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All Journal CALYPTRA : Jurnal Ilmiah Mahasiswa Universitas Surabaya MPI (Media Pharmaceutica Indonesiana) Indonesian Journal of Chemistry Dinamisia: Jurnal Pengabdian Kepada Masyarakat JSFK (Jurnal Sains Farmasi & Klinis) Pharmaceutical Journal of Indonesia Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Journal Of World Science Pharmaceutical Sciences and Research (PSR) Eduvest - Journal of Universal Studies Jurnal Sains dan Kesehatan
Azminah Azminah
Fakultas Farmasi Universitas Surabaya
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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ANTIVIRAL ACTIVITY OF FABACEAE AND ASTERACEAE FLAVONOID COMPOUNDS AGAINST SARS-CoV-2 ON SPIKE PROTEIN, MAIN PROTEASE (Mpro) AND RNA DEPENDENT RNA POLYMERASE (RdRp) RECEPTORS WITH IN SILICO METHOD: ANTIVIRAL ACTIVITY OF FABACEAE AND ASTERACEAE FLAVONOID COMPOUNDS AGAINST SARS-CoV-2 ON SPIKE PROTEIN, MAIN PROTEASE (Mpro) AND RNA DEPENDENT RNA POLYMERASE (RdRp) RECEPTORS WITH IN SILICO METHOD Lekal, Tresia; Kesuma, Dini; Azminah, Azminah
Pharmaceutical Journal of Indonesia Vol. 8 No. 2 (2023)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2023.008.02.2

Abstract

This study was conducted to test the antiviral activity of flavonoid compounds of Fabaceae tribe (Clitoria ternatea, Caesalpinia sappan, Leucaena leucocephala, Indigofera tinctoria) and Asteraceae tribe (Eclipta prostrata, Artemisia vulgaris, Blumea balsamifera, Chromolaena odorata) against SARS-CoV-2 on spike protein, Mpro and RdRp receptors by molecular docking method in silico. The results of molecular docking with AutoDock Vina showed that the flavonoid compounds apigenin and juglanin (Leucaena leucocephala), semiglabrin and glabratephrin (Indigofera tinctoria), apigetrin (Eclipta prostrata), acacetin (Chromolaena odorata) had binding energies close to, equivalent and better than the original ligand and Comparator of each receptor.
Co-Authors Abdul Mun’im Ahdyani, Risa Amarila Malik Andika Andika Andre Tanzil Angga Cipta Narsa Ardiansyahmiraja, Bobby Arry Yanuar Berna Elya Ebry Ryanata Ebry Ryanata, Ebry Erlina, Linda Erwin Samsul Erwin Samsul Gemini Alam Hadi Kuncoro Hanita Omar Hariyanti Hariyanti Hayun Hayun, Hayun Islamudin Ahmad Iswahyudi Iswahyudi Kesuma, Dini Kusuma Hendrajaya Lekal, Tresia M. Arifuddin Marisca Evalina Gondokesumo, Marisca Evalina Michella Michella Muhammad Hanafi Neneng Siti Silfi Ambarwati Noor Linda Febrianie Nur Jamailah Raden Mohamad Herdian Bhakti Rika Yulia Risna Agustina Risna Agustina Sajekti Palupi Sajekti Palupi Santoso, Vania Joceline Suryaningsih, Dwie Retna Wisnu Cahyo Prabowo Wulandini Putri, Adquinta Yuditya Artha