani Widjajaseputra; . Harijono; . Yunianta; Teti Estiasih
Jurnal Teknologi dan Industri Pangan Vol. 22 No. 2 (2011): Jurnal Teknologi dan Industri Pangan
Publisher : Departemen Ilmu dan Teknologi Pangan, IPB Indonesia bekerjasama dengan PATPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (339.268 KB)

Abstract

Flour to water ratio in batter compositions affected water availability which was needed to provide physical and chemical changes during fresh rice-based spring rolls wrappers processing, such as gel forming of starches and heat-induced gels, flour’s components interactions in batter systems. Degree of water-starch, water-protein and protein–starch-water interactions were depend on water amount, temperature and duration of heating. The mechanical strength of spring rolls wrappers is one of problems when it is being used. The wrappers could be torn apart due to moisture absorption from the filling and the environment. The goal of this study was to determine the optimum flour to water ratio in formulation of fresh rice-based spring rolls wrappers. The investigation was provided by Randomized Completely Block Design with single factor and three replicates. The factor was rice flour to water ratio in six levels (3.0:4.5; 3.0:5.0;3.0:5.5; 3.0:6.0; 3.0:6.5; and 3.0:7.0) the data were analyzed by Analysis of Variance with 95% degree of confident. Flour to water ratio greatly influenced elongation at break which is important in the utilization of fresh rice-based spring rolls wrappers. Its ratio also influenced the size of swelled rice starch granules, pores size and moisture content of the products. Optimal ratio flour to water is 3.0:6.0 which produced the highest elongation at break.
Optimasi Media Fermentasi Aspergillus oryzae, Penghasil Antijamur Patogen Buah Kakao (Phytophthora palmivora) Rizka Aulia Rahma; Simon Bambang Widjanarko; Rofiq Sunaryanto; Yunianta Yunianta
agriTECH Vol 35, No 3 (2015)
Publisher : Faculty of Agricultural Technology, Universitas Gadjah Mada, Yogyakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (795.849 KB) | DOI: 10.22146/agritech.9343

