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All Journal International Journal of Renewable Energy Development Jurnal Riset Kimia Biology, Medicine, & Natural Product Chemistry CHEMPUBLISH JOURNAL IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Jurnal Zarah Indonesian Journal of Chemistry Eksakta : Berkala Ilmiah Bidang MIPA Molekul: Jurnal Ilmiah Kimia Majalah Kedokteran Andalas Majalah Farmasetika Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Hydrogen: Jurnal Kependidikan Kimia Indonesian Journal of Chemical Studies (Indones. J. Chem. Stud.) Molekul: Jurnal Ilmiah Kimia International Journal of Renewable Energy Development Bulletin of Chemical Reaction Engineering & Catalysis Journal of The Indonesian Society of Integrated Chemistry Jurnal Kimia Unand Biodiversitas Journal of Biological Diversity
Mai Efdi
Departemen Kimia FMIPA Universitas Andalas
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Other

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Profil Fitokimia dan Uji Toksisitas Daun Tumbuhan Aglaia Odorata dengan Metode Brine Shrimp Lethality Test Mai Efdi; Ridho Sahary Adha; Adlis Santoni
Jurnal Kimia Unand Vol. 11 No. 2 (2022): November 2022
Publisher : Departemen Kimia Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jku.11.2.1-4.2022

Abstract

Toxicity and phytochemistry assay have been conducted on extracts and fractions of Aglaia odorata leaves using brine shrimp lethality test. Aglaia odorata is one of the plants that are found in Indonesia. To investigate Aglaia odorata leaves potential as anticancer, air-dried and powdered leaves were extracted with n-hexane, ethyl acetat, and metanol by using maceration method. Extract of ethyl acetat showed the highest toxicity with LC50 value is 125.89 mg/L
Review Pembuatan Kokristal Farmasi dengan Metode Mekanokimia Yenti, Revi; Zulhadjri, Zulhadjri; Efdi, Mai; Zaini, Erizal
Majalah Farmasetika Vol 9, No 1 (2024)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v9i1.48094

Abstract

Pengembangan bahan aktif farmasi saat ini cukup pesat, salah satunya adalah pengembangan kokristal. Kokristal dibuat dengan menggabungkan antara bahan aktif farmasi dan koformernya dengan berbagai metode misalnya pelarutan dan penggilingan. Mekanokimia adalah metode yang efektif untuk persiapan sistem kristal multikomponen. Mekanokimia dianggap sebagai alternatif pendekatan ramah lingkungan karena dilakukan dalam kondisi bebas pelarut atau dengan adanya pelarut dalam jumlah minimal. Artikel review ini dibuat dengan metode instrumen pencarian online terbitan internasional yang akan membahas definisi dan sejarah kokristal farmasi, teknik pembuatan kokristal, sejarah dan definisi mekanokimia, metode mekanokimia pada pembuatan kokristal farmasi, mekanisme metode mekanokimia, serta keuntungan dan kerugian metode mekanokimia. Oleh karena itu pada ulasan ini dijelaskan dan dibahas relevansi prosedur mekanokimia dalam pembentukan kristal multikomponen yang fokus pada kokristal farmasi. Selain itu pada akhir tinjauan ini juga dilaporkan ringkasan makalah ilmiah tentang sintesis mekanokimia kokristal farmasi.
Potential Toxicity of Legundi Leaf Extract (Vitex Trifolia L) Using the Brine Shrimp Lethality Test (BSLT) Method Arifah, Zil; Efdi, Mai; Syafrizayanti, Syafrizayanti
Journal of The Indonesian Society of Integrated Chemistry Vol. 16 No. 1 (2024): Journal of The Indonesian Society of Integrated Chemistry
Publisher : Pendidikan Kimia FKIP Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jisic.v16i1.33115

