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All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences Jurnal Kedokteran Diponegoro WMJ (Warmadewa Medical Journal) JURNAL PENDIDIKAN KEPERAWATAN INDONESIA Jurnal Ilmiah Kedokteran Wijaya Kusuma Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Syntax Literate: Jurnal Ilmiah Indonesia Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Oceana Biomedicina Journal Medical and Health Science Journal Medika Kartika : Jurnal Kedokteran dan Kesehatan Medicra (Journal of Medical Laboratory Science/Technology) Indonesian Journal of Medical Sciences and Public Health Oceana Biomedicina Journal CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal Hang Tuah Medical Journal Surabaya Biomedical Journal Svāsthya: Trends in General Medicine and Public Health Surabaya Biomedical Journal International Journal of Biomedical Science and Travel Medicine
Prawesty Diah Utami
Fakultas Kedokteran Universitas Hang Tuah
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Neutrophil–lymphocyte ratio as a predictor of dengue hemorrhagic fever severity in Indonesian pediatric patients: A Single-center retrospective study Dewi, I Gusti Ayu Ajeng Widia Kencana; Adiwinoto, Ronald Pratama; Rokhmadhoni Pikir, Rizqi; Rusli, Christina; Biutifasari, Verna; Diah Utami, Prawesty
Svāsthya: Trends in General Medicine and Public Health Vol. 2 No. 4 (2025): July 2025
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v2i4.104

Abstract

Dengue hemorrhagic fever (DHF) is a significant health burden in Indonesia, necessitating reliable prognostic markers for early clinical intervention. The neutrophil‒lymphocyte ratio (NLR) has emerged as a potential biomarker for disease severity assessment, although its utility in pediatric populations requires further validation. This study aimed to to determine the relationship between the neutrophil‒lymphocyte ratio and DHF severity grade in pediatric patients and evaluate its potential as a prognostic indicator for clinical decision-making. This retrospective cross-sectional study analyzed 111 pediatric patients aged 5-14 years who were diagnosed with DHF at RSPAL Dr. Ramelan, Surabaya, between January 2022 and December 2024. Patients were classified according to the WHO severity grades (I-IV), with the NLR calculated from complete blood counts obtained during days 3-6 of illness. Statistical analysis with Spearman's rank correlation was used to examine the relationship between the NLR and disease severity. The study population predominantly demonstrated Grade I DHF (56.8%), followed by Grade II DHF (20.7%), Grade III DHF (18.0%), and Grade IV DHF (4.5%). Patients with lower severity grades (I-II) predominantly presented low NLR values (<1) in 46.0% and 47.8% of cases, respectively, whereas those with higher severity grades (III-IV) primarily presented normal NLR values (1-3) in 65.0% and 60.0% of cases, respectively. Spearman's correlation analysis revealed no statistically significant relationship between the NLR and DHF severity (ρ = 0.120, p = 0.208). The neutrophil‒lymphocyte ratio has limited utility as a standalone predictor of DHF severity in pediatric patients. These findings suggest the need for alternative biomarkers or composite indices for accurate prediction of pediatric DHF severity.
Efek Inhibisi Senyawa Aktif Spoge Haliclona sp. terhadap Pertumbuhan Plasmodium falciparum Berdasarkan Studi In Slico Wulandari, Ni Made Diah; Utami, Prawesty Diah; Sukmana, Judya
Syifa'Medika Vol 16, No 1 (2025): Syifa Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v16i1.9077

Abstract

Malaria is still a problem in many places, caused by a parasite Plasmodium falciparum spreaded by mosquitoes. Haliclona sp. is a sea sponge that contains active compounds, some of which are Manzamine and Haliclonacyclamine A, and have antimalarial activity. This study aimed to find the potential effects of different active compounds on the sponge Haliclona sp. on the growth of Plasmodium falciparum based on in silico. This was an experimental study using in silico method. The materials were prepared and taken from the PubChem web, predicted the potential of compounds, predicted pathways using Discovery Studio version 21.1.1, molecular docking using Molegro virtual Docker 5.0, predicted ADME using SWISS ADME, and predicted toxicity via Protox web. The results showed that Haliclona sp. contained several active compounds, namely Manzamine and Haliclonacyclamine A. The study of the active compounds in Haliclona sp. showed that there was a link between the Plasmodium falciparum enzymes. The PfTK and PfDHODH enzymes are responsible for breaking down malaria parasites. In the ADME prediction analysis of the active compounds contained in Haliclona sp., Haliclonacyclamine A can meet Lipinski's criteria. The last test performed was a toxicity test where it was found that Haliclonacyclamine.
INHIBITORY ACTIVITY OF BIOACTIVE COMPOUNDS IN BLACK SEA CUCUMBER (HOLOTHURIA ATRA) AGAINST FALCIPAIN-2 PROTEIN IN PLASMODIUM FALCIPARUM AS ANTIMALARIA BASED ON IN SILICO STUDY Alifiah Wahyu Nur Fadilah; Prawesty Diah Utami; Nita Pranitasari
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 3 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v14i3.49141

