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All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences WMJ (Warmadewa Medical Journal) JURNAL PENDIDIKAN KEPERAWATAN INDONESIA Jurnal Ilmiah Kedokteran Wijaya Kusuma Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Syntax Literate: Jurnal Ilmiah Indonesia Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Oceana Biomedicina Journal Medical and Health Science Journal Medika Kartika : Jurnal Kedokteran dan Kesehatan Medicra (Journal of Medical Laboratory Science/Technology) Indonesian Journal of Medical Sciences and Public Health Oceana Biomedicina Journal Hang Tuah Medical Journal Surabaya Biomedical Journal Surabaya Biomedical Journal
Prawesty Diah Utami
Fakultas Kedokteran Universitas Hang Tuah
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Hubungan Status Gizi Pasien Penyakit Hirschsprung dengan Infeksi Luka Operasi di RSPAL dr. Ramelan Surabaya Periode Waktu 2016-2020 PUTU SITHA AISHWARYA SARASWATI GIUR Giur; SAPTA PRIHARTONO RACHMAN; DIAH PURWANINGSARI; PRAWESTY DIAH UTAMI
HANG TUAH MEDICAL JOURNAL Vol 20 No 1 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v20i1.279

Abstract

Background: Hirschsprung's disease is a congenital intestinal motility disorder that causes functional intestinal obstruction due to the absence of enteric ganglion cells in the distal intestine. The management of each case of Hirschsprung's disease is surgery, where surgery on the digestive tract increases the occurrence of surgical site infections. Disturbances in the gut cause decreased resistance to infection, delayed cognitive development, and problems with nutritional status. Methods: This study was a descriptive and analytical observational study, where the primary data were taken from the registration data of Hirschprung's disease patients at RSPAL dr. Ramelan Surabaya in 2016-2020. The nutritional status of the patient was determined by plotting the weight per age curve according to WHO for children aged 0-5 years. Results: Observations of 38 patients who met the study requirements, obtained 4 patients who had poor nutritional status and 1 patient who had excess nutritional status, none of which experienced complications in the form of surgical wound infections. In 10 patients with poor nutritional status, 2 experienced complications in the form of surgical wound infection and 23 patients with good nutritional status, 1 experienced complications in the form of surgical wound infection. The results of the contingency coefficient correlation test showed P-value = 0.408 (p>α). Conclusion: There was no relationship between the nutritional status of Hirschprung's disease patients with surgical wound infections at RSPAL dr. Ramelan Surabaya Keywords: Hirschsprung's disease, nutritional status of children, surgical site infection.
Efek Pemberian Oksigen Hiperbarik Pada Efektivitas Ekstrak Cacing Tanah (Lumbricus terrestris) Terhadap Pertumbuhan Salmonella Typhi Secara In Vitro VARIDIANTO YUDO TJAHJONO; RETNO BUDIARTI; PRAWESTY DIAH UTAMI
HANG TUAH MEDICAL JOURNAL Vol 20 No 1 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v20i1.341

Abstract

Background: Typhoid fever is an infectious disease of the small intestine caused by the bacterium Salmonella typhi, and causes a fairly high mortality rate. These bacteria have developed resistance to many antibiotics. Earthworm extract (ECT) has been widely used as an alternative to treat typhoid fever. Hyperbaric oxygen therapy (OHB) has been used to treat various diseases and can suppress the growth of bacteria. Objective: To determine the effect of hyperbaric oxygen (OHB) 3 ATA on the effectiveness of earthworm (Lumbricus terrestris) extract on the growth of Salmonella typhi in vitro. Methods: This experimental study used the post-test only control group design method. Thirty-six samples of S.typhi bacteria in liquid medium (broth) were divided into four groups. The first group (K-) was not given any treatment, the second group (P1) was given earthworm extract, the third group (P2) was given hyperbaric oxygen 3 ATA, and the fourth group (P3) was given a combination of earthworm extract and hyperbaric oxygen 3 ATA. The results of bacterial growth in each group were calculated in colony forming units (CFU) / ml and analyzed statistically. Results: The growth of S.typhi bacteria in the first group (K-) was 108.51 x 106 CFU/ml, the second group (P1) was 483 CFU/ml, the third group was 1.4 x 106 CFU/ml, and the fourth group (P3) was 215 CFU/ml. The fourth group (P3) had the smallest number of bacterial growth and had a significant difference compared to the first (P1) and third (P3) groups (p = 0.001; p < α ; α = 0.05), but the difference was not significant compared to the second group (P1 ) (p = 0.308; p > α; α = 0.05). Conclusion: Giving earthworm extract (ECT) with hyperbaric oxygen (OHB) 3 ATA (combination) was most effective in inhibiting the growth of Salmonella typhi bacteria compared to giving earthworm extract (ECT) alone or giving hyperbaric oxygen (OHB) 3 ATA alone.
Literature Study: The Effect of Giving Chitosan Water Gel (Hydrogel) on Healing Diabetic Ulcers Based on In Vivo Studies with Animal Models Zahratul Noreisza Rakhmadi; Erina Yatmasari; Prawesty Diah Utami
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 11, No 2 (2022): SEPTEMBER 2022
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (381.341 KB) | DOI: 10.30742/jikw.v11i2.1957

