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PERBANDINGAN KADAR SUKROSA DALAM MADU RANDU DAN MADU KELENGKENG DARI PETERNAK LEBAH DAN MADU PERDAGANGAN DI KOTA SEMARANG Sumantri Sumantri; Aqnes Budiarti; Indah Parameita
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.10 No.1 Juni 2013
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (258.089 KB) | DOI: 10.31942/jiffk.v10i1.867

Abstract

 ABSTRACT Key words: cottonwoods honey, longan honey, sucrose, KCKT   Honey is a natural liquid that generally has a sweet taste and produced by the bees. Along with the increase in consumption of honey, honey adulteration grew a way to get the benefits. Sucrose sugar often added because its price is relative cheap. The content of sucrose become a measurement of the authenticity of honey. The spurious honey harm consumers because of different composition so that its benefits are also different.The purpose of this research is to determine the sucrose content and the quantitation of sucrose in longan honey and honey cottonwoods from beekeepers and honey trade in the City of Semarang using HPLC.Honey samples were taken randomized with three sample of cottonwoods and three longan honey from beekeepers area in Ngaliyan, Gringsing dan Ambarawa and honey trade in the City of Semarang. The determination of sucrose using HPLC system (Waters ec 2695) equipped with C18 column (C18 5um Sunfire; 4.6 x150mm) and detector UV (UV/Visible Waters 2489) at wavelength 190 nm. Mobile phase consisted of a mixture of acetonitrile and aquabides (75:25, v/v) with a flow rate of 1.0 mL/min.Research results showed that the average content of sucrose in honey samples cottonwoods and longan honey from beekeepers respectively 4,03% dan 2,98%, while the average level for the sample of cottonwoods and longan honey trade in the City of Semarang respectively 2,11% and 2,59%. The average level of sucrose from twelve samples meet requirements but the there are two samples that does not comply requirement of honey based on SNI-2004. There was no significant difference between the levels of sucrose honey cottonwoods and honey longan from beekeepers and honey trade in the City of Semarang.
UJI AKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK ETANOL DAUN ALPUKAT DAN RIMPANG TEMULAWAK PADA TIKUS DM TIPE-2 YANG MENGALAMI RESISTENSI INSULIN Mamik Dwi Anggraini; Yance Anas; Sumantri Sumantri
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 14 No 2 Desember 2017
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (506.279 KB) | DOI: 10.31942/jiffk.v14i2.2059

Abstract

ABSTRACT Avocado’s leaves and Curcuma xanthorrizarhizoma contain compounds of flavonoids, alcaloids,triterpenoids and curcumin, where the compounds are effective as antidiabetic agents. This study aims to prove the effect of antidiabetic combination of extracts on insulin resistence type-2 diabetic rats then to compare it with a single extract. This research used pre-test and post-test control group design. The 30 test animals were divided into two treatment groups. Five control groups of rats were they given 1,25 mL aquabides/KgBW/day, and 25 rats were divided into five groups and given were given 1,8 IU insulin/KgBW/day for 14 days. Group I was control of 12,5 mL CMC-Na/KgBW/day 0,5%, group II was positive control of 150 mg metformin/KgBW/day, group III was avocado’s leaves extract, group IV was extract of Curcuma xanthorriza rhizoma, and group V was combination extract. The extracts of group III-V were given the same dose, that was given 200 mg/KgBW/day for 14 days. The meansurement of antidiabetic effect was done by comparing the GDP value of rats before and after treatment. The GDP concentrations of rats were analyzed using T-paired testand Wilxocon test, whereas the comparative data of percentage GDP decrease was tested using Kruskall Wallis test then followed by Mann-Whitney test. The results showed that the effect of antidiabetic combination of extract in insulin resistence type-2 diabetic rats as the percentage GDP decrease was 22.03%. The effect of decreasing GDP concentration at the ratio of 1:1 extract did not differ significantly with the single extract of 200 mg Curcuma xanthorrizarhizoma/KgBW/day. Keywords: Avocado’s leaves, Curcuma xanthorriza rhizoma, Antidiabetic effect test, Comparison combination of both extracts with single extract.
EVALUASI KANDUNGAN VITAMIN CDALAM MADU RANDU DAN MADU KELENGKENG DARI PETERNAK LEBAH DAN MADU PERDAGANGAN DI KOTA SEMARANG Aqnes Budiarti; Sumantri Sumantri; Diah Fahmisul Istiyaningrum
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.9 No.2 Desember 2012
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (275.654 KB) | DOI: 10.31942/jiffk.v9i2.865

