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All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences WMJ (Warmadewa Medical Journal) JURNAL PENDIDIKAN KEPERAWATAN INDONESIA Jurnal Ilmiah Kedokteran Wijaya Kusuma Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Syntax Literate: Jurnal Ilmiah Indonesia Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Oceana Biomedicina Journal Medical and Health Science Journal Medika Kartika : Jurnal Kedokteran dan Kesehatan Medicra (Journal of Medical Laboratory Science/Technology) Indonesian Journal of Medical Sciences and Public Health Oceana Biomedicina Journal Hang Tuah Medical Journal Surabaya Biomedical Journal Surabaya Biomedical Journal International Journal of Biomedical Science and Travel Medicine
Prawesty Diah Utami
Fakultas Kedokteran Universitas Hang Tuah
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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In Vitro Study: Antimalarial Activity of Rivet Sea Cucumber Extract (Holothuria atra) With Ethyl Acetate Solvent Against Plasmodium falciparum : none Prawesty Diah Utami; Zuhro Putri Febrianti Febrianti
WMJ (Warmadewa Medical Journal) Vol 7 No 1 (2022): May 2022
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.7.1.4287.23-32

Abstract

Abstract Indonesia is experiencing a decreased cure rate of malaria caused by the species Plasmodium falciparum. Alternative medicine, in this case, uses marine biota, namely lollyfish (Holothuria atra), which has a lot of active compound content; the purpose uses the biota because many reports that there is a failure of malaria treatment therapy due to Artemisinin-based Combination Therapy (ACT) resistance. The purpose of this study was to find out the antimalarial activity of Holothuria atra extract with ethyl acetate solvent at dose 0.01; 0.1; 1; 10; and 100 Ug/ml against Plasmodium falciparum in vitro. Extract lollyfish using the maceration method. The lollyfish powder will be dissolved with ethyl acetate solvent for 24 hours. Antimalarial activity testing is measured through 4 parameters, namely the measurement of parasitemia rates, % parasite growth, % inhibitory rate, and IC50. Antimalarial activity with ethyl acetate solvent belongs to a very active category with an IC50 value of 1.52 µg/mL. These results can kill the P. falciparum parasite with a percentage that reaches 0%. A decrease in the percentage of growth occurs when the dose given is too low so that the parasite can grow and survive. The result of higher concentrations of extracts will have a higher percentage of resistance to the growth of parasites. The potential for antimalarial activity in lollyfish extract is influenced by the presence of active content such as alkaloids, flavonoids, catechins, and pyrogallol owned by marine biota animals. This study suggests that lollyfish (H. atra) can be developed as an alternative treatment for malaria. Keywords: Holothuria atra, antimalarial, Plasmodium falciparum, in vitro
Phytotherapy for Bacterial Vaginosis with Piper Betle: from Mechanism to Safety Satria Bintang Samudra; Prawesty Diah Utami; Grissabel Bethrin Jiantoro; Jessica Euodia Adidharma; Rayhan Ali Fadli
International Journal of Biomedical Science and Travel Medicine Vol. 3 No. 1 (2026)
Publisher : Publication Department, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/ijbstm.3.1.2026.7-16

Abstract

Background: Bacterial vaginosis (BV) is a prevalent vaginal dysbiosis characterized by depletion of Lactobacillus and overgrowth of anaerobic bacteria, commonly including Gardnerella vaginalis. Clinical management is complicated by high recurrence rates, which are closely linked to polymicrobial biofilm persistence and the limited microbiome selectivity of conventional antimicrobials. This narrative review aimed to synthesize current evidence on the phytotherapeutic potential of Piper betle in BV, focusing on antimicrobial and anti-biofilm mechanisms, modulation of vaginal microbiome ecology, and safety and standardization considerations relevant to translational development and recurrence prevention. Methods: An exploratory literature search (2015–2025) was conducted using PubMed/MEDLINE, ScienceDirect, and Google Scholar, complemented by manual reference screening, and last searched on 30 September 2025. Results: Findings across in vitro studies, observational reports, and mechanistic literature indicate that P. betle extracts and key phenolic constituents, particularly hydroxychavicol and eugenol, exhibit antibacterial activity against BV-associated taxa and anti-virulence effects consistent with biofilm weakening and interference with quorum-sensing–regulated behaviors. Importantly, several studies suggest comparatively limited inhibitory effects on Lactobacillus spp., supporting the plausibility of a microbiome-sparing profile that may facilitate restoration of vaginal eubiosis. Nevertheless, the evidence base is constrained by heterogeneous methodologies, predominance of preclinical models, and substantial variability in phytochemical composition across preparations. Conclusion: Overall, P. betle emerges as a biologically plausible adjunctive or preventive candidate for preventing BV recurrence, warranting standardized formulations, marker-based quality control, and rigorous clinical evaluation with recurrence-focused endpoints.
Pengaruh Diet Ketogenik terhadap C-Reactive Protein dan Glasgow Prognostic Score pada Pasien Kanker Payudara Metastatik (Uji Klinis Fase 2) Anang Mufti; Prawesty Diah Utami
Surabaya Biomedical Journal Vol. 1 No. 2 (2022): January
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v1i2.14