Abstract

Diabetic ulcers are one of the most common chronic complications and cause infection, gangrene to leg amputation if the treatment given is not appropriate. Chitosan has anti-microbial properties that make the wound area smaller and are anti-inflammatory to reduce pain. Water gel (hydrogel), which is water, is easily absorbed by the skin and penetrates perfectly into the wound so that it provides a moist effect and prevents bacteria from entering. This study aims to determine the effect of giving chitosan water gel (hydrogel) on the healing of diabetic ulcers. This study uses a literature study method by searching for related journals using keywords, then selected based on the last 5 years and indexed in SINTA, Google Scholar or Scopus, and the final results are 13 journals. This study took place in May - November 2021. The results of this study reported that the administration of chitosan water gel (hydrogel) combined with other ingredients for healing diabetic ulcers gave the same results. The results obtained are reducing inflammation, re-epithelializing wounds, accelerating angiogenesis, accelerating the formation of collagen and granulation tissue, and accelerating wound healing. Although all studies have the same results, the healing time produced by each study is different, this is because each ingredient used has a different content. The average wound changes were seen on the 3rd, 5th, 7th day and the wound healed completely on the 14th day. This study concludes that the administration of chitosan water gel (hydrogel) affects the healing of diabetic ulcer wounds in combination with other ingredients. because the time needed to close the wound is faster.
STUDI IN VITRO: EFEK ANTIPLASMODIAL EKSTRAK ETANOL TERIPANG KELING (Holothuria atra) TERHADAP Plasmodium falciparum Rizka Indah Ramadina; Prawesty Diah Utami; Djatiwidodo Edi Pratiknya
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 6 No 2 (2023): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Malaria merupakan penyakit menular yang disebabkan oleh parasit apicomplexa darah yaitu Plasmodium sp. khususnya Plasmodium falciparum yang dibawa oleh nyamuk Anopheles. Teripang keling (Holothuria atra) merupakan invertebrata yang mengandung komponen aktif seperti saponin, terpenoid, flavonoid dan alkaloid yang memiliki efektivitas sebagai antiplasmodium. Tujuan dari penelitian ini adalah untuk menganalisis efektivitas antiplasmodial dari ekstrak etanol teripang keling (Holothuria atra) terhadap perkembangan P.falciparum melalui studi in vitro. Dalam studi in vitro penelitian ini menggunakan sampel kultur P.falciparum strain 3D7 dan ekstrak etanol H.atra. Media kultur akan terbagi menjadi 3 kelompok yakni kontrol negatif, kontrol positif serta dengan penambahan ekstrak etanol H.atra. Ketiga kelompok tersebut akan diinkubasi selama 48 jam pada suhu 37oC lalu dilakukan pemeriksaan kadar parasitemia dan inhibitory rate menggunakan mikroskop cahaya serta pengukuran IC50 menggunakan analisis probit melalui program SPSS versi 23. Hasil penelitian memperlihatkan adanya efek antiplasmodial dalam menghambat perkembangan P.falciparum. Semakin besar dosis yang diberikan maka efek hambatannya juga semakin besar. Nilai IC50 ekstrak etanol H.atra adalah 1,54 µg/ml. Penggunaan ekstrak teripang keling (Holothuria atra) memiliki efek antiplasmodial yang mampu menekan perkembangan P.falciparum dan nilai IC50 ekstrak etanol mempunyai aktivitas yang tinggi sebagai antiplasmodial. Kata Kunci: antiplasmodial, Holothuria atra, in vitro, malaria, Plasmodium falciparum DOI : 10.35990/mk.v6n2.p113-122
Upaya Peningkatan Pengetahuan Serta Penerapan Perilaku Hidup Bersih dan Sehat pada Ibu Balita Stunting Prawesty D. Utami; Retno Budiarti; Herin Setianingsih; Pramita A. Nugraheni; Wahyu P. Mutiadesi; Annisa U. Rasyida; Mita Herdiyanti; Ronald P. Adiwinoto
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v8i9.13072

