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Journal : Paediatrica Indonesiana

Comparison of the efficacy and safety of hydroxyethyl starch 130/0.4 and Ringer's lactate in children with grade III dengue hemorrhagic fever Risky Vitria Prasetyo; Abdul Latief Azis; Soegeng Soegijanto
Paediatrica Indonesiana Vol 49 No 2 (2009): March 2009
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (126.221 KB) | DOI: 10.14238/pi49.2.2009.97-103

Abstract

Background Theoretically hydroxyethyl starch (HES) will givemore rapid recovery from shock, including in dengue shocksyndrome (DSS) and currently gained popularity for its lessdeleterious effects on renal function and blood coagulation.Objectives To compare the efficacy and safety ofHES 130/0.4 andRinger's lactate (RL) for shock recovery in children with DSS.Methods A randomized controlled study was performed on 39children admitted with DSS at Dr. Soetomo Hospital, Surabaya,between March and May 2007. Children were grouped intograde III (n=25) and grade IV (n=14) dengue hemorrhagicfever (DHF) according to the WHO criteria. Within eachgroup, subjects were randomly assigned to receive initial fluidresuscitation with either HES 130/0.4 (n=9 in the DHF grade IIIgroup, 10 in the DHF grade IV) or RL (n= 16 in the DHF gradeIII group, 4 in the DHF grade IV). Clinical and laboratory datawere collected to determine improvements in shock recovery andadverse reactions.Results In both the grades III and IV DHF, HES 130/0.4significantly decreased hemoglobin and hematocrit levels. Clinicalimprovements in pulse pressure and pulse rate were seen aftertreatment with HES 130/0.4 although these were statisticallyinsignificant if compared to the RL group. No differences in fluidrequirement and recurrent shock episodes were noted betweenthe RL and HES groups. No adverse reactions were found duringthe study.Conclusion HES 130/0.4 administration is effective and safe inchildren with DSS.
Early protection against measles infection in children Immunized with DPT-measles Vaccine at the Age of 4 Months Soegeng Soegijanto; Dwi Atmaji Soejono; Parwati Setiono B.
Paediatrica Indonesiana Vol 33 No 3-4 (1993): March - April 1993
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (862.386 KB) | DOI: 10.14238/pi33.3-4.1993.52-8

Abstract

A study on early immunization with DPT-measles vaccine at the age of 4 months, was earned out during 1990 - 1991 on 348 babies at the Health Centre of Surabaya regency. Three hundred and forty eight babies were served as control. The results of the study reported here were : (a) By giving a mixture of DPT and measles at an early age (4 months of age) the coverage of measles immunization could be increased to 21% - 27%. (b) 1'wenty two percents of measles cases could be prevented. (c) The geometric mean titer using hemagglutination inhibition test of the babies who got a mixture DP7~measles vaccination at an early age was significantly higher than that of the GMT HI test of babies who got measles vaccination at the age of 9 months ( z test, p <0, 05 ) . The result of analysis of data showed that an early immunization program using a mixture of DPT-measles could protect babies under 9 months and thus prevent them from measles infection.