Abstract

Indonesia was known as a producer and exporter of cacao, but nowadays Indonesia had an issue in cacao production caused by microorganisms (Phytophtora palmivora) that capable of reducing the amount of cacao production each year. This study follows up a previous study that had found compounds that are actively against at Phytophtora palmivora from Aspergillus oryzae metabolites. In this study the compound will be produced in greater numbers to optimize fermentation medium. The first stage was conducted to determine the profile of the active compound and to analyze the best carbon, nitrogen source for Aspergillus oryzae fermentation medium. The second stage was designed by using Response Surface Method (RSM) with Central Composite Design (CCD) to optimize two variables in the fermentation medium, glucose concentration (the best carbon source) and the concentration of peptone (best nitrogen source). The expected response was the most active compounds percentage of the area. Data analysis was performed by Design Expert DX 7.1.5 program. The first stage of this study presumed that Tenuazonic acid compounds with a molecular weight of 198.1126 gram.mol was an antifungal compound produced by Aspergillus oryzae fungus to prevent Phythopthora palmivora fungus pathogens cacao pods. In addition the results are that glucose was the best carbon source (mean % relative area of  antifungal compounds: 85.39%) and that peptone was selected as the best source of nitrogen (mean % relative area of  antifungal compounds: 91.07%). The second stage showed the optimum conditions of fermentation medium antifungal Aspergillus oryzae was the composition of glucose 35.25 g/L and peptone 16.7 g/L. The combination of both compositions would yield a mean response of laboratory data % relative area of antifungal compounds 91.2217% and the estimated value (prediction) by Design Expert models 92.2936%. Difference in the estimated values (the response of the model) to the value of the results of response in laboratory experiments at 1.1614%, then it could be concluded that the model used was appropriate and able to explain the applied experimental data.ABSTRAKIndonesia dikenal sebagai produsen dan eksportir buah kakao, tetapi saat ini Indonesia memiliki masalah dalam produksi buah kakao dikarenakan adanya mikroorganisme penyebab penyakit (Phytophtora palmivora) yang menurunkan jumlah produksi buah kakao tiap tahunnya. Penelitian ini melanjutkan penelitian sebelumnya yang telah menemukan senyawa aktif yang bersifat antijamur terhadap Phytophtora palmivora dari metabolit Aspergillus oryzae. Pada penelitian ini senyawa tersebut akan diproduksi dalam jumlah yang lebih banyak melalui optimasi media fermentasi. Penelitian tahap I dilakukan untuk mengetahui profil senyawa aktif yang dominan dan mendapatkan sumber karbon, nitrogen yang terbaik untuk media fermentasi Aspergillus oryzae. Penelitian tahap II dirancang menggunakan Response Surface Method (RSM) dengan Central Composite Design (CCD) untuk mengoptimasi 2 variabel dalam media fermentasi yaitu konsentrasi glukosa (sumber karbon terbaik) dan konsentrasi pepton (sumber nitrogen terbaik). Respon yang diinginkan adalah persentase luas area senyawa aktif yang paling besar. Analisis data dilakukan dengan program Design Expert D.X. 7.1.5. Tahap I penelitian ini menduga bahwa senyawa Tenuazonic acid dengan bobot molekul 198.1126 gram.mol-1 adalah senyawa antijamur yang dihasilkan jamur Aspergillus oryzae untuk jamur patogen buah kakao Phythopthora palmivora. Selain itu, diperoleh hasil bahwa glukosa merupakan sumber karbon terbaik (rerata % relatif luas area senyawa antijamur: 85.39%) dan pepton dipilih sebagai sumber nitrogen yang terbaik (rerata % relatif luas area senyawa antijamur: 91,07%). Penelitian tahap II menghasilkan kondisi optimum media fermentasi antijamur dari A. oryzae dengan komposisi glukosa sebesar 35,25 gram/L dan pepton sebesar 16,7 gram/L. Kombinasi kedua komposisi tersebut akan menghasilkan data laboratorium respon rerata % relatif luas area senyawa antijamur sebesar 91,2217% dan nilai dugaan (prediksi) oleh model Design Expert sebesar 92,2936%. Perbedaan nilai dugaan (respon dari model) dengan nilai respon hasil percobaan di laboratorium sebesar 1,1614% sehingga dapat disimpulkan bahwa model yang digunakan telah sesuai dan mampu menjelaskan data percobaan yang digunakan.
PERUBAHAN AKTIVITAS ENZIM LIPASE DARI BUAH KELAPA SELAMA PERTUNASAN Moh. Su'i; Harijono; Yunianta; Aulani'am
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 16 No 2 (2011): June 2011
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23869/302

Abstract

This research learned about lipases activity from coconut during germination. Coconut was growth for 0, 15, 30, 45 and 60 days in the darkplace and rate temperature. Shoot, houstorium, radicless and endosperm were taken and then they were measured weigh and long. Lipases was extracted from each of them and measured volume and activity. The results of research showd that highest lipases activity was in shoot that were grew for 45 days with enzyme activity was 0,060 unit/mg protein.
Immunomodulatory Activity of Methanol Leaf Extract of Neem (Azadirachta indica Juss) Against Suppressor and Proinflammatory Molecules Supriyanto Supriyanto; Simon Bambang Widjanarko; Muhaimin Rifa'i; Yunianta Yunianta
Journal of Tropical Life Science Vol. 11 No. 3 (2021)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.11.03.07

Abstract

Neem plant is rich in bioactive constituents, which make it massively discussed the treatment of various diseases. A study on the immunomodulatory activities of neem is given here. This current work aimed to investigate the effects of neem leaf extract on immunocompetent cells. In vivo experiment was carried out using mice (Mus musculus)  induced with DMBA, comprising positive control, negative control, and treatments of neem leaf extracts (250, 500, and 1000 ppm). Data obtained from flow cytometric analysis were evaluated using BD Cellquest ProTM software, then statistically analyzed in SPSS version 21. Parametric analysis in one-way ANOVA was performed at a significance level of 5%. The significant difference was compared in the Duncan test. The results showed that administration of neem leaf extracts significantly affected the expression of CD4+, CD8+, CD25+, CD62L, IL-10, and IL-17 cells .Neem leaf extract has immunomodulatory activities by increasing pressure molecules and decreasing pro-inflammatory molecules
Potential Use of Compounds from Neem Leaves (Azadirachta indica Juss) as PPARg and ERa Inhibitors to Control Breast Cancer Cell Growth In Silico Model Supriyanto Supriyanto; Muhaimin Rifa'i; Yunianta Yunianta; Simon Bambang Widjanarko
ALCHEMY:Journal of Chemistry Vol 8, No 1 (2020): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (430.121 KB) | DOI: 10.18860/al.v8i1.9863

