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All Journal International Journal of Power Electronics and Drive Systems (IJPEDS) Physics Student Journal Indonesian Journal of Cancer Chemoprevention Natural B Jurnal Respirasi (JR) Medica Hospitalia Indonesian Journal of Cancer Journal of Applied Science and Advanced Engineering
Arinto Yudi Ponco Wardoyo
Brawijaya University
Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Dentistry Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health

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Potential of Volatile Organic Compound (VOC) and Serum Interleukin-17 for Evaluation of Lung Cancer Therapy Based on Response Evaluation Criteria in Solid Tumors (RECIST) Permatasari, Adinda Pramitra; Setyawan, Ungky Agus; Rakhma, Sastia; Djajalaksana, Susanthy; Wardoyo, Arinto Yudi Ponco
Indonesian Journal of Cancer Vol 18, No 4 (2024): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i4.1127

Abstract

Background: Lung cancer is the second leading cause of death in the world due to delays in diagnosis. Non-invasive Volatile Organic Compound (VOC) method to diagnose and monitor the progressivity of lung cancer. Interleukin-17 (IL-17) has an important role in the progression and treatment of lung cancer. Objective evaluation of chemotherapy using Response Evaluation Criteria in Solid Tumors (RECIST 1.1). This study aims to determine the relationship between VOC, IL-17, and lung cancer chemotherapy response based on RECIST at Saiful Anwar General Hospital, East Java.Methods: In a prospective cohort study, 47 lung cancer patients received first-line chemotherapy pre and post-three series of chemotherapy. Exhaled breath was collected with Tedlar Bags and then analyzed with µβreath for VOC. IL-17 in blood serum is determined by an enzyme-linked immunosorbent assay (ELISA). The data were analyzed using the Wilcoxon, Mann-Whitney, and Spearman tests.Results: There were significant in VOC Components (p 0.05) Formaldehyde (CH2O), Toluene (C7H8), Acetone (C3H6O), Hexane (C6H14), Methane (CH4), RECIST non-target lesions, and new lesions pre and post-three series of chemotherapy but not found in IL-17. Acetone (C3H6O) pre and Methane (CH4), IL-17 post-three series of chemotherapy based on RECIST Overall Response (OR) found significant. The analysis showed a positive correlation between Formaldehyde (CH2O) pre and Methane (CH4), IL-17 post-three series of chemotherapy based on RECIST OR, but a negative correlation between Acetone (C3H6O) pre-chemotherapy. Conclusions: There was a significant decrease in formaldehyde, toluene, hexane, methane and an increase in acetone in lung cancer patients pre and post-three series of chemotherapy. There was a significant relationship between formaldehyde, acetone pre-chemotherapy, and methane, IL-17 post-three series of chemotherapy based on the RECIST overall response
A Design of Ammonia Concentration Monitoring System Using Radio Communication Asmoro, Renetha Salma Myesha; Wardoyo, Arinto Yudi Ponco; Anggraeni, Dewi; Pramundhitya, Maria; Widhowati, Azarine Aisyah; Adi, Eko Teguh Purwito
Journal of Applied Science and Advanced Engineering Vol. 2 No. 1 (2024): JASAE: March 2024
Publisher : Master Program in Mechanical Engineering, Gunadarma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59097/jasae.v2i1.29

Abstract

The adverse effects of air pollution on human health, climate change, and ecosystems have made air pollution a major problem in the last four years. Ammonia is a pollutant that has an impact on human health. This study aims to develop a monitoring system for NH3 concentrations using radio communication. The radio module used in data communication is SX1278. The sensor used in this system is MICS-6814, which is integrated with Arduino Nano. The sensor used has been tested and can be used in emission detection. Monitoring results data is displayed on the LCD and serial monitor. Data communication performance for the monitoring process was tested at various distances. This system can reach a measurement distance of 80 meters, with the best distance used for monitoring being less than 50 meters. This system was tested to be able to monitor a different level building. The result shows that the system's performance is the RSSI at a distance of 0 meters is -28 dBm. At the same time, the farthest distance of 80 meters is -101 dBm. The data transmission has a delay time of 1,300 ms and an accuracy of 91%. The ambient NH3 concentration in the area of Malang is found in the range of 0.001 ppm.
Measurement of Benzo [a]pyrene concentration in motor vehicle emissions using STM32F103-based TGS822 sensor Hawa, Anjani Anil; Wardoyo, Arinto Yudi Ponco; Anggraeni, Dewi; A, Renetha Salma Myesha; Efendi, Yahya
Journal of Applied Science and Advanced Engineering Vol. 3 No. 2 (2025): JASAE: September 2025
Publisher : Master Program in Mechanical Engineering, Gunadarma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59097/jasae.v3i2.59