Abstract

malaria treatment, one of which is Holothuria atra. Indonesia is reported as the second-largest contributor to malaria in the Asian. Plasmodium falciparum is the most common malaria-causing parasite in Indonesia. The high incidence of resistance of the malaria parasite Plasmodium falciparum to malaria drugs makes the bioactive compounds in Holothuria atra a very advantageous discovery as a new antimalarial drug. Objective: to determine the inhibitory effects of active compounds in Holothuria atra on the development of Plasmodium falciparum based on in silico studies. Method: The research design used was a one-shot experimental study, contained several stages, including protein and ligand preparation; prediction of bioactive compound potential and target protein; molecular docking and visualization of docking results; and prediction of drug-likeness and absorption, distribution, metabolism, excretion, toxicity (ADMET) Results: Based on the test results, the active compounds are chlorogenic acid, catechin, rutin, coumaric acid, pyrogallol, and ascorbic acid, show inhibition of Falcipain-2, which is used to degrade hemoglobin and erythrocytes in the acidic digestive vacuole. Chlorogenic acid and catechin have the highest binding affinity values. The ADME analysis show that four active compounds, are catechin, coumaric acid, pyrogallol, and ascorbic acid, comply the Lipinski criteria, making them potential candidates for oral drugs. Catechin is the safest compound classified as class 6 toxicity (non-toxic). Conclusion: The research that has been carried out describes the results, that Holothuria atra has the potential to be an antimalarial drug
In Vitro Study: Antimalarial Activity of Rivet Sea Cucumber Extract (Holothuria atra) With Ethyl Acetate Solvent Against Plasmodium falciparum : none Prawesty Diah Utami; Zuhro Putri Febrianti Febrianti
WMJ (Warmadewa Medical Journal) Vol 7 No 1 (2022): May 2022
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.7.1.4287.23-32

Abstract

Abstract Indonesia is experiencing a decreased cure rate of malaria caused by the species Plasmodium falciparum. Alternative medicine, in this case, uses marine biota, namely lollyfish (Holothuria atra), which has a lot of active compound content; the purpose uses the biota because many reports that there is a failure of malaria treatment therapy due to Artemisinin-based Combination Therapy (ACT) resistance. The purpose of this study was to find out the antimalarial activity of Holothuria atra extract with ethyl acetate solvent at dose 0.01; 0.1; 1; 10; and 100 Ug/ml against Plasmodium falciparum in vitro. Extract lollyfish using the maceration method. The lollyfish powder will be dissolved with ethyl acetate solvent for 24 hours. Antimalarial activity testing is measured through 4 parameters, namely the measurement of parasitemia rates, % parasite growth, % inhibitory rate, and IC50. Antimalarial activity with ethyl acetate solvent belongs to a very active category with an IC50 value of 1.52 µg/mL. These results can kill the P. falciparum parasite with a percentage that reaches 0%. A decrease in the percentage of growth occurs when the dose given is too low so that the parasite can grow and survive. The result of higher concentrations of extracts will have a higher percentage of resistance to the growth of parasites. The potential for antimalarial activity in lollyfish extract is influenced by the presence of active content such as alkaloids, flavonoids, catechins, and pyrogallol owned by marine biota animals. This study suggests that lollyfish (H. atra) can be developed as an alternative treatment for malaria. Keywords: Holothuria atra, antimalarial, Plasmodium falciparum, in vitro
In-Silico Study of Black Sea Cucumber (Holothuria atra) Active Compounds against Plasmepsin 2 Protein of Plasmodium falciparum De. Bima Kurnia Ramadhan; Prawesty Diah Utami; Nita Pranitasari; I Dewa Made Widi Hersana; Dody Taruna
WMJ (Warmadewa Medical Journal) Vol 10 No 1 (2025): May 2025
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.10.1.11823.12-27