Abstract

 ABSTRACT Key words: vitamin C, cottonwoods honey, longan honey, HPLC Honey is a natural product that containing several vitamins, including vitamin C, which has an important role to maintain health, among others helps healing wound, increase body resistance fight infection and as antioxidant. This research aimed to determine the levels of vitamin C in the cottonwoods honey and longan honey from beekeepers and honey trade in the city of Semarang using HPLC.Samples consisted of three samples of honey and three cottonwoods honey and longan honey from beekeepers different (Ambarawa, Ngaliyan, Gringsing) and honey trade in the city of Semarang. HPLC (waters ec 2695) operational conditions is equipped stationary phase C18 column (C18 5um sunfire; 4.6 X150 mm), and the mobile phase is a mixture of phosphate buffer pH 3.6 and acetonitrile with the ratio 70: 30, v / v, flow rate of 0.5 ml / min. Detection use UV detector (UV / vis water in 2489) at 260 nm wavelength.Research results show ed that the average levels of vitamin C in the cottonwoods honey from beekeepers and honey cottonwoods trade in the city of Semarang are 0,034% and 0,016%, while for longan honey respectively 0,027% and 0,032%. The average level of the twelve samples of honey contain vitamin C, but there are two samples that does not contain vitamin C. There was no significant difference between the levels of vitamin C and cottonwoods honey and longan honey from beekeepers and honey trade in the City of Semarang.
PERBANDINGAN METODE PENETAPAN KADAR SIMETIDIN MENGGUNAKAN SPEKTROFOTOMETRI UV DAN KROMATOGRAFI CAIR KINERJA TINGGI Aqnes Budiarti; Adina Fitria K.W.; Sumantri Sumantri
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI & FARMASI KLINIK VOL. 13 NO. 1 JUNI 2016
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (287.813 KB) | DOI: 10.31942/jiffk.v13i1.1441

Abstract

ABSTRACT Determination ofdrug substance is one of the drug quality control to ensure the safetyof drug. Determination of cimetidine could use UV spectrophotometry and HPLC. The aim  ofthis study were to validate the methode using two instruments, to compare both of  the method and to apply it intablet dosage forms. Determination of cimetidin using UV spectrophotometry was set on wave length 219 nm. Determination using HPLC with coloumn C18 and mobile phase mixture of  methanol: water-phosphoric acid (30:70, v/v), flow rateat 1mL/min and UV detector. The method was validated in terms of accuracy, precision,  linearity,  selectivity and sensivity. The method of determination of cimetidine using both instruments were campared by analysis of variant. Validation method using UV spectrophotometry showed precision of 0.94%,  recovery from 97.50 to 100.91%, good linearity, LOD 0.76 µg/mL and  LOQ 2.52µg/mL.Validation using HPLC method resulted value of precision 0.30%, recovery from 98.42 to 101.83%, good linearity, LOD and LOQ of 0.46 and 0.56  µg/mL.  The average concentration of cimetidine in tablets by spectrophotometry UV was 101.95%, while in HPLC was 99.69%.The methods accomplied to the requirements according The Indonesian Pharmacopoeia Edition IV. Both methods provided the same results and did not significantly different. Keyword : validation method, cimetidine, UV spectrophotometry, HPLC
PEMERIKSAAN ANGKA KUMAN DAN JAMUR SERTA IDENTIFIKASINYA PADA JAMU GENDONG TEMU IRENG DAN KUNYIT ASAM DI KECAMATAN GAJAHMUNGKUR SEMARANG maulita cut nuria; yeni lutfiani; sulasmi sulasmi; sumantri sumantri
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 5 NO. 1 JUNI 2008
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (206.432 KB) | DOI: 10.31942/jiffk.v5i1.827