Abstract

Benzo[a]pyrene is one of the PAHs (Polycyclic Aromatic Hydrocarbons) pollutants originating from incomplete combustion or pyrolysis of organic materials. Benzo[a]pyrene is classified in GRUB 1 materials that have a carcinogenic impact on humans. Benzo [a]pyrene sources can be found in air, surface water, and soil. Benzo[a]pyrene can be sourced from motor vehicle emissions as a pollutant in the air. The incomplete combustion of fossil fuels used as motor vehicle fuel can be a source of Benzo[a]pyrene in the air. Therefore, research is needed to quantify the Benzo[a]pyrene concentration. This study aims to measure the concentration of Benzo[a]pyrene gas produced from motor vehicle emissions. The vehicle to be measured is two-wheeled vehicles with pertalite fuel. Vehicle smoke flows into the collection chamber through a hose with three different injection time durations. The measurement was conducted using a system based on the calibrated sensor of TG822. The average total concentration of B [a] P in the chamber depends on the injection time. The concentration is 63.572 ppb for 20s, 64.822 ppb for t40s, and 95.284 ppb for 60s.
Analysis of Urinary Midkine and Volatile Organic Compound (VOC) Levels Using a Breath Analyzer for Screening and Early Diagnosis of Lung Cancer Mafisah, Saidah; Setyawan, Ungky Agus; Tantular, Rezki; Permana, Deden; Djajalaksana, Susanthy; Wardoyo, Arinto Yudi Ponco; Listyoko, Aditya Sri
Jurnal Respirasi Vol. 11 No. 3 (2025): September 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.3.2025.223-231

Abstract

Introduction: Lung cancer is the leading cause of cancer-related mortality worldwide. Midkine, a heparin-binding growth factor, promotes proliferation, angiogenesis, and metastasis. Volatile organic compounds (VOCs) reflect cellular and molecular changes, aiding in cancer diagnosis. This study explored urinary midkine and VOC profiles as biomarkers for lung cancer screening and early diagnosis. Methods: A case-control, cross-sectional study was conducted on 20 controls (family members of lung cancer patients) and 20 lung cancer patients who had not received therapy. Volatile organic compounds breath analysis and urinary midkine measurements were performed. Volatile organic compounds, including total volatile organic compounds (TVOCs), ethanol (C2H5OH), formaldehyde (CH2O), toluene (C7H8), acetone (C3H6O), hexane (C6H14), and methane (CH4), were collected from exhaled breath using Tedlar bags and measured with a µβreath analyzer. Meanwhile, urinary midkine levels were determined using the Enzyme-Linked ImmunoSorbent Assay (ELISA) method. Statistical analyses included an independent t-test, Mann-Whitney U test, Spearman correlation, and diagnostic testing with receiver operating characteristic (ROC) analysis. Results: Urinary midkine levels were higher in lung cancer patients than in controls (330.56±120.50 vs. 282.18±146.28 pg/mL), although not significant (p>0.05). The independent t-test revealed that ethanol levels were significantly elevated in lung cancer patients (p < 0.001), whereas methane levels were not (p > 0.50). Receiver operating characteristic analysis demonstrated sensitivity and specificity: urinary midkine (60%, 60%), ethanol (75%, 75%), and methane (45%, 45%). Conclusion: Ethanol VOC appears to be a promising non-invasive biomarker for the early detection of lung cancer, whereas elevated urinary midkine levels did not demonstrate significant diagnostic value.
Measurement Of Ethanol Concentration in Liquid Organic Fertilizer Fermentation Emissions Using The MQ-8 Sensor Safitri, Dewi Ayu; Wardoyo, Arinto Yudi Ponco; Istiroyah; Adi, Eko Teguh Purwito
Journal of Applied Science and Advanced Engineering Vol. 2 No. 1 (2024): JASAE: March 2024
Publisher : Master Program in Mechanical Engineering, Gunadarma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59097/jasae.v2i1.31