Abstract

The existence of evidence of resistance to artemisinin derivatives as first-line malaria therapy is a problem that must be resolved. One of them is a marine biota, which has the potential to act as an anti-malarial, namely the black sea cucumber (Holothuria atra/ H.atra). The aim of this research is to analyze H. atra antimalarial activity against P. falciparum - plasmepsin 2 protein used in-silico approach. This type of research is experimental, using in-silico tests (computerized tests) on bioactive compounds and target proteins. This research analyzes several aspects: the preparation of materials and tools, the preparation of P. falciparum protein, the preparation of active compounds for H. atra, the prediction of compound and pathway potential, the prediction of interactions between plasmepsin protein and bioactive compounds, and the prediction of antimalarial inhibitors on active compounds. The results of Quantitative Structure–Activity Relationship/ analysis show that the biologically active compounds of sea cucumbers have anti-parasitic properties. Furthermore, the docking results show that 3 biologically active compounds from sea cucumbers have quite good inhibitory activity against Plasmepsin2 proteins, especially the compounds chlorogenic acid, catechin, and rutin. Chlorogenic acid compounds also have high PA values as antiparasitic agents, especially greater than 0.4. ADME/T demonstrated that chlorogenic acid and catechin conform to Lipinski's rule, but rutin fails to satisfy Lipinski's rule. Toxicity analysis showed that catechin (level 6) has lower toxicity than chlorogenic acid (level 4), and rutin (level 5). Therefore, it can be predicted that chlorogenic acid is the most potent compound in sea cucumbers with anti-malarial effects
The active compound of the sponge Niphates olemda against Plasmodium falciparum phosphoethanolamine methyltransferase (pfpmt) based on in silico study F. Frederick; Prawesty Diah Utami; Olivia Mahardani Adam; Fitri Handajani
International Journal of Biomedical Science and Travel Medicine Vol. 1 No. 2 (2024)
Publisher : Publication Department, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/ijbstm.1.2.2024.50-55

Abstract

Antimalarial drug resistance to P. falciparum has become a global problem in recent decades. This encourages the need for exploration to find alternative treatments, which come from marine product like Sponge Niphates olemda that contain active substrat. This research was conducted to determine the activity sponge Niphates olemda on P. falciparum phosphoethanolamine methyltransferase (PfPMT) through an in silico study.This research is a pure experimental research using the One Shot Experimental Study research design method. Observations were only made once between the variables studied through three analyzes, namely molecular docking analysis, ADME prediction analysis, and active compound toxicity analysis.The results showed that there were 4 active compounds (Niphateolide A, Kapakahine A, Kapakahine B, and Kapakahine F) that had a better binding affinity than artemisinin so that they had antimalarial potential. However, only Niphateolide A met Lipinski's criteria in ADME analysis, but was more toxic than the other three active compounds and also artemisinin. Based on the results of molecular docking analysis, it was found that the active compound Niphateolide A from the sea sponge Niphates olemda has antimalarial potential on target protein Plasmodium falciparum phosphoethanolamine methyltransferase.
A Systematic Review: The Effectiveness of Triple Drug versus Dual Drug Approach Against Lymphatic Filariasis Devina Hanalily Maharani Ferguszon; Putri Cahya Purwaningrum; Raihanah labibah; Prawesty Diah Utami
International Journal of Biomedical Science and Travel Medicine Vol. 2 No. 1 (2025)
Publisher : Publication Department, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/ijbstm.2.1.2025.7-13