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ABSTRACTThe herbal tonic is a product made from natural ingredients processed in traditional ways. A traditional herb made from Temu Ireng (Curcuma aeruginosa) is a kind of herb that still consumed by relatively many Indonesian citizens for enhanching appetite and acid turmeric often consumed by female for reducing the problems when they get haid. However, bacteria and fungi might grow in this traditional herb because of contaminated water (the diluting agent) and moisture, hygiene and sanitation factors. This study, therefore, was intended to find out the quantities and the species of these bacteria and fungi growing in the herb as it is sold in Gajah Mungkur district of Semarang City. This study also intended to compare these quantities to the prevailing standard stipulated. The samples for this study were taken from 36 producers Temu Ireng and acid turmeric herb, located in Gajah Mungkur District. The medium used for growing the material in an aerobic manner was PCA (Plate Count Agar), that used for growing in an anaerobic manner were TSA (Tripticase Soya Agar) and that used for growing the fungi were PDA (Potato Dextrose Agar). For counting the bacteria, we used the method of Standard Plate Count, for identifying the bacteria we used Gram Painting and chemical tested, and for identifying the fungi we used a 100-times amplifying microscope. The analysis showed in the sample Temu Ireng and acid turmeric are the average number of bacteria at the aerobic media were 7,4 x 106 and 2,1 x 105 CFU/ml, the average number of bacteria at the anaerobic media were 4,2 x 102 and 4,3 x 102 CFU/ml, the average number of fungi were 1,5 x 102 and 1,0 x 102 CFU/ml. The aerobic bacteria found in the study were Staphylococcus aureus, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, the anaerobic bacteria was peptococcus, and the fungi were Penisillium, Moniliaceae, A. niger, dan Rhizopus. Nearly all samples examined in this study did not meet the conditions based on statement Indonesia Minister of Health No 661/MENKES/SK/VII/1994 because they exceeded the upper limit bacteria (104 CFU/ml) and also contain pathogenic bacterias. However, the number of fungi did not exceed the prevailing standard. Keywords: Temu Ireng Herb, Acid Turmeric Herbs, Bacteria Number and Fungi Number.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOLIK HERBA ALFALFA (Medicago sativa L.) DENGAN METODE DPPH (1,1-difenil-2-pikrilhidrazil) herni widyowati; Maria Ulfah; sumantri sumantri
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL.11 NO.1 JUNI 2014
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.089 KB) | DOI: 10.31942/jiffk.v11i1.1285

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ABSTRACT Alfalfa (Medicago Sativa L.) plant is known to have compounds of flavonoid and vitamine C which can serve as antioxidants. This research aims knowing the antioxidant activity of alfalfa herbal ethanolic extract using DPPH (1,1-diphenyl-2-pikrilhydrazil method and knowing the content of its active compound have wan. The research was performed by making alfalfa herbal ethanolic extract by maceration method using ethanol extracting solvent 70%. The extract was divided into some concentrations of 10, 20, 40 and 80 μg/ml. As a comparison, vitamine C was used with concentrations of 1, 2, 4, and 8 μg/ml. The test of antioxidant activity was conducted by reacting 50 μl of alfalfa herbal ethanolic extract with 4.0 ml DPPH 0.1 mM, then it was measured for the absorbance using visible spectrophotometry with a wavelength of 525 nm. The obtained data was calculated to discover its antioxidant activity. The statistical analysis used was Mann-Whitney test. The IC50 value was gained using probit analysis and the statistical analysis used t-test and to discover the content of active compound in alfalfa herbal ethanolic extract, TLC test was performed. The research result indicated that the alfalfa herbal ethanolic extract had antioxidant activities with alfalfa herbal ethanolic extract IC50 value of 59.339 μg/ml, and standard solution of vitamine C IC50 value of 4.768 μg/ml. The result of statistical test for IC50 indicated an unsignificant difference between alfalfa herbal ethanolic extract and vitamine C. Otherside it could be concluded that the alfalfa herbal ethanolic extract containing flavonoid had antioxidant activities. Keywords: Alfalfa (Medicago sativa L.) herbal ethanolic extract, IC50, antioxidant
PEMERIKSAAN ANGKA KUMAN DAN JAMUR SERTA IDENTIFIKASINYA PADA JAMU GENDONG BERAS KENCUR DAN TEMU LAWAK (Curcuma xanthorhiza Roxb.) DI KABUPATEN SEMARANG BAGIAN SELATAN maulita cut nuria; dedeh ratna dewi; septaningsih septaningsih; sumantri sumantri
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 5 NO. 2 DESEMBER 2008
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (166.932 KB) | DOI: 10.31942/jiffk.v5i2.822