Abstract

Stunting or stunted toddlers are a national health issue that jeopardizes a generation's survival. Infection is one of the risks that stunted toddlers frequently face. Promoting learning and adopting healthy and clean lifestyle practices (PHBS) are two ways to lower the risk of illness. This cross-sectional, analytical observational study was carried out in the Ngagel Rejo Community Health Center in Surabaya, East Java, in Indonesia. A questionnaire assessed mothers with stunted toddlers' knowledge and application of PHBS before and after education. Efforts to increase knowledge and implementation of PHBS are being made by educating mothers of stunted toddlers. Indicators of PENMAS activities’ success include the participation of mothers of stunted toddlers of at least 70%, increased knowledge, and implementation of PHBS of at least 20%. Knowledge and application of PHBS of mothers of stunted toddlers were assessed using a questionnaire before and after providing education. The achievement of PENMAS activities exceeded the success indicators, with PENMAS participants by 89.13% (above the target of 70%), a rise in PHBS application by 41.30%, a rise in PHBS knowledge by 31.23% (over the aim of 20%). Considering on these findings, it can be stated that this PENMAS activity might assist mothers of toddlers with stunting to raise their level of awareness and PHBS application, so that it is expected to prevent morbidity and mortality rates of stunting toddlers in the Ngagel Rejo Surabaya Puskesmas area.
Pengaruh Diet Ketogenik terhadap C-Reactive Protein dan Glasgow Prognostic Score pada Pasien Kanker Payudara Metastatik (Uji Klinis Fase 2) Anang Mufti; Prawesty Diah Utami
Surabaya Biomedical Journal Vol 1 No 2 (2022): Januari
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v1i2.14

Abstract

Abstrak Bahan pembentuk energi utama bagi sel kanker berupa glukosa dengan residual laktat yang tinggi akibat efek Warburg. Diet ketogenik akan merubah sumber energi dari glukosa menjadi badan keton, sehingga sel kanker akan mengalami reaksi inflamasi dan kelaparan. Pada pasien kanker payudara metastatik yang belum mendapatkan terapi onkologi spesifik, inflamasi sistemik yang terjadi dapat diukur dengan serum C-Reactive Protein (CRP) dan skor inflamasi sistemik menggunakan Glasgow Prognostic Score (GPS) modified. GPS merupakan salah satu faktor. prediktor independen kelangsungan hidup. Pelaksanaan penelitian ini diawali pada Februari sampai Juli 2018 di Unit Rawat Jalan Bedah Onkologi RSUP Dr. Saiful Anwar Malang, Indonesia. Pada subyek penelitian terjadi penurunan kadar CRP serum yang menunjukkan nilai signifikan sebesar 0,020 (< 0,050) dengan penurunan nilai persentase sebesar 21,1% (>20%). Terjadi pula penurunan skor GPS/mGPS yang menunjukkan nilai signifikan sebesar 0,011 (< 0,050). Abstract The main energy-forming material for cancer cells is glucose with high residual lactate due to the Warburg effect. By converting the energy source from glucose to ketone bodies through a ketogenic diet, cancer cells will experience inflammatory reactions and starvation. For patients with metastatic breast cancer who haven't already obtained specific oncology therapy, the systemic inflammation that occurs can be measured by serum C-Reactive Protein (CRP) and systemic inflammatory scores using the Glasgow Prognostic Score (GPS)/modified GPS, which is a one-factor independent predictor of survival. The implementation of this research started from February to July 2018 at the Outpatient Unit of Surgical Oncology of Dr. Saiful Anwar General Hospital, Malang, Indonesia. In the study subjects, there was a decrease in serum CRP levels which showed a significant value of 0.020 (< 0.050) with a reduction in the percentage value of 21.1% (> 20%). There was also a decrease in the GPS/mGPS score, which showed a significant value of 0.011 (< 0.050).
STUDI EKSPERIMENTAL: PENURUNAN PROFIL NETROFIL DAN TNF-α SETELAH PEMBERIAN EKSTRAK TERIPANG EMAS (STICHOPUS HERMANNI) R. Varidianto Yudo Tjahjono; Prawesty Diah Utami; Herin Setianingsih
Surabaya Biomedical Journal Vol 1 No 2 (2022): Januari
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v1i2.23