Abstract

Background: Lymphatic Filariasis (LF) is a neglected tropical disease caused by filarial nematode parasites (Wuchereria bancrofti, Brugia malayi, and B. timori), which is transmitted via mosquitoes in the form of microfilariae (Mf). The transmission cycle for each species is the same parasites or worms transmitted through the bite of all types of mosquitoes. The most severe clinical manifestations of LF are lymphedema and elephantiasis. The treatment of filariasis receives mass drug administration with a single dose of the triple-drug oral regimen. Therefore, the World Health Organization (WHO) reported that the triple-drug oral regimen was an LF treatment.Methods: The research is in the form of systematic review research using the PRISMA (Preferred Reporting Items for Systematic Review and Meta-analysis) method, which is carried out systematically. The research was conducted in December-February with a review of articles published in the last 5 years (2018-2023). Researchers searched for literature independently through PubMed and Science Direct.Results:Triple drug therapy or a combination of Ivermectin-Diethylcarbamazine -Albendazole (IDA) is safer and more tolerable for filariasis than dual drug (combination of Diethylcarbamazine -Albendazole/DA), according to various articles. In addition, IDA reduces microfilaria formation more than DA. Most filariasis treatment side effects are modest, such as fever and soreness.Conclusion: In comparison to dual drug therapy, triple drug therapy exhibits a substantial advantage; however, the level of endemicity and the species of the causative agents must be considered when applying this approach.
Screening and Risk Factor Assessment of Cataract and Glaucoma in Hypertensive and Diabetic Populations along the Surabaya Coast Irma Andriani Pasaribu; Aditya Wira Buana; Prawesty Diah Utami
International Journal of Biomedical Science and Travel Medicine Vol. 2 No. 2 (2025)
Publisher : Publication Department, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/ijbstm.2.2.2025.60-64

Abstract

Background: The coexistence of cataract, glaucoma, diabetes mellitus, and hypertension imposes a substantial ocular health burden in aging populations, especially in coastal communities exposed to ultraviolet radiation. Methods: This observational-analytical study evaluated the influence of hypertension and diabetes mellitus on the incidence of cataract and glaucoma among residents of Kedung Cowek, Surabaya (April 2025). Direct clinical examinations, demographic and medical histories, and ocular assessments were performed on all eligible patients presenting with blurred vision and documented hypertension or diabetes (total sampling). Results: Among 12 hypertensive patients along the Surabaya Coast, 8 (66.7%) had ocular abnormalities. Cataract was the most common finding (5 cases, 41.7%), followed by glaucoma (3 cases, 25%). Pterygium occurred in 4 cases (33.3%), likely linked to high UV exposure. Conclusion: Diabetes, and hypertension appears to accelerate cataract and glaucoma development in this coastal population. Oxidative stress from combined metabolic and environmental factors may overwhelm ocular defenses, increasing vision-related risk.
Phytotherapy for Bacterial Vaginosis with Piper Betle: from Mechanism to Safety Satria Bintang Samudra; Prawesty Diah Utami; Grissabel Bethrin Jiantoro; Jessica Euodia Adidharma; Rayhan Ali Fadli
International Journal of Biomedical Science and Travel Medicine Vol. 3 No. 1 (2026)
Publisher : Publication Department, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/ijbstm.3.1.2026.7-16

Abstract

Background: Bacterial vaginosis (BV) is a prevalent vaginal dysbiosis characterized by depletion of Lactobacillus and overgrowth of anaerobic bacteria, commonly including Gardnerella vaginalis. Clinical management is complicated by high recurrence rates, which are closely linked to polymicrobial biofilm persistence and the limited microbiome selectivity of conventional antimicrobials. This narrative review aimed to synthesize current evidence on the phytotherapeutic potential of Piper betle in BV, focusing on antimicrobial and anti-biofilm mechanisms, modulation of vaginal microbiome ecology, and safety and standardization considerations relevant to translational development and recurrence prevention. Methods: An exploratory literature search (2015–2025) was conducted using PubMed/MEDLINE, ScienceDirect, and Google Scholar, complemented by manual reference screening, and last searched on 30 September 2025. Results: Findings across in vitro studies, observational reports, and mechanistic literature indicate that P. betle extracts and key phenolic constituents, particularly hydroxychavicol and eugenol, exhibit antibacterial activity against BV-associated taxa and anti-virulence effects consistent with biofilm weakening and interference with quorum-sensing–regulated behaviors. Importantly, several studies suggest comparatively limited inhibitory effects on Lactobacillus spp., supporting the plausibility of a microbiome-sparing profile that may facilitate restoration of vaginal eubiosis. Nevertheless, the evidence base is constrained by heterogeneous methodologies, predominance of preclinical models, and substantial variability in phytochemical composition across preparations. Conclusion: Overall, P. betle emerges as a biologically plausible adjunctive or preventive candidate for preventing BV recurrence, warranting standardized formulations, marker-based quality control, and rigorous clinical evaluation with recurrence-focused endpoints.
Pengaruh Diet Ketogenik terhadap C-Reactive Protein dan Glasgow Prognostic Score pada Pasien Kanker Payudara Metastatik (Uji Klinis Fase 2) Anang Mufti; Prawesty Diah Utami
Surabaya Biomedical Journal Vol. 1 No. 2 (2022): January
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v1i2.14