Abstract

Many natural products can be used as starting points in developing modern medicines because of their capabilities in pharmacological activities. Vitex trifolia L is an herbal plant that has been used to treat diseases such as fever, inflammation, colds, irregular menstruation, and diseases related to the female reproductive organs. This study aims to identify the cytotoxic ability of Vitex trifolia L leaf extract using the Brine Shrimp Lethality Test (BSLT) method. Extraction was carried out by maceration and fractionation methods, followed by phytochemical assay and cytotoxic assay using BSLT method. The results showed that the n-hexane extract had a moderate cytotoxic effect (LC50 241 µg/ml), the methanol extract included in the low toxic category (LC50 995 µg/ml) and the other two extracts involved in the non-toxic category (ethyl acetate and butanol).
Cytotoxic Potensial and Molecular Docking of Essential Oil Piper Aduncum Flowers Against Cervical Cancer Cells Rahmadani, Indah; Efdi, Mai; Suryati, Suryati
Hydrogen: Jurnal Kependidikan Kimia Vol 12, No 4 (2024): August 2024
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v12i4.12479

Abstract

Piper aduncum L., commonly known as spiked pepper, is a medicinal plant traditionally used to treat various diseases due to its diverse, active compounds. This article investigates the chemical composition, cytotoxic bioactivity in vitro and the silico of the essential oil (EO) from the flowers of Piper aduncum collected in Padang City, Indonesia. The EO was obtained by hydrodistillation using a Clevenger-type apparatus and characterized by gas chromatography-mass spectrometry (GC-MS). The in vitro cytotoxicity of the EO was assessed against cervical cancer (HeLa cancer cell line) using the MTT assay and further explored through molecular docking approaches. The main constituent of the essential oil from the flowers was dillapiol (31.68%). The LC50 and IC50 values were 31.3471 µg/mL and 65.83 µg/mL, respectively. Computational screening was performed to observe the interactions between active compounds and proteins AKT and ERK2 using molecular docking. AKT and ERK2 act as critical regulators in the PI3K/Akt and ERK/MEK signaling pathways and are potential drug targets for cancer therapy. The compounds used complied with ADMET analysis and toxicity profile. However, it is noteworthy that there have been no previous reports on the essential oil from Piper aduncum flowers from Padang City specifically targeting cervical cancer, which molecular docking studies have complemented. The results suggest that the essential oil from the flowers of Piper aduncum can be further studied as a potential lead in drug discovery for cervical cancer.
Investigation into the Phytochemical Profiles, Antibacterial and Antioxidant Potentials of Toona sinensis Stem Bark Part Santoni, Adlis; Efdi, Mai; Salim, Emil
Molekul Vol 19 No 3 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.3.6434

Abstract

Toona sinensis has been used as a traditional medicine to treat diarrhea, dysentery, and fever. In the present study, the stem bark extracts of T. sinensis were investigated to determine the antibacterial activity, total phenolic content, 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity, and chemical constituent using gradual extraction by maceration method with hexane, ethyl acetate, and methanol respectively. In vitro, antibacterial activity was evaluated against Staphylococcus aureus and Escherichia coli by agar well diffusion method. The hexane fraction was more sensitive to S. aureus and the ethyl acetate and methanol fractions were more sensitive to E. coli. The methanol extract showed the highest total phenolic content and antioxidant activity. Phytochemically, Toona sinensis stem bark extract contained phenolic, flavonoid, steroid, triterpenoid, and coumarin. Investigation of ethyl acetate extract produced 5,7,3',4'-tetrahydroxyflavan-3-ol (catechin). Keywords: Antibacterial, antioxidant, catechin, Toona sinensis, total phenolic content
Phytochemical Screening and In Vitro Antidiabetic Test of Ethyl Acetate Fraction of Tiger’s Betel (Piper porphyrophyllum) Hanifah, Nurul; Santoni, Adlis; Efdi, Mai
Hydrogen: Jurnal Kependidikan Kimia Vol 12, No 5 (2024): October 2024
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v12i5.13118

Abstract

Piper porphyrophyllum or known as tiger’s betel, is a medicinal plant of the Piper genus that is quite widespread in Indonesia, especially on Java, Sumatra, and Kalimantan island. Tiger’s betel is widely used traditionally to treat headaches, bone pain, chest tightness, skin diseases, relieve inflammation, and diabetes mellitus. This study aims to determine the type of secondary metabolite compounds contained in the ethyl acetate fraction of tiger’s betel and determine its antidiabetic activity. Determination of the type of compound is conducted by phytochemical screening by a qualitative test using various reagents to identify flavonoids, phenolics, saponins, triterpenoids, steroids, alkaloids, and coumarins. The antidiabetic assay was carried out by inhibiting α-glucosidase activity and the results were reported as IC50 values. The ethyl acetate fraction of tiger’s betel positively contains alkaloids, flavonoids, and phenolics. The antidiabetic activity is classified as very strong, with an IC50 value of 14.06 µg/mL.
Antioxidant of Ethanol Extract and Toxicity of Fractions from Aspergillus unguis a Marine Sponge Symbiont of Aaptos suberitoides Masyerli, Scify Bilqis Nawafi; Efdi, Mai; Bashari, Muhammad Hasan; Untung Kurnia Agung, Mochamad; Subhan, Beginer; Efahmi, Efahmi; Andriani, Yosie; Syafrizayanti, Syafrizayanti
Hydrogen: Jurnal Kependidikan Kimia Vol 13, No 1 (2025): February 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i1.14645