Abstract

Ethanol is beneficial for the sterilization process and increases the rate of photosynthesis. Measurement of ethanol concentration is necessary because ethanol in high concentrations can cause several health problems, such as eye irritation, coughing, lacerations, and ineffective plant sterilization processes. Therefore, a sensor-based measurement system is needed to measure the total gas concentration in liquid organic fertilizer. This research aims to characterize the MQ-8 sensor and analyze the ethanol concentration for the fermentation process. The results of this study indicate that the MQ-8 sensor can work well in measuring the concentration of a single ethanol compound with an accuracy of 91%. The total concentration of ethanol gas in each sample liquid organic fertilizer is measured between 216 ppm to 1583 ppm, depending on the fermented plant.
The Use of MQ 3 Sensor in Measuring Benzo[a]Pyrene Compound From Wood Husk Combustion Process with Robotdyn Uno R3 WiFi Putra, Alga Pradipta Ananda; Wardoyo, Arinto Yudi Ponco; Anggraeni, Dewi; A, Renetha Salma Myesha
Journal of Applied Science and Advanced Engineering Vol. 2 No. 2 (2024): JASAE: September 2024
Publisher : Master Program in Mechanical Engineering, Gunadarma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59097/jasae.v2i2.37

Abstract

BaP (Benzo[a]pyrene) is one of the Polycyclic Aromatic Hydrocarbon (PAH) compounds produced from the combustion process of organic materials such as wood husks. This study aims to utilize the MQ 3 sensor integrated with RobotDyn Uno R3 WiFi microcontroller to measure BaP concentration in gas emissions from wood husk combustion. The MQ 3 sensor was chosen for its sensitivity to BaP compounds. In this experiment, the MQ-3 sensor achieved an accuracy of 85% with a BaP measurement range from 0 to 26 ppm. Measurements were conducted on wood husks with BaP concentrations varying from 0 to 4 ppm. The results indicate that this method is effective for real-time monitoring of BaP levels in wood husk combustion processes, with potential applications in controlling toxic gas emissions from such processes
Real-time surveillance of formaldehyde gas levels in sugar carbonation processes through web-enabled MS1100 sensor monitoring Afifah, Arsa; Wardoyo, Arinto Yudi Ponco; Jatra, Ananta S; A, Renetha Salma Myesha
Journal of Applied Science and Advanced Engineering Vol. 2 No. 2 (2024): JASAE: September 2024
Publisher : Master Program in Mechanical Engineering, Gunadarma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59097/jasae.v2i2.38

Abstract

The refining process of sugar cane juice includes a crucial stage termed carbonation, which is pivotal for achieving pH balance through the utilization of carbon dioxide (). The need for is fulfilled by burning biomass, including rice husks and sugarcane bagasse. However, this process can generate hazardous compounds, notably Formaldehyde (), posing significant health risks. To address elevated Formaldehyde concentration, a monitoring system is implemented, employing an MS1100 sensor for real-time monitoring within the carbonation tank. The data is transmitted to a web-based platform via Robotdyn Uno Wi-Fi R3, with direct data storage on a micro SD card to ensure persistence even during Wi-Fi disruptions. The system confirms the efficacy of monitoring the formaldehyde concentrations both indoors and outdoors, maintaining levels within the safe thresholds. The system demonstrates high accuracy, making it a viable solution for monitoring and regulating Formaldehyde emissions during biomass burning in the sugar industry.
Measurement of Benzo[a]pyrene Concentration in Tobacco Combustion using MQ-6 Gas Sensor Cantika, Faradisa Aprilicha; Wardoyo, Arinto Yudi Ponco; Putro, Triswantoro; A, Renetha Salma Myesha
Journal of Applied Science and Advanced Engineering Vol. 2 No. 2 (2024): JASAE: September 2024
Publisher : Master Program in Mechanical Engineering, Gunadarma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59097/jasae.v2i2.40