Abstract

Latar Belakang: Vaginitis candida adalah penyakit infeksi jamur yang diderita hampir setiap wanita di dunia. Meningkatnya jumlah netrofil dan kadar faktor nekrosis tumor alfa (TNF-α) merupakan ciri khas dari penyakit ini. Ekstrak teripang emas (Stichopus hermanni) telah banyak diteliti terutama untuk anti jamur dan bakteri, anti peradangan , anti oksidan dan lain-lain. Tujuan: Membandingkan profil netrofil dan TNF-α antara kelompok kontrol dengan kelompok studi lain yang mendapatkan ekstrak teripang emas (S.hermanni) melalui studi eksperimental menggunakan mencit coba. Metode: Penelitian eksperimental dengan desain “post-test only control group design”. Unit eksperimentalnya terdiri dari 24 mencit BALB/c yang diinokulasi C.albicans per vaginam dan dibagi menjadi empat grup terdiri dari : (K-) kelompok yang tidak mendapatkan perlakuan; (P1)kelompok yang mendapatkan ekstrak S.hermanni dosis 8,5mg/kgBB; (P2) kelompok dengan dosis ekstrak 17mg/kgBB; dan (P3) kelompok dengan dosis ektrak 34 mg/kgBB. Jumlah netrofil dilihat dari pemeriksaan mikroskopis jaringan mukosa vagina. Kadar sitokin TNF-α dilihat dari pemeriksaan ELISA sampel darah. Hasil: Hasil pengamatan profil netrofil pada jaringan mukosa vagina mencit coba menunjukkan bahwa kelompok P2 mengalami penurunan netrofil tertinggi namun secara statistic tidak signifikan penurunannya (p=0,156; p>α). Pengamatan profil TNF-α padai serum darah mencit pada kelompok P2 menunukkan penurunan yang signifikan dibanding kelompk lain (p=0,001; p< α). Perbedaan ini terutama bila dibandingkan kelompok K- (p=0,004; p< α) dan kelompok P1(p=0,004; p< α) Kesimpulan: Pemberian ekstrak S.hermanni terbukti mampu menurunkan profil netrofil dan kadar TNF-α pada mencit coba, dengan dosis efektifnya sebesar 17 mg/kgBB.
STUDI IN VITRO: PENGARUH PEMBERIAN EKSTRAK Holothuria athra DENGAN PELARUT N-HEKSANA TERHADAP PERTUMBUHAN Plasmodium falciparum Prawesty Diah Utami
Surabaya Biomedical Journal Vol 1 No 3 (2022): Mei
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v1i3.30

Abstract

Malaria adalah penyakit yang disebabkan oleh Plasmodium yang ditularkan nyamuk Anopheles betina infektif. Teripang keling (Holothuria atra) adalah biota laut yang mengandung berbagai komponen bioaktif yaitu alkaloid, flavonoid, saponin dan terpenoid sebagai antimalaria. Penelitian dilakukan untuk mengetahui pengaruh pemberian ekstrak teripang keling (Holothuria athra) terhadap pertumbuhan P. falciparum berdasarkan studi in vitro. Penelitian ini menggunakan sampel kultur P.falciparum strain 3D7 dan ekstrak H.atra yang diberikan pelarut n-heksana. Media kultur dibagi menjadi 3 kelompok kontrol yaitu kontrol negatif, kontrol positif dan dengan penambahan ekstrak H.atra pelarut n-heksana. Ketiga kelompok kontrol ini akan di inkubasi selama 48 jam pada suhu 37o C. Setelah itu dilakukan pemeriksaan kadar pemeriksaan kadar parasitemia dan inhibitory rate menggunakan mikroskop cahaya serta pengukuran IC50 menggunakan analisis probit melalui program SPSS. Pada penelitian ini memperlihatkan adanya efek antimalaria dalam menghambat pertumbuhan P.falciparum. Semakin besar dosis yang diberikan maka efek hambatannya juga semakin besar. Nilai IC50 ekstrak n-heksana H.atra adalah 1,23 µg/ml. Dari hasil analisis membuktikan bahwa ekstrak teripang keling (Holothuria atra) dengan pelarut N-heksana memiliki efek antimalaria yang dapat menghambat pertumbuhan P.falciparum dan mempunyai aktivitas yang tinggi sebagai antimalaria.
A Case Report :Alprazolam Therapy in A Dextra Fronto-Parietal Meningioma Patient With Anxiety Disorders: Efektivitas Alprazolam Pada Pasien Meningioma Fronto-Parietal Dextra Dengan Gangguan Cemas Wibowo, Prajogo; Utami, Prawesty Diah
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 4 No. 1 (2021): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v4i1.1409