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ABSTRACTTradisional herbs made from natural ingredients containing many organic elements as the material feed for microbe that caused self decompose during storage. On the previously result of research did by Subhan Ratnawati (2002) shows there were many bacteria, including pathogen bacteria on galian singset herbal tonic carried in Jogjakarta city. The purpose study was intended to find out quantities and identified of bacteria and fungus present in the herbal tonic at ten regions in southern Semarang District. This study was conducted using 52 samples of „beras kencur and temulawak herbs‟ sold in Southern Semarang District. ALT method was used on this experiment and the medium used for growing in an aerobic manner was PCA (Plate Count Agar), while that used for growing in an anaerobic condition were TSA (Tripticase Soya Agar) and was incubated at 37oC for 24 hours. The media used for fungi were PDA (Potato Dextrose Agar). We used a 100-times amplifying microscope for identifying the fungi. The analysis on the data were conducted by calculating the numbers of bacteria and fungi for each sample and by identifying the bacteria and fungi present in the herbs. These numbers then compared to the prerequisites contained in the Indonesian Health Office (MENKES RI) No. 661/MENKES/SK/VII/1994. The analysis showed that the average number of bacteria in the sample of „beras kencur and temulawak herbs‟ that grown at the aerobic media was 4.7x105 CFU/ml and 3.1x104 CFU/ml, but we found no bacteria in the sample grown in an anaerobic manner. The numbers of bacteria grown in the aerobic manner exceeded the upper limits for bacteria number 104 (10000 CFU/ml). The average number of fungi from all samples was 50.7 CFU/ml and 40.5 CFU/ml, which was below the standard of 103 (1000 CFU/ml). The aerobic bacteria found in this study were Pseudomonas aeruginosa and Eschericia coli while the fungi found were Rhizopus, Aspergillus niger, Moniliaceae and Penisillium. Nearly all samples that examined in this study did not meet the conditions stipulated by Indonesian Health Office (MENKES RI) Number 661/MENKES/SK/VII/1994. Keywords: Herbal tonic carried, Bacteria Number and Fungi Number
Kinerja Keuangan dan Kinerja Non Keuangan terhadap Daya Saing Daerah Kabupaten Bungo Musthafa Luthfi; Albetris Albetris; Rahayu Rahayu; Sumantri Sumantri
J-MAS (Jurnal Manajemen dan Sains) Vol 8, No 1 (2023): April
Publisher : Universitas Batanghari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33087/jmas.v8i1.1269

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This study aims first, to determine the effect of financial performance and non-financial performance on regional competitiveness in Bungo Regency. Second, to determine the effect of capital expenditure on regional competitiveness in Bungo Regency. Third, to determine the effect of budget management on regional competitiveness in Bungo Regency. Fourth, to determine the effect of financial performance and non-financial performance on regional competitiveness through capital expenditure in Bungo Regency. Fifth, to determine the effect of financial performance and non-financial performance on regional competitiveness through budget management in Bungo Regency. The data used in this study is primary data collected by direct interviews with respondents with predetermined criteria. This research uses Structural Equation Model (SEM) Analysis and uses Smart PLS tool. The results of the study are that first, financial performance and non-financial performance have a significant effect on regional competitiveness in Muaro Bungo Regency. Second, capital expenditure has no significant effect on regional competitiveness in Muaro Bungo Regency. Third, budget management has a significant effect on regional competitiveness in Muaro Bungo Regency. Fourth, financial performance and non-financial performance have no significant effect on regional competitiveness through capital expenditure in Muaro Bungo Regency. Fifth, financial performance and non-financial performance have a significant effect on regional competitiveness through budget management in Muaro Bungo Regency.
Effectiveness of Black Cumin Extract (Nigella Sativa) in Inhibiting The Growth of Staphylococcus Aureus Bacteria in Vitro Lusi Ernawati; Sumantri Sumantri; Wedagama Wedagama; Ari Astuti; Diyah Fatmasari
Jurnal Kesehatan Gigi Vol 10, No 1: Juni 2023
Publisher : Jurusan Kesehatan Gigi, Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkg.v10i1.9531