Abstract

Benzo[a]pyrene is one of the compounds from the Polycyclic Aromatic Hydrocarbons (PAHs) group that is found in various places as a by-product of combustion. In addition, this compound also has carcinogenic properties so it has a bad impact on human health. Therefore, research is needed to detect the presence of benzo[a]pyrene compounds by designing a measurement system for this detection, especially in burning tobacco. The measurement system that has been designed uses a RobotDyn Mega WiFi 2560 microcontroller and an MQ-6 gas sensor that has been calibrated with benzo[a]pyrene compounds. The results showed that the concentration of benzo[a]pyrene detected when burning tobacco at a mass of 0.33 gram was 4.86 ppb, 7.38 ppb for 0.436 grams mass burning, and was 8.81 ppb for burning at a mass of 0.52 grams. Therefore, this measurement system has been able to detect benzo[a]pyrene compounds
The Role of Serum IL-23 and Volatile Organic Compound Levels to RECIST 1.1 in The Evaluation of Therapeutic Response in Lung Cancer Tjahyadi, Rizal Muldani; Setyawan, Ungky Agus; Astuti, Tri Wahju; Djajalaksana, Susanthy; Wardoyo, Arinto Yudi Ponco
Indonesian Journal of Cancer Chemoprevention Vol 14, No 3 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss3pp171-180

Abstract

The Response Evaluation Criteria in Solid Tumors (RECIST 1.1) is the gold standard for the assessment of lung cancer progression. However, the assessment and diagnosis of early treatment failure is challenging due to the limitations of current tools, as well as the long intervals and unavoidable side effects.This study aims to correlate volatile organic compound (VOC) patterns, serum level of interleukin-23 (IL-23), and RECIST 1.1 to assess chemotherapy response in lung cancer patients at Saiful Anwar Hospital. A prospective observational study was performed to 47 lung cancer patients who received three cycles of platinum-based chemotherapy. Using the Breath Analyzer to measure certain volatile organic compounds (VOCs), the study observed that three of the seven VOCs examined, formaldehyde (CH2O), toluene (C7H8), and hexane (C6H14), showed lower levels after three cycles of chemotherapy. Furthermore, there was a negative correlation between RECIST1.1 and acetone (C3H6O) (p=0.023), while RECIST1.1 and methane (CH4) had a positive correlation (p=0.011). Moreover, a significant positive correlation was observed between IL-23 after-chemotherapy and RECIST 1.1 (p=0.000). According to this study, a correlation exists between methane, IL-23, and RECIST 1.1 after three cycles of chemotherapy. The increase in methane and IL-23 aligns with the disease progression determined by RECIST 1.1. Furthermore, The decrease in acetone after chemotherapy showed a negative correlation with RECIST1.1, consistent with disease progression.Keywords: Volatile Organic Compound, Interleukin-23, RECIST 1.1.
Co-Authors A, Renetha Salma Myesha Abdurrouf Abdurrouf Adi, Eko Teguh Purwito Afifah, Arsa Arsyal Karismadika Rumpoko Asmoro, Renetha Salma Myesha Cantika, Faradisa Aprilicha Chomsin Sulistya Widodo Dewi ANGGRAENI Didik Rahadi Santoso Djajalaksana, Susanthy dyah triwinarti Efendi, Yahya Hari Arief Dharmawan Hawa, Anjani Anil Istiroyah Jatra, Ananta S Kevin Wahyudy Prasetyo Listyoko, Aditya Sri Mafisah, Saidah Nanik Setijowati Permana, Deden Permatasari, Adinda Pramitra Pramundhitya, Maria Putra, Alga Pradipta Ananda Putra, Ngakan Putu Parsama Rakhma, Sastia Reza Sativan Safitri, Dewi Ayu Santosa, Andrew Setyawan Purnomo Sakti Setyawan, Ungky Agus Sitti Maysaroh Tantular, Rezki Tjahyadi, Rizal Muldani Tri Wahju Astuti, Tri Wahju Triswantoro Putro Umi Hajar Unggul Punjung Juswono Widhowati, Azarine Aisyah