Abstract

Meningiomas in the frontoparietal lobe may cause anxiety disorders and panic attacks. While alprazolam is one of the most widely used medications for anxiety disorders, long-term use may result in adverse side effects (withdrawal and rebound effects). This case study aims to describe the efficacy of long-term alprazolam administration in patients with meningiomas for regulating anxiety disorders. Case report :The asymmetrical face is the primary concern of a 65-year-old female when she is anxious. The results of the physical assessment and laboratory tests are within normal ranges. However, The HARS procedure showed moderate anxiety, and the CT scan revealed a meningioma in the right frontoparietal lobe. To regulate patient anxiety disorders, doctors give alprazolam 0.5 mg per day single dose for 4 months and tapering off for 3 months. Conclusion: Long-term administration of alprazolam in these patients can reduce the patient's anxiety disorder without causing withdrawal or rebound effects. A low dosage of alprazolam, a mild level of anxiety illness, and a slow tapering off phase were factors that contributed to the effectiveness of alprazolam treatment to suppress anxiety symptoms in this situation.
Profil Pasien Kanker Payudara Yang Menjalani Kemoterapi Di Rspal Dr. Ramelan Surabaya Periode Januari – Desember 2021 SEKAR KURNIA CAHYA; ANANG MUFTI SUMARSONO; PRAWESTY DIAH UTAMI
Hang Tuah Medical Journal Vol 22 No 1 (2024): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i1.416

Abstract

Background : Breast cancer is the most frequent cancer that occurs in Indonesia and becomes the main cause of mortality. Progression of breast cancer is affected by various factors, such as age, occupational status, menopause, estrogens, and lifestyle with high-fat dietary and alcohol consumption. Breast cancer progressivity may be stopped by surgery, chemotherapy, radiation, and hormonal therapy. Chemotherapy is an anticancer treatment management with the aim of killing cancer cells in the body and preventing recurrence and metastasis by administering cytotoxic agents. Chemotherapy may be performed previous to surgery (neoadjuvant) to achieve the decreased size of the tumor and facilitate the resection surgery. It may be performed as well after the surgery (adjuvant) to destroy any residual tumor cells. This study aimed to describe the profile of breast cancer patients who underwent chemotherapy from January to December 2021 at RSPAL Dr. Ramelan Surabaya. Methods: This study was descriptive with a retrospective design. Data collected from secondary sources of medical records patients with breast cancer in RSPAL Dr. Ramelan Surabaya from January to December 2021. Results: From the 79 samples, the most frequent age group in this study was a group of pre-elderly (45-59 years old). Most breast cancer patients are housewife. Breast cancer was commonly found in stage III. The most frequent chemotherapy management implemented for the breast cancer patient was adjuvant chemotherapy. Conclusion: women aged 45-59 years, not working, stage III, receiving adjuvant chemotherapy. Keywords : breast cancer, age, occupation, staging, chemotherapy
Co-Authors Anang Mufti ANANG MUFTI SUMARSONO Annisa U. Rasyida AZARINE NEIRA AVISHA Diah Purwaningsari Djatiwidodo Edi Pratiknya Erina Yatmasari Felly Moelyadi I Made Prasetya Kurniawan Indi Jazilah Irma Andriani Pasaribu Irmawati Dikman Irmawati M. Dikman Ismy Azizah Sisnawati Kusbijantoro, Yemima Billyana Luh Putu Diah Ayuning Mita Herdiyanti Mufti, Anang Muhammad Reyhan Arsya Pramita A. Nugraheni Purwoko, Agus Putri, Jeanaya Hedya Alfara PUTU SITHA AISHWARYA SARASWATI GIUR Giur R. Varidianto Yudo Tjahjono Retno Budiarti Retno Budiarti RISMA Rizka Indah Ramadina Ronald P. Adiwinoto SAPTA PRIHARTONO RACHMAN SEKAR KURNIA CAHYA Setianingsih, Herin Sukmana, Judya Tjahjono, R. Varidianto Yudo Wahyu P. Mutiadesi Wibowo, Prajogo Widjaja, Jordan Steven Wulandari, Ni Made Diah Zahratul Noreisza Rakhmadi Zuhro Putri Febrianti Febrianti