Abstract

Abstrak Bahan pembentuk energi utama bagi sel kanker berupa glukosa dengan residual laktat yang tinggi akibat efek Warburg. Diet ketogenik akan merubah sumber energi dari glukosa menjadi badan keton, sehingga sel kanker akan mengalami reaksi inflamasi dan kelaparan. Pada pasien kanker payudara metastatik yang belum mendapatkan terapi onkologi spesifik, inflamasi sistemik yang terjadi dapat diukur dengan serum C-Reactive Protein (CRP) dan skor inflamasi sistemik menggunakan Glasgow Prognostic Score (GPS) modified. GPS merupakan salah satu faktor. prediktor independen kelangsungan hidup. Pelaksanaan penelitian ini diawali pada Februari sampai Juli 2018 di Unit Rawat Jalan Bedah Onkologi RSUP Dr. Saiful Anwar Malang, Indonesia. Pada subyek penelitian terjadi penurunan kadar CRP serum yang menunjukkan nilai signifikan sebesar 0,020 (< 0,050) dengan penurunan nilai persentase sebesar 21,1% (>20%). Terjadi pula penurunan skor GPS/mGPS yang menunjukkan nilai signifikan sebesar 0,011 (< 0,050). Abstract The main energy-forming material for cancer cells is glucose with high residual lactate due to the Warburg effect. By converting the energy source from glucose to ketone bodies through a ketogenic diet, cancer cells will experience inflammatory reactions and starvation. For patients with metastatic breast cancer who haven't already obtained specific oncology therapy, the systemic inflammation that occurs can be measured by serum C-Reactive Protein (CRP) and systemic inflammatory scores using the Glasgow Prognostic Score (GPS)/modified GPS, which is a one-factor independent predictor of survival. The implementation of this research started from February to July 2018 at the Outpatient Unit of Surgical Oncology of Dr. Saiful Anwar General Hospital, Malang, Indonesia. In the study subjects, there was a decrease in serum CRP levels which showed a significant value of 0.020 (< 0.050) with a reduction in the percentage value of 21.1% (> 20%). There was also a decrease in the GPS/mGPS score, which showed a significant value of 0.011 (< 0.050).
STUDI EKSPERIMENTAL: PENURUNAN PROFIL NETROFIL DAN TNF-α SETELAH PEMBERIAN EKSTRAK TERIPANG EMAS (STICHOPUS HERMANNI) R. Varidianto Yudo Tjahjono; Prawesty Diah Utami; Herin Setianingsih
Surabaya Biomedical Journal Vol. 1 No. 2 (2022): January
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v1i2.23