Abstract

Abstrak Bahan pembentuk energi utama bagi sel kanker berupa glukosa dengan residual laktat yang tinggi akibat efek Warburg. Diet ketogenik akan merubah sumber energi dari glukosa menjadi badan keton, sehingga sel kanker akan mengalami reaksi inflamasi dan kelaparan. Pada pasien kanker payudara metastatik yang belum mendapatkan terapi onkologi spesifik, inflamasi sistemik yang terjadi dapat diukur dengan serum C-Reactive Protein (CRP) dan skor inflamasi sistemik menggunakan Glasgow Prognostic Score (GPS) modified. GPS merupakan salah satu faktor. prediktor independen kelangsungan hidup. Pelaksanaan penelitian ini diawali pada Februari sampai Juli 2018 di Unit Rawat Jalan Bedah Onkologi RSUP Dr. Saiful Anwar Malang, Indonesia. Pada subyek penelitian terjadi penurunan kadar CRP serum yang menunjukkan nilai signifikan sebesar 0,020 (< 0,050) dengan penurunan nilai persentase sebesar 21,1% (>20%). Terjadi pula penurunan skor GPS/mGPS yang menunjukkan nilai signifikan sebesar 0,011 (< 0,050). Abstract The main energy-forming material for cancer cells is glucose with high residual lactate due to the Warburg effect. By converting the energy source from glucose to ketone bodies through a ketogenic diet, cancer cells will experience inflammatory reactions and starvation. For patients with metastatic breast cancer who haven't already obtained specific oncology therapy, the systemic inflammation that occurs can be measured by serum C-Reactive Protein (CRP) and systemic inflammatory scores using the Glasgow Prognostic Score (GPS)/modified GPS, which is a one-factor independent predictor of survival. The implementation of this research started from February to July 2018 at the Outpatient Unit of Surgical Oncology of Dr. Saiful Anwar General Hospital, Malang, Indonesia. In the study subjects, there was a decrease in serum CRP levels which showed a significant value of 0.020 (< 0.050) with a reduction in the percentage value of 21.1% (> 20%). There was also a decrease in the GPS/mGPS score, which showed a significant value of 0.011 (< 0.050).
Co-Authors Aditya Wira Buana Alifiah Wahyu Nur Fadilah Anang Mufti Anang Mufti Anang Mufti Sumarsono Annisa U. Rasyida ARSYA, MUHAMMAD REYHAN AVISHA, AZARINE NEIRA AZARINE NEIRA AVISHA Brilliant , Fahridho Ramadhana Christina Rusli De. Bima Kurnia Ramadhan Devina Hanalily Maharani Ferguszon Dewi, I Gusti Ayu Ajeng Widia Kencana Diah Purwaningsari Djatiwidodo Edi Pratiknya Dody Taruna Erina Yatmasari F. Frederick Felly Moelyadi Fitri Handajani Grissabel Bethrin Jiantoro Hendra Widjajanto I Dewa Made Widi Hersana I Made Prasetya Kurniawan Indi Jazilah Irma Andriani Pasaribu Irmawati Dikman Irmawati Irmawati Irmawati M. Dikman Ismy Azizah Sisnawati Jessica Euodia Adidharma Kusbijantoro, Yemima Billyana Luh Putu Diah Ayuning Mita Herdiyanti Muhammad Reyhan Arsya Nita Pranitasari Nita Pranitasari Olivia Mahardani Adam Pramita A. Nugraheni Purwoko, Agus Putri Cahya Purwaningrum Putri, Jeanaya Hedya Alfara PUTU SITHA AISHWARYA SARASWATI GIUR Giur R. Varidianto Yudo Tjahjono Raihanah labibah Rayhan Ali Fadli Retno Budiarti Risma Rizka Indah Ramadina Rokhmadhoni Pikir, Rizqi Ronald P. Adiwinoto Ronald Pratama Adiwinoto SAPTA PRIHARTONO RACHMAN Satria Bintang Samudra SEKAR KURNIA CAHYA Setianingsih, Herin Sukmana, Judya Verna Biutifasari Wahyu P. Mutiadesi Wibowo, Prajogo Widjaja, Jordan Steven Wulandari, Ni Made Diah Zahratul Noreisza Rakhmadi Zuhro Putri Febrianti Febrianti