Abstract

The marine sponge Aaptos suberitoides has been shown to have anticancer properties, with clear evidence of its capacity to suppress the growth of cancer cells. However, the pharmaceutical exploration of chemicals from marine organisms causes significant environmental concerns. Aspergillus unguis, a fungal symbiont of the marine sponge A. suberitoides, has been isolated for its potential in sustainable natural products resources. This study assesses the antioxidant activity of ethanol extract and the toxicity of four levels fractions from ethanol extracts of A. unguis mycelium and these results were reported for the first time in this study. The antioxidant of ethanol extract was determined using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) method. The fractions were examined for toxicity using the Brine Shrimp Lethality Test (BSLT). The ethanol extract of A. unguis shows very strong antioxidant bioactivity (IC50 = 42.84 mg/L). The LC50 values for hexane, chloroform, ethyl acetate, and butanol fractions were determined to be 74.11 µg/mL, 93.84 µg/mL, 59.37 µg/mL, and 142.79 µg/mL, respectively. It indicates significant toxicity. These preliminary results are important knowledge for further research into the bioactivity potential of the metabolites as candidate anticancer compounds, aligning with marine pharmaceutical drug development.
Pembuatan Teh Daun Kelor untuk Peningkatan Ekonomi Masyarakat di Kecamatan Ulakan Tapakis, Padang Pariaman Matlal Fajri Alif; Yulizar Yusuf; Emriadi Emriadi; Deswati Deswati; Mai Efdi; Novesar Jamarun; Syukri Arief; Adlis Santoni; Bustanul Arifin; Suryati Suryati; Yetria Rilda; Safni Safni; Zilfa Zilfa; Olly Norita Tetra
Warta Pengabdian Andalas Vol 31 No 4 (2024)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.31.4.682-688.2024

Abstract

The Moringa plant, a tropical species, exhibits prolific growth and is abundantly present in Indonesia and other tropical regions worldwide. An extended lifespan, continuous flowering, and a high tolerance for elevated temperatures characterize it. Utilizing its components, including leaves, bark, seeds, and roots, this multifaceted plant is renowned for its therapeutic properties. The plant's antioxidants and various nutrients, including vitamins and minerals (iron, magnesium, vitamin B6, vitamin B2, vitamin C, and vitamin A), have led to studies on the plant's potential health benefits. In order to develop the local economy in Ulakan village, Padang Pariaman Regency, Moringa plants were processed by using the plant leaves to manufacture herbal tea, which can then be sold. This community service program was significant given the widespread presence and ease of cultivation of Moringa plants within the local region. The program involved the planning and selection of the activity site, the implementation of training sessions, and the assessment of the program's outcomes. The result of this community engagement initiative was the demonstrated interest of many participants in producing Moringa leaf tea.
Review: Melastoma malabathricum Natural Compounds as Inhibitors of Resistant Bacterial Development Susanti, Febria Elvy; Efdi, Mai; Syafrizayanti; Septama, Abdi Wira
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.41114

Abstract

The abundance of natural medicines in nature is very capable of being used and developed in various lives both individually and in combination in the modern medical field. Various developments and treatments as well as the discovery of new concepts will be able to interact with human physiology. One plant that has the potential to be developed is Melastoma malabathricum, also known as senduduk. This plant from the Melastomataceae family is easily found in tropical Asia and has long been used as an herb in traditional Chinese medicine. Based on the data collected, various studies have shown the pharmacological bioactivity of Melastoma malabathricum which has antibacterial potential and is able to fight resistant bacteria. Chemicals in this plant, including flavonoids, terpenoids, alkaloids, and steroids have been detected and shown to be inhibitors of bacterial growth, including resistant bacteria.
Minyak Atsiri Serai Wangi (Cymbopogon nardus L. Rendle): Diisolasi dengan Dua Metode Berbeda, Kualitas dan Aktivitas Antibakterinya Afrizal; Defitriani, Anggun; Efdi, Mai
Jurnal Riset Kimia Vol. 15 No. 1 (2024): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v15i1.653