Abstract

Latar Belakang: Vaginitis candida adalah penyakit infeksi jamur yang diderita hampir setiap wanita di dunia. Meningkatnya jumlah netrofil dan kadar faktor nekrosis tumor alfa (TNF-α) merupakan ciri khas dari penyakit ini. Ekstrak teripang emas (Stichopus hermanni) telah banyak diteliti terutama untuk anti jamur dan bakteri, anti peradangan , anti oksidan dan lain-lain. Tujuan: Membandingkan profil netrofil dan TNF-α antara kelompok kontrol dengan kelompok studi lain yang mendapatkan ekstrak teripang emas (S.hermanni) melalui studi eksperimental menggunakan mencit coba. Metode: Penelitian eksperimental dengan desain “post-test only control group design”. Unit eksperimentalnya terdiri dari 24 mencit BALB/c yang diinokulasi C.albicans per vaginam dan dibagi menjadi empat grup terdiri dari : (K-) kelompok yang tidak mendapatkan perlakuan; (P1)kelompok yang mendapatkan ekstrak S.hermanni dosis 8,5mg/kgBB; (P2) kelompok dengan dosis ekstrak 17mg/kgBB; dan (P3) kelompok dengan dosis ektrak 34 mg/kgBB. Jumlah netrofil dilihat dari pemeriksaan mikroskopis jaringan mukosa vagina. Kadar sitokin TNF-α dilihat dari pemeriksaan ELISA sampel darah. Hasil: Hasil pengamatan profil netrofil pada jaringan mukosa vagina mencit coba menunjukkan bahwa kelompok P2 mengalami penurunan netrofil tertinggi namun secara statistic tidak signifikan penurunannya (p=0,156; p>α). Pengamatan profil TNF-α padai serum darah mencit pada kelompok P2 menunukkan penurunan yang signifikan dibanding kelompk lain (p=0,001; p< α). Perbedaan ini terutama bila dibandingkan kelompok K- (p=0,004; p< α) dan kelompok P1(p=0,004; p< α) Kesimpulan: Pemberian ekstrak S.hermanni terbukti mampu menurunkan profil netrofil dan kadar TNF-α pada mencit coba, dengan dosis efektifnya sebesar 17 mg/kgBB.
STUDI IN VITRO: PENGARUH PEMBERIAN EKSTRAK Holothuria athra DENGAN PELARUT N-HEKSANA TERHADAP PERTUMBUHAN Plasmodium falciparum Prawesty Diah Utami
Surabaya Biomedical Journal Vol. 1 No. 3 (2022): May
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v1i3.30

Abstract

Malaria adalah penyakit yang disebabkan oleh Plasmodium yang ditularkan nyamuk Anopheles betina infektif. Teripang keling (Holothuria atra) adalah biota laut yang mengandung berbagai komponen bioaktif yaitu alkaloid, flavonoid, saponin dan terpenoid sebagai antimalaria. Penelitian dilakukan untuk mengetahui pengaruh pemberian ekstrak teripang keling (Holothuria athra) terhadap pertumbuhan P. falciparum berdasarkan studi in vitro. Penelitian ini menggunakan sampel kultur P.falciparum strain 3D7 dan ekstrak H.atra yang diberikan pelarut n-heksana. Media kultur dibagi menjadi 3 kelompok kontrol yaitu kontrol negatif, kontrol positif dan dengan penambahan ekstrak H.atra pelarut n-heksana. Ketiga kelompok kontrol ini akan di inkubasi selama 48 jam pada suhu 37o C. Setelah itu dilakukan pemeriksaan kadar pemeriksaan kadar parasitemia dan inhibitory rate menggunakan mikroskop cahaya serta pengukuran IC50 menggunakan analisis probit melalui program SPSS. Pada penelitian ini memperlihatkan adanya efek antimalaria dalam menghambat pertumbuhan P.falciparum. Semakin besar dosis yang diberikan maka efek hambatannya juga semakin besar. Nilai IC50 ekstrak n-heksana H.atra adalah 1,23 µg/ml. Dari hasil analisis membuktikan bahwa ekstrak teripang keling (Holothuria atra) dengan pelarut N-heksana memiliki efek antimalaria yang dapat menghambat pertumbuhan P.falciparum dan mempunyai aktivitas yang tinggi sebagai antimalaria.
Co-Authors Anang Mufti Anang Mufti ANANG MUFTI SUMARSONO Annisa U. Rasyida AZARINE NEIRA AVISHA Diah Purwaningsari Djatiwidodo Edi Pratiknya Erina Yatmasari Felly Moelyadi Grissabel Bethrin Jiantoro I Made Prasetya Kurniawan Indi Jazilah Irma Andriani Pasaribu Irmawati Dikman Irmawati M. Dikman Ismy Azizah Sisnawati Jessica Euodia Adidharma Kusbijantoro, Yemima Billyana Luh Putu Diah Ayuning Mita Herdiyanti Muhammad Reyhan Arsya Pramita A. Nugraheni Purwoko, Agus Putri, Jeanaya Hedya Alfara PUTU SITHA AISHWARYA SARASWATI GIUR Giur R. Varidianto Yudo Tjahjono Rayhan Ali Fadli Retno Budiarti Retno Budiarti RISMA Rizka Indah Ramadina Ronald P. Adiwinoto SAPTA PRIHARTONO RACHMAN Satria Bintang Samudra SEKAR KURNIA CAHYA Setianingsih, Herin Sukmana, Judya Wahyu P. Mutiadesi Wibowo, Prajogo Widjaja, Jordan Steven Wulandari, Ni Made Diah Zahratul Noreisza Rakhmadi Zuhro Putri Febrianti Febrianti