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Karies gigi yang mencapai pulpa dapat menyebabkan nekrosis pulpa. Bakteri yang dapat menyebabkan nekrosis pulpa, salah satunya Staphylococcus aureus. Perawatan terhadap nekrosis pulpa adalah dengan melakukan perawatan saluran akar (PSA). Salah satu tahapan dalam PSA adalah sterilisasi saluran akar dengan menggunakan kalsium hidroksida (calcium hydroxide) atau kresotin (cresotin). Penggunaan obat kimia, utamanya dalam jangka panjang, dapat menimbulkan efek samping, sehingga diperlukan bahan alternatif lain yang lebih aman dan alami, seperti penggunaan jintan hitam (Nigella sativa). Zat aktif yang terkandung dalam jinten hitam dapat bersifat sebagai antibakteri diantaranya adalah tannin, terpenoid, saponins, alkaloids. Penelitian ini bertujuan untuk mengetahui efektifitas ekstrak jinten hitam dalam menghambat pertumbuhan bakteri Staphylococcus aureus secara invitro dengan metode difusi agar.  Penelitian ini menggunakan  ekstrak biji jintan hitam (Nigella sativa) dengan konsentrasi 50%, 75% dan 100%. Rancangan penelitian yang digunakan adalah penelitian Post Test Only Control Group Design, yang terdiri dari lima kelompok yakni, kelompok kontrol negatif (aquadest steril), kelompok perlakuan 1 (ekstrak jintan hitam konsentrasi 50%), kelompok perlakuan 2 (ekstrak jintan hitam konsentrasi 75%), kelompok perlakuan 3 (ekstrak jintan hitam konsentrasi 100%) dan kelompok kontrol positif (cresotin). Sampel yang digunakan dalam penelitian ini adalah bakteri Staphylococcus aureus ATCC 25923, dan besar sampel yakni pengulangan sebanyak lima kali untuk setiap kelompok. Hasil uji statistik dengan man witney U terdapat perbedaan yang signifikan antar kelompok dalam menghambat pertumbuhan bakteri Staphylococcus aureus secara in vitro. Simpulan deari penelitian ini bahwa ekstrak jintan hitam (Nigella sativa) dengan konsentrasi 50%, 75% dan 100% dapat menghambat pertumbuhan bakteri Staphylococcus aureus secara in vitro.
FUNDAMENTAL MAKRO, CSRD MEMPENGARUHI KINERJA PERUSAHAAN DENGAN STRUKTUR KEPEMILIKAN, STRUKTUR MODAL DAN OPINI AUDIT SEBAGAI VARIABEL INTERVENING PADA PERUSAHAAN SUB SEKTOR TELEKOMUNIKASI YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2018-2021 Sumantri Sumantri; Hwihanus Hwihanus
Journal of Creative Student Research Vol. 1 No. 3 (2023): Juni : Journal of Creative Student Research
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jcsrpolitama.v1i3.1794

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Penelitian ini bertujuan untuk mengetahui pengaruh fundamental makro,csrd mempengaruhi kinerja perusahaan dengan struktur kepemilikan, struktur modal dan opini audit sebagai variabel intervening. Populasi dalam penelitian ini adalah seluruh perusahaan infrastruktur sub sektor telekomunikasi yang terdaftar di Bursa Efek Indonesia (BEI) pada tahun 2018-2021. Teknik analisis data dan pengujian Hipotesis menggunakan Partial Least Square dengan uji outer model dan inner model. Hasil penelitian ini membuktikan bahwa Fundamental makro tidak berpengaruh signifikan terhadap Struktur kepemilikan, Fundamental makro tidak berpengaruh signifikan terhadap kinerja perusahaan, Fundamental makro tidak berpengaruh signifikan terhadap Struktur modal, Fundamental makro tidak berpengaruh signifikan terhadap Opini audit, CSRD tidak berpengaruh signifikan terhadap Struktur kepemilikan, CSRD tidak berpengaruh signifikan terhadap Struktur modal , CSRD tidak berpengaruh signifikan terhadap Opini audit, CSRD tidak berpengaruh signifikan terhadap Kinerja perusahaan, Struktur Kepemilikan tidak berpengaruh signifikan terhadap Kinerja perusahaan, Struktur modal terdapat pengaruh signifikan terhadap Kinerja perusahaan, Opini audit tidak berpengaruh signifikan terhadap Kinerja perusahaan