Abstract

Cymbopogon nardus L. Rendle is one of the world trades essential oil plants. The high selling value of citronella oil is determined by the characteristics of its physical and chemical properties. In this study, determined the physical and chemical properties of citronellal oil isolated by two different methods, namely method of laboratory distillation (M1) and local community distillation (M2). The result showed that the essential oil produce from both methods match with SNI 06-3953-1995 on its physical properties. The results of the chemical composition using Gas Chromatography-Mass Spectrometry (GC-MS) indicated there are 38 and 48 compounds in the essential oil of M1 and M2, respectively with the main compositions are citronellal, citronellol, and geraniol. The antibacterial activity evaluated using the disc diffusion method showed inhibitory ability against the growth of Staphylococcus aureus and Staphylococcus epidermidis, but no inhibitory ability of Pseudomonas aeruginosa. Both, these M1 and M2 essential oils are categorized as a very strong antibacterial at concentration of 3.125% and 50%, respectively.
Co-Authors -, Sabariah A.A. Ketut Agung Cahyawan W ABDI WIRA SEPTAMA Abdi Wira Septama Adlis Santoni Afritunando, Yogi Afrizal Afrizal Afrizal Afrizal Afrizal Afrizal Afrizal Afrizal Itam Aju Deska Akmel Suhada Alvionita, Jessica Andre Priandoko Ardi, Lucy Prima Aried Eriadi Arifah, Zil Aziz, Enda Desriansyah Bashari, Muhammad Hasan Beginer Subhan Bumali, Restu Bustanul Arifin Bustanul Arifin Bustanul Arifin Dara Pratama Defitriani, Anggun Deswati Deswati Devi Purnamasari Dian Handayani Dian Kumala Sari, Dian Kumala Dira Hefni Djaswir Darwis Djaswir Darwis Efahmi, Efahmi Elida Mardiah Emil Salim Emriadi - Enda Desriansyah Aziz Erizal Zaini Fadhil Ferdian Farid Algani Fatma Sri Wahyuni FEBRIA ELVY SUSANTI Febriana, Nindi Antika Hamzar Suyani HERLAND SATRIAWAN Hermansyah Aziz Ibnu Irawan Ida Ayu Putu Sri Widnyani Imelda Imelda Jessica Alvionita Kartika MZ Kartika MZ Kartika Kevin Septioga Koketsu, Mamoru Kunitomo Watanabe Kuntum Suci Mawarni Lestari Ningsih M. Iqbal Alfarisyi M. Iqbal Alfarisyi Mamoru Koketsu Marniati Salim Masyerli, Scify Bilqis Nawafi Matlal Fajri Alif Mochamad Untung Kurnia Agung Mudinillah, Adam Mulia, Melindra NIKY AFRILIA ZAIMI Nindi Antika Febriana Niza Lian Pernadi Novesar Jamarun Nurainas Nurainas Nurul Fadhillah Nurul Hanifah NURYANI TURABBY Olly Norita Tetra Putri Arwanda Rahmadani, Indah Refilda Refilda Refinel - REGINA ANDAYANI Ria Januarti Ridho Sahary Adha Sabariah - Safni Safni Salim, Emil Sari Ramadhani Solly Aryza Suhada, Akmel Suhada, Akmel Suryati Suryati Suryati Suryati Suryati Susanti, Febria Elvy SYAFRIZAYANTI SYAFRIZAYANTI Syafrizayanti, Syafrizayanti Syukri - Syukri Arief Syukri Arief Syukri Syukri Tia Okselni TRINA EKAWATI TALLEI Upita Septiani Watanabe, Kunitomo Wulandari, Annisa Yefrida - Yeni Stiadi Yetria Rilda Yogi Afritunando Yosie Andriani Yulia Eka Putri, Yulia Eka Yulizar Yusuf Yuni Malasari Zilfa Zilfa Zulhadjri Zulhadjri