Abstract

Treatment using herbs is currently growing rapidly. Compounds in herbal plants can cure various degenerative diseases. The study aims to analyze the potency of nimbin, deacetylnimbin, salanin, and deacetylsalanin compounds in the neem leaves extract to inhibit target proteins namely PPARg and ERa. PPARg is the main regulator of the function of adipose tissue microvascular endothelial cells (aMVECs) while ERa is a protein that mediates all estrogen effects and it is important in the growth of prostate and breast cancer. Inhibition of ERa can prevent the proliferation and growth of breast cancer cells by affecting the performance of estrogen which binds to hormonal receptors and causes inhibition of breast cancer cell proliferation. The results of in silico analysis show that deacetylnimbin can inhibit ERa protein. The docking analysis shows that deacetylnimbin has the potential to replace tamoxifen as a breast cancer drug. The other studies such in vitro and in vivo are needed to validate in silico study.
Bahasa Inggris Elya Putri Pane; Yenny Risjani; Yunianta Yunianta; Gilang Drajat Maulana
Jurnal Penelitian Pendidikan IPA Vol 9 No 2 (2023): February
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i2.2911

Abstract

Indonesia is an archipelagic country with a water area of up to 5.9 million km2, where this water area is a habitat for marine diversity. One such diversity consists of macroalgae and microalgae. Diatoms are a group of microalgae with high diversity. Diatoms are one of a group of microscopic algae that can live in various habitats and are abundant in various ecosystems. Diatoms can be used as bioindicators of aquatic environmental quality. Navicula genus is an isolate that was successfully isolated from the waters of Pari Island, Kepulauan Seribu Regency. The total protein was analyzed by the Lowry-Follin method. The total fat content was determined by the soxhletation method. This genus Navicula contains a total protein content of 30,944 mg/L and a lipid content of 3.17%.
Co-Authors . Harijono A. Harijono Achmad Fauzie Wahyunanto, Achmad Fauzie Aji Sutrisno Anna Ingani Widjajaseputra Apriliastuti Apriliastuti Aulani'am Bella Ayu Shafira Budi Satriyanto Dedi Dedi Dego Yusa Ali Della Rosalita, Della Dhian Imani Prihardhani, Dhian Imani Elya Putri Pane Erryana Martati Estri Laras Arumingtyas Fadiyah Safitri Fadiyah Safitri Gilang Drajat Maulana H., Nunuk Hidayat Sujuti Ida Ayu Putu Sri Widnyani Ida Ayu Ulifah Indria Purwantiningrum Indria Purwantiningrum Jaya Mahar Maligan Joni Kusnadi Kurnia Rahmawati, Kurnia Lukman Azis M, Rifa'i Maemunah Mawardi, Nanang Kusuma Moh. Sui Muhaimin Rifa'i Muhaimin Rifa'i Ni Made Ayu Octaviana, Ni Made Ayu Ni Made Wartini Nur Ida Panca Nugrahini Pane, Elya Putri Rahmani Rahmani Resti, Arin Riyanti Rifa'i, Muhaimin Rizka Aulia Rahma Rofiq Sunaryanto Rurini Retnowati SATRIYAS ILYAS Shinta Chandra Rahmawati, Shinta Chandra Simon B. Widjanarko SIMON BAMBANG WIDJANARKO Simon Bambang Widjanarko Simon Bambang Widjanarko Siti Narsito Wulan Sudarma Dita Wijayanti Supriyanto Supriyanto Supriyanto Supriyanto Supriyanto, Supriyanto Suryayuliana, Ifan Dwi Sutendi, Faktori Syarifah Rohaya Teti Estiasih Teti Estiasih Tri Sulistyo Tri Susanto Wahyu Setya Ratri, Wahyu Setya WB, Simon WB, Simon Yenny Risjani Zohan Efendi