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Tiene Rostini, Tiene
Departemen Patologi Klinik, Fakultas Kedokteran Universitas Padjadjaran/ Rumah Sakit Umum Pusat Dokter Hasan Sadikin Bandung
Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Pemeriksaan Laboratorium pada Hemoglobin Terglikasi (HbA1C) : Review Standarisasi dan Implementasi Klinis Mulya Harahap, Raja Iqbal; Rostini, Tiene; Suraya, Nida
Action Research Literate Vol. 8 No. 6 (2024): Action Research Literate
Publisher : Ridwan Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/arl.v8i6.409

Abstract

Diabetes melitus merupakan masalah kesehatan masyarakat di seluruh dunia. Hemoglobin A1c (HbA1c) adalah derivat dari hemoglobin A (HbA), dengan penambahan glukosa pada rantai ß. Pada tahun 2010 ADA memasukkan HbA1c sebagai salah satu kriteria diagnosis diabetes. Jum Tujuan dari penelitian untuk mengevaluasi metode-metode standar yang digunakan dalam pengukuran HbA1C serta meninjau bagaimana hasil pengukuran tersebut diterapkan dalam praktik klinis. Metode pemeriksaan HbA1c cukup banyak namun yang telah terstandardisasi oleh NGSP dan saat ini banyak dipakai diantaranya yaitu metode immunoassay, ion-exchange HPLC (High Performance Liquid Chromatography), enzimatik, boronate affinity chromatography, dan capillary electrophoresis. Pemilihan metode sangat dipengaruhi oleh populasi pasien dan biaya. Metode yang dapat dipilih untuk populasi hemoglobinopati yaitu metode boronate affinity HPLC dan enzimatik. Pelaporan hasil HbA1c dalam persen sesuai dengan standar NGSP atau mmol/mol sesuai dengan standar IFCC yang keduanya dapat dikonversi satu sama lain dengan master of equation. Hasil pemeriksaan HbA1c dipengaruhi oleh berbagai faktor yang paling penting adalah Hb varian.Kesimpulan dari penelitian ini yaitu standardisasi metode pemeriksaan HbA1c oleh NGSP dan IFCC telah memastikan konsistensi hasil yang memungkinkan konversi nilai HbA1c antar sistem yang berbeda.
Pemeriksaan Laboratorium pada Resistansi Insulin Mulya Harahap, Raja Iqbal; Rostini, Tiene; Suraya, Nida
Action Research Literate Vol. 8 No. 12 (2024): Action Research Literate
Publisher : Ridwan Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/arl.v8i12.2569

Abstract

Resistansi insulin merupakan kondisi metabolik yang ditandai dengan gangguan respons tubuh terhadap insulin, yang berperan penting dalam metabolisme glukosa. Kondisi ini berkontribusi pada perkembangan berbagai gangguan kesehatan, seperti diabetes melitus tipe 2, hipertensi, dislipidemia, dan penyakit kardiovaskular. Studi ini mengevaluasi metode pemeriksaan laboratorium dalam mendeteksi resistansi insulin, mencakup metode langsung seperti Hyperinsulinemic Euglycemic Clamp (HIEC) dan metode tidak langsung seperti HOMA-IR, QUICKI, dan Indeks TyG. Metode langsung memberikan hasil yang sangat akurat, namun membutuhkan fasilitas dan prosedur yang kompleks, sedangkan metode tidak langsung menawarkan alternatif praktis dengan tingkat prediksi yang baik. Selain itu, indeks pengganti berbasis biomarker seperti adiponektin dan leptin terus dikembangkan untuk meningkatkan efisiensi diagnosis. Studi ini menekankan pentingnya pemilihan metode yang tepat sesuai kebutuhan klinis atau penelitian untuk deteksi resistansi insulin yang lebih efektif.
Correlation between De Ritis Ratio with Severity of Covid-19 Patients Severity Rostini, Tiene; Khairunnissa, Khairunnissa; Turbawaty, Dewi Kartika
Jurnal Kedokteran Brawijaya Vol. 33 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2024.033.02.14

