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All Journal CALYPTRA : Jurnal Ilmiah Mahasiswa Universitas Surabaya MPI (Media Pharmaceutica Indonesiana) Indonesian Journal of Chemistry Dinamisia: Jurnal Pengabdian Kepada Masyarakat JSFK (Jurnal Sains Farmasi & Klinis) Pharmaceutical Journal of Indonesia Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Journal Of World Science Pharmaceutical Sciences and Research (PSR) Eduvest - Journal of Universal Studies Jurnal Sains dan Kesehatan
Azminah Azminah
Fakultas Farmasi Universitas Surabaya
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Journal : Journal Of World Science

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Diabetic Foot Ulcer (DFU) Gene Expression in Homo Sapiens Species Wulandini Putri, Adquinta; Azminah, Azminah
Journal of World Science Vol. 2 No. 6 (2023): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v2i6.329

Abstract

Diabetic foot ulcer (DFU) is a major problem in people with diabetes because more than 15% of patients have to treat DFU during their lifetime. 1 out of people with diabetes can experience a diabetic foot ulcer (DFU). At least a quarter of diabetic foot ulcer (DFU) sufferers cannot recover completely. The prevalence of diabetic foot ulcers (DFU) in Indonesia reaches 8.7%. The current DFU treatment approved by the FDA uses Becaplermin, a recombinant platelet-derived growth factor derivative. However, this treatment has a weakness in systemic bioavailability. FAgene expression analysis method is needed. to develop other therapies. This article aims to discover specific genes that play a role in diabetic foot ulcer (DFU) wound healing. In this systematic review, we searched the GEO Data Sets database to identify articles published from 2018 to 2023. The search results for DFU gene expression data for all species obtained 130 articles. Then, the DFU gene expression data series of Homo sapiens species was filtered to obtain ten related articles. This research has implications in providing better insight into the specific genes involved in the healing process of DFU wounds. This research also has the potential to contribute to early diagnosis of DFU injuries and better treatment.
Gene Expression Data Analysis In Response to Nicotine Exposure: a Literature Study Revealing Differentially Expressed Genes In Biological Pathways Azminah, Azminah; Munawwarah, Munawwarah
Journal of World Science Vol. 2 No. 12 (2023): Journal Of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v2i12.500

Abstract

This research aims to deepen our understanding of the effects of nicotine usage through a descriptive literature review, with the primary focus on exploring GEO DataSets via the analysis of Differentially Expressed Genes (DEGs) in response to nicotine exposure. The GEO DataSet search was obtained from the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO), a relevant biomedical data source. The results of our investigation revealed a total of 11 GEO DataSets of Homo sapiens that met the inclusion and exclusion criteria for identifying Differentially Expressed Genes (DEGs). These datasets, namely GSE125217, GSE148812, GSE125416, GSE105445, GSE56398, GSE51284, GSE71795, GSE56383, GSE40689, GSE11208, and GSE11142, contained genes that underwent altered expression in response to nicotine exposure. The results of the gene analysis were further categorized based on their functional classifications. They encompass receptor genes such as CHRNA9, nAChRs, and TLR4, regulatory genes including CDK1, CHK1, ERBB2, EGFR, and E2F1, structural genes like H-Caldesmon, L-Caldesmon, SM22, CDH1/3, BDNF/NT-3, and MLL3, immunological genes such as TNF-?, IL-1?, IL-6, IL-10, MCSF, MCP-1, and ICAM-1, metabolic genes like CYP2A6 and APOE, and enzymatic genes such as PITRM1, DDR2, DHRS7, and SLC16A7. This review search provides a comprehensive insight into the molecular-level impact of nicotine, with potential implications for the development of treatment strategies and the discovery of relevant biomarkers associated with nicotine use.
Co-Authors Abdul Mun’im Ahdyani, Risa Amarila Malik Andika Andika Andre Tanzil Angga Cipta Narsa Ardiansyahmiraja, Bobby Arry Yanuar Berna Elya Ebry Ryanata Ebry Ryanata, Ebry Erlina, Linda Erwin Samsul Erwin Samsul Gemini Alam Hadi Kuncoro Hanita Omar Hariyanti Hariyanti Hayun Hayun, Hayun Islamudin Ahmad Iswahyudi Iswahyudi Kesuma, Dini Kusuma Hendrajaya Lekal, Tresia M. Arifuddin Marisca Evalina Gondokesumo, Marisca Evalina Michella Michella Muhammad Hanafi Munawwarah Munawwarah, Munawwarah Neneng Siti Silfi Ambarwati Noor Linda Febrianie Nur Jamailah Rika Yulia Risna Agustina Risna Agustina Sajekti Palupi Sajekti Palupi Santoso, Vania Joceline Suryaningsih, Dwie Retna Wisnu Cahyo Prabowo Wulandini Putri, Adquinta Yuditya Artha