Abstract

SARS COV-2 is the causative agent of the infectious disease Corona Virus Illness-19 (Covid-19). Covid-19 can cause damage to multiple organs, including the liver. The de Ritis ratio is a ratio between AST and ALT in blood serum, which may be a useful indicator for assessing liver damage in Covid-19 patients. The aim of this study is to determine the association between the severity of liver injury and an increase in the de Ritis ratio in Covid-19. The study population included patients with acute Covid-19 disease whose infection was validated using real-time PCR. A retrospective cross-sectional study was conducted.  There were 1.983 subjects included, and 1.123 belonged to the moderate, 673 severe, and 181 to the critical groups. Calculations using Spearman rank revealed a strong significant association between De Ritis ratio and Covid-19 grade severity (rs=0.624, p<0.001). The more severe Covid-19, the higher de Ritis ratio values. The ROC curve of de Ritis ratio with Covid-19 severity shows AUC of 0.771 (P<0.001), sensitivity of 63.5%, specificity of 90.6%, PPV of 98.5% and an NPV of 20.02%. In conclusion, the severity of Covid-19 symptoms increases proportionally with the de Ritis ratio.
Correlation Between P-Selectin Level and Platelet Aggregation in Cerebral Venous Sinus Thrombosis Patients Nurmin, Rahmawati; Lismayanti, Leni; Rostini, Tiene; Indrati, Agnes Rengga; Amalia, Lisda
Majalah Kedokteran Bandung Vol 55, No 3 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n3.2777

Abstract

One of the causes of cerebral venous sinus thrombosis (CVST) is platelet hyperactivity. Adhesion and secretion are the beginning of platelet activation, which is indicated by a change in the Platelet-selectin (P-selectin) level. The end result of platelet activation is platelet aggregation. However, it is unknown whether the beginning of platelet activation ends with platelet aggregation. This study aimed to discover the correlation between P-selectin level and platelet aggregation in CVST. This study used a cross-sectional escriptive observational correlative approach. Subjects were the CVST outpatients visiting the Neurology Department of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, from July to September 2021. A total of 49 subjects met the inclusion and exclusion criteria. This study used citrate plasma samples for platelet aggregation and serum for P-selectin assessment. Platelet aggregation were assessed using the light transmission platelet aggregation method while P-selectin was assessed using Enzyme-linked immunosorbent assay (ELISA). Platelet aggregation median was 10.6% (range 0.2–82.4%), which reflected normoaggregation. Platelet hyperaggregation were seen in 9 samples (8.4%). Median of P-selectin was 2.4 ng/mL (range 0.1–10.1 ng/mL) which were normal. High P-selectin level was observed in 16 (32.7%) with 4/16 (25%) experiencing platelet hyperaggregation. Statistical analysis showed a weak negative correlation between P-selectin and platelet aggregation (r=-0.012; p=0.467). In conclusion, no correlation is seen between P-selectin and platelet aggregation, which may be due to the fact that platelets are influenced by many factors that are not examined in this study.
Co-Authors Agnes Rengga Indrati Anna Tjandrawati Arto Yuwono Astuti, Yunita Puji Coriejati Rita David Rustandi Delita Prihatni Dewi Kartika Turbawaty Dewi Nurhayati Fatya Annisa Haryandini Fatya Annisa Haryandini, Fatya Annisa Fiva Aprillia Kadi Hartanto Bayuaji Ida Parwati Istriati Istriati Jane Haryanto Justine Sim Wei Yang Kadi, Fiva Aprillia Khairunnissa, Khairunnissa Kurnia Pramono, Laila Leni Lismayanti Lisda Amalia Muhammad Alamsyah Mulya Harahap, Raja Iqbal Mustari, Asri Dini Namira Bening Nurani neli sumanti Nida Suraya Nida Suraya Nina Tristina Noormartany Novi Vicahyani Utami Nurani, Namira Bening Nurmin, Rahmawati Pujiyanti, Hapsari Raja Iqbal Mulya Harahap Rita Rachmayanti Rizki Andriyani Ryan Bayusantika Sylvia Rachmayati Towifah Fauziah Choerunisa Yunita Puji Astuti